Matthew Lew

Research output

Research output per year 2007 2010 2013 2018 2019 2020 2021 2022 2024 2024

• 38 Article
• 37 Conference contribution
• 2 Comment/debate
• 2 Review article
• 1 More
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2024

  6D single-fluorogen orientation-localization microscopy for elucidating the architecture of beta-sheet assemblies and biomolecular condensates

  Wu, T., Zhou, W., Rudra, J. S., Pappu, R. V. & Lew, M. D., 2024, High-Speed Biomedical Imaging and Spectroscopy IX. Tsia, K. K. & Goda, K. (eds.). SPIE, 1285302. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 12853).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Fluorophore 100%
  • Biomolecular Condensates 100%
  • Beta Sheet 100%
  • Localization Microscopy 100%
  • Amyloid Beta 100%

• PERISCOPE: Detecting and Mapping Organic Compounds in the Near Subsurface

  Eshelman, E., Willis, M., Foreman, C., Michels, J., Cerrud, A., Schattner, L., Singh, G., Van Hoesen, D., Medina, W., Carlson, T. & Lew, M., 2024, 2024 IEEE Aerospace Conference, AERO 2024. IEEE Computer Society, (IEEE Aerospace Conference Proceedings).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Organic Compounds 100%
  • Mars 100%
  • Mid-latitude 100%
  • Organics Detection 100%
  • Micro-Organism 100%
• 2021

  Imaging chemical environments and amyloid architectures using single-molecule orientation-localization microscopy

  Ding, T., Lu, J., Wu, T. & Lew, M. D., 2021, Imaging Systems and Applications, ISA 2021. The Optical Society, ITu7A.6. (Optics InfoBase Conference Papers).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Chemical Environment 100%
  • Single-molecule Orientation 100%
  • Localization Microscopy 100%
  • Imaging in Chemistry 100%
  • Point Spread Function 50%

• Robustly detecting imaging model mismatches and reconstruction artifacts in single-molecule localization microscopy

  Mazidi, H., Ding, T., Nehorai, A. & Lew, M. D., 2021, Computational Optical Sensing and Imaging, COSI 2021. The Optical Society, CTu4B.5. (Optics InfoBase Conference Papers).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Imaging Model 100%
  • Reconstruction Artifacts 100%
  • Single-molecule Localization Microscopy 100%
  • Model Reconstruction 100%
  • Wasserstein 100%
• 2020

  A computationally-efficient bound for the variance of measuring the orientation of single molecules

  Wu, T., Ding, T., Mazidi, H., Zhang, O. & Lew, M. D., 2020, Single Molecule Spectroscopy and Superresolution Imaging XIII. Gregor, I., Koberling, F. & Erdmann, R. (eds.). SPIE, 1124616. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11246).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Single Molecule 100%
  • Computationally Efficient 100%
  • Cramér-Rao Bound 100%
  • Engineering 100%
  • Diagonal Element 100%

• Measuring localization confidence for quantifying accuracy and heterogeneity in single-molecule super-resolution microscopy

  Mazidi, H., Ding, T., Nehorai, A. & Lew, M. D., 2020, Single Molecule Spectroscopy and Superresolution Imaging XIII. Gregor, I., Koberling, F. & Erdmann, R. (eds.). SPIE, 1124611. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11246).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Single Molecule 100%
  • Super-resolution Microscopy 100%
  • Wasserstein 100%
  • Quantifying Accuracy 100%
  • Localization Confidence 100%
  1 Scopus citations
• 2019

  Dense super-resolution imaging of molecular orientation via joint sparse basis deconvolution and spatial pooling

  Mazidi, H., King, E. S., Zhang, O., Nehorai, A. & Lew, M. D., Apr 2019, ISBI 2019 - 2019 IEEE International Symposium on Biomedical Imaging. IEEE Computer Society, p. 325-329 5 p. 8759444. (Proceedings - International Symposium on Biomedical Imaging; vol. 2019-April).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Point Spread Function 100%
  • Super-resolution Imaging 100%
  • Image-based 100%
  • Spatial Features 100%
  • Deconvolution 100%
  15 Scopus citations

• Fundamental limits of measuring single-molecule rotational mobility

  Zhang, O. & Lew, M. D., 2019, Single Molecule Spectroscopy and Superresolution Imaging XII. Gryczynski, Z. K., Gregor, I. & Koberling, F. (eds.). SPIE, 1088412. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10884).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Single Molecule 100%
  • Fundamental Limits 100%
  • Order Moments 100%
  • Rotational Mobility 100%
  • Molecular Orientation 100%

• Fundamental limits on imaging the orientational dynamics of dipole-like emitters

  Zhang, O. & Lew, M. D., 2019, Mathematics in Imaging, MATH 2019. Optica Publishing Group (formerly OSA), (Optics InfoBase Conference Papers; vol. Part F158-MATH 2019).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • 3D Motion 100%
  • Fluorescent Molecules 100%
  • Fundamental Limits 100%
  • Orientational Dynamics 100%
  • Dipole 100%

• Long-term, super-resolution imaging of amyloid structures using transient amyloid binding microscopy

  Ding, T., Spehar, K., Bieschke, J. & Lew, M. D., 2019, Single Molecule Spectroscopy and Superresolution Imaging XII. Koberling, F., Gryczynski, Z. K. & Gregor, I. (eds.). SPIE, 108840J. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10884).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Super-resolution Imaging 100%
  • Microscopy 100%
  • Amyloid Binding 100%
  • Amyloid Structure 100%
  • Amyloid Fibril 100%
  5 Scopus citations

• Long-term super-resolution imaging of amyloid structures using transient binding of thioflavin T

  Spehar, K., Ding, T., Sun, Y., Kedia, N., Lu, J., Nahass, G. R., Lew, M. D. & Bieschke, J., Apr 8 2019, Optical Molecular Probes, Imaging and Drug Delivery - Proceedings Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA, BRAIN, NTM, OMA, OMP). Optical Society of America (OSA), (Optical Molecular Probes, Imaging and Drug Delivery - Proceedings Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA, BRAIN, NTM, OMA, OMP)).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Super-resolution Imaging 100%
  • Reversible Binding 100%
  • Thioflavin T 100%
  • Amyloid Structure 100%
  • Amyloid Protein 100%

• Long-term super-resolution imaging of amyloid structures using transient binding of Thioflavin T

  Spehar, K., Ding, T., Sun, Y., Kedia, N., Lu, J., Nahass, G. R., Lew, M. D. & Bieschke, J., 2019, Optical Molecular Probes, Imaging and Drug Delivery, OMP 2019. Optica Publishing Group (formerly OSA), (Optics InfoBase Conference Papers; vol. Part F163-OMP 2019).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  Open Access

  • Super-resolution Imaging 100%
  • Reversible Binding 100%
  • Thioflavin T 100%
  • Amyloid Structure 100%
  • Amyloid Protein 100%

• Measuring rotational dynamics with high accuracy and precision using a tri-spot point spread function

  Zhang, O. & Lew, M. D., Apr 8 2019, Novel Techniques in Microscopy - Proceedings Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA, BRAIN, NTM, OMA, OMP). Optical Society of America (OSA), NTM-2019-NS2B.2. (Novel Techniques in Microscopy - Proceedings Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA, BRAIN, NTM, OMA, OMP)).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Point Spread Function 100%
  • Rotational Dynamics 100%
  • Dynamics 100%
  • Fluorescence Microscopy 100%
  • Order Moments 50%

• Single-molecule super-resolution imaging of molecular orientation using a tri-spot point spread function

  Mazidi, H., King, E. S., Zhang, O., Nehorai, A. & Lew, M. D., 2019, Computational Optical Sensing and Imaging, COSI 2019. Optica Publishing Group (formerly OSA), (Optics InfoBase Conference Papers; vol. Part F170-COSI 2019).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Point Spread Function 100%
  • Super-resolution Imaging 100%
  • Single Molecule 100%
  • Molecular Orientation 100%
  • Super-Resolution Imaging 100%
• 2018

  A robust statistical estimation (RoSE) algorithm jointly recovers the 3D location and intensity of single molecules accurately and precisely

  Mazidi, H., Nehorai, A. & Lew, M. D., 2018, Single Molecule Spectroscopy and Superresolution Imaging XI. Koberling, F., Gregor, I., Enderlein, J., Erdmann, R. & Gryczynski, Z. K. (eds.). SPIE, 105000E. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10500).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Single Molecule 100%
  • Estimation Algorithms 100%
  • Robust Estimation 100%
  • 3D Location 100%
  • Estimation Algorithm 100%
  1 Scopus citations

• Measuring 3D molecular orientation and rotational mobility using a Tri-spot point spread function

  Zhang, O., Ding, T., Lu, J., Mazidi, H. & Lew, M. D., 2018, Single Molecule Spectroscopy and Superresolution Imaging XI. Koberling, F., Gregor, I., Enderlein, J., Erdmann, R. & Gryczynski, Z. K. (eds.). SPIE, 105000B. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10500).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Point Spread Function 100%
  • Rotational Mobility 100%
  • Molecular Orientation 100%
  • Rotational 100%
  • Single Molecule 25%
  2 Scopus citations

• Speckle-Free Non-Invasive Imaging with Speckle-Modulating Optical Coherence Tomography

  Liba, O., Lew, M. D., Sorelle, E. D., Dutta, R., Sen, D., Moshfeghi, D. M., Chu, S. & De La Zerda, A., Aug 6 2018, 2018 Conference on Lasers and Electro-Optics, CLEO 2018 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 8426268. (2018 Conference on Lasers and Electro-Optics, CLEO 2018 - Proceedings).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Optical Coherence Tomography 100%
  • Non-invasive Imaging 100%
  • Speckle-free 100%
  • Optics 100%
  • Speckle Noise 66%

• Speckle-free non-invasive imaging with Speckle- Modulating Optical Coherence Tomography

  Liba, O., Lew, M. D., SoRelle, E. D., Dutta, R., Sen, D., Moshfeghi, D. M., Chu, S. & de la Zerda, A., 2018, CLEO: Applications and Technology, CLEO_AT 2018. Optica Publishing Group (formerly OSA), (Optics InfoBase Conference Papers; vol. Part F92-CLEO_AT 2018).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Optical Coherence Tomography 100%
  • Non-invasive Imaging 100%
  • Speckle-free 100%
  • Optics 100%
  • Speckle Noise 66%

• Speckle-modulation for speckle reduction in optical coherence tomography

  Liba, O., Lew, M. D., Sorelle, E. D., Dutta, R., Sen, D., Moshfeghi, D. M., Chu, S. & De La Zerda, A., 2018, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII. Tuchin, V. V., Tuchin, V. V., Fujimoto, J. G. & Izatt, J. A. (eds.). SPIE, 104832D. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10483).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Optical Coherence Tomography 100%
  • Speckle Modulation 100%
  • Speckle Reduction 100%
  • Tomography 100%
  • Coherence 100%
• 2015

  Accurate 3D Nanoscale Imaging of Dipole-like Emitters

  Lew, M. D., 2015, Laser Science, LS 2015. Optica Publishing Group (formerly OSA), LW3I.2. (Optics InfoBase Conference Papers).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Image Processing 100%
  • Point Spread Function 100%
  • 3D Position 100%
  • Single Molecule 100%
  • Nanoscale Imaging 100%

• An azimuthal polarizer assures localization accuracy in single-molecule super-resolution fluorescence microscopy

  Lew, M. D. & Moerner, W. E., May 4 2015, CLEO: Science and Innovations, CLEO-SI 2015. Optical Society of America (OSA), p. 2267 1 p. (CLEO: Science and Innovations, CLEO-SI 2015).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Single Molecule 100%
  • Fluorescent Molecules 100%
  • Assure 100%
  • Measurement Accuracy 100%
  • Localization Accuracy 100%

• An azimuthal polarizer assures localization accuracy in single-molecule super-resolution fluorescence microscopy

  Lew, M. D. & Moerner, W. E., Aug 10 2015, 2015 Conference on Lasers and Electro-Optics, CLEO 2015. Institute of Electrical and Electronics Engineers Inc., 7184107. (Conference on Lasers and Electro-Optics Europe - Technical Digest; vol. 2015-August).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Single Molecule 100%
  • Fluorescent Molecules 100%
  • Assure 100%
  • Measurement Accuracy 100%
  • Localization Accuracy 100%
• 2014

  Single-molecule orientation measurements with a quadrated pupil

  Backer, A. S., Backlund, M. P., Lew, M. D., Diezmann, A. R., Sahl, S. J. & Moerner, W. E., 2014, Single Molecule Spectroscopy and Superresolution Imaging VII. SPIE, 89500L. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 8950).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  Open Access

  • Orientation Measurement 100%
  • Single-molecule Orientation 100%
  • Phase Mask 100%
  • Liquid Crystal 100%
  • Imaging Studies 50%
• 2013

  Measuring the 3D position and orientation of single molecules simultaneously and accurately with the double helix microscope

  Lew, M. D., Backlund, M. P., Backer, A. S., Sahl, S. J., Grover, G., Agrawal, A., Piestun, R. & Moerner, W. E., 2013, CLEO: Science and Innovations, CLEO_SI 2013. p. CTu3N.3 (CLEO: Science and Innovations, CLEO_SI 2013).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • 3D Position 100%
  • Single Molecule 100%
  • Diffraction Limit 100%
  • System Level 100%
  • Optical Devices 100%

• Measuring the 3D position and orientation of single molecules simultaneously and accurately with the double helix microscope

  Lew, M. D., Backlund, M. P., Backer, A. S., Sahl, S. J., Grover, G., Agrawal, A., Piestun, R. & Moerner, W. E., 2013, 2013 Conference on Lasers and Electro-Optics, CLEO 2013. IEEE Computer Society, 6833636. (2013 Conference on Lasers and Electro-Optics, CLEO 2013).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • 3D Position 100%
  • Single Molecule 100%
  • 3D Orientation 100%
  • Double Helix 100%
  • Helix 100%

• Optical methods for measuring single-molecule orientation and position: Implications for super-resolution microscopy

  Lew, M. D., Backlund, M. P., Backer, A. S. & Moerner, W. E., 2013, Frontiers in Optics, FIO 2013. Optical Society of America, (Optics InfoBase Conference Papers).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Optical Methods 100%
  • Super-resolution Microscopy 100%
  • Single-molecule Orientation 100%
  • Optics 100%
  • Super-Resolution Microscopy 100%

• Single-molecule orientation measurements with a quadrated pupil

  Backer, A. S., Backlund, M. P., Lew, M. D. & Moerner, W. E., 2013, Imaging Systems and Applications, ISA 2013. Optical Society of America (OSA), (Optics InfoBase Conference Papers).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  Open Access

  • Orientation Measurement 100%
  • Single-molecule Orientation 100%
  • Phase Mask 100%
  • Liquid Crystal 100%
  • Imaging Studies 50%

• The double-helix point spread function enables precise and accurate measurement of 3D single-molecule localization and orientation

  Backlund, M. P., Lew, M. D., Backer, A. S., Sahl, S. J., Grover, G., Agrawal, A., Piestun, R. & Moerner, W. E., 2013, Single Molecule Spectroscopy and Superresolution Imaging VI. 85900L. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 8590).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  Open Access

  • Three-dimensional (3D) 100%
  • Single Molecule 100%
  • Measurement Accuracy 100%
  • Precise Measurement 100%
  • Double-helix Point Spread Function 100%
  34 Scopus citations
• 2011

  Super-resolution 3D co-localization of protein superstructures and the cellular surface in live caulobacter crescentus

  Lew, M. D., Lee, S. F., Ptacin, J. L., Lee, M. K., Shapiro, L. & Moerner, W. E., 2011, Frontiers in Optics, FiO 2011. Optical Society of America (OSA), (Optics InfoBase Conference Papers).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Colocalization 100%
  • Cell Surface 100%
  • Imaging Techniques 100%
  • Living Cells 100%
  • Super-resolution 100%

• Three-dimensional super-resolution imaging with a corkscrew point spread function

  Lew, M. D., Lee, S. F. & Moerner, W. E., 2011, Novel Techniques in Microscopy, NTM 2011. Optical Society of America (OSA), (Optics InfoBase Conference Papers).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Point Spread Function 100%
  • Super-resolution Imaging 100%
  • Corkscrew 100%
  • 3D Super-resolution 100%
  • Super-Resolution Imaging 100%
• 2010

  In vivo three-dimensional superresolution fluorescence tracking using a double-helix point spread function

  Lew, M. D., Thompson, M. A., Badieirostami, M. & Moerner, W. E., 2010, Single Molecule Spectroscopy and Imaging III. 75710Z. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 7571).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Double-helix Point Spread Function 100%
  • 3D Super-resolution 100%
  • Fluorescence Tracking 100%
  • Point Spread Function 100%
  • Quantum Dot 100%
  21 Scopus citations

• Localizing and tracking single emitters in three dimensions using a double-helix point spread function

  Thompson, M. A., Lew, M. D., Badieirostami, M. & Moerner, W. E., 2010, Conference on Lasers and Electro-Optics, CLEO 2010. (Optics InfoBase Conference Papers).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Quantum Dots 100%
  • Living Cells 100%
  • Fluorescent Emitter 100%
  • Double-helix Point Spread Function 100%
  • Single Emitter 100%

• Localizing and tracking single emitters in three dimensions using a Double-Helix Point Spread Function

  Thompson, M. A., Lew, M. D., Badieirostami, M. & Moerner, W. E., 2010, Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference: 2010 Laser Science to Photonic Applications, CLEO/QELS 2010. Association for Computing Machinery, 5499680. (Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference: 2010 Laser Science to Photonic Applications, CLEO/QELS 2010).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Quantum Dots 100%
  • Living Cells 100%
  • Fluorescent Emitter 100%
  • Double-helix Point Spread Function 100%
  • Single Emitter 100%
• 2009

  Localization precision of three-dimensional superresolution fluorescence imaging using a double-helix point spread function

  Lew, M., Thompson, M. A., Badieirostami, M. & Moerner, W. E., 2009, Computational Optical Sensing and Imaging, COSI 2009. Optical Society of America (OSA), (Optics InfoBase Conference Papers).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Point Spread Function 100%
  • Living Cells 100%
  • Diffraction Limit 100%
  • Fluorescent Beads 100%
  • Localization Precision 100%

• Three-dimensional superresolution using single-molecule photoswitches and a double-helix PSF

  Moerner, W. E., Thompson, M., Lew, M., Badieirostami, M., Lord, S. J., Conley, N. R., Lee, H. L. D., Pavani, S. R. P. & Piestun, R., 2009, Computational Optical Sensing and Imaging, COSI 2009. Optical Society of America (OSA), (Optics InfoBase Conference Papers).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Single Molecule 100%
  • Double-helix PSF 100%
  • 3D Super-resolution 100%
  • Photoswitches 100%
  • Fluorescence Imaging 100%
• 2008

  Two-dimensional differential interference contrast microscopy based on four-hole variation of Young's interference

  Lew, M., Cui, X., Heng, X. & Yang, C., Feb 29 2008, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VI. SPIE, 685916. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 6859).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  Open Access

  • Two Dimensional 100%
  • Incident Light 100%
  • Differential Interference Contrast Microscopy 100%
  • Interference Pattern 100%
  • Phase Gradient 100%
• 2007

  Oil-chip differential interference contrast (DIC) phase imager and beam profiler based on Young's interference

  Cui, X., Lew, M., Heng, X. & Yang, C., 2007, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V. 64411F. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 6441).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Differential Interference Contrast 100%
  • Young's Interference 100%
  • Contrast Phase 100%
  • Beam Profiler 100%
  • Phase Contrast 100%