Michael Iglesia

2025

Nonoperative Management of Rectal Cancer: Is “Near-Complete” Response Safe to Surveil?

Zivanov, C. N., Kau, N. S., Nalluri-Butz, H., Oduyale, O. K., Eltahir, A. A., Yee, J. T., Dosch, A. R., Zhang, L., Kim, H., Iglesia, M. D., Cowan, M., Ohman, K. A., Wise, P. E., Hunt, S., Silviera, M. L., Mutch, M. G. & Chapman, W., 2025, (Accepted/In press) In: Annals of Surgical Oncology.

Research output: Contribution to journal › Article › peer-review

2024

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages

Iglesia, M. D., Jayasinghe, R. G., Chen, S., Terekhanova, N. V., Herndon, J. M., Storrs, E., Karpova, A., Zhou, D. C., Naser Al Deen, N., Shinkle, A. T., Lu, R. J. H., Caravan, W., Houston, A., Zhao, Y., Sato, K., Lal, P., Street, C., Martins Rodrigues, F., Southard-Smith, A. N. & Targino da Costa, A. L. N. & 40 others, Zhu, H., Mo, C. K., Crowson, L., Fulton, R. S., Wyczalkowski, M. A., Fronick, C. C., Fulton, L. A., Sun, H., Davies, S. R., Appelbaum, E. L., Chasnoff, S. E., Carmody, M., Brooks, C., Liu, R., Wendl, M. C., Oh, C., Bender, D., Cruchaga, C., Harari, O., Bredemeyer, A., Lavine, K., Bose, R., Margenthaler, J., Held, J. M., Achilefu, S., Ademuyiwa, F., Aft, R., Ma, C., Colditz, G. A., Ju, T., Oh, S. T., Fitzpatrick, J., Hwang, E. S., Shoghi, K. I., Chheda, M. G., Veis, D. J., Chen, F., Fields, R. C., Gillanders, W. E. & Ding, L., Nov 2024, In: Nature Cancer. 5, 11, p. 1713-1736 24 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Tumour evolution and microenvironment interactions in 2D and 3D space

Mo, C. K., Liu, J., Chen, S., Storrs, E., Targino da Costa, A. L. N., Houston, A., Wendl, M. C., Jayasinghe, R. G., Iglesia, M. D., Ma, C., Herndon, J. M., Southard-Smith, A. N., Liu, X., Mudd, J., Karpova, A., Shinkle, A., Goedegebuure, S. P., Abdelzaher, A. T. M. A., Bo, P. & Fulghum, L. & 26 others, Livingston, S., Balaban, M., Hill, A., Ippolito, J. E., Thorsson, V., Held, J. M., Hagemann, I. S., Kim, E. H., Bayguinov, P. O., Kim, A. H., Mullen, M. M., Shoghi, K. I., Ju, T., Reimers, M. A., Weimholt, C., Kang, L. I., Puram, S. V., Veis, D. J., Pachynski, R., Fuh, K. C., Chheda, M. G., Gillanders, W. E., Fields, R. C., Raphael, B. J., Chen, F. & Ding, L., Oct 31 2024, In: Nature. 634, 8036, p. 1178-1186 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2023

A phase II study of palbociclib plus letrozole plus trastuzumab as neoadjuvant treatment for clinical stages II and III ER+ HER2+ breast cancer (PALTAN)

Ademuyiwa, F. O., Northfelt, D. W., O’Connor, T., Levine, E., Luo, J., Tao, Y., Hoog, J., Laury, M. L., Summa, T., Hammerschmidt, T., Guo, Z., Frith, A., Weilbaecher, K., Opyrchal, M., Aft, R., Clifton, K., Suresh, R., Bagegni, N., Hagemann, I. S. & Iglesia, M. D. & 1 others, Ma, C. X., Dec 2023, In: npj Breast Cancer. 9, 1, 1.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Epigenetic regulation during cancer transitions across 11 tumour types

Terekhanova, N. V., Karpova, A., Liang, W. W., Strzalkowski, A., Chen, S., Li, Y., Southard-Smith, A. N., Iglesia, M. D., Wendl, M. C., Jayasinghe, R. G., Liu, J., Song, Y., Cao, S., Houston, A., Liu, X., Wyczalkowski, M. A., Lu, R. J. H., Caravan, W., Shinkle, A. & Naser Al Deen, N. & 24 others, Herndon, J. M., Mudd, J., Ma, C., Sarkar, H., Sato, K., Ibrahim, O. M., Mo, C. K., Chasnoff, S. E., Porta-Pardo, E., Held, J. M., Pachynski, R., Schwarz, J. K., Gillanders, W. E., Kim, A. H., Vij, R., DiPersio, J. F., Puram, S. V., Chheda, M. G., Fuh, K. C., DeNardo, D. G., Fields, R. C., Chen, F., Raphael, B. J. & Ding, L., Nov 9 2023, In: Nature. 623, 7986, p. 432-441 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

2022

Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer

Cui Zhou, D., Jayasinghe, R. G., Chen, S., Herndon, J. M., Iglesia, M. D., Navale, P., Wendl, M. C., Caravan, W., Sato, K., Storrs, E., Mo, C. K., Liu, J., Southard-Smith, A. N., Wu, Y., Naser Al Deen, N., Baer, J. M., Fulton, R. S., Wyczalkowski, M. A., Liu, R. & Fronick, C. C. & 46 others, Fulton, L. A., Shinkle, A., Thammavong, L., Zhu, H., Sun, H., Wang, L. B., Li, Y., Zuo, C., McMichael, J. F., Davies, S. R., Appelbaum, E. L., Robbins, K. J., Chasnoff, S. E., Yang, X., Reeb, A. N., Oh, C., Serasanambati, M., Lal, P., Varghese, R., Mashl, J. R., Ponce, J., Terekhanova, N. V., Yao, L., Wang, F., Chen, L., Schnaubelt, M., Lu, R. J. H., Schwarz, J. K., Puram, S. V., Kim, A. H., Song, S. K., Shoghi, K. I., Lau, K. S., Ju, T., Chen, K., Chatterjee, D., Hawkins, W. G., Zhang, H., Achilefu, S., Chheda, M. G., Oh, S. T., Gillanders, W. E., Chen, F., DeNardo, D. G., Fields, R. C. & Ding, L., Sep 2022, In: Nature Genetics. 54, 9, p. 1390-1405 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

112 Scopus citations

2018

Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer

Lei, J. T., Shao, J., Zhang, J., Iglesia, M., Chan, D. W., Cao, J., Anurag, M., Singh, P., He, X., Kosaka, Y., Matsunuma, R., Crowder, R., Hoog, J., Phommaly, C., Goncalves, R., Ramalho, S., Peres, R. M. R., Punturi, N., Schmidt, C. & Bartram, A. & 23 others, Jou, E., Devarakonda, V., Holloway, K. R., Lai, W. V., Hampton, O., Rogers, A., Tobias, E., Parikh, P. A., Davies, S. R., Li, S., Ma, C. X., Suman, V. J., Hunt, K. K., Watson, M. A., Hoadley, K. A., Thompson, E. A., Chen, X., Kavuri, S. M., Creighton, C. J., Maher, C. A., Perou, C. M., Haricharan, S. & Ellis, M. J., Aug 7 2018, In: Cell Reports. 24, 6, p. 1434-1444.e7

Research output: Contribution to journal › Article › peer-review

Open Access

82 Scopus citations

2017

Treg depletion potentiates checkpoint inhibition in claudin-low breast cancer

Taylor, N. A., Vick, S. C., Iglesia, M. D., Brickey, W. J., Midkiff, B. R., McKinnon, K. P., Reisdorf, S., Anders, C. K., Carey, L. A., Parker, J. S., Perou, C. M., Vincent, B. G. & Serody, J. S., Sep 1 2017, In: Journal of Clinical Investigation. 127, 9, p. 3472-3483 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

118 Scopus citations

2016

Assembly-based inference of B-cell receptor repertoires from short read RNA sequencing data with V'DJer

Mose, L. E., Selitsky, S. R., Bixby, L. M., Marron, D. L., Iglesia, M. D., Serody, J. S., Perou, C. M., Vincent, B. G. & Parker, J. S., Dec 15 2016, In: Bioinformatics. 32, 24, p. 3729-3734 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

Claudin-low bladder tumors are immune infiltrated and actively immune suppressed

Kardos, J., Chai, S., Mose, L. E., Selitsky, S. R., Krishnan, B., Saito, R., Iglesia, M. D., Milowsky, M. I., Parker, J. S., Kim, W. Y. & Vincent, B. G., Mar 17 2016, In: JCI Insight. 1, 3, e85902.

Research output: Contribution to journal › Article › peer-review

Open Access

172 Scopus citations

Genomic analysis of immune cell infiltrates across 11 tumor types

Iglesia, M. D., Parker, J. S., Hoadley, K. A., Serody, J. S., Perou, C. M. & Vincent, B. G., Nov 2016, In: Journal of the National Cancer Institute. 108, 11

Research output: Contribution to journal › Article › peer-review

Open Access

271 Scopus citations

Molecular heterogeneity and response to neoadjuvant human epidermal growth factor receptor 2 targeting in CALGB 40601, a randomized phase III trial of paclitaxel plus trastuzumab with or without lapatinib

Carey, L. A., Berry, D. A., Cirrincione, C. T., Barry, W. T., Pitcher, B. N., Harris, L. N., Ollila, D. W., Krop, I. E., Henry, N. L., Weckstein, D. J., Anders, C. K., Singh, B., Hoadley, K. A., Iglesia, M., Cheang, M. C. U., Perou, C. M., Winer, E. P. & Hudis, C. A., Feb 20 2016, In: Journal of Clinical Oncology. 34, 6, p. 542-549 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

338 Scopus citations

2014

Prognostic B-cell signatures using mRNA-seq in patients with subtype-specific breast and ovarian cancer

Iglesia, M. D., Vincent, B. G., Parker, J. S., Hoadley, K. A., Carey, L. A., Perou, C. M. & Serody, J. S., Jul 15 2014, In: Clinical Cancer Research. 20, 14, p. 3818-3829 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

227 Scopus citations

2012

Comprehensive molecular portraits of human breast tumours

Koboldt, D. C., Fulton, R. S., McLellan, M. D., Schmidt, H., Kalicki-Veizer, J., McMichael, J. F., Fulton, L. L., Dooling, D. J., Ding, L., Mardis, E. R., Wilson, R. K., Ally, A., Balasundaram, M., Butterfield, Y. S. N., Carlsen, R., Carter, C., Chu, A., Chuah, E., Chun, H. J. E. & Coope, R. J. N. & 323 others, Dhalla, N., Guin, R., Hirst, C., Hirst, M., Holt, R. A., Lee, D., Li, H. I., Mayo, M., Moore, R. A., Mungall, A. J., Pleasance, E., Robertson, A. G., Schein, J. E., Shafiei, A., Sipahimalani, P., Slobodan, J. R., Stoll, D., Tam, A., Thiessen, N., Varhol, R. J., Wye, N., Zeng, T., Zhao, Y., Birol, I., Jones, S. J. M., Marra, M. A., Cherniack, A. D., Saksena, G., Onofrio, R. C., Pho, N. H., Carter, S. L., Schumacher, S. E., Tabak, B., Hernandez, B., Gentry, J., Nguyen, H., Crenshaw, A., Ardlie, K., Beroukhim, R., Winckler, W., Getz, G., Gabriel, S. B., Meyerson, M., Chin, L., Kucherlapati, R., Hoadley, K. A., Auman, J. T., Fan, C., Turman, Y. J., Shi, Y., Li, L., Topal, M. D., He, X., Chao, H. H., Prat, A., Silva, G. O., Iglesia, M. D., Zhao, W., Usary, J., Berg, J. S., Adams, M., Booker, J., Wu, J., Gulabani, A., Bodenheimer, T., Hoyle, A. P., Simons, J. V., Soloway, M. G., Mose, L. E., Jefferys, S. R., Balu, S., Parker, J. S., Hayes, D. N., Perou, C. M., Malik, S., Mahurkar, S., Shen, H., Weisenberger, D. J., Triche, T., Lai, P. H., Bootwalla, M. S., Maglinte, D. T., Berman, B. P., Van Den Berg, D. J., Baylin, S. B., Laird, P. W., Creighton, C. J., Donehower, L. A., Noble, M., Voet, D., Gehlenborg, N., Di Cara, D., Zhang, J., Zhang, H., Wu, C. J., Yingchun Liu, S., Lawrence, M. S., Zou, L., Sivachenko, A., Lin, P., Stojanov, P., Jing, R., Cho, J., Sinha, R., Park, R. W., Nazaire, M. D., Robinson, J., Thorvaldsdottir, H., Mesirov, J., Park, P. J., Reynolds, S., Kreisberg, R. B., Bernard, B., Bressler, R., Erkkila, T., Lin, J., Thorsson, V., Zhang, W., Shmulevich, I., Ciriello, G., Weinhold, N., Schultz, N., Gao, J., Cerami, E., Gross, B., Jacobsen, A., Sinha, R., Aksoy, B. A., Antipin, Y., Reva, B., Shen, R., Taylor, B. S., Ladanyi, M., Sander, C., Anur, P., Spellman, P. T., Lu, Y., Liu, W., Verhaak, R. R. G., Mills, G. B., Akbani, R., Zhang, N., Broom, B. M., Casasent, T. D., Wakefield, C., Unruh, A. K., Baggerly, K., Coombes, K., Weinstein, J. N., Haussler, D., Benz, C. C., Stuart, J. M., Benz, S. C., Zhu, J., Szeto, C. C., Scott, G. K., Yau, C., Paull, E. O., Carlin, D., Wong, C., Sokolov, A., Thusberg, J., Mooney, S., Ng, S., Goldstein, T. C., Ellrott, K., Grifford, M., Wilks, C., Ma, S., Craft, B., Yan, C., Hu, Y., Meerzaman, D., Gastier-Foster, J. M., Bowen, J., Ramirez, N. C., Black, A. D., Pyatt, R. E., White, P., Zmuda, E. J., Frick, J., Lichtenberg, T. M., Brookens, R., George, M. M., Gerken, M. A., Harper, H. A., Leraas, K. M., Wise, L. J., Tabler, T. R., McAllister, C., Barr, T., Hart-Kothari, M., Tarvin, K., Saller, C., Sandusky, G., Mitchell, C., Iacocca, M. V., Brown, J., Rabeno, B., Czerwinski, C., Petrelli, N., Dolzhansky, O., Abramov, M., Voronina, O., Potapova, O., Marks, J. R., Suchorska, W. M., Murawa, D., Kycler, W., Ibbs, M., Korski, K., Spychała, A., Murawa, P., Brzeziński, J. J., Perz, H., Łaźniak, R., Teresiak, M., Tatka, H., Leporowska, E., Bogusz-Czerniewicz, M., Malicki, J., Mackiewicz, A., Wiznerowicz, M., Van Le, X., Kohl, B., Viet Tien, N., Thorp, R., Van Bang, N., Sussman, H., Phu, B. D., Hajek, R., Hung, N. P., Phuong, T. V. T., Thang, H. Q., Khan, K. Z., Penny, R., Mallery, D., Curley, E., Shelton, C., Yena, P., Ingle, J. N., Couch, F. J., Lingle, W. L., King, T. A., Gonzalez-Angulo, A. M., Dyer, M. D., Liu, S., Meng, X., Patangan, M., Waldman, F., Stöppler, H., Rathmell, W. K., Thorne, L., Huang, M., Boice, L., Hill, A., Morrison, C., Gaudioso, C., Bshara, W., Daily, K., Egea, S. C., Pegram, M. D., Gomez-Fernandez, C., Dhir, R., Bhargava, R., Brufsky, A., Shriver, C. D., Hooke, J. A., Campbell, J. L., Mural, R. J., Hu, H., Somiari, S., Larson, C., Deyarmin, B., Kvecher, L., Kovatich, A. J., Ellis, M. J., Stricker, T., White, K., Olopade, O., Luo, C., Chen, Y., Bose, R., Chang, L. W., Beck, A. H., Pihl, T., Jensen, M., Sfeir, R., Kahn, A., Chu, A., Kothiyal, P., Wang, Z., Snyder, E., Pontius, J., Ayala, B., Backus, M., Walton, J., Baboud, J., Berton, D., Nicholls, M., Srinivasan, D., Raman, R., Girshik, S., Kigonya, P., Alonso, S., Sanbhadti, R., Barletta, S., Pot, D., Sheth, M., Demchok, J. A., Shaw, K. R. M., Yang, L., Eley, G., Ferguson, M. L., Tarnuzzer, R. W., Zhang, J., Dillon, L. A. L., Buetow, K., Fielding, P., Ozenberger, B. A., Guyer, M. S., Sofia, H. J. & Palchik, J. D., Oct 4 2012, In: Nature. 490, 7418, p. 61-70 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9500 Scopus citations

Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription

Patel, M., Simon, J. M., Iglesia, M. D., Wu, S. B., McFadden, A. W., Lieb, J. D. & Davis, I. J., Feb 2012, In: Genome research. 22, 2, p. 259-270 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

87 Scopus citations

Michael Iglesia

Research output

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