• 8182 Citations
1987 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2019

Genetics of group A streptococci

Cho, K. H., Port, G. C. & Caparon, M., Mar 1 2019, In : Microbiology spectrum. 7, 2, GPP3-0056-2018.

Research output: Contribution to journalArticle

Glutathione synthesis contributes to virulence of streptococcus agalactiae in a murine model of sepsis

Walker, E. A., Port, G. C., Caparon, M. G. & Janowiak, B. E., Jan 1 2019, In : Journal of bacteriology. 201, 20, e00367-19.

Research output: Contribution to journalArticle

High-resolution imaging reveals microbial biofilms on patient urinary catheters despite antibiotic administration

Walker, J. N., Flores-Mireles, A. L., Lynch, A. J. L., Pinkner, C., Caparon, M. G., Hultgren, S. J. & Desai, A., Jan 1 2019, (Accepted/In press) In : World Journal of Urology.

Research output: Contribution to journalArticle

Mucosal infection rewires TNFα signaling dynamics to skew susceptibility to recurrence

Yu, L., O’Brien, V. P., Livny, J., Dorsey, D., Bandyopadhyay, N., Colonna, M., Caparon, M. G., Roberson, E. D. O., Hultgren, S. J. & Hannan, T. J., Aug 2019, In : eLife. 8, e46677.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2018

CcpA Coordinates Growth/Damage Balance for Streptococcus pyogenes Pathogenesis

Paluscio, E., Watson, M. E. & Caparon, M. G., Dec 1 2018, In : Scientific reports. 8, 1, 14254.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2017

Catheterization alters bladder ecology to potentiate Staphylococcus aureus infection of the urinary tract

Walker, J. N., Flores-Mireles, A. L., Pinkner, C. L., Schreiber, H. L., Joens, M. S., Park, A. M., Potretzke, A. M., Bauman, T. M., Pinkner, J. S., Fitzpatrick, J. A. J., Desai, A., Caparon, M. G. & Hultgren, S. J., Oct 10 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 41, p. E8721-E8730

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection

Xu, W., Flores-Mireles, A. L., Cusumano, Z. T., Takagi, E., Hultgren, S. J. & Caparon, M. G., Dec 1 2017, In : npj Biofilms and Microbiomes. 3, 1, 28.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells

Cervantes-Barragan, L., Chai, J. N., Tianero, M. D., Di Luccia, B., Ahern, P. P., Merriman, J., Cortez, V. S., Caparon, M. G., Donia, M. S., Gilfillan, S., Cella, M., Gordon, J. I., Hsieh, C. S. & Colonna, M., Aug 25 2017, In : Science. 357, 6353, p. 806-810 5 p.

Research output: Contribution to journalArticle

143 Scopus citations

SpxA1 and SpxA2 act coordinately to fine-tune stress responses and virulence in Streptococcus pyogenes

Port, G. C., Cusumano, Z. T., Tumminello, P. R. & Caparon, M. G., Mar 1 2017, In : mBio. 8, 2, e00288-17.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2016

Antibody-based therapy for enterococcal catheter-associated urinary tract infections

Flores-Mireles, A. L., Walker, J. N., Potretzke, A., Schreiber, H. L., Pinkner, J. S., Bauman, T. M., Park, A. M., Desai, A., Hultgren, S. J. & Caparon, M. G., Sep 1 2016, In : mBio. 7, 5, e01653-16.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Fibrinogen Release and Deposition on Urinary Catheters Placed during Urological Procedures

Flores-Mireles, A. L., Walker, J. N., Bauman, T. M., Potretzke, A. M., Schreiber, H. L., Park, A. M., Pinkner, J. S., Caparon, M. G., Hultgren, S. J. & Desai, A., Aug 1 2016, In : Journal of Urology. 196, 2, p. 416-421 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Interleukin-17A contributes to the control of streptococcus pyogenes colonization and inflammation of the female genital tract

Carey, A. J., Weinberg, J. B., Dawid, S. R., Venturini, C., Lam, A. K., Nizet, V., Caparon, M. G., Walker, M. J., Watson, M. E. & Ulett, G. C., May 31 2016, In : Scientific reports. 6, 26836.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

The NADase-negative variant of the Streptococcus pyogenes toxin NAD+ glycohydrolase induces JNK1-mediated programmed cellular necrosis

Chandrasekaran, S. & Caparon, M. G., Feb 2 2016, In : mBio. 7, 1, e02215-15.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
2015

Citrulline protects Streptococcus pyogenes from acid stress using the arginine deiminase pathway and the F1Fo-ATPase

Cusumano, Z. T. & Caparon, M. G., Jan 1 2015, In : Journal of bacteriology. 197, 7, p. 1288-1296 9 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Complete genome sequences of emm6 Streptococcus pyogenes JRS4 and parental strain D471

Port, G. C., Paluscio, E. & Caparon, M. G., 2015, In : Genome Announcements. 3, 4, e00725-15.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Dual modes of membrane binding direct pore formation by Streptolysin O

Mozola, C. C. & Caparon, M. G., Sep 1 2015, In : Molecular Microbiology. 97, 6, p. 1036-1050 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Streptococcus pyogenes malate degradation pathway links pH regulation and virulence

Paluscio, E. & Caparon, M. G., 2015, In : Infection and immunity. 83, 3, p. 1162-1171 10 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

The Streptococcus pyogenesNAD+ glycohydrolase modulates epithelial cell PARylation and HMGB1 release

Chandrasekaran, S. & Caparon, M. G., Sep 1 2015, In : Cellular microbiology. 17, 9, p. 1376-1390 15 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations
2014

A novel cholesterol-insensitive mode of membrane binding promotes cytolysin-mediated translocation by Streptolysin O

Mozola, C. C., Magassa, NG. & Caparon, M. G., Nov 1 2014, In : Molecular Microbiology. 94, 3, p. 675-687 13 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

EbpA vaccine antibodies block binding of Enterococcus faecalis to fibrinogen to prevent catheter-associated bladder infection in mice

Flores-Mireles, A. L., Pinkner, J. S., Caparon, M. G. & Hultgren, S. J., Sep 17 2014, In : Science translational medicine. 6, 254, 254ra127.

Research output: Contribution to journalArticle

65 Scopus citations

Streptococcus pyogenes arginine and citrulline catabolism promotes infection and modulates innate immunity

Cusumano, Z. T., Watson, M. E. & Caparon, M. G., Jan 2014, In : Infection and immunity. 82, 1, p. 233-242 10 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Streptococcus pyogenes polymyxin B-resistant mutants display enhanced exportal integrity

Port, G. C., Vega, L. A., Nylander, A. B. & Caparon, M. G., Jul 2014, In : Journal of bacteriology. 196, 14, p. 2563-2577 15 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations
2013

Adaptive evolution of the streptococcus pyogenes regulatory aldolase lacD.1

Cusumano, Z. & Caparon, M., Mar 1 2013, In : Journal of bacteriology. 195, 6, p. 1294-1304 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Analysis of polymorphic residues reveals distinct enzymatic and cytotoxic activities of the streptococcus pyogenes NAD+ glycohydrolase

Chandrasekaran, S., Ghosh, J., Port, G. C., Koh, E. I. & Caparon, M. G., Jul 5 2013, In : Journal of Biological Chemistry. 288, 27, p. 20064-20075 12 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

An association between peptidoglycan synthesis and organization of the Streptococcus pyogenes ExPortal

Vega, L. A., Port, G. C. & Caparon, M. G., Sep 24 2013, In : mBio. 4, 5, e00485-13.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Complete genome sequence of emm type 14 Streptococcus pyogenes strain HSC5

Port, G. C., Paluscio, E. & Caparon, M. G., 2013, In : Genome Announcements. 1, 4, e00612-13.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections

Guiton, P. S., Hannan, T. J., Ford, B., Caparon, M. G. & Hultgren, S. J., Jan 2013, In : Infection and immunity. 81, 1, p. 329-339 11 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis

Kandaswamy, K., Liew, T. H., Wang, C. Y., Huston-Warren, E., Meyer-Hoffert, U., Hultenby, K., Schröder, J. M., Caparon, M. G., Normark, S., Henriques-Normark, B., Hultgren, S. J. & Kline, K. A., Dec 10 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 50, p. 20230-20235 6 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

Murine vaginal colonization model for investigating asymptomatic mucosal carriage of streptococcus pyogenes

Watson, M. E., Nielsen, H. V., Hultgren, S. J. & Caparon, M. G., May 2013, In : Infection and immunity. 81, 5, p. 1606-1617 12 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis

Nielsen, H. V., Flores-Mireles, A. L., Kau, A. L., Kline, K. A., Pinkner, J. S., Neiers, F., Normark, S., Henriques-Normark, B., Caparon, M. G. & Hultgren, S. J., 2013, In : Journal of bacteriology. 195, 19, p. 4484-4495 12 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations
2012

Cationic antimicrobial peptides disrupt the Streptococcus pyogenes ExPortal

Vega, L. A. & Caparon, M. G., Sep 1 2012, In : Molecular Microbiology. 85, 6, p. 1119-1132 14 p.

Research output: Contribution to journalArticle

24 Scopus citations
Open Access
58 Scopus citations

The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection

Nielsen, H. V., Guiton, P. S., Kline, K. A., Port, G. C., Pinkner, J. S., Neiers, F., Normark, S., Henriques-Normark, B., Caparon, M. G. & Hultgren, S. J., 2012, In : mBio. 3, 4, e00177-12.

Research output: Contribution to journalArticle

Open Access
53 Scopus citations
2011

Distinct time-resolved roles for two catabolite-sensing pathways during Streptococcus pyogenes infection

Kietzman, C. C. & Caparon, M. G., Feb 2011, In : Infection and immunity. 79, 2, p. 812-821 10 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Mapping the protein-protein interface between a toxin and its cognate antitoxin from the bacterial pathogen Streptococcus pyogenes

Sperry, J. B., Smith, C. L., Caparon, M. G., Ellenberger, T. & Gross, M. L., May 17 2011, In : Biochemistry. 50, 19, p. 4038-4045 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Structural basis of Streptococcus pyogenes immunity to Its NAD+ glycohydrolase toxin

Smith, C. L., Ghosh, J., Elam, J. S., Pinkner, J. S., Hultgren, S. J., Caparon, M. G. & Ellenberger, T., Feb 9 2011, In : Structure. 19, 2, p. 192-202 11 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations
2010

CcpA and LacD.1 affect temporal regulation of Streptococcus pyogenes virulence genes

Kietzman, C. C. & Caparon, M. G., Jan 2010, In : Infection and immunity. 78, 1, p. 241-252 12 p.

Research output: Contribution to journalArticle

Open Access
51 Scopus citations

Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence

Kline, K. A., Ingersoll, M. A., Nielsen, H. V., Sakinc, T., Henriques-Normark, B., Gatermann, S., Caparon, M. G. & Hultgren, S. J., May 2010, In : Infection and immunity. 78, 5, p. 1943-1951 9 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

Characterization of Streptococcus pyogenes β-NAD+ glycohydrolase: Re-evaluation of enzymatic properties associated with pathogenesis

Ghosh, J., Anderson, P. J., Chandrasekaran, S. & Caparon, M. G., Feb 19 2010, In : Journal of Biological Chemistry. 285, 8, p. 5683-5694 12 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Enterococcal biofilm formation and virulence in an optimized murine model of foreign body-associated urinary tract infections

Guiton, P. S., Hung, C. S., Hancock, L. E., Caparon, M. G. & Hultgren, S. J., Oct 2010, In : Infection and immunity. 78, 10, p. 4166-4175 10 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations

Streptococcus pyogenes cytolysin-mediated translocation does not require pore formation by streptolysin O

Magassa, NG., Chandrasekaran, S. & Caparon, M. G., May 1 2010, In : EMBO Reports. 11, 5, p. 400-405 6 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

Variation in Streptococcus pyogenes NAD+ glycohydrolase is associated with tissue tropism

Riddle, D. J., Bessen, D. E. & Caparon, M. G., Jul 2010, In : Journal of bacteriology. 192, 14, p. 3735-3746 12 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations
Open Access
58 Scopus citations
2009

Contribution of autolysin and sortase A during Enterococcus faecalis DNA-dependent biofilm development

Guiton, P. S., Hung, C. S., Kline, K. A., Roth, R., Kau, A. L., Hayes, E., Heuser, J., Dodson, K. W., Caparon, M. G. & Hultgren, S. J., Sep 2009, In : Infection and immunity. 77, 9, p. 3626-3638 13 p.

Research output: Contribution to journalArticle

Open Access
96 Scopus citations

Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis

Kline, K. A., Kau, A. L., Chen, S. L., Lim, A., Pinkner, J. S., Rosch, J., Nallapareddy, S. R., Murray, B. E., Henriques-Normark, B., Beatty, W., Caparon, M. G. & Hultgren, S. J., May 2009, In : Journal of bacteriology. 191, 10, p. 3237-3247 11 p.

Research output: Contribution to journalArticle

Open Access
59 Scopus citations

Streptolysin S inhibits neutrophil recruitment during the early stages of Streptococcus pyogenes infection

Lin, A., Loughman, J. A., Zinselmeyer, B. H., Miller, M. J. & Caparon, M. G., Nov 2009, In : Infection and immunity. 77, 11, p. 5190-5201 12 p.

Research output: Contribution to journalArticle

Open Access
44 Scopus citations

The metal homeostasis protein, Lsp, of Streptococcus pyogenes is necessary for acquisition of zinc and virulence

Weston, B. F., Brenot, A. & Caparon, M. G., Jul 2009, In : Infection and immunity. 77, 7, p. 2840-2848 9 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations
2008

The signal recognition particle pathway is required for virulence in Streptococcus pyogenes

Rosch, J. W., Vega, L. A., Beyer, J. M., Lin, A. & Caparon, M. G., Jun 1 2008, In : Infection and immunity. 76, 6, p. 2612-2619 8 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations
Open Access
45 Scopus citations
2007

Anionic lipids enriched at the ExPortal of Streptococcus pyogenes

Rosch, J. W., Hsu, F. F. & Caparon, M. G., Feb 2007, In : Journal of bacteriology. 189, 3, p. 801-806 6 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations