If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

I am interested in the development and application of statistical genetics analysis methods for human complex traits and diseases. This includes gene discovery and validation in genomic scans (association, gene expression, and copy number), pathway analysis, and the design of family/genetic observational studies and clinical trials. I have developed growth curve pharmacogenetic models of treatment effect, Poisson-Process genetic models, frailty (age-at-onset) models, recursive partitioning genetic methods, meta-analysis procedures, and novel Sequential Multiple Decision Procedures to simultaneously identify all signals in a genome scan while controlling for overall type I and type II error rates. I have also developed a generalized systems biology model and program for performing multivariate and multilocus genetic analysis (SEGPATH). I am the PI (Coordinating Center) of several national, and international multicenter genetic studies, including the NHLBI Family Heart Study (heart disease genetics), the GOLDN Study (lipid pharmacogenetics), and the Long Life Family Study (longevity genetics).

Fingerprint Dive into the research topics where Michael Province is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 12 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output

A comparison of genetic imputation methods using Long Life Family Study genotypes and sequence data with the 1000 Genome reference panel

Kraja, A., Warwick Daw, E., Lenzini, P., Wang, L., Lin, S. J., Williams, C. A., Wells, A. B., Lunetta, K. L., Murabito, J. M., Sebastiani, P., Tosto, G., Barral, S., Minster, R. L., Yashin, A., Perls, T. & Province, M. A., Jan 1 2020, In : International Journal of Bioinformatics Research and Applications. 16, 1, p. 59-84 26 p.

Research output: Contribution to journalArticle

  • Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies

    Feitosa, M. F., Lunetta, K. L., Wang, L., Wojczynski, M. K., Kammerer, C. M., Perls, T., Schupf, N., Christensen, K., Murabito, J. M. & Province, M. A., Mar 2020, In : Atherosclerosis. 297, p. 102-110 9 p.

    Research output: Contribution to journalArticle

  • Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

    Lifelines Cohort Study, 2020, (Accepted/In press) In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Leukocyte Telomere Length Is Unrelated to Cognitive Performance among Non-Demented and Demented Persons: An Examination of Long Life Family Study Participants

    Ashrafi, A., Cosentino, S., Kang, M. S., Lee, J. H., Schupf, N., Andersen, S. L., Christensen, K., Province, M. A., Thyagarajan, B., Zmuda, J. M. & Honig, L. S., Jan 1 2020, (Accepted/In press) In : Journal of the International Neuropsychological Society.

    Research output: Contribution to journalArticle

  • Mechanisms underlying familial aggregation of exceptional health and survival: A three-generation cohort study

    Christensen, K., Wojczynski, M., Pedersen, J. K., Larsen, L. A., Kløjgaard, S., Skytthe, A., McGue, M., Vaupel, J. W. & Province, M. A., 2020, (Accepted/In press) In : Aging Cell.

    Research output: Contribution to journalArticle

    Open Access