Personal profile
Research interests
The lab is interested in the interaction of pathogenic bacteria with their hosts, with an emphasis on the pathogenesis of infections caused by Gram-positive bacteria. Using Streptococcus pyogenes as a model pathogen, the lab investigates the signal transduction mechanisms used by the bacterium to modulate transcriptome behavior in response to tissue-specific nutrional cues. Also of interest are the pathways for protein secretion that the streptococcus uses to target its various protein toxins to specific host cell compartments during infection.
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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Host cysteine proteases promote the severity of catheter-associated urinary tract infection and kidney fibrosis
Xu, W., Chen, J., McLellan, L. K., Flores-Mireles, A. L., Hunstad, D. A. & Caparon, M. G., Nov 12 2025, In: mBio. 16, 11, p. 1-20 20 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Reprogramming aerobic metabolism mitigates Streptococcus pyogenes tissue damage in a mouse necrotizing skin infection model
Xu, W., Bradstreet, T. R., Zou, Z., Hickerson, S., Zhou, Y., He, H., Edelson, B. T. & Caparon, M. G., Dec 2025, In: Nature communications. 16, 1, 2559.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations -
Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat Streptococcus pyogenes skin and soft tissue infection
Zou, Z., Singh, P., Pinkner, J. S., Obernuefemann, C. L. P., Xu, W., Nye, T. M., Dodson, K. W., Almqvist, F., Hultgren, S. J. & Caparon, M. G., Aug 2024, In: Science Advances. 10, 31, adn7979.Research output: Contribution to journal › Article › peer-review
Open Access7 Link opens in a new tab Scopus citations -
Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI
Molina, J. J., Kohler, K. N., Gager, C., Andersen, M. J., Wongso, E., Lucas, E. R., Paik, A., Xu, W., Donahue, D. L., Bergeron, K., Klim, A., Caparon, M. G., Hultgren, S. J., Desai, A., Ploplis, V. A., Flick, M. J., Castellino, F. J. & Flores-Mireles, A. L., Dec 2024, In: Nature communications. 15, 1, 2704.Research output: Contribution to journal › Article › peer-review
Open Access14 Link opens in a new tab Scopus citations -
Microbial co-occurrences on catheters from long-term catheterized patients
Nye, T. M., Zou, Z., Obernuefemann, C. L. P., Pinkner, J. S., Lowry, E., Kleinschmidt, K., Bergeron, K., Klim, A., Dodson, K. W., Flores-Mireles, A. L., Walker, J. N., Wong, D. G., Desai, A., Caparon, M. G. & Hultgren, S. J., Dec 2024, In: Nature communications. 15, 1, 61.Research output: Contribution to journal › Article › peer-review
Open Access52 Link opens in a new tab Scopus citations