Personal profile
Research interests
One focus of my research is to test whether our chimeric suicide gene (CD34-TK) can be used to separate the life-threatening development of graft-versus-host disease from the beneficial graft-versus-leukemia effect after allogeneic hematopoietic stem cell transplantation. The CD34-TK gene consists of a HSV thymidine kinase fused to the extracellular and transmembrane domains of CD34. A second focus of my research is to characterize the quantity, phenotype and function of human T lymphocytes, CD34+ hematopoietic stem cells (HSCs) and acute myeloid leukemia stem cells (LSCs) in the peripheral blood before and after treatment of normal donors or leukemic patients with granulocyte colony stimulating factor (G-CSF) or the CXCR4 antagonist, AMD3100. Egress (mobilization) of HSCs and LSCs from the bone marrow to the peripheral blood can be induced by cytokines like G-CSF or by small molecule inhibitors of CXCR4 like AMD3100. AMD3100 is the most promising mobilizing agent currently in clinical development.
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma
Immune Atlas Consortium, Jan 2026, In: Nature Cancer. 7, 1, p. 224-246 23 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
Itacitinib for prevention of graft-versus-host disease and cytokine release syndrome in haploidentical transplantation
Abboud, R., Schroeder, M. A., Rettig, M. P., Jayasinghe, R. G., Gao, F., Eisele, J., Gehrs, L., Ritchey, J., Choi, J., Abboud, C. N., Pusic, I., Jacoby, M., Westervelt, P., Christopher, M., Cashen, A., Ghobadi, A., Stockerl-Goldstein, K., Uy, G. L. & DiPersio, J. F., Mar 27 2025, In: Blood. 145, 13, p. 1382-1394 13 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Link opens in a new tab Scopus citations -
Phase 1/2 trial of anti-CD7 allogeneic WU-CART-007 for patients with relapsed/refractory T-cell malignancies
Ghobadi, A., Aldoss, I., Maude, S. L., Bhojwani, D., Wayne, A. S., Bajel, A., Dholaria, B., Faramand, R., Mattison, R. J., Rijneveld, A., Zwaan, C. M., Calkoen, F., Baruchel, A., Boissel, N., Rettig, M., Wood, B., Jacobs, K., Christ, S., Irons, H. & Capoccia, B. & 13 others, , Sep 4 2025, In: Blood. 146, 10, p. 1163-1173 11 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Link opens in a new tab Scopus citations -
A simplified G-CSF–free procedure allows for in vivo HSC gene therapy of sickle cell disease in a mouse model
Li, C., Anderson, A. K., Ruminski, P., Rettig, M., Karpova, D., Kiem, H. P., DiPersio, J. F. & Lieber, A., Aug 13 2024, In: Blood Advances. 8, 15, p. 4089-4101 13 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Link opens in a new tab Scopus citations -
Blinatumomab consolidation post–autologous stem cell transplantation in patients with diffuse large B-cell lymphoma
Ghobadi, A., Foley, N. C., Cohen, J., Rettig, M. P., Cashen, A. F., Gehrs, L., Christ, S., Street, E., Wallace, N., Ritchey, J., Mehta-Shah, N., Westervelt, P., Fehniger, T. A., Kahl, B., Bartlett, N. L. & DiPersio, J. F., Feb 13 2024, In: Blood Advances. 8, 3, p. 513-522 10 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Link opens in a new tab Scopus citations