Skip to main navigation Skip to search Skip to main content
Michael Brent

View Scopus Profile

Michael Brent

Henry Edwin Sever Professor of Engineering, Professor of Computer Science & Engineering, Professor of Biomedical Engineering, Professor of Genetics

 https://orcid.org/0000-0002-8689-0299

    Willing to Mentor

    Available to Mentor:

    PhD Students

    • 43624
      Citations
    1990 …2026

    Research activity per year

    Personal profile

    Research interests

    The Brent lab is interested in how gene expression is regulated, how it affects phenotypes, and how it is affected by genetic variants. Our work includes fungi (baker's yeast and Cryptococcus neoformans, a fungal pathogen) and humans. Longstanding projects include determining which genes in yeast and Cryptococcus are regulated by each transcription factor (TF), using both computational and experimental methods. We are currently applying our computational methods for mapping TF targets to integrate a wide variety of human datasets. We are also developing models to predict the expression level of any gene in any individual from their genome sequence. In human genetics, we are members of the Long Life Family Study consortium, which aims to find genetic variants that confer long life and long health. This work involves integrating DNA sequence, DNA methylation, and gene expression data, in the context of networks and other knowledge bases that formalize biological knowledge. Our methods include traditional statistics, network analysis, and machine learning.

    Available to Mentor:

    • PhD Students

    Fingerprint

    Dive into the research topics where Michael Brent is active. These topic labels come from the works of this person and are generated automatically. Together they form a unique fingerprint. Contact the Profiles team with questions.
    • 6 Similar Profiles
    View full fingerprint

    Collaborations and top research areas from the last five years

    Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
    Explore network further

    • A Robust Serum Proteomic Signature of the E2 Allele of Apolipoprotein E

      Sebastiani, P., Reed, E., Chandler, K. B., Lopez, P., Lords, H., Bae, H., Costello, C. E., Au, M., Deng, L. L., Li, M., Xiang, Q., Noh, H., Pflieger, L., Funk, C., Rappaport, N., Nygaard, M., Short, M. I., Brent, M., Monti, S. & Andersen, S. L. & 1 others, Perls, T. T., Jan 19 2026, In: Advanced Science. 13, 4, e09764.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      1   Link opens in a new tab Scopus citations

    • Association of genetic variation with age at diagnosis in type 1 diabetes

      Vollenbrock, C. E., Roshandel, D., Lee, K. E., Klein, B. E., Mul, D., Van Der Klauw, M. M., Tack, C. J., Rewers, M., Snell-Bergeon, J. K., Costacou, T., Miller, R. G., Caramori, M. L., Mauer, M., Aanstoot, H. J., Wolffenbuttel, B. H. R., Paterson, A. D., Nathan, D. M., Zinman, B., Crofford, O. & Genuth, S. & 379 others, Gubitosi-Klug, R., Mayer, L., Wood, J., Greanoff, G., Miller, D., Novak, M., Pendegast, S., Rath, S., Singerman, L., Weiss, D., Zegarra, H., Brown, E., Crawford, P., Palmert, M., Pugsley, P., Smith-Brewer, S., Dahms, W., McConnell, J., Gregory, N. S., Hanna, R., Chan, R., Kiss, S., Orlin, A., Rubin, M., Barron, S., Bosco, B., Brillon, D., Chang, S., Dwoskin, A., Heinemann, M., Jovanovic, L., Lackaye, M. E., Lee, T., Levy, B., Reppucci, V., Richardson, M., Campbell, R., Bhan, A., Jones, J. K., Kruger, D., Edwards, P. A., Mukhashen, S., Angus, E., Galprin, A., McLellan, M., Remtema, H., Thomas, A., Carey, J. D., Whitehouse, F., Bergenstal, R., Dunnigan, S., Johnson, M., Carlson, A., Thomas, L., Birk, R., Callahan, P., Castle, G., Cuddihy, R., Franz, M., Freking, D., Gill, L., Gott, J., Gunyou, K., Hollander, P., Kendall, D., Laechelt, J., List, S., Matfin, G., Mestrezat, W., Nelson, J., Olson, B., Rude, N., Spencer, M., Aiello, L. P., Golden, E., Arrigg, P., Beaser, R., Cavallerano, J., Cavicchi, R., Ganda, O., Hamdy, O., Murtha, T., Schlossman, D., Shah, S., Sharuk, G., Silva, P., Silver, P., Stockman, M., Sun, J., Weimann, E., Larkin, M. E., Chu, K., Heier, J., Joseph, A., Leandre, F., Shah, C., Thangthaeng, N., Vella, A., Zipse, A., Barkmeier, A., Sivitz, W. I., Vittetoe, B., Bayless, M., Fountain, C., Hoffman, R., Kramer, J., MacIndoe, J., Olson, N., Schrott, H., Snetselaar, L., Weingeist, T., Zeitler, R., Miller, R., Johnsonbaugh, S., Carney, M., Counts, D., Donner, T., Gordon, J., Hebdon, M., Hemady, R., Jones, B., Kowarski, A., Liss, R., Mendley, S., Ostrowski, D., Patronas, M., Salemi, P., Steidl, S., Herman, W. H., Pop-Busui, R., Martin, C. L., Lee, P., Albers, J. W., Feldman, E. L., Burkhart, N., Greene, D. A., Sandford, T., Stevens, M. J., Floyd, J., Bantle, A., Bantle, J., Rhodes, M., Koozekanani, D., Montezuma, S., Terry, J., Flaherty, N., Goetz, F., Kwong, C., McKenzie, L., Mech, M., Olson, J., Rogness, B., Strand, T., Warhol, R., Wimmergren, N., Goldstein, D., Hainsworth, D., Hitt, S., Jarvis, A., Giangiacomo, J., Schade, D. S., Bancroft, A., Avery, R. B., Burge, M. R., Chapin, J. E., Das, A., Ketai, L. H., Canady, J. L., Hornbeck, D., Johannes, C., Rich, J., Schluter, M. L., Schutta, M., Bourne, P. A., Brucker, A., Braunstein, S., Maschak-Carey, B. J., Schwartz, S., Baker, L., Costacou, T., Toledo, F., Orchard, T., Coonrod, B. A., Becker, D., Cimino, L., Doft, B., Finegold, D., Kelly, K., Lobes, L., Rubinstein, D., Silvers, N., Songer, T., Steinberg, D., Steranchak, L., Wesche, J., Drash, A., Malone, J. I., Morrison, A., Rodriguez, H., O’Brian, J., Pavan, P. R., Babbione, L., Bernal, M. L., DeClue, T. J., Grove, N., McMillan, D., Solc, H., Tanaka, E. A., Vaccaro-Kish, J., Dagogo-Jack, S., Wilson, R., Huddleston, S., Bryer-Ash, M., Chaum, E., Iannacone, A., Lambeth, H., Meyer, D., Moser, S., Murphy, M. B., Patel, A., Ricks, H., Schussler, S., Wigley, C., Yoser, S., Kitabchi, A., Raskin, P., Jordan, L., He, Y. G., Mendelson, E., Ufret-Vincenty, R. L., Basco, M., Cercone, S., Strowig, S., Perkins, B. A., Barnie, A., Bakshi, N., Brent, M., Devenyi, R., Koushan, K., Mandelcorn, M., Olegario, D., Perdikaris, F., Daneman, D., Ehrlich, R., Ferguson, S., Gordon, A., Perlman, K., Rogers, S., Tuason, L., Hirsch, I., Fahlstrom, R., Van Ottingham, L., de Boer, I. H., Olmos de Koo, L., Catton, S., Ginsberg, J., Kinyoun, J., Palmer, J., McDonald, C., Driscoll, M., Bylsma, J., Sheidow, T., Brown, W., Canny, C., Colby, P., Debrabandere, S., Dupre, J., Harth, J., Hramiak, I., Jenner, M., Mahon, J., Nicolle, D., Rodger, N. W., Smith, T., May, M., Marksbury, T., Adkins, T., Agarwal, A., Lovell, C., Feman, S., Hagan, J. L., Lorenz, R., Ramker, R., Survant, L., White, N. H., Hoffman, E., Levandoski, L., Boniuk, I., Santiago, J., Tamborlane, W., Gatcomb, P., Stoessel, K., Brown-Friday, J., Crandall, J., Engel, H., Engel, S., Martinez, H., Phillips, M., Reid, M., Shamoon, H., Sheindlin, J., Farrell, K., Beck, C., Gaston, P., Quin, J., Trail, R., Lachin, J., Bebu, I., Braffett, B., Backlund, J., Bott, M., Diminick, L., El ghormli, L., Gao, X., Ho, S., Kenny, D., Klumpp, K., Lin, M., Trapani, V., Anderson, K., Chan, K., Cleary, P., Determan, A., Dews, L., Hsu, W., McGee, P., Pan, H., Petty, B., Rosenberg, D., Rutledge, B., Sun, W., Villavicencio, S., Younes, N., Williams, C., Leschek, E., Cowie, C., Siebert, C., Steffes, M., Karger, A., Seegmiller, J., Arends, V., Bucksa, J., Chavers, B., Killeen, A., Nowicki, M., Saenger, A., Soliman, E. Z., Barr, M., Campbell, C., Hensley, S., Hu, J., Keasler, L., Li, Y., Taylor, T., Zhang, Z. M., Pokharel, Y., Prineas, R., Blodi, B., Danis, R., Lawrence, D., Wabers, H., Burger, M., Davis, M., Dingledine, J., Gama, V., Gangaputra, S., Hubbard, L., Neill, S., Sussman, R., Jacobson, A., Ryan, C., Saporito, D., Burzuk, B., Cupelli, E., Geckle, M., Sandstrom, D., Thoma, F., Williams, T. & Woodfill, T., Jan 16 2026, In: BMJ Open Diabetes Research and Care. 14, 1, e003877.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Finding Significant Hits in Networks: a network-based tool for analyzing gene-level P-values to identify significant genes missed by standard methods

      Acharya, S., Moghaddam, V. A., Jung, W. J., Kang, Y. S., Liao, S., Province, M. A. & Brent, M. R., Mar 1 2026, In: Briefings in Bioinformatics. 27, 2, bbag061.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Mapping the transcriptional regulatory network of a fungal pathogen by exploiting transcription factor perturbation

      Abid, D., Brown, H., Mateusiak, C., Doering, T. L. & Brent, M. R., Jan 14 2026, In: mBio. 17, 1, p. 1-19 19 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Whole blood transcriptional signatures of age and survival identified in long life family and integrative longevity omics studies

      Li, M., Song, Z., Reed, E., Karagiannis, T. T., Andersen, S., Brent, M., Mateusiak, C., Acharya, S., Jung, W. J., Liao, S., Wojczynski, M. K., Feitosa, M. F., O’Connell, J. R., Montasser, M. E., Thorpe, R. J., Arbeev, K., Milman, S., Tai, A., Perls, T. T. & Sebastiani, P. & 1 others, Monti, S., 2026, (Accepted/In press) In: GeroScience.

      Research output: Contribution to journal › Article › peer-review

      Open Access
    View all 107 Research outputs