Matthew Walter

Edward P. Evans Endowed Professor of Myelodysplastic Syndromes, Professor of Genetics

    • 16267 Citations
    1994 …2020

    Research output per year

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    Personal profile

    Research interests

    The main interest of our laboratory is the discovery and characterization of gene mutations in patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) with the long term goal of understanding the molecular mechanisms that control abnormal hematopoiesis. MDS results from the expansion of one or more dominant hematopoietic clones that contain initiating mutations, while transformation from MDS to AML occurs as these clones accumulate additional progression factors (including point mutations in genes and cytogenetic abnormalities).

    Areas of Clinical Interest

    Hematology, oncology, bone marrow transplant

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    Research Output

    • 16267 Citations
    • 62 Article
    • 8 Letter
    • 6 Comment/debate
    • 6 Review article

    Genetics of progression from MDS to secondary leukemia

    Menssen, A. J. & Walter, M. J., Jul 2 2020, In : Blood. 136, 1, p. 50-60 11 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Haploinsufficiency of multiple del(5q) genes induce B cell abnormalities in mice

    Liu, T., Ahmed, T., Krysiak, K., Shirai, C. L., Shao, J., Nunley, R., Bucala, R., McKenzie, A., Ndonwi, M. & Walter, M. J., Sep 2020, In : Leukemia Research. 96, 106428.

    Research output: Contribution to journalLetter

    SF3B1-mutant MDS as a distinct disease subtype: A proposal from the International Working Group for the Prognosis of MDS

    Malcovati, L., Stevenson, K., Papaemmanuil, E., Neuberg, D., Bejar, R., Boultwood, J., Bowen, D. T., Campbell, P. J., Ebert, B. L., Fenaux, P., Haferlach, T., Heuser, M., Jansen, J. H., Komrokji, R. S., MacIejewski, J. P., Walter, M. J., Fontenay, M., Garcia-Manero, G., Graubert, T. A., Karsan, A. & 16 others, Meggendorfer, M., Pellagatti, A., Sallman, D. A., Savona, M. R., Sekeres, M. A., Steensma, D. P., Tauro, S., Thol, F., Vyas, P., Loosdrecht, A. A. V. D., Haase, D., Tüchler, H., Greenberg, P. L., Ogawa, S., Hellstrom-Lindberg, E. & Cazzola, M., Jul 9 2020, In : Blood. 136, 2, p. 157-170 14 p.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Scopus citations

    Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling

    Pollyea, D. A., Harris, C., Rabe, J. L., Hedin, B. R., De Arras, L., Katz, S., Wheeler, E., Bejar, R., Walter, M. J., Jordan, C. T., Pietras, E. M. & Alper, S., Aug 31 2019, In : Haematologica. 104, 9, p. E388-E392

    Research output: Contribution to journalLetter

    Open Access
    4 Scopus citations

    The National MDS Natural History Study: design of an integrated data and sample biorepository to promote research studies in myelodysplastic syndromes

    Sekeres, M. A., Gore, S. D., Stablein, D. M., DiFronzo, N., Abel, G. A., DeZern, A. E., Troy, J. D., Rollison, D. E., Thomas, J. W., Waclawiw, M. A., Liu, J. J., Al Baghdadi, T., Walter, M. J., Bejar, R., Gorak, E. J., Starczynowski, D. T., Foran, J. M., Cerhan, J. R., Moscinski, L. C., Komrokji, R. S. & 2 others, Deeg, H. J. & Epling-Burnette, P. K., Nov 10 2019, In : Leukemia and Lymphoma. 60, 13, p. 3161-3171 11 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations