Meaghan Creed

Assistant Professor of Anesthesiology, Assistant Professor of Psychiatry, Assistant Professor of Neuroscience

    • 720 Citations
    20102020

    Research output per year

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    Personal profile

    Research interests

    Research in our lab focuses on how chronic pain, stress and addictive drugs induces changes in neural circuits that underlie symptoms of psychiatric disorders. We use a range of techniques including in vivo and patch clamp electrophysiology, genetic sequencing, neuroanatomy, optogenetics and behavior to study changes in function in the ventral basal ganglia in models of addiction, mood and chronic pain disorders. The main goal of the lab is to leverage insight from circuit studies to develop novel neuromodulation therapies for these disorders, including deep brain stimulation (DBS) and targeted drug delivery and neurostimulation with focused ultrasound (FUS). By first establishing links of causality between changes in circuit function and maladaptive behavior, we first establish a rationale for targeted circuit manipulation in a disease state. We then design novel neuromodulation paradigms ex vivo and validate their efficacy in vivo to provide novel, effective neuromodulation strategies for neurological and psychiatric disease.

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    Research Output

    • 720 Citations
    • 28 Article
    • 8 Review article
    • 2 Comment/debate

    A Key Role for Prefrontocortical Small Conductance Calcium-Activated Potassium Channels in Stress Adaptation and Rapid Antidepressant Response

    Bambico, F. R., Li, Z., Creed, M., De Gregorio, D., DIwan, M., Li, J., McNeill, S., Gobbi, G., Raymond, R. & Nobrega, J. N., Mar 14 2020, In : Cerebral Cortex. 30, 3, p. 1559-1572 14 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Continuous representations of speed by striatal medium spiny neurons

    Fobbs, W. C., Bariselli, S., Licholai, J. A., Miyazaki, N. L., Matikainen-Ankney, B. A., Creed, M. C. & Kravitz, A. V., Feb 19 2020, In : Journal of Neuroscience. 40, 8, p. 1679-1688 10 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity

    Bariselli, S., Miyazaki, N. L., Creed, M. C. & Kravitz, A. V., Dec 1 2020, In : Nature communications. 11, 1, 3996.

    Research output: Contribution to journalArticle

    Open Access
  • Projection-specific deficits in synaptic transmission in adult Sapap3-knockout mice

    Hadjas, L. C., Schartner, M. M., Cand, J., Creed, M. C., Pascoli, V., Lüscher, C. & Simmler, L. D., 2020, (Accepted/In press) In : Neuropsychopharmacology. 45, 12, p. 2020-2029 10 p.

    Research output: Contribution to journalArticle

  • A competitive model for striatal action selection

    Bariselli, S., Fobbs, W. C., Creed, M. C. & Kravitz, A. V., Jun 15 2019, In : Brain Research. 1713, p. 70-79 10 p.

    Research output: Contribution to journalReview article

  • 13 Scopus citations