• 15024 Citations
1973 …2020

Research output per year

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Personal profile

Research interests

I have been an NIH-funded investigator since 1991. My research focuses on the regulation of oxidant production by the phagocyte NADPH oxidase, its role in innate immunity and inflammation and inherited defects in Chronic Granulomatous Disease (CGD), where we recently identified a new genetic subgroup of this disorder. The NADPH oxidase is increasingly recognized to have immunomodulatory functions in addition to its role in microbial killing. My laboratory is investigating the regulation and assembly of NADPH oxidase in phagocytic leukocytes, its role in innate immunity and inflammation, inherited defects in CGD, and strategies for treatment of CGD by gene modification of hematopoietic stem cells. We have developed both a human myeloid cell line model and mouse model of X-linked CGD using gene targeting for use as pre-clinical model systems, in addition to studies in human neutrophils and marrow cells from healthy controls and patients with CGD.

Areas of Clinical Interest

Neutrophil disorders, chronic granulomatous disease

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Research Output

NADPH oxidase controls pulmonary neutrophil infiltration in the response to fungal cell walls by limiting LTB4

Song, Z., Huang, G., Paracatu, L. C., Grimes, D., Gu, J., Luke, C. J., Clemens, R. A. & Dinauer, M. C., Mar 19 2020, In : Blood. 135, 12, p. 891-903 13 p.

Research output: Contribution to journalArticle

  • 1 Scopus citations

    Neutrophil Defects and Diagnosis Disorders of Neutrophil Function: An Overview

    Dinauer, M. C., Jan 1 2020, Methods in Molecular Biology. Humana Press Inc., p. 11-29 19 p. (Methods in Molecular Biology; vol. 2087).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Neutrophil swarming delays the growth of clusters of pathogenic fungi

    Alex, H., Scherer, A., Kreuzburg, S., Abers, M. S., Zerbe, C. S., Dinauer, M. C., Mansour, M. K. & Irimia, D., Dec 1 2020, In : Nature communications. 11, 1, 2031.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Publisher Correction: Neutrophil swarming delays the growth of clusters of pathogenic fungi (Nature Communications, (2020), 11, 1, (2031), 10.1038/s41467-020-15834-4)

    Hopke, A., Scherer, A., Kreuzburg, S., Abers, M. S., Zerbe, C. S., Dinauer, M. C., Mansour, M. K. & Irimia, D., Dec 1 2020, In : Nature communications. 11, 1, 2492.

    Research output: Contribution to journalComment/debate

    Open Access
  • Inflammatory consequences of inherited disorders affecting neutrophil function

    Dinauer, M. C., May 16 2019, In : Blood. 133, 20, p. 2130-2139 10 p.

    Research output: Contribution to journalReview article

  • 8 Scopus citations