Personal profile
Research interests
The Lew Lab builds advanced imaging systems to study biological and chemical systems at the nanoscale. Our technology leverages innovations in applied optics, signal and image processing, design optimization, and physical chemistry. Super-resolution is a key feature of many of our imaging systems–the ability to overcome the resolution limit of wave physics, called the diffraction limit, in order to visualize the nanoscale world. Single-molecule imaging is also a central theme of our research–enabling our technology to see individual molecules as they drive biological and chemical dynamics at the nanoscale.
Our research spans three areas: 1) Sensing nanoscale environments using single fluorescent molecules; 2) Designing microscopes for optimal multidimensional nanoscale imaging; and 3) Building multidimensional image analysis algorithms that are robust against bias and noise.
Education activities and interests
In addition to my regular teaching commitments on the Danforth campus, I am the Associate Chair of Academic Affairs in the Department of Electrical and Systems Engineering. I have received the 2020 Emerson Electric. Co. “Excellence in Teaching” award (https://source.wustl.edu/2020/11/seven-faculty-honored-with-2020-emerson-teaching-awards/) and the 2019-2020 Outstanding Teaching Award (https://lewlab.wustl.edu/files/McKelvey_Honors_Program_2020.pdf) from the Department of Electrical and Systems Engineering. I also serve as the faculty advisor for Washington University Spectra (https://sites.wustl.edu/spectra/home/), a student chapter of Optica and SPIE.
Mentoring
I am committed to fostering a supportive research environment that prioritizes members’ well-being and professional development. I have participated in #MentorFirst (https://mentorfirst.org/) training in the McKelvey School of Engineering.
Available to Mentor:
- Undergraduate Students
- Post-Baccalaureate Students
- PhD Students
- Postdocs
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Collaborations and top research areas from the last five years
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Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases
Shinn, M. K., Tomares, D. T., Liu, V., Pant, A., Qiu, Y., Vitalis, A., Song, Y. J., Ayala, Y., Ruff, K. M., Strout, G. W., Lew, M. D., Prasanth, K. V. & Pappu, R. V., Feb 5 2026, In: Cell. 189, 3, p. 832-852.e24Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Scopus citations -
Combining Excitation and Emission Modulation Resolves the Angular Separation between a Pair of Dipole Emitters
Chen, Y., Qiu, Y. & Lew, M. D., 2025.Research output: Contribution to conference › Paper › peer-review
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Correction to “Single-Molecule Orientation Imaging Reveals the Nano-Architecture of Amyloid Fibrils Undergoing Growth and Decay”
Sun, B., Ding, T., Zhou, W., Porter, T. S. & Lew, M. D., Sep 10 2025, In: Nano Letters. 25, 36, p. 13720 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
Differential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates
Erkamp, N. A., Farag, M., Qiu, Y., Qian, D., Sneideris, T., Wu, T., Welsh, T. J., Ausserwöger, H., Krug, T. J., Chauhan, G., Weitz, D. A., Lew, M. D., Knowles, T. P. J. & Pappu, R. V., Dec 2025, In: Nature communications. 16, 1, 3463.Research output: Contribution to journal › Article › peer-review
Open Access12 Link opens in a new tab Scopus citations -
Painting rich six-dimensional pictures using polarized fluorescence microscopy
Lew, M. D., Apr 8 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 14, e2501914122.Research output: Contribution to journal › Comment/debate
Open Access