Research output per year
Research output per year
- 47 results
Search results
-
2024
Assessing Cardiac Contractility From Single Molecules to Whole Hearts
Garg, A., Lavine, K. J. & Greenberg, M. J., Mar 2024, In: JACC: Basic to Translational Science. 9, 3, p. 414-439 26 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
CRISPR Activation Reverses Haploinsufficiency and Functional Deficits Caused by TTN Truncation Variants
Ghahremani, S., Kanwal, A., Pettinato, A., Ladha, F., Legere, N., Thakar, K., Zhu, Y., Tjong, H., Wilderman, A., Stump, W. T., Greenberg, L., Greenberg, M. J., Cotney, J., Wei, C. L. & Hinson, J. T., Apr 16 2024, In: Circulation. 149, 16, p. 1285-1297 13 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
2023
Distinct effects of two hearing loss–associated mutations in the sarcomeric myosin MYH7b
Lee, L. A., Barrick, S. K., Buvoli, A. E., Walklate, J., Stump, W. T., Geeves, M., Greenberg, M. J. & Leinwand, L. A., May 2023, In: Journal of Biological Chemistry. 299, 5, 104631.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains
Meller, A., Lotthammer, J. M., Smith, L. G., Novak, B., Lee, L. A., Kuhn, C. C., Greenberg, L., Leinwand, L. A., Greenberg, M. J. & Bowman, G. R., Jan 2023, In: eLife. 12, e83602.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Functional assays reveal the pathogenic mechanism of a de novo tropomyosin variant identified in patient with dilated cardiomyopathy
Barrick, S. K., Garg, A., Greenberg, L., Zhang, S., Lin, C. Y., Stitziel, N. O. & Greenberg, M., Mar 2023, In: Journal of Molecular and Cellular Cardiology. 176, p. 58-67 10 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Functional divergence of the sarcomeric myosin, MYH7b, supports species-specific biological roles
Lee, L. A., Barrick, S. K., Meller, A., Walklate, J., Lotthammer, J. M., Tay, J. W., Stump, W. T., Bowman, G., Geeves, M. A., Greenberg, M. J. & Leinwand, L. A., Jan 2023, In: Journal of Biological Chemistry. 299, 1, 102657.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Multiscale biophysical models of cardiomyopathies reveal complexities challenging existing dogmas
Scott, B. & Greenberg, M. J., Dec 19 2023, In: Biophysical Journal. 122, 24, p. 4632-4634 3 p.Research output: Contribution to journal › Editorial
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Single-molecule mechanics and kinetics of cardiac myosin interacting with regulated thin filaments
Clippinger Schulte, S. R., Scott, B., Barrick, S. K., Stump, W. T., Blackwell, T. & Greenberg, M. J., Jun 20 2023, In: Biophysical Journal. 122, 12, p. 2544-2555 12 p.Research output: Contribution to journal › Article › peer-review
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2022
A pathogenic mechanism associated with myopathies and structural birth defects involves TPM2-directed myogenesis
McAdow, J., Yang, S., Ou, T., Huang, G., Dobbs, M. B., Gurnett, C. A., Greenberg, M. J. & Johnson, A. N., Jun 22 2022, In: JCI Insight. 7, 12, e152466.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Myofilament glycation in diabetes reduces contractility by inhibiting tropomyosin movement, is rescued by cMyBPC domains
Papadaki, M., Kampaengsri, T., Barrick, S. K., Campbell, S. G., von Lewinski, D., Rainer, P. P., Harris, S. P., Greenberg, M. J. & Kirk, J. A., Jan 2022, In: Journal of Molecular and Cellular Cardiology. 162, p. 1-9 9 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
2021
A troponin T variant linked with pediatric dilated cardiomyopathy reduces the coupling of thin filament activation to myosin and calcium binding
Barrick, S. K., Greenberg, L. & Greenberg, M. J., Aug 19 2021, In: Molecular biology of the cell. 32, 18, p. 1677-1689 13 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Beyond genomics—technological advances improving the molecular characterization and precision treatment of heart failure
Lavine, K. J. & Greenberg, M. J., Mar 2021, In: Heart Failure Reviews. 26, 2, p. 405-415 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access7 Scopus citations -
Cardiac myosin contraction and mechanotransduction in health and disease
Barrick, S. K. & Greenberg, M. J., Nov 1 2021, In: Journal of Biological Chemistry. 297, 5, 101297.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations -
Complexity in genetic cardiomyopathies and new approaches for mechanism-based precision medicine
Greenberg, M. J. & Tardiff, J. C., Jan 2021, In: Journal of General Physiology. 153, 3, e202012662.Research output: Contribution to journal › Review article › peer-review
Open Access23 Scopus citations -
Computational Tool for Ensemble Averaging of Single-Molecule Data
Blackwell, T., Stump, W. T., Clippinger, S. R. & Greenberg, M. J., Jan 5 2021, In: Biophysical Journal. 120, 1, p. 10-20 11 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Mechanical dysfunction of the sarcomere induced by a pathogenic mutation in troponin t drives cellular adaptation
Clippinger, S. R., Cloonan, P. E., Wang, W., Greenberg, L., Stump, W. T., Angsutararux, P., Nerbonne, J. M. & Greenberg, M. J., May 3 2021, In: Journal of General Physiology. 153, 5, e202012787.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Resident cardiac macrophages mediate adaptive myocardial remodeling
Wong, N. R., Mohan, J., Kopecky, B. J., Guo, S., Du, L., Leid, J., Feng, G., Lokshina, I., Dmytrenko, O., Luehmann, H., Bajpai, G., Ewald, L., Bell, L., Patel, N., Bredemeyer, A., Weinheimer, C. J., Nigro, J. M., Kovacs, A., Morimoto, S. & Bayguinov, P. O. & 10 others, , Sep 14 2021, In: Immunity. 54, 9, p. 2072-2088.e7Research output: Contribution to journal › Article › peer-review
Open Access94 Scopus citations -
SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
Bailey, A. L., Dmytrenko, O., Greenberg, L., Bredemeyer, A. L., Ma, P., Liu, J., Penna, V., Winkler, E. S., Sviben, S., Brooks, E., Nair, A. P., Heck, K. A., Rali, A. S., Simpson, L., Saririan, M., Hobohm, D., Stump, W. T., Fitzpatrick, J. A., Xie, X. & Zhang, X. & 9 others, , Apr 2021, In: JACC: Basic to Translational Science. 6, 4, p. 331-345 15 p.Research output: Contribution to journal › Article › peer-review
Open Access124 Scopus citations -
2020
Conformational distributions of isolated myosin motor domains encode their mechanochemical properties
Porter, J. R., Meller, A., Zimmerman, M. I., Greenberg, M. J. & Bowman, G. R., May 2020, In: eLife. 9, e55132.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Variant r94c in tnnt2-encoded troponin t predisposes to pediatric restrictive cardiomyopathy and sudden death through impaired thin filament relaxation resulting in myocardial diastolic dysfunction
Ezekian, J. E., Clippinger, S. R., Garcia, J. M., Yang, Q., Denfield, S., Jeewa, A., Dreyer, W. J., Zou, W., Fan, Y., Allen, H. D., Kim, J. J., Greenberg, M. J. & Landstrom, A. P., 2020, In: Journal of the American Heart Association. 9, 5, e015111.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
2019
Computational Tool to Study Perturbations in Muscle Regulation and Its Application to Heart Disease
Barrick, S. K., Clippinger, S. R., Greenberg, L. & Greenberg, M. J., Jun 18 2019, In: Biophysical Journal. 116, 12, p. 2246-2252 7 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Cooperative Changes in Solvent Exposure Identify Cryptic Pockets, Switches, and Allosteric Coupling
Porter, J. R., Moeder, K. E., Sibbald, C. A., Zimmerman, M. I., Hart, K. M., Greenberg, M. J. & Bowman, G. R., Mar 5 2019, In: Biophysical Journal. 116, 5, p. 818-830 13 p.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
Disrupted mechanobiology links the molecular and cellular phenotypes in familial dilated cardiomyopathy
Clippinger, S. R., Cloonan, P. E., Greenberg, L., Ernst, M., Stump, W. T. & Greenberg, M. J., Sep 3 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 36, p. 17831-17840 10 p.Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations -
2018
Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery
Greenberg, M. J., Daily, N. J., Wang, A., Conway, M. K. & Wakatsuki, T., Sep 19 2018, In: Frontiers in Cardiovascular Medicine. 5, 120.Research output: Contribution to journal › Review article › peer-review
Open Access14 Scopus citations -
Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke
Woody, M. S., Greenberg, M. J., Barua, B., Winkelmann, D. A., Goldman, Y. E. & Ostap, E. M., Dec 1 2018, In: Nature communications. 9, 1, 3838.Research output: Contribution to journal › Article › peer-review
Open Access87 Scopus citations -
2017
Measuring the kinetic and mechanical properties of non-processive myosins using optical tweezers
Greenberg, M. J., Shuman, H. & Ostap, E. M., 2017, Methods in Molecular Biology. Humana Press Inc., p. 483-509 27 p. (Methods in Molecular Biology; vol. 1486).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Open Access16 Scopus citations -
2016
A Perspective on the Role of Myosins as Mechanosensors
Greenberg, M. J., Arpaǧ, G., Tüzel, E. & Ostap, E. M., Jun 21 2016, In: Biophysical Journal. 110, 12, p. 2568-2576 9 p.Research output: Contribution to journal › Review article › peer-review
Open Access52 Scopus citations -
Corrigendum to An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake [Traic, (2015), 16, 7, 691-711]
Kee, A. J., Yang, L., Lucas, C. A., Greenberg, M. J., Martel, N., Leong, G. M., Hughes, W. E., Cooney, G. J., James, D. E., Ostap, E. M., Han, W., Gunning, P. W. & Hardeman, E. C., Jan 1 2016, In: Traffic. 17, 1, p. 80-81 2 p.Research output: Contribution to journal › Comment/debate
Open Access4 Scopus citations -
MEMLET: An Easy-to-Use Tool for Data Fitting and Model Comparison Using Maximum-Likelihood Estimation
Woody, M. S., Lewis, J. H., Greenberg, M. J., Goldman, Y. E. & Ostap, E. M., Jul 26 2016, In: Biophysical Journal. 111, 2, p. 273-282 10 p.Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations -
2015
An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake
Kee, A. J., Yang, L., Lucas, C. A., Greenberg, M. J., Martel, N., Leong, G. M., Hughes, W. E., Cooney, G. J., James, D. E., Ostap, E. M., Han, W., Gunning, P. W. & Hardeman, E. C., Jul 1 2015, In: Traffic. 16, 7, p. 691-711 21 p.Research output: Contribution to journal › Article › peer-review
Open Access59 Scopus citations -
Mechanochemical tuning of myosin-I by the N-terminal region
Greenberg, M. J., Lin, T., Shuman, H. & Ostap, E. M., Jun 30 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 26, p. E3337-E3344Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
2014
A vertebrate myosin-I structure reveals unique insights into myosin mechanochemical tuning
Shuman, H., Greenberg, M. J., Zwolak, A., Lin, T., Sindelar, C. V., Dominguez, R. & Ostap, E. M., Feb 11 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 6, p. 2116-2121 6 p.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
Inherent force-dependent properties of β-cardiac myosin contribute to the force-velocity relationship of cardiac muscle
Greenberg, M. J., Shuman, H. & Ostap, E. M., Dec 16 2014, In: Biophysical Journal. 107, 12, p. L41-L44Research output: Contribution to journal › Article › peer-review
Open Access75 Scopus citations -
2013
Regulation and control of myosin-I by the motor and light chain-binding domains
Greenberg, M. J. & Ostap, E. M., Feb 2013, In: Trends in Cell Biology. 23, 2, p. 81-89 9 p.Research output: Contribution to journal › Review article › peer-review
Open Access47 Scopus citations -
2012
Calcium regulation of Myosin-I tension sensing
Lewis, J. H., Greenberg, M. J., Laakso, J. M., Shuman, H. & Ostap, E. M., Jun 20 2012, In: Biophysical Journal. 102, 12, p. 2799-2807 9 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
Kinetic schemes for post-synchronized single molecule dynamics
Chen, C., Greenberg, M. J., Laakso, J. M., Ostap, E. M., Goldman, Y. E. & Shuman, H., Mar 21 2012, In: Biophysical Journal. 102, 6, p. L23-L25Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Myosin IC generates power over a range of loads via a new tension-sensing mechanism
Greenberg, M. J., Lin, T., Goldman, Y. E., Shuman, H. & Ostap, E. M., Sep 11 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 37, p. E2433-E2440Research output: Contribution to journal › Article › peer-review
Open Access73 Scopus citations -
2011
A hearing loss-associated myo1c mutation (R156W) decreases the myosin duty ratio and force sensitivity
Lin, T., Greenberg, M. J., Moore, J. R. & Ostap, E. M., Mar 22 2011, In: Biochemistry. 50, 11, p. 1831-1838 8 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
2010
Actin in action and inaction: The differential effects of hypertrophic and dilated cardiomyopathy actin mutations on thin filament regulation
Greenberg, M. J. & Moore, J. R., Feb 1 2010, In: Journal of Molecular and Cellular Cardiology. 48, 2, p. 277-278 2 p.Research output: Contribution to journal › Editorial
2 Scopus citations -
Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry
Greenberg, M. J., Kazmierczak, K., Szczesna-Cordary, D. & Moore, J. R., Oct 5 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 40, p. 17403-17408 6 p.Research output: Contribution to journal › Article › peer-review
65 Scopus citations -
The direct molecular effects of fatigue and myosin regulatory light chain phosphorylation on the actomyosin contractile apparatus
Greenberg, M. J., Mealy, T. R., Jones, M., Szczesna-Cordary, D. & Moore, J. R., Apr 2010, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 298, 4, p. R989-R996Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
The molecular basis of frictional loads in the in vitro motility assay with applications to the study of the loaded mechanochemistry of molecular motors
Greenberg, M. J. & Moore, J. R., May 2010, In: Cytoskeleton. 67, 5, p. 273-285 13 p.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
2009
Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics
Greenberg, M. J., Watt, J. D., Jones, M., Kazmierczak, K., Szczesna-Cordary, D. & Moore, J. R., Jan 2009, In: Journal of Molecular and Cellular Cardiology. 46, 1, p. 108-115 8 p.Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
Removal of the cardiac myosin regulatory light chain increases isometric force production
Pant, K., Watt, J., Greenberg, M., Jones, M., Szczesna-Cordary, D. & Moore, J. R., Oct 2009, In: FASEB Journal. 23, 10, p. 3571-3580 10 p.Research output: Contribution to journal › Article › peer-review
41 Scopus citations -
The molecular effects of skeletal muscle myosin regulatory light chain phosphorylation
Greenberg, M. J., Mealy, T. R., Watt, J. D., Jones, M., Szczesna-Cordary, D. & Moore, J. R., Aug 2009, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 297, 2, p. R265-R274Research output: Contribution to journal › Article › peer-review
55 Scopus citations -
2008
Modulation of actin mechanics by caldesmon and tropomyosin
Greenberg, M. J., Wang, C. L. A., Lehman, W. & Moore, J. R., Feb 2008, In: Cell Motility and the Cytoskeleton. 65, 2, p. 156-164 9 p.Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
2005
Observation of magnetoreceptive behavior in a multicellular magnetotactic prokaryote in higher than geomagnetic fields
Greenberg, M., Canter, K., Mahler, I. & Tornheim, A., Feb 2005, In: Biophysical Journal. 88, 2, p. 1496-1499 4 p.Research output: Contribution to journal › Article › peer-review
Open Access55 Scopus citations