Research output per year
Research output per year
Personal profile
Research interests
The Silva lab studies bone. We are focused on two main questions. 1) How does mechanical loading (e.g., weight-bearing exercise) stimulate bone formation and increase bone mass? 2) How do bones heal after injury (e.g., stress fracture and full fracture)? By studying how the skeleton responds to mechanical stimulation and how it heals after injury, we aim to contribute to the discovery of new approaches to treat reduced bone mass and strength in aging/osteoporosis, and to enhance bone repair in patients who suffer from non-healing fractures.
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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Multi-organ phenotypes in mice lacking latent TGFβ binding protein 2 (LTBP2)
Bodmer, N. K., Knutsen, R. H., Roth, R. A., Castile, R. M., Brodt, M. D., Gierasch, C. M., Broekelmann, T. J., Gibson, M. A., Haspel, J. A., Lake, S. P., Koenitzer, J. R., Brody, S. L., Silva, M. J., Mecham, R. P. & Ornitz, D. M., 2023, (Accepted/In press) In: Developmental Dynamics.Research output: Contribution to journal › Article › peer-review
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Postnatal Osterix but not DMP1 lineage cells significantly contribute to intramembranous ossification in three preclinical models of bone injury
Buettmann, E. G., Yoneda, S., Hu, P., McKenzie, J. A. & Silva, M. J., Jan 4 2023, In: Frontiers in Physiology. 13, 1083301.Research output: Contribution to journal › Article › peer-review
Open Access -
T cells heal bone fractures with help from the gut microbiome
Aurora, R. & Silva, M. J., Apr 17 2023, In: Journal of Clinical Investigation. 133, 8, e167311.Research output: Contribution to journal › Review article › peer-review
Open Access -
Cortical bone relationships are maintained regardless of sex and diet in a large population of LGXSM advanced intercross mice
Migotsky, N., Brodt, M. D., Cheverud, J. M. & Silva, M. J., Dec 2022, In: Bone Reports. 17, 101615.Research output: Contribution to journal › Article › peer-review
Open Access -
Cryogel Scaffold-Mediated Delivery of Adipose-Derived Stem Cells Promotes Healing in Murine Model of Atrophic Non-Union
Hixon, K. R., Katz, D. B., McKenzie, J. A., Miller, A., Guilak, F. & Silva, M., May 5 2022, In: Frontiers in Bioengineering and Biotechnology. 10, 851904.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations