Research output per year
Research output per year
Personal profile
Research interests
The Silva lab studies bone. We are focused on two main questions. 1) How does mechanical loading (e.g., weight-bearing exercise) stimulate bone formation and increase bone mass? 2) How do bones heal after injury (e.g., stress fracture and full fracture)? By studying how the skeleton responds to mechanical stimulation and how it heals after injury, we aim to contribute to the discovery of new approaches to treat reduced bone mass and strength in aging/osteoporosis, and to enhance bone repair in patients who suffer from non-healing fractures.
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Cortical bone relationships are maintained regardless of sex and diet in a large population of LGXSM advanced intercross mice
Migotsky, N., Brodt, M. D., Cheverud, J. M. & Silva, M. J., Dec 2022, In: Bone Reports. 17, 101615.Research output: Contribution to journal › Article › peer-review
Open Access -
Cryogel Scaffold-Mediated Delivery of Adipose-Derived Stem Cells Promotes Healing in Murine Model of Atrophic Non-Union
Hixon, K. R., Katz, D. B., McKenzie, J. A., Miller, A., Guilak, F. & Silva, M., May 5 2022, In: Frontiers in Bioengineering and Biotechnology. 10, 851904.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Dmp1 Lineage Cells Contribute Significantly to Periosteal Lamellar Bone Formation Induced by Mechanical Loading But Are Depleted from the Bone Surface During Rapid Bone Formation
Harris, T. L. & Silva, M. J., Mar 2022, In: JBMR Plus. 6, 3, e10593.Research output: Contribution to journal › Article › peer-review
Open Access -
Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling
Sun, K., Wang, C., Xiao, J., Brodt, M. D., Yuan, L., Yang, T., Alippe, Y., Hu, H., Hao, D., Abu-Amer, Y., Silva, M. J., Shen, J. & Mbalaviele, G., Mar 2022, In: eLife. 11, e75753.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
KIF26B Silencing Prevents Osseous Transdifferentiation of Progenitor/Stem Cells and Attenuates Ectopic Calcification in a Murine Model
Yan, M., Duan, X., Cai, L., Zhang, W., Silva, M., Brophy, R. H. & Rai, M. F., Feb 2022, In: Journal of Bone and Mineral Research. 37, 2, p. 349-368 20 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations