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Michael Province

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Michael Province

Professor of Genetics, Professor of Biostatistics

 https://orcid.org/0000-0001-6102-774X

    Willing to Mentor

    Available to Mentor:

    PhD Students

    • 51380
      Citations
    1980 …2026

    Research activity per year

    Personal profile

    Research interests

    I am interested in the development and application of statistical genetics analysis methods for human complex traits and diseases. This includes gene discovery and validation in genomic scans (association, gene expression, and copy number), pathway analysis, and the design of family/genetic observational studies and clinical trials. I have developed growth curve pharmacogenetic models of treatment effect, Poisson-Process genetic models, frailty (age-at-onset) models, recursive partitioning genetic methods, meta-analysis procedures, and novel Sequential Multiple Decision Procedures to simultaneously identify all signals in a genome scan while controlling for overall type I and type II error rates. I have also developed a generalized systems biology model and program for performing multivariate and multilocus genetic analysis (SEGPATH). I am the PI (Coordinating Center) of several national, and international multicenter genetic studies, including the NHLBI Family Heart Study (heart disease genetics), the GOLDN Study (lipid pharmacogenetics), and the Long Life Family Study (longevity genetics).

    Available to Mentor:

    • PhD Students

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    • BioMedGraphica: an all-in-one platform for joint textual biomedical prior knowledge and numeric graph generation

      Zhang, H., Liang, S., Xu, T., Li, W., Huang, D., Dong, Y., Li, G., Miller, P., Goedegebuure, P., Sardiello, M., Cooper, J., Buchser, W., Dickson, P., Fields, R. C., Cruchaga, C., Chen, Y., Province, M., Payne, P. & Li, F., Jun 2026, In: Bioinformatics. 42, 6, btag355.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Finding Significant Hits in Networks: a network-based tool for analyzing gene-level P-values to identify significant genes missed by standard methods

      Acharya, S., Moghaddam, V. A., Jung, W. J., Kang, Y. S., Liao, S., Province, M. A. & Brent, M. R., Mar 1 2026, In: Briefings in Bioinformatics. 27, 2, bbag061.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants

      Noordam, R., Wang, W., Nagarajan, P., Wang, H., Brown, M. R., Bentley, A. R., Hui, Q., Kraja, A. T., Morrison, J. L., O'Connel, J. R., Lee, S., Schwander, K., Bartz, T. M., de las Fuentes, L., Feitosa, M. F., Guo, X., Hanfei, X., Harris, S. E., Huang, Z. & Kals, M. & 129 others, Lefevre, C., Mangino, M., Milaneschi, Y., van der Most, P. J., Pacheco, N. L., Palmer, N. D., Rao, V., Rauramaa, R., Sun, Q., Tabara, Y., Vojinovic, D., Wang, Y., Weiss, S., Yang, Q., Zhao, W., Zhu, W., Ansari, M. A. Y., Aschard, H., Anugu, P., Assimes, T. L., Attia, J., Baker, L. D., Ballantyne, C., Bazzano, L., Boerwinkle, E., Cade, B., Chen, H. H., Chen, W., Ida Chen, Y. D., Chen, Z., Cho, K., De Anda-Duran, I., Dimitrov, L., Do, A., Edwards, T., Faquih, T., Hingorani, A., Fisher-Hoch, S. P., Gaziano, J. M., Gharib, S. A., Giri, A., Ghanbari, M., Grabe, H. J., Graff, M., Charles Gu, C., He, J., Heikkinen, S., Hixson, J., Ho, Y. L., Hood, M. M., Houghton, S. C., Karvonen-Gutierrez, C. A., Kawaguchi, T., Kilpeläinen, T. O., Komulainen, P., Lin, H. J., Linchangco, G. V., Luik, A. I., Ma, J., Meigs, J. B., McCormick, J. B., Menni, C., Nolte, I. M., Norris, J. M., Petty, L. E., Polikowsky, H. G., Raffield, L. M., Rich, S. S., Riha, R. L., Russ, T. C., Ruiz-Narvaez, E. A., Sitlani, C. M., Smith, J. A., Snieder, H., Sofer, T., Shen, B., Tang, J., Taylor, K. D., Teder-Laving, M., Triatin, R., Tsai, M. Y., Völzke, H., Westerman, K. E., Xia, R., Yao, J., Young, K. L., Zhang, R., Zonderman, A. B., Zhu, X., Below, J. E., Cox, S. R., Evans, M., Fornage, M., Fox, E. R., Franceschini, N., Harlow, S. D., Holliday, E., Ikram, M. A., Kelly, T., Lakka, T. A., Lawlor, D. A., Li, C., Liu, C. T., Mägi, R., Manning, A. K., Matsuda, F., Morrison, A. C., Nauck, M., North, K. E., Penninx, B. W. J. H., Province, M. A., Psaty, B. M., Rotter, J. I., Spector, T. D., Wagenknecht, L. E., van Dijk, K. W., Jaquish, C. E., Wilson, P. W. F., Peyser, P. A., Munroe, P. B., de Vries, P. S., Gauderman, W. J., Sun, Y. V., Chen, H., Miller, C. L., Winkler, T. W., Rao, D. C., Redline, S. & van Heemst, D., Jan 2026, In: Atherosclerosis. 412, 120603.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      1   Link opens in a new tab Scopus citations

    • Large-scale blood pressure GWAS accounting for gene-depression interactions in 564,680 individuals from diverse populations

      Lee, S., Miller, C. L., Bentley, A. R., Brown, M. R., Nagarajan, P., Noordam, R., Morrison, J. L., Schwander, K., Westerman, K., Kho, M., Kraja, A. T., de Vries, P. S., Ammous, F., Aschard, H., Bartz, T. M., Do, A., Dupont, C. T., Feitosa, M. F., Gudmundsdottir, V. & Guo, X. & 129 others, Harris, S. E., Hikino, K., Huang, Z., Lefevre, C., Lyytikäinen, L. P., Milaneschi, Y., Nardone, G. G., Santin, A., Schmidt, H., Shen, B., Sofer, T., Sun, Q., Tan, Y. A., Tang, J., Thériault, S., van der Most, P. J., Ware, E. B., Weiss, S., Xing, W. Y., Yu, C., Zhao, W., Ansari, M. A. Y., Anugu, P., Attia, J. R., Bazzano, L. A., Bis, J. C., Breyer, M., Cade, B., Chen, G., Collins, S., Corley, J., Davies, G., Dörr, M., Du, J., Edwards, T. L., Faquih, T., Faul, J. D., Fohner, A. E., Fretts, A. M., Gangireddy, S., Gepner, A., Graff, M. E., Hofer, E., Homuth, G., Hood, M. M., Jie, X., Kähönen, M., Kardia, S. L. R., Karvonen-Gutierrez, C. A., Launer, L. J., Levy, D., Maheshwari, M., Martin, L. W., Matsuda, K., McNeil, J. J., Nolte, I. M., Okochi, T., Raffield, L. M., Raitakari, O. T., Risch, L., Risch, M., Roux, A. D., Ruiz-Narvaez, E. A., Russ, T. C., Saito, T., Schreiner, P. J., Scott, R. J., Shikany, J., Smith, J. A., Snieder, H., Spedicati, B., Tai, E. S., Taylor, A. M., Taylor, K. D., Tesolin, P., van Dam, R. M., Wang, R., Wenbin, W., Xie, T., Yao, J., Young, K. L., Zhang, R., Zonderman, A. B., Concas, M. P., Conen, D., Cox, S. R., Evans, M. K., Fox, E. R., de las Fuentes, L., Giri, A., Girotto, G., Grabe, H. J., Gu, C., Gudnason, V., Harlow, S. D., Holliday, E., Jost, J. B., Lacaze, P., Lee, S., Lehtimäki, T., Li, C., Liu, C. T., Morrison, A. C., North, K. E., Penninx, B. W. J. H., Peyser, P. A., Province, M. M., Psaty, B. M., Redline, S., Rosendaal, F. R., Rotimi, C. N., Rotter, J. I., Schmidt, R., Sim, X., Terao, C., Weir, D. R., Zhu, X., Franceschini, N., O’Connell, J. R., Jaquish, C. E., Wang, H., Manning, A., Munroe, P. B., Rao, D. C., Chen, H., Gauderman, W. J., Bierut, L. J., Winkler, T. W. & Fornage, M., Apr 9 2026, In: Human Genetics and Genomics Advances. 7, 2, 100566.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations

      Million Veteran Program, Nagarajan, P., Winkler, T. W., Bentley, A. R., Miller, C. L., Kraja, A. T., Schwander, K., Lee, S., Wang, W., Brown, M. R., Morrison, J. L., Giri, A., O’Connell, J. R., Bartz, T. M., de las Fuentes, L., Gudmundsdottir, V., Guo, X., Harris, S. E., Huang, Z. & Kals, M. & 181 others, Kho, M., Lefevre, C., Luan, J., Lyytikäinen, L. P., Mangino, M., Milaneschi, Y., Palmer, N. D., Rao, V., Rauramaa, R., Shen, B., Stadler, S., Sun, Q., Tang, J., Thériault, S., van der Graaf, A., van der Most, P. J., Wang, Y., Weiss, S., Westerman, K. E., Yang, Q., Yasuharu, T., Zhao, W., Zhu, W., Altschul, D., Ansari, M. A. Y., Anugu, P., Argoty-Pantoja, A. D., Arzt, M., Aschard, H., Attia, J. R., Bazzanno, L., Breyer, M. A., Brody, J. A., Cade, B. E., Chen, H. H., Chen, Y. D. I., Chen, Z., de Vries, P. S., Dimitrov, L. M., Do, A., Du, J., Dupont, C. T., Edwards, T. L., Evans, M. K., Faquih, T., Felix, S. B., Fisher-Hoch, S. P., Floyd, J. S., Graff, M., Gu, C., Gu, D., Hairston, K. G., Hanley, A. J., Heid, I. M., Heikkinen, S., Highland, H. M., Hood, M. M., Kähönen, M., Karvonen-Gutierrez, C. A., Kawaguchi, T., Kazuya, S., Kelly, T. N., Komulainen, P., Levy, D., Lin, H. J., Liu, P. Y., Marques-Vidal, P., McCormick, J. B., Mei, H., Meigs, J. B., Menni, C., Nam, K., Nolte, I. M., Pacheco, N. L., Petty, L. E., Polikowsky, H. G., Province, M. A., Psaty, B. M., Raffield, L. M., Raitakari, O. T., Rich, S. S., Riha, R. L., Risch, L., Risch, M., Ruiz-Narvaez, E. A., Scott, R. J., Sitlani, C. M., Smith, J. A., Sofer, T., Teder-Laving, M., Völker, U., Vollenweider, P., Wang, G., Willems van Dijk, K., Wilson, O. D., Xia, R., Yao, J., Young, K. L., Zhang, R., Zhu, X., Below, J. E., Böger, C. A., Conen, D., Cox, S. R., Dörr, M., Feitosa, M. F., Fox, E. R., Franceschini, N., Gharib, S. A., Gudnason, V., Harlow, S. D., He, J., Holliday, E. G., Kutalik, Z., Lakka, T. A., Lawlor, D. A., Lee, S., Lehtimäki, T., Li, C., Liu, C. T., Mägi, R., Matsuda, F., Morrison, A. C., Penninx, B. W. J. H., Peyser, P. A., Rotter, J. I., Snieder, H., Spector, T. D., Wagenknecht, L. E., Wareham, N. J., Zonderman, A. B., North, K. E., Fornage, M., Yen, A. W., Yeh, S. S., Xu, J., Wilson, P., Whooley, M., Whittle, J., Wells, J., Walsh, J., Villareal, G., Tandon, N., Strollo, P., Sriram, P., Smith, R., Sharma, S., Servatius, R., Rai, A. S., Rauchman, M., Potter, E., Poon, S., Petrakis, I., Oursler, K. A., Ong, M. K., Okusaga, O., Norton, J., Naik, E., Murdoch, M., Morgan, T., Morales, P., Moorman, J., Meyer, P., Mattocks, K., Mastorides, S., Marrache, R., Mahan, C. S., Lo, T. S., Lichy, J., Liangpunsakul, S., Liang, P., Landry, M., Kinlay, S., Jhala, D., Jacono, F., Iruvanti, P., Hurley, R., Hogan, D. J., Hamner, M., Harley, J. & Rao, D. C., Aug 2025, In: Molecular Psychiatry. 30, 8, p. 3660-3672 13 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
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