Research output per year
Research output per year
Personal profile
Research interests
I have been an NIH-funded investigator since 1991. My research focuses on the regulation of oxidant production by the phagocyte NADPH oxidase, its role in innate immunity and inflammation and inherited defects in Chronic Granulomatous Disease (CGD), where we recently identified a new genetic subgroup of this disorder. The NADPH oxidase is increasingly recognized to have immunomodulatory functions in addition to its role in microbial killing. My laboratory is investigating the regulation and assembly of NADPH oxidase in phagocytic leukocytes, its role in innate immunity and inflammation, inherited defects in CGD, and strategies for treatment of CGD by gene modification of hematopoietic stem cells. We have developed both a human myeloid cell line model and mouse model of X-linked CGD using gene targeting for use as pre-clinical model systems, in addition to studies in human neutrophils and marrow cells from healthy controls and patients with CGD.
Clinical interests
Neutrophil disorders, chronic granulomatous disease
Available to Mentor:
- PhD/MSTP Students
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Derivation of extra-embryonic and intra-embryonic macrophage lineages from human pluripotent stem cells
Bredemeyer, A. L., Amrute, J. M., Koenig, A. L., Idol, R. A., He, L., Luff, S. A., Dege, C., Leid, J. M., Schilling, J. D., Hinson, J. T., Dinauer, M. C., Sturgeon, C. M. & Lavine, K. J., Apr 2022, In: Development (Cambridge). 149, 8, dev200016.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice
Bhattacharya, S., Idol, R. A., Yang, W., Rojas Márquez, J. D., Li, Y., Huang, G., Beatty, W. L., Atkinson, J. J., Brumell, J. H., Bagaitkar, J., Magee, J. A. & Dinauer, M. C., May 12 2022, In: Blood. 139, 19, p. 2855-2870 16 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Neutrophil and Macrophage NADPH Oxidase 2 Differentially Control Responses to Inflammation and to Aspergillus fumigatus in Mice
Idol, R. A., Bhattacharya, S., Huang, G., Song, Z., Huttenlocher, A., Keller, N. P. & Dinauer, M. C., Nov 15 2022, In: Journal of Immunology. 209, 10, p. 1960-1972 13 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
A Novel CYBB Variant Causing X-Linked Chronic Granulomatous Disease in a Patient with Empyema
Kitcharoensakkul, M., Song, Z., Bednarski, J. J. & Dinauer, M., Jan 2021, In: Journal of Clinical Immunology. 41, 1, p. 266-269 4 p.Research output: Contribution to journal › Letter › peer-review
1 Scopus citations -
A sustained type i ifn-neutrophil-il-18 axis drives pathology during mucosal viral infection
Lebratti, T., Lim, Y. S., Cofie, A., Andhey, P., Jiang, X., Scott, J., Fabbrizi, M. R., Ozantürk, A. N., Pham, C., Clemens, R., Artyomov, M., Dinauer, M. & Shin, H., May 2021, In: eLife. 10, e65762.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations