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Research interests

I am interested in the development and application of statistical genetics analysis methods for human complex traits and diseases. This includes gene discovery and validation in genomic scans (association, gene expression, and copy number), pathway analysis, and the design of family/genetic observational studies and clinical trials. I have developed growth curve pharmacogenetic models of treatment effect, Poisson-Process genetic models, frailty (age-at-onset) models, recursive partitioning genetic methods, meta-analysis procedures, and novel Sequential Multiple Decision Procedures to simultaneously identify all signals in a genome scan while controlling for overall type I and type II error rates. I have also developed a generalized systems biology model and program for performing multivariate and multilocus genetic analysis (SEGPATH). I am the PI (Coordinating Center) of several national, and international multicenter genetic studies, including the NHLBI Family Heart Study (heart disease genetics), the GOLDN Study (lipid pharmacogenetics), and the Long Life Family Study (longevity genetics).

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  • Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation

    Longchamps, R. J., Yang, S. Y., Castellani, C. A., Shi, W., Lane, J., Grove, M. L., Bartz, T. M., Sarnowski, C., Liu, C., Burrows, K., Guyatt, A. L., Gaunt, T. R., Kacprowski, T., Yang, J., De Jager, P. L., Yu, L., Bergman, A., Xia, R., Fornage, M., Feitosa, M. F. & 32 others, Wojczynski, M. K., Kraja, A. T., Province, M. A., Amin, N., Rivadeneira, F., Tiemeier, H., Uitterlinden, A. G., Broer, L., Van Meurs, J. B. J., Van Duijn, C. M., Raffield, L. M., Lange, L., Rich, S. S., Lemaitre, R. N., Goodarzi, M. O., Sitlani, C. M., Mak, A. C. Y., Bennett, D. A., Rodriguez, S., Murabito, J. M., Lunetta, K. L., Sotoodehnia, N., Atzmon, G., Ye, K., Barzilai, N., Brody, J. A., Psaty, B. M., Taylor, K. D., Rotter, J. I., Boerwinkle, E., Pankratz, N. & Arking, D. E., Jan 2022, In: Human genetics. 141, 1, p. 127-146 20 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • NIA Long Life Family Study: Objectives, Design, and Heritability of Cross-Sectional and Longitudinal Phenotypes

    Wojczynski, M. K., Jiuan Lin, S., Sebastiani, P., Perls, T. T., Lee, J., Kulminski, A., Newman, A., Zmuda, J. M., Christensen, K. & Province, M. A., Apr 1 2022, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 77, 4, p. 717-727 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1 Scopus citations
  • Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol

    Wu, P., Moon, J. Y., Daghlas, I., Franco, G., Porneala, B. C., Ahmadizar, F., Richardson, T. G., Isaksen, J. L., Hindy, G., Yao, J., Sitlani, C. M., Raffield, L. M., Yanek, L. R., Feitosa, M. F., Cuadrat, R. R. C., Qi, Q., Ikram, M. A., Ellervik, C., Ericson, U., Goodarzi, M. O. & 32 others, Brody, J. A., Lange, L., Mercader, J. M., Vaidya, D., An, P., Schulze, M. B., Masana, L., Ghanbari, M., Olesen, M. S., Cai, J., Guo, X., Floyd, J. S., Jager, S., Province, M. A., Kalyani, R. R., Psaty, B. M., Orho-Melander, M., Ridker, P. M., Kanters, J. K., Uitterlinden, A., Smith, G. D., Gill, D., Kaplan, R. C., Kavousi, M., Raghavan, S., Chasman, D. I., Rotter, J. I., Meigs, J. B., Florez, J. C., Dupuis, J., Liu, C. T. & Merino, J., Jan 2022, In: Diabetes care. 45, 1, p. 232-240 9 p.

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations
  • Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer's disease and myocardial infarction

    Palmer, N. D., Kahali, B., Kuppa, A., Chen, Y., Du, X., Feitosa, M. F., Bielak, L. F., O'Connell, J. R., Musani, S. K., Guo, X., Smith, A. V., Ryan, K. A., Eirksdottir, G., Allison, M. A., Bowden, D. W., Budoff, M. J., Carr, J. J., Chen, Y. D. I., Taylor, K. D., Correa, A. & 16 others, Crudup, B. F., Halligan, B., Yang, J., Kardia, S. L. R., Launer, L. J., Fu, Y. P., Mosley, T. H., Norris, J. M., Terry, J. G., O'Donnell, C. J., Rotter, J. I., Wagenknecht, L. E., Gudnason, V., Province, M. A., Peyser, P. A. & Speliotes, E. K., Aug 1 2021, In: Human molecular genetics. 30, 15, p. 1443-1456 14 p.

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations
  • A Noncoding Variant near PPP1R3B Promotes Liver Glycogen Storage and MetS, but Protects against Myocardial Infarction

    Kahali, B., Chen, Y., Feitosa, M. F., Bielak, L. F., Oconnell, J. R., Musani, S. K., Hegde, Y., Chen, Y., Stetson, L. C., Guo, X., Fu, Y. P., Smith, A. V., Ryan, K. A., Eiriksdottir, G., Cohain, A. T., Allison, M., Bakshi, A., Bowden, D. W., Budoff, M. J., Carr, J. J. & 26 others, Carskadon, S., Chen, Y. D. I., Correa, A., Crudup, B. F., Du, X., Harris, T. B., Yang, J., Kardia, S. L. R., Launer, L. J., Liu, J., Mosley, T. H., Norris, J. M., Terry, J. G., Palanisamy, N., Schadt, E. E., O'Donnell, C. J., Yerges-Armstrong, L. M., Rotter, J. I., Wagenknecht, L. E., Handelman, S. K., Gudnason, V., Province, M. A., Peyser, P. A., Halligan, B., Palmer, N. D. & Speliotes, E. K., Feb 1 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 2, p. 372-387 16 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    3 Scopus citations