Research output per year
Research output per year
Personal profile
Research interests
The main interest of our laboratory is the discovery and characterization of gene mutations in patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) with the long term goal of understanding the molecular mechanisms that control abnormal hematopoiesis. MDS results from the expansion of one or more dominant hematopoietic clones that contain initiating mutations, while transformation from MDS to AML occurs as these clones accumulate additional progression factors (including point mutations in genes and cytogenetic abnormalities).
Clinical interests
Hematology, oncology, bone marrow transplant
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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HSPA9/mortalin inhibition disrupts erythroid maturation through a TP53-dependent mechanism in human CD34+ hematopoietic progenitor cells
Butler, C., Dunmire, M., Choi, J., Szalai, G., Johnson, A., Lei, W., Chen, X., Liu, L., Li, W., Walter, M. J. & Liu, T., Apr 2024, In: Cell Stress and Chaperones. 29, 2, p. 300-311 12 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Monitoring clonal burden as an alternative to blast count for myelodysplastic neoplasm treatment response
Jacoby, M. A., Duncavage, E. D., Khanna, A., Chang, G. S., Nonavinkere Srivatsan, S., Miller, C. A., Gao, F., Robinson, J., Shao, J., Fulton, R. S., Fronick, C. C., O’Laughlin, M., Heath, S. E., Brendel, K., Chavez, M., DiPersio, J. F., Abboud, C. N., Stockerl-Goldstein, K., Westervelt, P. & Cashen, A. & 7 others, , 2024, (Accepted/In press) In: Leukemia.Research output: Contribution to journal › Article › peer-review
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Plasma Proteomic Signature Predicts Myeloid Neoplasm Risk
Tran, D., Beeler, J. S., Liu, J., Wiley, B., Chan, I. C. C., Xin, Z., Kramer, M. H., Batchi-Bouyou, A. L., Zong, X., Walter, M. J., Petrone, G. E. M., Chlamydas, S., Ferraro, F., Oh, S. T., Link, D. C., Busby, B., Cao, Y. & Bolton, K. L., Aug 1 2024, In: Clinical Cancer Research. 30, 15, p. 3220-3228 9 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription–Replication Conflicts
Liu, Z. S., Sinha, S., Bannister, M., Song, A., Arriaga-Gomez, E., McKeeken, A. J., Bonner, E. A., Hanson, B. K., Sarchi, M., Takashima, K., Zong, D., Corral, V. M., Nguyen, E., Yoo, J., Chiraphapphaiboon, W., Leibson, C., McMahon, M. C., Rai, S., Swisher, E. M. & Sachs, Z. & 10 others, , 2024, In: Cancer research. 84, 4, p. 577-597 21 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
The DNA Methyltransferase Inhibitor 5-Aza-40-thio-20-Deoxycytidine Induces C>G Transversions and Acute Lymphoid Leukemia Development
Bertoli, R. M., Chung, Y. J., Difilippantonio, M. J., Wokasch, A., Marasco, M. R. B., Klimaszewski, H., Gammell, S., Zhu, Y. J., Walker, R. L., Cao, D., Khanna, A., Walter, M. J., Doroshow, J. H., Meltzer, P. S. & Aplan, P. D., Aug 1 2024, In: Cancer research. 84, 15, p. 2518-2532 15 p.Research output: Contribution to journal › Article › peer-review