Research output per year
Research output per year
Personal profile
Research interests
The gut microbiota plays a pivotal role in many aspects of human health and modulates susceptibility to a wide spectrum of diseases.
Stromal cells possess a fundamental yet often underestimated role in maintaining tissue homeostasis and influencing immune responses during health and disease.
Our goal is to understand the intricate molecular mechanisms through which microbes modulate the function of stromal cells, acting as intermediaries between microbes and immunity. This comprehension offers the potential to capitalize on therapeutic interventions that target stromal cells and the microbiota.
To achieve this, we will employ comprehensive strategies like single-cell transcriptomics, spatial transcriptomics, metagenomics, and mouse/bacterial genetics to study highly controlled gnotobiotic model systems and human samples.
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production
Bao, B., Wang, Y., Boudreau, P., Song, X., Wu, M., Chen, X., Patik, I., Tang, Y., Ouahed, J., Ringel, A., Barends, J., Wu, C., Balskus, E., Thiagarajah, J., Liu, J., Wessels, M. R., Lencer, W. I., Kasper, D. L., An, D. & Horwitz, B. H. & 1 others, , Jan 2024, In: CMGH. 18, 2, 101350.Research output: Contribution to journal › Article › peer-review
Open Access -
Gut complement induced by the microbiota combats pathogens and spares commensals
Wu, M., Zheng, W., Song, X., Bao, B., Wang, Y., Ramanan, D., Yang, D., Liu, R., Macbeth, J. C., Do, E. A., Andrade, W. A., Yang, T., Cho, H. S., Gazzaniga, F. S., Ilves, M., Coronado, D., Thompson, C., Hang, S., Chiu, I. M. & Moffitt, J. R. & 4 others, , Feb 15 2024, In: Cell. 187, 4, p. 897-913.e18Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Gut microbial fatty acid isomerization modulates intraepithelial T cells
Song, X., Zhang, H., Zhang, Y., Goh, B., Bao, B., Mello, S. S., Sun, X., Zheng, W., Gazzaniga, F. S., Wu, M., Qu, F., Yin, Q., Gilmore, M. S., Oh, S. F. & Kasper, D. L., Jul 27 2023, In: Nature. 619, 7971, p. 837-843 7 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
Publisher Correction: Targeting PD-L2–RGMb overcomes microbiome-related immunotherapy resistance (Nature, (2023), 617, 7960, (377-385), 10.1038/s41586-023-06026-3)
Park, J. S., Gazzaniga, F. S., Wu, M., Luthens, A. K., Gillis, J., Zheng, W., LaFleur, M. W., Johnson, S. B., Morad, G., Park, E. M., Zhou, Y., Watowich, S. S., Wargo, J. A., Freeman, G. J., Kasper, D. L. & Sharpe, A. H., Jun 22 2023, In: Nature. 618, 7966, p. E27Research output: Contribution to journal › Comment/debate
Open Access2 Scopus citations -
Targeting PD-L2–RGMb overcomes microbiome-related immunotherapy resistance
Park, J. S., Gazzaniga, F. S., Wu, M., Luthens, A. K., Gillis, J., Zheng, W., LaFleur, M. W., Johnson, S. B., Morad, G., Park, E. M., Zhou, Y., Watowich, S. S., Wargo, J. A., Freeman, G. J., Kasper, D. L. & Sharpe, A. H., May 11 2023, In: Nature. 617, 7960, p. 377-385 9 p.Research output: Contribution to journal › Article › peer-review
Open Access55 Scopus citations