Michael Province

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Michael Province

Professor of Genetics, Professor of Biostatistics

 https://orcid.org/0000-0001-6102-774X

    Willing to Mentor

    Available to Mentor:

    PhD/MSTP Students

    • 39645
      Citations
    1980 …2023

    Research activity per year

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    Search results

    • 2011

      Chromosome 9p21 haplotypes and prognosis in white and black patients with coronary artery disease

      Gong, Y., Beitelshees, A. L., Cooper-DeHoff, R. M., Lobmeyer, M. T., Langaee, T. Y., Wu, J., Cresci, S., Province, M. A., Spertus, J. A., Pepine, C. J. & Johnson, J. A., Apr 2011, In: Circulation: Cardiovascular Genetics. 4, 2, p. 169-178 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      26 Scopus citations

    • Do gender, disability, and morbidity affect aging rate in the LLFS? Application of indices of cumulative deficits

      Kulminski, A. M., Arbeev, K. G., Christensen, K., Mayeux, R., Newman, A. B., Province, M. A., Hadley, E. C., Rossi, W., Perls, T. T., Elo, I. T. & Yashin, A. I., Apr 2011, In: Mechanisms of Ageing and Development. 132, 4, p. 195-201 7 p.

      Research output: Contribution to journal › Article › peer-review

      18 Scopus citations

    • Five blood pressure loci identified by an updated genome-wide linkage scan: Meta-analysis of the family blood pressure program

      Simino, J., Shi, G., Kume, R., Schwander, K., Province, M. A., Gu, C. C., Kardia, S., Chakravarti, A., Ehret, G., Olshen, R. A., Turner, S. T., Ho, L. T., Zhu, X., Jaquish, C., Paltoo, D., Cooper, R. S., Weder, A., Curb, J. D., Boerwinkle, E., Hunt, S. C., & 1 othersRao, D. C., Mar 2011, In: American Journal of Hypertension. 24, 3, p. 347-354 8 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      16 Scopus citations

    • Genetics of hypertension and cardiovascular disease and their interconnected pathways: Lessons from large studies

      Kraja, A. T., Hunt, S. C., Rao, D. C., Dávila-Román, V. G., Arnett, D. K. & Province, M. A., Feb 2011, In: Current Hypertension Reports. 13, 1, p. 46-54 9 p.

      Research output: Contribution to journal › Article › peer-review

      28 Scopus citations

    • Genomewide analysis of inherited variation associated with phosphorylation of PI3K/AKT/mTOR signaling proteins

      Hutz, J. E., Manning, W. A., Province, M. A. & McLeod, H. L., Sep 19 2011, In: PloS one. 6, 9, e24873.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      8 Scopus citations

    • Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits

      GIANT Consortium, Global BPgen Consortium, NASH CRN, GIANT Consortium, MAGIC Investigators, GOLD Consortium, MAGIC, on behalf of Procardis Consortium & DIAGRAM Consortium, Mar 1 2011, In: PLoS genetics. 7, 3, e1001324.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      693 Scopus citations

    • Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction

      Odonnell, C. J., Kavousi, M., Smith, A. V., Kardia, S. L. R., Feitosa, M. F., Hwang, S. J., Sun, Y. V., Province, M. A., Aspelund, T., Dehghan, A., Hoffmann, U., Bielak, L. F., Zhang, Q., Eiriksdottir, G., Van Duijn, C. M., Fox, C. S., De Andrade, M., Kraja, A. T., Sigurdsson, S., Elias-Smale, S. E., & 47 othersMurabito, J. M., Launer, L. J., Van Der Lugt, A., Kathiresan, S., Krestin, G. P., Herrington, D. M., Howard, T. D., Liu, Y., Post, W., Mitchell, B. D., Oconnell, J. R., Shen, H., Shuldiner, A. R., Altshuler, D., Elosua, R., Salomaa, V., Schwartz, S. M., Siscovick, D. S., Voight, B. F., Bis, J. C., Glazer, N. L., Psaty, B. M., Boerwinkle, E., Heiss, G., Blankenberg, S., Zeller, T., Wild, P. S., Schnabel, R. B., Schillert, A., Ziegler, A., Münzel, T. F., White, C. C., Rotter, J. I., Nalls, M., Oudkerk, M., Johnson, A. D., Newman, A. B., Uitterlinden, A. G., Massaro, J. M., Cunningham, J., Harris, T. B., Hofman, A., Peyser, P. A., Borecki, I. B., Cupples, L. A., Gudnason, V. & Witteman, J. C. M., Dec 20 2011, In: Circulation. 124, 25, p. 2855-2864 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      223 Scopus citations

    • Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

      Alcohol Genome-wide Association (AlcGen) Consortium; Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study; Genetic Investigation of Anthropometric Traits (GIANT) Consortium; Global Lipids Genetics Consortium; Genetics of Liver Disease (GOLD) Consortium; International Consortium for Blood Pressure (ICBP-GWAS); Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC) & Collaborators, Nov 1 2011, In: Nature Genetics. 43, 11, p. 1131-1138 8 p.

      Research output: Contribution to journal › Article › peer-review

      404 Scopus citations

    • Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

      Lifelines Cohort Study, EchoGen consortium, AortaGen Consortium, CHARGE Consortium Heart Failure Working Group, KidneyGen Consortium & CKDGen consortium; Cardiogenics consortium; CardioGram, Oct 1 2011, In: Nature Genetics. 43, 10, p. 1005-1012 8 p.

      Research output: Contribution to journal › Article › peer-review

      340 Scopus citations

    • Meta-analysis of gene-environment interaction: Joint estimation of SNP and SNP × environment regression coefficients

      Manning, A. K., LaValley, M., Liu, C. T., Rice, K., An, P., Liu, Y., Miljkovic, I., Rasmussen-Torvik, L., Harris, T. B., Province, M. A., Borecki, I. B., Florez, J. C., Meigs, J. B., Cupples, L. A. & Dupuis, J., Jan 2011, In: Genetic Epidemiology. 35, 1, p. 11-18 8 p.

      Research output: Contribution to journal › Article › peer-review

      124 Scopus citations

    • Methods for adjusting population structure and familial relatedness in association test for collective effect of multiple rare variants on quantitative traits

      Zhang, Q., Chung, D., Kraja, A., Borecki, I. I. & Province, M. A., 2011, In: BMC Proceedings. 5, SUPPL. 9, S35.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      5 Scopus citations

    • Peroxisome proliferator-activated receptor pathway gene polymorphism associated with extent of coronary artery disease in patients with type 2 diabetes in the bypass angioplasty revascularization investigation 2 diabetes trial

      Cresci, S., Wu, J., Province, M. A., Spertus, J. A., Steffes, M., McGill, J. B., Alderman, E. L., Brooks, M. M., Kelsey, S. F., Frye, R. L. & Bach, R. G., Sep 27 2011, In: Circulation. 124, 13, p. 1426-1434 9 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      23 Scopus citations

    • Pharmacogenomic characterization of US FDA-approved cytotoxic drugs

      Peters, E. J., Motsinger-Reif, A., Havener, T. M., Everitt, L., Hardison, N. E., Watson, V. G., Wagner, M., Richards, K. L., Province, M. A. & McLeod, H. L., Oct 2011, In: Pharmacogenomics. 12, 10, p. 1407-1415 9 p.

      Research output: Contribution to journal › Article › peer-review

      38 Scopus citations

    • Response to letter regarding article "chromosome 9p21 haplotypes and prognosis in white and black patients with coronary artery disease"

      Gong, Y., Beitelshees, A. L., Cooper-DeHoff, R. M., Lobmeyer, M. T., Langaee, T. Y., Wu, J., Cresci, S., Province, M. A., Spertus, J. A., Pepine, C. J. & Johnson, J. A., Aug 2011, In: Circulation: Cardiovascular Genetics. 4, 4, p. e12

      Research output: Contribution to journal › Letter › peer-review

    • 2010

      ADAM17_i33708A>G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the Genetics of Lipid Lowering Drugs and Diet Network study

      Junyent, M., Parnell, L. D., Lai, C. Q., Arnett, D. K., Tsai, M. Y., Kabagambe, E. K., Straka, R. J., Province, M., An, P., Smith, C. E., Lee, Y. C., Borecki, I. & Ordovás, J. M., Dec 2010, In: Nutrition, Metabolism and Cardiovascular Diseases. 20, 10, p. 698-705 8 p.

      Research output: Contribution to journal › Article › peer-review

      26 Scopus citations

    • Aromatase gene polymorphisms are associated with survival among patients with cardiovascular disease in a sex-specific manner

      Beitelshees, A. L., Johnson, J. A., Hames, M. L., Gong, Y., Cooper-Dehoff, R. M., Wu, J., Cresci, S., Ma, C. X., Pepine, C. J., Province, M. A., Spertus, J. A. & McLeod, H. L., 2010, In: PloS one. 5, 12, p. 1-6 6 p., e15180.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      27 Scopus citations

    • Avoiding the high bonferroni penalty in genome-wide association studies

      Gao, X., Becker, L. C., Becker, D. M., Starmer, J. D. & Province, M. A., Jan 2010, In: Genetic Epidemiology. 34, 1, p. 100-105 6 p.

      Research output: Contribution to journal › Article › peer-review

      230 Scopus citations

    • Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Nature Genetics (2010) 42 (105-116))

      Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U., Wheeler, E., Glazer, N. L., Bouatia-Naji, N., Gloyn, A. L., Lindgren, C. M., Mägi, R., Morris, A. P., Randall, J., Johnson, T., Elliott, P., Rybin, D., Thorleifsson, G., Steinthorsdottir, V., Henneman, P., & 287 othersGrallert, H., Dehghan, A., Hottenga, J. J., Franklin, C. S., Navarro, P., Song, K., Goel, A., Perry, J. R. B., Egan, J. M., Lajunen, T., Grarup, N., Sparsø, T., Doney, A., Voight, B. F., Stringham, H. M., Li, M., Kanoni, S., Shrader, P., Cavalcanti-Proença, C., Kumari, M., Qi, L., Timpson, N. J., Gieger, C., Zabena, C., Rocheleau, G., Ingelsson, E., An, P., O'Connell, J., Luan, JA., Elliott, A., McCarroll, S. A., Payne, F., Roccasecca, R. M., Pattou, F., Sethupathy, P., Ardlie, K., Ariyurek, Y., Balkau, B., Barter, P., Beilby, J. P., Ben-Shlomo, Y., Benediktsson, R., Bennett, A. J., Bergmann, S., Bochud, M., Boerwinkle, E., Bonnefond, A., Bonnycastle, L. L., Borch-Johnsen, K., Böttcher, Y., Brunner, E., Bumpstead, S. J., Charpentier, G., Chen, Y. D. I., Chines, P., Clarke, R., Coin, L. J. M., Cooper, M. N., Cornelis, M., Crawford, G., Crisponi, L., Day, I. N. M., De Geus, E. J. C., Delplanque, J., Dina, C., Erdos, M. R., Fedson, A. C., Fischer-Rosinsky, A., Forouhi, N. G., Fox, C. S., Frants, R., Franzosi, M. G., Galan, P., Goodarzi, M. O., Graessler, J., Groves, C. J., Grundy, S., Gwilliam, R., Gyllensten, U., Hadjadj, S., Hallmans, G., Hammond, N., Han, X., Hartikainen, A. L., Hassanali, N., Hayward, C., Heath, S. C., Hercberg, S., Herder, C., Hicks, A. A., Hillman, D. R., Hingorani, A. D., Hofman, A., Hui, J., Hung, J., Isomaa, B., Johnson, P. R. V., Jørgensen, T., Jula, A., Kaakinen, M., Kaprio, J., Kesaniemi, Y. A., Kivimaki, M., Knight, B., Koskinen, S., Kovacs, P., Kyvik, K. O., Lathrop, G. M., Lawlor, D. A., Le Bacquer, O., Lecoeur, C., Li, Y., Lyssenko, V., Mahley, R., Mangino, M., Manning, A. K., Martínez-Larrad, M. T., McAteer, J. B., McCulloch, L. J., McPherson, R., Meisinger, C., Melzer, D., Meyre, D., Mitchell, B. D., Morken, M. A., Mukherjee, S., Naitza, S., Narisu, N., Neville, M. J., Oostra, B. A., Orr, M., Pakyz, R., Palmer, C. N. A., Paolisso, G., Pattaro, C., Pearson, D., Peden, J. F., Pedersen, N. L., Perola, M., Pfeiffer, A. F. H., Pichler, I., Polasek, O., Posthuma, D., Potter, S. C., Pouta, A., Province, M. A., Psaty, B. M., Rathmann, W., Rayner, N. W., Rice, K., Ripatti, S., Rivadeneira, F., Roden, M., Rolandsson, O., Sandbaek, A., Sandhu, M., Sanna, S., Sayer, A. A., Scheet, P., Scott, L. J., Seedorf, U., Sharp, S. J., Shields, B., Sigursson, G., Sijbrands, E. J. G., Silveira, A., Simpson, L., Singleton, A., Smith, N. L., Sovio, U., Swift, A., Syddall, H., Syvänen, A. C., Tanaka, T., Thorand, B., Tichet, J., Tönjes, A., Tuomi, T., Uitterlinden, A. G., Van Dijk, K. W., Van Hoek, M., Varma, D., Visvikis-Siest, S., Vitart, V., Vogelzangs, N., Waeber, G., Wagner, P. J., Walley, A., Walters, G. B., Ward, K. L., Watkins, H., Weedon, M. N., Wild, S. H., Willemsen, G., Witteman, J. C. M., Yarnell, J. W. G., Zeggini, E., Zelenika, D., Zethelius, B., Zhai, G., Zhao, J. H., Zillikens, M. C., Consortium, D., Consortium, G., Consortium, G. B., Borecki, I. B., Loos, R. J. F., Meneton, P., Magnusson, P. K. E., Nathan, D. M., Williams, G. H., Hattersley, A. T., Silander, K., Salomaa, V., Smith, G. D., Bornstein, S. R., Schwarz, P., Spranger, J., Karpe, F., Shuldiner, A. R., Cooper, C., Dedoussis, G. V., Serrano-Ríos, M., Morris, A. D., Lind, L., Palmer, L. J., Hu, F. B., Franks, P. W., Ebrahim, S., Marmot, M., Kao, W. H. L., Pankow, J. S., Sampson, M. J., Kuusisto, J., Laakso, M., Hansen, T., Pedersen, O., Pramstaller, P. P., Wichmann, H. E., Illig, T., Rudan, I., Wright, A. F., Stumvoll, M., Campbell, H., Wilson, J. F., Hamsten, A., Bergman, R. N., Buchanan, T. A., Collins, F. S., Mohlke, K. L., Tuomilehto, J., Valle, T. T., Altshuler, D., Rotter, J. I., Siscovick, D. S., Penninx, B. W. J. H., Boomsma, D. I., Deloukas, P., Spector, T. D., Frayling, T. M., Ferrucci, L., Kong, A., Thorsteinsdottir, U., Stefansson, K., Van Duijn, C. M., Aulchenko, Y. S., Cao, A., Scuteri, A., Schlessinger, D., Uda, M., Ruokonen, A., Jarvelin, M. R., Waterworth, D. M., Vollenweider, P., Peltonen, L., Mooser, V., Abecasis, G. R., Wareham, N. J., Sladek, R., Froguel, P., Watanabe, R. M., Meigs, J. B., Groop, L., Boehnke, M., McCarthy, M. I., Florez, J. C. & Barroso, I., May 2010, In: Nature Genetics. 42, 5, p. 464 1 p.

      Research output: Contribution to journal › Comment/debate

      Open Access
      14 Scopus citations

    • Fenofibrate and metabolic syndrome

      Kraja, A. T., Province, M. A., Straka, R. J., Ordovas, J. M., Borecki, I. B. & Arnett, D. K., 2010, In: Endocrine, Metabolic and Immune Disorders - Drug Targets. 10, 2, p. 138-148 11 p.

      Research output: Contribution to journal › Article › peer-review

      33 Scopus citations

    • Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology

      Levy, D., Neuhausen, S. L., Hunt, S. C., Kimura, M., Hwang, S. J., Chen, W., Bis, J. C., Fitzpatrick, A. L., Smith, E., Johnson, A. D., Gardner, J. P., Srinivasan, S. R., Schork, N., Rotter, J. I., Herbig, U., Psaty, B. M., Sastrasinh, M., Murray, S. S., Vasan, R. S., Province, M. A., & 9 othersGlazer, N. L., Lu, X., Cao, X., Kronmal, R., Mangino, M., Soranzo, N., Spector, T. D., Berenson, G. S. & Aviv, A., May 18 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 20, p. 9293-9298 6 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      213 Scopus citations

    • Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists

      Johnson, A. D., Yanek, L. R., Chen, M. H., Faraday, N., Larson, M. G., Tofler, G., Lin, S. J., Kraja, A. T., Province, M. A., Yang, Q., Becker, D. M., O'Donnell, C. J. & Becker, L. C., Jul 2010, In: Nature Genetics. 42, 7, p. 608-613 6 p.

      Research output: Contribution to journal › Article › peer-review

      208 Scopus citations

    • High-throughput discovery of rare insertions and deletions in large cohorts

      Vallania, F. L. M., Druley, T. E., Ramos, E., Wang, J., Borecki, I., Province, M. & Mitra, R. D., Dec 2010, In: Genome research. 20, 12, p. 1711-1718 8 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      44 Scopus citations

    • Hundreds of variants clustered in genomic loci and biological pathways affect human height

      Allen, H. L., Estrada, K., Lettre, G., Berndt, S. I., Weedon, M. N., Rivadeneira, F., Willer, C. J., Jackson, A. U., Vedantam, S., Raychaudhuri, S., Ferreira, T., Wood, A. R., Weyant, R. J., Segrè, A. V., Speliotes, E. K., Wheeler, E., Soranzo, N., Park, J. H., Yang, J., Gudbjartsson, D., & 273 othersHeard-Costa, N. L., Randall, J. C., Qi, L., Smith, A. V., Mägi, R., Pastinen, T., Liang, L., Heid, I. M., Luan, JA., Thorleifsson, G., Winkler, T. W., Goddard, M. E., Lo, K. S., Palmer, C., Workalemahu, T., Aulchenko, Y. S., Johansson, Å., Zillikens, M. C., Feitosa, M. F., Esko, T., Johnson, T., Ketkar, S., Kraft, P., Mangino, M., Prokopenko, I., Absher, D., Albrecht, E., Ernst, F., Glazer, N. L., Hayward, C., Hottenga, J. J., Jacobs, K. B., Knowles, J. W., Kutalik, Z., Monda, K. L., Polasek, O., Preuss, M., Rayner, N. W., Robertson, N. R., Steinthorsdottir, V., Tyrer, J. P., Voight, B. F., Wiklund, F., Xu, J., Zhao, J. H., Nyholt, D. R., Pellikka, N., Perola, M., Perry, J. B., Surakka, I., Tammesoo, M. L., Altmaier, E. L., Amin, N., Aspelund, T., Bhangale, T., Boucher, G., Chasman, D. I., Chen, C., Coin, L., Cooper, M. N., Dixon, A. L., Gibson, Q., Grundberg, E., Hao, K., Junttila, M. J., Kaplan, L. M., Kettunen, J., König, I. R., Kwan, T., Lawrence, R. W., Levinson, D. F., Lorentzon, M., McKnight, B., Morris, A. P., Müller, M., Ngwa, J. S., Purcell, S., Rafelt, S., Salem, R. M., Salvi, E., Sanna, S., Shi, J., Sovio, U., Thompson, J. R., Turchin, M. C., Vandenput, L., Verlaan, D. J., Vitart, V., White, C. C., Ziegler, A., Almgren, P., Balmforth, A. J., Campbell, H., Citterio, L., De Grandi, A., Dominiczak, A., Duan, J., Elliott, P., Elosua, R., Eriksson, J. G., Freimer, N. B., Geus, E. J. C., Glorioso, N., Haiqing, S., Hartikainen, A. L., Havulinna, A. S., Hicks, A. A., Hui, J., Igl, W., Illig, T., Jula, A., Kajantie, E., Kilpeläinen, T. O., Koiranen, M., Kolcic, I., Koskinen, S., Kovacs, P., Laitinen, J., Liu, J., Lokki, M. L., Marusic, A., Maschio, A., Meitinger, T., Mulas, A., Paré, G., Parker, A. N., Peden, J. F., Petersmann, A., Pichler, I., Pietiläinen, K. H., Pouta, A., Ridderstråle, M., Rotter, J. I., Sambrook, J. G., Sanders, A. R., Schmidt, C. O., Sinisalo, J., Smit, J. H., Stringham, H. M., Walters, G. B., Widen, E., Wild, S. H., Willemsen, G., Zagato, L., Zgaga, L., Zitting, P., Alavere, H., Farrall, M., McArdle, W. L., Nelis, M., Peters, M. J., Ripatti, S., Van Meurs, J. B. J., Aben, K. K., Ardlie, K. G., Beckmann, J. S., Beilby, J. P., Bergman, R. N., Bergmann, S., Collins, F. S., Cusi, D., Den Heijer, M., Eiriksdottir, G., Gejman, P. V., Hall, A. S., Hamsten, A., Huikuri, H. V., Iribarren, C., Kähönen, M., Kaprio, J., Kathiresan, S., Kiemeney, L., Kocher, T., Launer, L. J., Lehtimäki, T., Melander, O., Mosley, T. H., Musk, A. W., Nieminen, M. S., O'Donnell, C. J., Ohlsson, C., Oostra, B., Palmer, L. J., Raitakari, O., Ridker, P. M., Rioux, J. D., Rissanen, A., Rivolta, C., Schunkert, H., Shuldiner, A. R., Siscovick, D. S., Stumvoll, M., Tönjes, A., Tuomilehto, J., Van Ommen, G. J., Viikari, J., Heath, A. C., Martin, N. G., Montgomery, G. W., Province, M. A., Kayser, M., Arnold, A. M., D.Atwood, L., Boerwinkle, E., Chanock, S. J., Deloukas, P., Gieger, C., Grönberg, H., Hall, P., Hattersley, A. T., Hengstenberg, C., Hoffman, W., Lathrop, G. M., Salomaa, V., Schreiber, S., Uda, M., Waterworth, D., Wright, A. F., Assimes, T. L., Barroso, I., Hofman, A., Mohlke, K. L., Boomsma, D. I., Caulfield, M. J., Cupples, L. A., Erdmann, J., Fox, C. S., Gudnason, V., Gyllensten, U., Harris, T. B., Hayes, R. B., Jarvelin, M. R., Mooser, V., Munroe, P. B., Ouwehand, W. H., Penninx, B. W., Pramstaller, P. P., Quertermous, T., Rudan, I., Samani, N. J., Spector, T. D., Völzke, H., Watkins, H., Wilson, J. F., Groop, L. C., Haritunians, T., Hu, F. B., Kaplan, R. C., Metspalu, A., North, K. E., Schlessinger, D., Wareham, N. J., Hunter, D. J., O'Connell, J. R., Strachan, D. P., Wichmann, H. E., Borecki, I. B., Van Duijn, C. M., Schadt, E. E., Thorsteinsdottir, U., Peltonen, L., Uitterlinden, A. G., Visscher, P. M., Chatterjee, N., Loos, R. J. F., Boehnke, M., McCarthy, M. I., Ingelsson, E., Lindgren, C. M., Abecasis, G. R., Stefansson, K., Frayling, T. M. & Hirschhorn, J. N., Oct 14 2010, In: Nature. 467, 7317, p. 832-838 7 p.

      Research output: Contribution to journal › Article › peer-review

      1471 Scopus citations

    • Interaction between the UCP2 -866 G>A polymorphism, diabetes, and β-blocker use among patients with acute coronary syndromes

      Beitelshees, A. L., Finck, B. N., Leone, T. C., Cresci, S., Wu, J., Province, M. A., Fabbrini, E., Kirk, E., Zineh, I., Klein, S., Spertus, J. A. & Kelly, D. R., Apr 2010, In: Pharmacogenetics and Genomics. 20, 4, p. 231-238 8 p.

      Research output: Contribution to journal › Article › peer-review

      12 Scopus citations

    • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

      Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U., Wheeler, E., Glazer, N. L., Bouatia-Naji, N., Gloyn, A. L., Lindgren, C. M., Mägi, R., Morris, A. P., Randall, J., Johnson, T., Elliott, P., Rybin, D., Thorleifsson, G., Steinthorsdottir, V., Henneman, P., & 283 othersGrallert, H., Dehghan, A., JanHottenga, J., Franklin, C. S., Navarro, P., Song, K., Goel, A., Perry, J. R. B., Egan, J. M., Lajunen, T., Grarup, N., Sparsø, T., Doney, A., Voight, B. F., Stringham, H. M., Li, M., Kanoni, S., Shrader, P., Cavalcanti-Proença, C., Kumari, M., Qi, L., Timpson, N. J., Gieger, C., Zabena, C., Rocheleau, G., Ingelsson, E., An, P., O'Connell, J., Luan, JA., Elliott, A., McCarroll, S. A., Payne, F., Roccasecca, R. M., Pattou, F., Sethupathy, P., Ardlie, K., Ariyurek, Y., Balkau, B., Barter, P., Beilby, J. P., Ben-Shlomo, Y., Benediktsson, R., Bennett, A. J., Bergmann, S., Bochud, M., Boerwinkle, E., Bonnefond, A., Bonnycastle, L. L., Borch-Johnsen, K., Böttcher, Y., Brunner, E., Bumpstead, S. J., Charpentier, G., Der IdaChen, Y., Chines, P., Clarke, R., McOin, L. J., Cooper, M. N., Cornelis, M., Crawford, G., Crisponi, L., Day, I. N. M., De Geus, E. J. C., Delplanque, J., Dina, C., Erdos, M. R., Fedson, A. C., Fischer-Rosinsky, A., Forouhi, N. G., Fox, C. S., Frants, R., GraziaFranzosi, M., Galan, P., Goodarzi, M. O., Graessler, J., Groves, C. J., Grundy, S., Gwilliam, R., Gyllensten, U., Hadjadj, S., Hallmans, G., Hammond, N., Han, X., -LiisaHartikainen, A., Hassanali, N., Hayward, C., Heath, S. C., Hercberg, S., Herder, C., Hicks, A. A., Hillman, D. R., Hingorani, A. D., Hofman, A., Hui, J., Hung, J., Isomaa, B., Johnson, P. R. V., Jørgensen, T., Jula, A., Kaakinen, M., Kaprio, J., AnteroKesaniemi, Y., Kivimaki, M., Knight, B., Koskinen, S., Kovacs, P., Kyvik, K. O., Lathrop, G. M., Lawlor, D. A., Bacquer, O. L., Lecoeur, C., Li, Y., Lyssenko, V., Mahley, R., Mangino, M., Manning, A. K., TeresaMartínez-Larrad, M., McAteer, J. B., McCulloch, L. J., McPherson, R., Meisinger, C., Melzer, D., Meyre, D., Mitchell, B. D., Morken, M. A., Mukherjee, S., Naitza, S., Narisu, N., Neville, M. J., Oostra, B. A., Orrù, M., Pakyz, R., APalmer, C. N., Paolisso, G., Pattaro, C., Pearson, D., Peden, J. F., Pedersen, N. L., Perola, M., Pfeiffer, A. F. H., Pichler, I., Polasek, O., Posthuma, D., Potter, S. C., Pouta, A., Province, M. A., Psaty, B. M., Rathmann, W., Rayner, N. W., Rice, K., Ripatti, S., Rivadeneira, F., Roden, M., Rolandsson, O., Sandbaek, A., Sandhu, M., Sanna, S., Sayer, A. A., Scheet, P., Scott, L. J., Seedorf, U., Sharp, S. J., Shields, B., Sigursson, G., Sijbrands, E. J. G., Silveira, A., Simpson, L., Singleton, A., Smith, N. L., Sovio, U., Swift, A., Syddall, H., -ChristineSyvänen, A., Tanaka, T., Thorand, B., Tichet, J., Tönjes, A., Tuomi, T., Uitterlinden, A. G., Van Dijk, K. W., Hoek, M. V., Varma, D., Visvikis-Siest, S., Vitart, V., Vogelzangs, N., Waeber, G., Wagner, P. J., Walley, A., BragiWalters, G., Ward, K. L., Watkins, H., Weedon, M. N., Wild, S. H., Willemsen, G., MWitteman, J. C., GYarnell, J. W., Zeggini, E., Zelenika, D., Zethelius, B., Zhai, G., Zhao, J. H., Zillikens, M. C., Borecki, I. B., Loos, R. J. F., Meneton, P., Magnusson, P. K. E., Nathan, D. M., Williams, G. H., Hattersley, A. T., Silander, K., Salomaa, V., Smith, G. D., Bornstein, S. R., Schwarz, P., Spranger, J., Karpe, F., Shuldiner, A. R., Cooper, C., Dedoussis, G. V., Serrano-Ríos, M., Morris, A. D., Lind, L., Palmer, L. J., Hu, F. B., Franks, P. W., Ebrahim, S., Marmot, M., Linda Kao, W. H., Pankow, J. S., Sampson, M. J., Kuusisto, J., Laakso, M., Hansen, T., Pedersen, O., Pramstaller, P. P., Wichmann, H. E., Illig, T., Rudan, I., Wright, A. F., Stumvoll, M., Campbell, H., Wilson, J. F., Bergman, R. N., Buchanan, T. A., Collins, F. S., Mohlke, K. L., Tuomilehto, J., Valle, T. T., Altshuler, D., Rotter, J. I., Siscovick, D. S., Penninx, B. W. J. H., Boomsma, D. I., Deloukas, P., Spector, T. D., Frayling, T. M., Ferrucci, L., Kong, A., Thorsteinsdottir, U., Stefansson, K., Van Duijn, C. M., Aulchenko, Y. S., Cao, A., Scuteri, A., Schlessinger, D., Uda, M., Ruokonen, A., -RiittaJarvelin, M., Waterworth, D. M., Vollenweider, P., Peltonen, L., Mooser, V., Abecasis, G. R., Wareham, N. J., Sladek, R., Froguel, P., Watanabe, R. M., Meigs, J. B., Groop, L., Boehnke, M., McCarthy, M. I., Florez, J. C. & Barroso, I., Feb 2010, In: Nature Genetics. 42, 2, p. 105-116 12 p.

      Research output: Contribution to journal › Article › peer-review

      1652 Scopus citations

    • New loci associated with kidney function and chronic kidney disease

      Köttgen, A., Pattaro, C., Böger, C. A., Fuchsberger, C., Olden, M., Glazer, N. L., Parsa, A., Gao, X., Yang, Q., Smith, A. V., O'Connel, J. R., Li, M., Schmidt, H., Tanaka, T., Isaacs, A., Ketkar, S., Hwang, S. J., Johnson, A. D., Dehghan, A., Teumer, A., & 112 othersParé, G., Atkinson, E. J., Zeller, T., Lohman, K., Cornelis, M. C., Probst-Hensch, N. M., Kronenberg, F., Tönjes, A., Hayward, C., Aspelund, T., Eiriksdottir, G., Launer, L. J., Harris, T. B., Rampersaud, E., Mitchel, B. D., Arking, D. E., Boerwinkle, E., Struchalin, M., Cavalieri, M., Singleton, A., Giallauria, F., Metter, J., De Boer, I. H., Haritunians, T., Lumley, T., Siscovick, D., Psaty, B. M., CarolaZillikens, M., Oostra, B. A., Feitosa, M., Province, M., Andrade, M. D., Turner, S. T., Schillert, A., Ziegler, A., Wild, P. S., Schnabel, R. B., Wilde, S., Munzel, T. F., Leak, T. S., Illig, T., Klopp, N., Meisinger, C., Wichmann, H. E., Koenig, W., Zgaga, L., Zemunik, T., Kolcic, I., Minelli, C., Hu, F. B., Johansson, Å., Igl, W., Zaboli, G., Wild, S. H., Wright, A. F., Campbell, H., Ellinghaus, D., Schreiber, S., Aulchenko, Y. S., Felix, J. F., Rivadeneira, F., Uitterlinden, A. G., Hofman, A., Imboden, M., Nitsch, D., Brandstätter, A., Kollerits, B., Kedenko, L., Mägi, R., Stumvoll, M., Kovacs, P., Boban, M., Campbell, S., Endlich, K., Völzke, H., Kroemer, H. K., Nauck, M., Völker, U., Polasek, O., Vitart, V., Badola, S., Parker, A. N., Ridker, P. M., Kardia, S. L. R., Blankenberg, S., Liu, Y., Curhan, G. C., Franke, A., Rochat, T., Paulweber, B., Prokopenko, I., Wang, W., Gudnason, V., Shuldine, A. R., Coresh, J., Schmidt, R., Ferrucci, L., Shlipak, M. G., Van Duijn, C. M., Borecki, I., Krämer, B. K., Rudan, I., Gyllensten, U., Wilson, J. F., Witteman, J. C., Pramstaller, P. P., Rettig, R., Hastie, N., Chasman, D. I., Kao, W. H., Heid, I. M. & Fox, C. S., May 2010, In: Nature Genetics. 42, 5, p. 376-384 9 p.

      Research output: Contribution to journal › Article › peer-review

      627 Scopus citations

    • The effect of a novel intergenic polymorphism (rs11774572) on HDL-cholesterol concentrations depends on TaqIB polymorphism in the cholesterol ester transfer protein gene

      Junyent, M., Lee, Y. C., Smith, C. E., Arnett, D. K., Tsai, M. Y., Kabagambe, E. K., Straka, R. J., Province, M., An, P., Lai, C. Q., Parnell, L. D., Shen, J., Borecki, I. & Ordovas, J. M., Jan 2010, In: Nutrition, Metabolism and Cardiovascular Diseases. 20, 1, p. 34-40 7 p.

      Research output: Contribution to journal › Article › peer-review

      8 Scopus citations

    • The genetics of obesity and the metabolic syndrome

      Monda, K. L., North, K. E., Hunt, S. C., Rao, D. C., Province, M. A. & Kraja, A. T., 2010, In: Endocrine, Metabolic and Immune Disorders - Drug Targets. 10, 2, p. 86-108 23 p.

      Research output: Contribution to journal › Article › peer-review

      57 Scopus citations
    • 2009

      ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: The GOLDN study

      Warodomwichit, D., Shen, J., Arnett, D. K., Tsai, M. Y., Kabagambe, E. K., Peacock, J. M., Hixson, J. E., Straka, R. J., Province, M. A., An, P., Lai, C. Q., Parnell, L. D., Borecki, I. B. & Ordovas, J. M., Mar 2009, In: Obesity. 17, 3, p. 510-517 8 p.

      Research output: Contribution to journal › Article › peer-review

      71 Scopus citations

    • A family longevity selection score: Ranking sibships by their longevity, size, and availability for study

      Sebastiani, P., Hadley, E. C., Province, M., Christensen, K., Rossi, W., Perls, T. T. & Ash, A. S., Dec 2009, In: American journal of epidemiology. 170, 12, p. 1555-1562 8 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      94 Scopus citations

    • A QTL on 12q Influencing an inflammation marker and obesity in white women: The NHLBI family heart study

      Wu, J., Pankow, J. S., Tracy, R. P., North, K. E., Myers, R. H., Feitosa, M. E., Province, M. A. & Borecki, I. B., Mar 2009, In: Obesity. 17, 3, p. 525-531 7 p.

      Research output: Contribution to journal › Article › peer-review

      11 Scopus citations

    • Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states

      Perez-Martinez, P., Corella, D., Shen, J., Arnett, D. K., Yiannakouris, N., Tai, E. S., Orho-Melander, M., Tucker, K. L., Tsai, M., Straka, R. J., Province, M., Chew, S. K., Perez-Jimenez, F., Lai, C. Q., Lopez-Miranda, J., Guillen, M., Parnell, L. D., Borecki, I., Kathiresan, S. & Ordovas, J. M., Jan 1 2009, In: American Journal of Clinical Nutrition. 89, 1, p. 391-399 9 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      50 Scopus citations

    • Association of thymidylate synthase variants with 5-fluorouracil cytotoxicity

      Peters, E. J., Kraja, A. T., Lin, S. J., Yen-Revollo, J. L., Marsh, S., Province, M. A. & McLeod, H. L., May 1 2009, In: Pharmacogenetics and Genomics. 19, 5, p. 399-401 3 p.

      Research output: Contribution to journal › Article › peer-review

      20 Scopus citations

    • CMDS: A population-based method for identifying recurrent DNA copy number aberrations in cancer from high-resolution data

      Zhang, Q., Ding, L., Larson, D. E., Koboldt, D. C., McLellan, M. D., Chen, K., Shi, X., Kraja, A., Mardis, E. R., Wilson, R. K., Borecki, I. B. & Province, M. A., Dec 23 2009, In: Bioinformatics. 26, 4, p. 464-469 6 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      52 Scopus citations

    • Genetic variants at the PDZ-interacting domain of the scavenger receptor class B type I interact with diet to influence the risk of metabolic syndrome in obese men and women

      Junyent, M., Arnett, D. K., Tsai, M. Y., Kabagambe, E. K., Straka, R. J., Province, M., An, P., Lai, C. Q., Parnell, L. D., Shen, J., Lee, Y. C., Borecki, I. & Ordovás, J. M., May 2009, In: Journal of Nutrition. 139, 5, p. 842-848 7 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      19 Scopus citations

    • Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute family heart study

      Ma, D., Feitosa, M. F., Wilk, J. B., Laramie, J. M., Yu, K., Leiendecker-Foster, C., Myers, R. H., Province, M. A. & Borecki, I. B., Mar 2009, In: Hypertension. 53, 3, p. 473-479 7 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      61 Scopus citations

    • LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion

      Feitosa, M. F., Myers, R. H., Pankow, J. S., Province, M. A. & Borecki, I. B., May 2009, In: Atherosclerosis. 204, 1, p. 171-177 7 p.

      Research output: Contribution to journal › Article › peer-review

      15 Scopus citations

    • Methods for analysis in pharmacogenomics: Lessons from the Pharmacogenetics Research Network Analysis group

      Srinivasan, B. S., Chen, J., Cheng, C., Conti, D., Duan, S., Fridley, B. L., Gu, X., Haines, J. L., Jorgenson, E., Kraja, A., Lasky-Su, J., Li, L., Rodin, A., Wang, D., Province, M. & Ritchie, M. D., 2009, In: Pharmacogenomics. 10, 2, p. 243-251 9 p.

      Research output: Contribution to journal › Article › peer-review

      10 Scopus citations

    • Multiple genes influence bmi on chromosome 7q31-34: The NHLBI family heart study

      Laramie, J. M., Wilk, J. B., Williamson, S. L., Nagle, M. W., Latourelle, J. C., Tobin, J. E., Province, M. A., Borecki, I. B. & Myers, R. H., Dec 2009, In: Obesity. 17, 12, p. 2182-2189 8 p.

      Research output: Contribution to journal › Article › peer-review

      15 Scopus citations

    • Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study

      Junyent, M., Parnell, L. D., Lai, C. Q., Lee, Y. C., Smith, C. E., Arnett, D. K., Tsai, M. Y., Kabagambe, E. K., Straka, R. J., Province, M., An, P., Borecki, I. & Ordovás, J. M., Sep 1 2009, In: American Journal of Clinical Nutrition. 90, 3, p. 686-694 9 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      21 Scopus citations

    • NRXN3Is a novel locus for waist circumference: A genome-wide association study from the CHARGE consortium

      Heard-Costa, N. L., Carola Zillikens, M., Monda, K. L., Johansson, Å., Harris, T. B., Fu, M., Haritunians, T., Feitosa, M. F., Aspelund, T., Eiriksdottir, G., Garcia, M., Launer, L. J., Smith, A. V., Mitchell, B. D., McArdle, P. F., Shuldiner, A. R., Bielinski, S. J., Boerwinkle, E., Brancati, F., Demerath, E. W., & 41 othersPankow, J. S., Arnold, A. M., Chen, Y. D. I., Glazer, N. L., McKnight, B., Psaty, B. M., Rotter, J. I., Amin, N., Campbell, H., Gyllensten, U., Pattaro, C., Pramstaller, P. P., Rudan, I., Struchalin, M., Vitart, V., Gao, X., Kraja, A., Province, M. A., Zhang, Q., Atwood, L. D., Dupuis, J., Hirschhorn, J. N., Jaquish, C. E., O'Donnell, C. J., Vasan, R. S., White, C. C., Aulchenko, Y. S., Estrada, K., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Witteman, J. C. M., Oostra, B. A., Kaplan, R. C., Gudnason, V., O'Connell, J. R., Borecki, I. B., Van Duijn, C. M., Cupples, L. A., Fox, C. S. & North, K. E., Jun 2009, In: PLoS genetics. 5, 6, e1000539.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      214 Scopus citations

    • Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: The genetics of lipid-lowering drugs and diet network study

      Liu, Y., Ordovas, J. M., Gao, G., Province, M., Straka, R. J., Tsai, M. Y., Lai, C. Q., Zhang, K., Borecki, I., Hixson, J. E., Allison, D. B. & Arnett, D. K., Feb 2009, In: Pharmacogenetics and Genomics. 19, 2, p. 161-169 9 p.

      Research output: Contribution to journal › Article › peer-review

      41 Scopus citations

    • Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemia

      Warodomwichit, D., Arnett, D. K., Kabagambe, E. K., Tsai, M. Y., Hixson, J. E., Straka, R. J., Province, M., An, P., Lai, C. Q., Borecki, I. & Ordovas, J. M., Mar 2009, In: Journal of Nutrition. 139, 3, p. 439-446 8 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      44 Scopus citations

    • The challenge of detecting epistasis (G x G interactions): Genetic analysis workshop 16

      An, P., Mukherjee, O., Chanda, P., Yao, L., Engelman, C. D., Huang, C. H., Zheng, T., Kovac, I. P., Dubé, M. P., Liang, X., Li, J., De Andrade, M., Culverhouse, R., Malzahn, D., Manning, A. K., Clarke, G. M., Jung, J. & Province, M. A., 2009, In: Genetic Epidemiology. 33, SUPPL. 1, p. S58-S67

      Research output: Contribution to journal › Article › peer-review

      15 Scopus citations

    • WDTC1, the ortholog of drosophila adipose gene, associates with human obesity, modulated by MUFA intake

      Lai, C. Q., Parnell, L. D., Arnett, D. K., García-Bailo, B., Tsai, M. Y., Kabagambe, E. K., Straka, R. J., Province, M. A., An, P., Borecki, I. B., Tucker, K. L. & Ordovás, J. M., Mar 2009, In: Obesity. 17, 3, p. 593-600 8 p.

      Research output: Contribution to journal › Article › peer-review

      28 Scopus citations
    • 2008

      Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response

      Shen, J., Arnett, D. K., Parnell, L. D., Peacock, J. M., Lai, C. Q., Hixson, J. E., Tsai, M. Y., Province, M. A., Straka, R. J. & Ordovas, J. M., May 2008, In: Diabetes care. 31, 5, p. 910-915 6 p.

      Research output: Contribution to journal › Article › peer-review

      40 Scopus citations

    • CANDID: A flexible method for prioritizing candidate genes for complex human traits

      Hutz, J. E., Kraja, A. T., McLeod, H. L. & Province, M. A., 2008, In: Genetic Epidemiology. 32, 8, p. 779-790 12 p.

      Research output: Contribution to journal › Article › peer-review

      64 Scopus citations

    • Epithelial neutrophil-activating peptide (ENA-78), acute coronary syndrome prognosis, and Modulatory effect of statins

      Zineh, I., Beitelshees, A. L., Welder, G. J., Hou, W., Chegini, N., Wu, J., Cresci, S., Province, M. A. & Spertus, J. A., Sep 3 2008, In: PloS one. 3, 9, e3117.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      29 Scopus citations

    • Gathering the gold dust: Methods for assessing the aggregate impact of small effect genes in genomic scans

      Province, M. A. & Borecki, I. B., 2008, Pacific Symposium on Biocomputing 2008, PSB 2008. p. 190-200 11 p. (Pacific Symposium on Biocomputing 2008, PSB 2008).

      Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

      15 Scopus citations

    • Genetic and genomic discovery using family studies

      Borecki, I. B. & Province, M. A., Sep 2 2008, In: Circulation. 118, 10, p. 1057-1063 7 p.

      Research output: Contribution to journal › Article › peer-review

      28 Scopus citations