Personal profile
Research interests
Our laboratory is interested in the origins of pediatric inborn errors of immunity and immune dysregulation. We use genomic sequencing to identify genetic causes of pediatric disease and work to better understand these diseases using in vitro and in vivo models. Our discoveries have led to the identification and characterization of new pediatric diseases including STAT3 gain-of-function and TLR8 gain-of-function. We also have a special interest in study natural killer (NK) cells, innate immune lymphocytes that produce cytokines and can kill target cells. NK cells are important for the early control of viral infection and also play a role in tumor immunosurveillance.
Clinical interests
rheumatology, immunodeficiency, dermatomyositis, systemic lupus erythematosus
Mentoring
The Cooper lab is committed to fostering a diverse and inclusive research environment for all trainees and staff. We appreciate that bringing together different voices is important for advancing science.
Keywords
- COVID-19
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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Clinical characteristics, management, and hematopoietic cell transplantation of patients with TLR8 gain-of-function
Arnold, D. E., Kaviany, S., Aluri, J., Calvo, K. R., Mehta, S. S., Tobin, J. M., Schuettpelz, L. G., Saucier, N., Schmitz, E. G., Murguía-Favela, L., Wright, N. A. M., De Ravin, S. S., Rao, V. K., Holland, S. M., Bleesing, J. J., Loughran, T. P., Feith, D. J., Powell, J., Ratan, A. & Warren, J. T. & 4 others, , Mar 24 2026, In: Blood Advances. 10, 6, p. 1967-1976 10 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Diagnostic Implications and Correlates of Plasma Adenosine Deaminase 2 Activity and ADA2 Variants
Yue, J., LeSon, C. E., Rimland, C. A., Brodeur, K., Weng, R., Hsu, E. E., Lam, M. T., Meyer, M., Okada, S., Hsu, A. L. D., Alhezam, M. A., Perron, M. M., Halyabar, O., Dedeoglu, F., Nigrovic, P. A., Shimamura, A., Rowe, R. G., Cooper, M. A., Vogel, T. P. & Gillispie-Taylor, M. & 36 others, , Mar 2026, In: Arthritis and Rheumatology. 78, 3, p. 734-742 9 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Disease-causing STAT3 variants can be discriminated by a functional flow cytometry test
Esteve-Sole, A., Freeman, A. F., Hsu, A., Vogel, T. P., Satter, L. F., Bergerson, J. R. E., Webb, T., Pechacek, J., McDaniels, K., Cooper, M. A., Bouso, C., Oleastro, M., Danielian, S., Gonzalez-Granados, L. I., Lionakis, M. S., Holland, S. M., Fleisher, T. A., Kuehn, H. S. & Rosenzweig, S. D., Feb 2026, In: Pediatric Allergy and Immunology. 37, 2, e70300.Research output: Contribution to journal › Article › peer-review
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Enhanced clinical decision-making to optimize targeted gene panel testing for inborn errors of immunity
Udomkittivorakul, N., Zhang, J., Arora, J., Peterson, L., Bigley, T. M., Schmitt, E., Cooper, M. & Kitcharoensakkul, M., 2026, (Accepted/In press) In: Annals of Allergy, Asthma and Immunology.Research output: Contribution to journal › Article › peer-review
Open Access -
Multiomic study of cutaneous T-cell lymphoma reveals single-cell clonal evolution in progression and therapy resistance
Dorando, H. K., Andrews, J. M., Khatavkar, O. U., Borcherding, N. C., Korshunova, Y., Hakeman, G., Panigassi, R., Vo, P., Tu, R. Y., Tran, D., Quinn, C. C., Schmidt, J. A., Aluri, J., Harmon, M. T., Watkins, M. P., Frank, A., Cooper, M. A., Musiek, A. C., Mehta-Shah, N. & Payton, J. E., May 21 2026, In: Blood. 147, 21, p. 2503-2517 15 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations