Research output per year
Research output per year
Personal profile
Research interests
The Silva lab studies bone. We are focused on two main questions. 1) How does mechanical loading (e.g., weight-bearing exercise) stimulate bone formation and increase bone mass? 2) How do bones heal after injury (e.g., stress fracture and full fracture)? By studying how the skeleton responds to mechanical stimulation and how it heals after injury, we aim to contribute to the discovery of new approaches to treat reduced bone mass and strength in aging/osteoporosis, and to enhance bone repair in patients who suffer from non-healing fractures.
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Research output
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Estimation of load conditions and strain distribution for in vivo murine tibia compression loading using experimentally informed finite element models
Pickering, E., Silva, M. J., Delisser, P., Brodt, M. D., Gu, Y. T. & Pivonka, P., Jan 22 2021, In: Journal of Biomechanics. 115, 110140.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Gene expression of intracortical bone demonstrates loading-induced increases in Wnt1 and Ngf and inhibition of bone remodeling processes
Harris, T. L. & Silva, M. J., Sep 2021, In: Bone. 150, 116019.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Interleukin-6 (IL-6) deficiency enhances intramembranous osteogenesis following stress fracture in mice
Coates, B. A., McKenzie, J. A., Yoneda, S. & Silva, M. J., Feb 2021, In: Bone. 143, 115737.Research output: Contribution to journal › Article › peer-review
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KIF26B Silencing Prevents Osseous Transdifferentiation of Progenitor/Stem Cells and Attenuates Ectopic Calcification in a Murine Model
Yan, M., Duan, X., Cai, L., Zhang, W., Silva, M., Brophy, R. H. & Rai, M. F., 2021, (Accepted/In press) In: Journal of Bone and Mineral Research.Research output: Contribution to journal › Article › peer-review
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MicroCT for Scanning and Analysis of Mouse Bones
Kim, Y., Brodt, M. D., Tang, S. Y. & Silva, M. J., 2021, Methods in Molecular Biology. Humana Press Inc., p. 169-198 30 p. (Methods in Molecular Biology; vol. 2230).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review