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Personal profile

Research interests

The Greenberg lab focuses on how cytoskeletal motors function in both health and disease. Currently, the lab is studying mutations that cause familial cardiomyopathies, the leading cause of sudden cardiac death in people under 30 years old. The lab uses an array of biochemical, biophysical, and cell biological techniques to decipher how these mutations affect heart contraction from the level of single molecules to the level of engineered tissues. We are also interesting in designing new in vitro disease models. Insights into the disease pathogenesis will guide efforts to develop novel therapies.

Fingerprint Dive into the research topics where Michael Greenberg is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 8 Similar Profiles
Myosins Medicine & Life Sciences
Myosin Type I Medicine & Life Sciences
Myosin Light Chains Medicine & Life Sciences
Actins Medicine & Life Sciences
Actin Cytoskeleton Medicine & Life Sciences
Mutation Medicine & Life Sciences
Tropomyosin Medicine & Life Sciences
Cardiac Myosins Medicine & Life Sciences

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Research Output 2005 2019

1 Citation (Scopus)

Computational Tool to Study Perturbations in Muscle Regulation and Its Application to Heart Disease

Barrick, S. K., Clippinger, S. R., Greenberg, L. & Greenberg, M. J., Jun 18 2019, In : Biophysical Journal. 116, 12, p. 2246-2252 7 p.

Research output: Contribution to journalArticle

Muscle Contraction
Heart Diseases
Familial Hypertrophic Cardiomyopathy
Physiological Adaptation
4 Citations (Scopus)

Cooperative Changes in Solvent Exposure Identify Cryptic Pockets, Switches, and Allosteric Coupling

Porter, J. R., Moeder, K. E., Sibbald, C. A., Zimmerman, M. I., Hart, K. M., Greenberg, M. J. & Bowman, G. R., Mar 5 2019, In : Biophysical Journal. 116, 5, p. 818-830 13 p.

Research output: Contribution to journalArticle

Allosteric Site
Microbial Drug Resistance
Computer Simulation
2 Citations (Scopus)

Disrupted mechanobiology links the molecular and cellular phenotypes in familial dilated cardiomyopathy

Clippinger, S. R., Cloonan, P. E., Greenberg, L., Ernst, M., Stump, W. T. & Greenberg, M. J., Sep 3 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 36, p. 17831-17840 10 p.

Research output: Contribution to journalArticle

Open Access
Dilated Cardiomyopathy
Cardiac Myocytes
12 Citations (Scopus)

Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke

Woody, M. S., Greenberg, M. J., Barua, B., Winkelmann, D. A., Goldman, Y. E. & Ostap, E. M., Dec 1 2018, In : Nature communications. 9, 1, 3838.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Measuring the kinetic and mechanical properties of non-processive myosins using optical tweezers

Greenberg, M. J., Shuman, H. & Ostap, E. M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 483-509 27 p. (Methods in Molecular Biology; vol. 1486).

Research output: Chapter in Book/Report/Conference proceedingChapter

Optical Tweezers
Actin Cytoskeleton