• 2724 Citations
20062020

Research output per year

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Personal profile

Research interests

I am broadly interested in the complicated interplay between three important factors: commensal microbes, the host immune system, and viral and bacterial pathogens. Previous work has involved characterization of the intestinal commensal microbiota and interrogation of its role in regulation of both enteric viral infection and the host immune system. The coordination of next-generation sequencing efforts with in vivo infections and treatments in mouse models makes the exploration of transkingdom interactions possible. Moving forward, I will be exploring inflammation in the intestine induced by commensal bacteria and by pathogens, and the signaling pathways and transcription factors that regulate it. I will also be identifying the specific commensal bacteria necessary and sufficient to enhance and regulate viral infection in the intestine, and studying viral adaptation strategies to take advantage of commensal microbes and to infect at alternate host sites.

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Research Output

CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus

Graziano, V. R., Walker, F. C., Kennedy, E. A., Wei, J., Ettayebi, K., Strine, M. S., Filler, R. B., Hassan, E., Hsieh, L. L., Kim, A. S., Kolawole, A. O., Wobus, C. E., Lindesmith, L. C., Baric, R. S., Estes, M. K., Orchard, R. C., Baldridge, M. T. & Wilen, C. B., Apr 1 2020, In : PLoS pathogens. 16, 4, e1008242.

Research output: Contribution to journalArticle

Open Access
  • 2 Scopus citations

    CD300LF polymorphisms of inbred mouse strains confer resistance to murine norovirus infection in a cell type-dependent manner

    Furlong, K., Biering, S. B., Choi, J., Wilen, C. B., Orchard, R. C., Wobus, C. E., Nelson, C. A., Fremont, D. H., Baldridge, M. T., Randall, G. & Hwang, S., Sep 2020, In : Journal of virology. 94, 17, e00837-20.

    Research output: Contribution to journalArticle

    Open Access
  • Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes

    Wang, Y. T., Zaitsev, K., Lu, Q., Li, S., Schaiff, W. T., Kim, K. W., Droit, L., Wilen, C. B., Desai, C., Balce, D. R., Orchard, R. C., Orvedahl, A., Park, S., Kreamalmeyer, D., Handley, S. A., Pfeifer, J. D., Baldridge, M. T., Artyomov, M. N., Stallings, C. L. & Virgin, S., Feb 1 2020, In : Nature microbiology. 5, 2, p. 272-281 10 p.

    Research output: Contribution to journalLetter

  • 1 Scopus citations

    T cell response kinetics determines neuroinfection outcomes during murine HSV infection

    Lee, A. G., Scott, J. M., Fabbrizi, M. R., Jiang, X., Sojka, D. K., Miller, M. J., Baldridge, M. T., Yokoyama, W. M. & Shin, H., Mar 12 2020, In : JCI Insight. 5, 5, e134258.

    Research output: Contribution to journalArticle

    Open Access
  • The intestinal regionalization of acute norovirus infection is regulated by the microbiota via bile acid-mediated priming of type III interferon

    Grau, K. R., Zhu, S., Peterson, S. T., Helm, E. W., Philip, D., Phillips, M., Hernandez, A., Turula, H., Frasse, P., Graziano, V. R., Wilen, C. B., Wobus, C. E., Baldridge, M. T. & Karst, S. M., Jan 1 2020, In : Nature microbiology. 5, 1, p. 84-92 9 p.

    Research output: Contribution to journalLetter

  • 5 Scopus citations