Research output per year
Research output per year
Personal profile
Research interests
The Silva lab studies bone. We are focused on two main questions. 1) How does mechanical loading (e.g., weight-bearing exercise) stimulate bone formation and increase bone mass? 2) How do bones heal after injury (e.g., stress fracture and full fracture)? By studying how the skeleton responds to mechanical stimulation and how it heals after injury, we aim to contribute to the discovery of new approaches to treat reduced bone mass and strength in aging/osteoporosis, and to enhance bone repair in patients who suffer from non-healing fractures.
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Research output
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Dmp1 Lineage Cells Contribute Significantly to Periosteal Lamellar Bone Formation Induced by Mechanical Loading But Are Depleted from the Bone Surface During Rapid Bone Formation
Harris, T. L. & Silva, M. J., Mar 2022, In: JBMR Plus. 6, 3, e10593.Research output: Contribution to journal › Article › peer-review
Open Access -
Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling
Sun, K., Wang, C., Xiao, J., Brodt, M. D., Yuan, L., Yang, T., Alippe, Y., Hu, H., Hao, D., Abu-Amer, Y., Silva, M. J., Shen, J. & Mbalaviele, G., Mar 2022, In: eLife. 11, e75753.Research output: Contribution to journal › Article › peer-review
Open Access -
KIF26B Silencing Prevents Osseous Transdifferentiation of Progenitor/Stem Cells and Attenuates Ectopic Calcification in a Murine Model
Yan, M., Duan, X., Cai, L., Zhang, W., Silva, M., Brophy, R. H. & Rai, M. F., Feb 2022, In: Journal of Bone and Mineral Research. 37, 2, p. 349-368 20 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Osteoblast-Specific Wnt Secretion Is Required for Skeletal Homeostasis and Loading-Induced Bone Formation in Adult Mice
Lawson, L. Y., Brodt, M. D., Migotsky, N., Chermside-Scabbo, C. J., Palaniappan, R. & Silva, M. J., Jan 2022, In: Journal of Bone and Mineral Research. 37, 1, p. 108-120 13 p.Research output: Contribution to journal › Article › peer-review
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Ablation of Proliferating Osteoblast Lineage Cells After Fracture Leads to Atrophic Nonunion in a Mouse Model
Hixon, K. R., McKenzie, J. A., Sykes, D. A. W., Yoneda, S., Hensley, A., Buettmann, E. G., Zheng, H., Skouteris, D., McAlinden, A., Miller, A. N. & Silva, M. J., Nov 2021, In: Journal of Bone and Mineral Research. 36, 11, p. 2243-2257 15 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations