Michael Diamond

Professor of Medicine, Professor of Molecular Microbiology, Professor of Pathology and Immunology, Herbert S Gasser Professor

  • 35517 Citations
1984 …2020

Research output per year

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Personal profile

Research interests

The research in the Diamond laboratory focuses on the interface between viral pathogenesis and the host immune response. For several years, we have been primarily focused on two globally important mosquito-borne human pathogens West Nile virus and Dengue virus. Both are single-stranded positive-sense RNA viruses of the same genus (Flavivirus) that cause human disease worldwide. Recently, we have begun to study another member of the same virus family, hepatitis C, which causes chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Investigations with hepatitis C virus are aimed at generating a novel mouse model and understanding the epitope specificity of protective antibodies against this virus.

Areas of Clinical Interest

West Nile virus, Dengue virus, Chikungunya virus, antibody immunity, interferon immunity

Keywords

  • COVID-19

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Research Output

A cross-reactive antibody protects against Ross River virus musculoskeletal disease despite rapid neutralization escape in mice

Fox, J. M., Huang, L., Tahan, S., Powell, L. A., Crowe, J. E., Wang, D. & Diamond, M. S., Aug 1 2020, In : PLoS pathogens. 16, 8, p. e1008743

Research output: Contribution to journalArticle

Open Access
  • An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis

    Kim, A. S., Zimmerman, O., Fox, J. M., Nelson, C. A., Basore, K., Zhang, R., Durnell, L., Desai, C., Bullock, C., Deem, S. L., Oppenheimer, J., Shapiro, B., Wang, T., Cherry, S., Coyne, C. B., Handley, S. A., Landis, M. J., Fremont, D. H. & Diamond, M. S., Mar 11 2020, In : Cell Host and Microbe. 27, 3, p. 428-440.e9

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection

    Alsoussi, W. B., Turner, J. S., Case, J. B., Zhao, H., Schmitz, A. J., Zhou, J. Q., Chen, R. E., Lei, T., Rizk, A. A., McIntire, K. M., Winkler, E. S., Fox, J. M., Kafai, N. M., Thackray, L., Hassan, A. O., Amanat, F., Krammer, F., Watson, C. T., Kleinstein, S. H., Fremont, D. & 2 others, Diamond, M. S. & Ellebedy, A., Aug 15 2020, In : Journal of immunology (Baltimore, Md. : 1950). 205, 4, p. 915-922 8 p.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Scopus citations

    A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

    Hassan, A. O., Case, J. B., Winkler, E. S., Thackray, L., Kafai, N. M., Bailey, A. L., McCune, B. T., Fox, J. M., Chen, R. E., Alsoussi, W. B., Turner, J. S., Schmitz, A. J., Lei, T., Shrihari, S., Keeler, S. P., Fremont, D., Greco, S., McCray, P. B., Perlman, S., Holtzman, M. J. & 2 others, Ellebedy, A. & Diamond, M. S., Jan 1 2020, (Accepted/In press) In : Cell.

    Research output: Contribution to journalArticle

    Open Access
  • 22 Scopus citations

    Author Correction: Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection (Nature Immunology, (2017), 18, 11, (1261-1269), 10.1038/ni.3849)

    Fernandez, E., Dejnirattisai, W., Cao, B., Scheaffer, S. M., Supasa, P., Wongwiwat, W., Esakky, P., Drury, A., Mongkolsapaya, J., Moley, K., Mysorekar, I. U., Screaton, G. R. & Diamond, M. S., Mar 1 2020, In : Nature immunology. 21, 3, 1 p.

    Research output: Contribution to journalComment/debate

    Open Access