Mark Watson

2012

Pathway-specific analysis of gene expression data identifies the PI3K/Akt pathway as a novel therapeutic target in cervical cancer

Schwarz, J. K., Payton, J. E., Rashmi, R., Xiang, T., Jia, Y., Huettner, P., Rogers, B. E., Yang, Q., Watson, M., Rader, J. S. & Grigsby, P. W., Mar 1 2012, In: Clinical Cancer Research. 18, 5, p. 1464-1471 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

97 Scopus citations

Structure, function and diversity of the healthy human microbiome

Huttenhower, C., Gevers, D., Knight, R., Abubucker, S., Badger, J. H., Chinwalla, A. T., Creasy, H. H., Earl, A. M., Fitzgerald, M. G., Fulton, R. S., Giglio, M. G., Hallsworth-Pepin, K., Lobos, E. A., Madupu, R., Magrini, V., Martin, J. C., Mitreva, M., Muzny, D. M., Sodergren, E. J. & Versalovic, J. & 228 others, Wollam, A. M., Worley, K. C., Wortman, J. R., Young, S. K., Zeng, Q., Aagaard, K. M., Abolude, O. O., Allen-Vercoe, E., Alm, E. J., Alvarado, L., Andersen, G. L., Anderson, S., Appelbaum, E., Arachchi, H. M., Armitage, G., Arze, C. A., Ayvaz, T., Baker, C. C., Begg, L., Belachew, T., Bhonagiri, V., Bihan, M., Blaser, M. J., Bloom, T., Bonazzi, V., Paul Brooks, J., Buck, G. A., Buhay, C. J., Busam, D. A., Campbell, J. L., Canon, S. R., Cantarel, B. L., Chain, P. S. G., Chen, I. M. A., Chen, L., Chhibba, S., Chu, K., Ciulla, D. M., Clemente, J. C., Clifton, S. W., Conlan, S., Crabtree, J., Cutting, M. A., Davidovics, N. J., Davis, C. C., Desantis, T. Z., Deal, C., Delehaunty, K. D., Dewhirst, F. E., Deych, E., Ding, Y., Dooling, D. J., Dugan, S. P., Michael Dunne, W., Scott Durkin, A., Edgar, R. C., Erlich, R. L., Farmer, C. N., Farrell, R. M., Faust, K., Feldgarden, M., Felix, V. M., Fisher, S., Fodor, A. A., Forney, L. J., Foster, L., Di Francesco, V., Friedman, J., Friedrich, D. C., Fronick, C. C., Fulton, L. L., Gao, H., Garcia, N., Giannoukos, G., Giblin, C., Giovanni, M. Y., Goldberg, J. M., Goll, J., Gonzalez, A., Griggs, A., Gujja, S., Kinder Haake, S., Haas, B. J., Hamilton, H. A., Harris, E. L., Hepburn, T. A., Herter, B., Hoffmann, D. E., Holder, M. E., Howarth, C., Huang, K. H., Huse, S. M., Izard, J., Jansson, J. K., Jiang, H., Jordan, C., Joshi, V., Katancik, J. A., Keitel, W. A., Kelley, S. T., Kells, C., King, N. B., Knights, D., Kong, H. H., Koren, O., Koren, S., Kota, K. C., Kovar, C. L., Kyrpides, N. C., La Rosa, P. S., Lee, S. L., Lemon, K. P., Lennon, N., Lewis, C. M., Lewis, L., Ley, R. E., Li, K., Liolios, K., Liu, B., Liu, Y., Lo, C. C., Lozupone, C. A., Dwayne Lunsford, R., Madden, T., Mahurkar, A. A., Mannon, P. J., Mardis, E. R., Markowitz, V. M., Mavromatis, K., McCorrison, J. M., McDonald, D., McEwen, J., McGuire, A. L., McInnes, P., Mehta, T., Mihindukulasuriya, K. A., Miller, J. R., Minx, P. J., Newsham, I., Nusbaum, C., Oglaughlin, M., Orvis, J., Pagani, I., Palaniappan, K., Patel, S. M., Pearson, M., Peterson, J., Podar, M., Pohl, C., Pollard, K. S., Pop, M., Priest, M. E., Proctor, L. M., Qin, X., Raes, J., Ravel, J., Reid, J. G., Rho, M., Rhodes, R., Riehle, K. P., Rivera, M. C., Rodriguez-Mueller, B., Rogers, Y. H., Ross, M. C., Russ, C., Sanka, R. K., Sankar, P., Fah Sathirapongsasuti, J., Schloss, J. A., Schloss, P. D., Schmidt, T. M., Scholz, M., Schriml, L., Schubert, A. M., Segata, N., Segre, J. A., Shannon, W. D., Sharp, R. R., Sharpton, T. J., Shenoy, N., Sheth, N. U., Simone, G. A., Singh, I., Smillie, C. S., Sobel, J. D., Sommer, D. D., Spicer, P., Sutton, G. G., Sykes, S. M., Tabbaa, D. G., Thiagarajan, M., Tomlinson, C. M., Torralba, M., Treangen, T. J., Truty, R. M., Vishnivetskaya, T. A., Walker, J., Wang, L., Wang, Z., Ward, D. V., Warren, W., Watson, M. A., Wellington, C., Wetterstrand, K. A., White, J. R., Wilczek-Boney, K., Wu, Y., Wylie, K. M., Wylie, T., Yandava, C., Ye, L., Ye, Y., Yooseph, S., Youmans, B. P., Zhang, L., Zhou, Y., Zhu, Y., Zoloth, L., Zucker, J. D., Birren, B. W., Gibbs, R. A., Highlander, S. K., Methé, B. A., Nelson, K. E., Petrosino, J. F., Weinstock, G. M., Wilson, R. K. & White, O., Jun 14 2012, In: Nature. 486, 7402, p. 207-214 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8935 Scopus citations

The origin and evolution of mutations in acute myeloid leukemia

Welch, J. S., Ley, T. J., Link, D. C., Miller, C. A., Larson, D. E., Koboldt, D. C., Wartman, L. D., Lamprecht, T. L., Liu, F., Xia, J., Kandoth, C., Fulton, R. S., McLellan, M. D., Dooling, D. J., Wallis, J. W., Chen, K., Harris, C. C., Schmidt, H. K., Kalicki-Veizer, J. M. & Lu, C. & 34 others, Zhang, Q., Lin, L., O'Laughlin, M. D., McMichael, J. F., Delehaunty, K. D., Fulton, L. A., Magrini, V. J., McGrath, S. D., Demeter, R. T., Vickery, T. L., Hundal, J., Cook, L. L., Swift, G. W., Reed, J. P., Alldredge, P. A., Wylie, T. N., Walker, J. R., Watson, M. A., Heath, S. E., Shannon, W. D., Varghese, N., Nagarajan, R., Payton, J. E., Baty, J. D., Kulkarni, S., Klco, J. M., Tomasson, M. H., Westervelt, P., Walter, M. J., Graubert, T. A., Dipersio, J. F., Ding, L., Mardis, E. R. & Wilson, R. K., Jul 20 2012, In: Cell. 150, 2, p. 264-278 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1320 Scopus citations

Whole-genome analysis informs breast cancer response to aromatase inhibition

Ellis, M. J., Ding, L., Shen, D., Luo, J., Suman, V. J., Wallis, J. W., Van Tine, B. A., Hoog, J., Goiffon, R. J., Goldstein, T. C., Ng, S., Lin, L., Crowder, R., Snider, J., Ballman, K., Weber, J., Chen, K., Koboldt, D. C., Kandoth, C. & Schierding, W. S. & 39 others, McMichael, J. F., Miller, C. A., Lu, C., Harris, C. C., McLellan, M. D., Wendl, M. C., Deschryver, K., Allred, D. C., Esserman, L., Unzeitig, G., Margenthaler, J., Babiera, G. V., Marcom, P. K., Guenther, J. M., Leitch, M., Hunt, K., Olson, J., Tao, Y., Maher, C. A., Fulton, L. L., Fulton, R. S., Harrison, M., Oberkfell, B., Du, F., Demeter, R., Vickery, T. L., Elhammali, A., Piwnica-Worms, H., McDonald, S., Watson, M., Dooling, D. J., Ota, D., Chang, L. W., Bose, R., Ley, T. J., Piwnica-Worms, D., Stuart, J. M., Wilson, R. K. & Mardis, E. R., Jun 21 2012, In: Nature. 486, 7403, p. 353-360 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

891 Scopus citations

2011

A new paradigm for biospecimen banking in the personalized medicine era

McDonald, S. A., Watson, M. A., Rossi, J., Becker, C. M., Jaques, D. P. & Pfeifer, J. D., Nov 2011, In: American journal of clinical pathology. 136, 5, p. 679-684 6 p.

Research output: Contribution to journal › Short survey › peer-review

Open Access

15 Scopus citations

Array-based comparative genomic hybridization identifies CDK4 and FOXM1 alterations as independent predictors of survival in malignant peripheral nerve sheath tumor

Yu, J., Deshmukh, H., Payton, J. E., Dunham, C., Scheithauer, B. W., Tihan, T., Prayson, R. A., Guha, A., Bridge, J. A., Ferner, R. E., Lindberg, G. M., Gutmann, R. J., Emnett, R. J., Salavaggione, L., Gutmann, D. H., Nagarajan, R., Watson, M. A. & Perry, A., Apr 1 2011, In: Clinical Cancer Research. 17, 7, p. 1924-1934 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

101 Scopus citations

Genome-wide polymorphism analysis demonstrates a monoclonal origin of pilocytic astrocytoma

Payton, J. E., Schmidt, J., Yu, J., Lusis, E. A., Watson, M. A. & Gutmann, D. H., Apr 2011, In: Neuropathology and Applied Neurobiology. 37, 3, p. 321-325 5 p.

Research output: Contribution to journal › Letter › peer-review

5 Scopus citations

Identification of transcriptional regulatory networks specific to pilocytic astrocytoma

Deshmukh, H., Yu, J., Shaik, J., MacDonald, T. J., Perry, A., Payton, J. E., Gutmann, D. H., Watson, M. A. & Nagarajan, R., 2011, In: BMC Medical Genomics. 4, 57.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Randomized phase II neoadjuvant comparison between letrozole, anastrozole, and exemestane for postmenopausal women with estrogen receptor-rich stage 2 to 3 breast cancer: Clinical and biomarker outcomes and predictive value of the baseline PAM50-based intrinsic subtype - ACOSOG Z1031

Ellis, M. J., Suman, V. J., Hoog, J., Lin, L., Snider, J., Prat, A., Parker, J. S., Luo, J., DeSchryver, K., Allred, D. C., Esserman, L. J., Unzeitig, G. W., Margenthaler, J., Babiera, G. V., Marcom, P. K., Guenther, J. M., Watson, M. A., Leitch, M., Hunt, K. & Olson, J. A., Jun 10 2011, In: Journal of Clinical Oncology. 29, 17, p. 2342-2349 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

477 Scopus citations

Retraction: A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer. N Engl J Med 2006;355:570-80

Potti, A., Mukherjee, S., Petersen, R., Dressman, H. K., Bild, A., Koontz, J., Kratzke, R., Watson, M. A., Kelley, M., Ginsburg, G. S., West, M., Harpole, D. H. & Nevins, J. R., Mar 24 2011, In: New England Journal of Medicine. 364, 12, p. 1176 1 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

17 Scopus citations

Use of whole-genome sequencing to diagnose a cryptic fusion oncogene

Welch, J. S., Westervelt, P., Ding, L., Larson, D. E., Klco, J. M., Kulkarni, S., Wallis, J., Chen, K., Payton, J. E., Fulton, R. S., Veizer, J., Schmidt, H., Vickery, T. L., Heath, S., Watson, M. A., Tomasson, M. H., Link, D. C., Graubert, T. A., DiPersio, J. F. & Mardis, E. R. & 2 others, Ley, T. J. & Wilson, R. K., Apr 20 2011, In: JAMA. 305, 15, p. 1577-1584 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

222 Scopus citations

2010

A gene expression signature that predicts the therapeutic response of the basal-like breast cancer to neoadjuvant chemotherapy

Lin, Y., Lin, S., Watson, M., Trinkaus, K. M., Kuo, S., Naughton, M. J., Weilbaecher, K., Fleming, T. P. & Aft, R. L., Oct 2010, In: Breast Cancer Research and Treatment. 123, 3, p. 691-699 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

A role for the epithelial microenvironment at tumor boundaries: Evidence from drosophila and human squamous cell carcinomas

Vidal, M., Salavaggione, L., Ylagan, L., Wilkins, M., Watson, M., Weilbaecher, K. & Cagan, R., Jun 2010, In: American Journal of Pathology. 176, 6, p. 3007-3014 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

DNMT3A mutations in acute myeloid leukemia

Ley, T. J., Ding, L., Walter, M. J., McLellan, M. D., Lamprecht, T., Larson, D. E., Kandoth, C., Payton, J. E., Baty, J., Welch, J., Harris, C. C., Lichti, C. F., Townsend, R. R., Fulton, R. S., Dooling, D. J., Koboldt, D. C., Schmidt, H., Zhang, Q., Osborne, J. R. & Lin, L. & 28 others, O'Laughlin, M., McMichael, J. F., Delehaunty, K. D., McGrath, S. D., Fulton, L. A., Magrini, V. J., Vickery, T. L., Hundal, J., Cook, L. L., Conyers, J. J., Swift, G. W., Reed, J. P., Alldredge, P. A., Wylie, T., Walker, J., Kalicki, J., Watson, M. A., Heath, S., Shannon, W. D., Varghese, N., Nagarajan, R., Westervelt, P., Tomasson, M. H., Link, D. C., Graubert, T. A., DiPersio, J. F., Mardis, E. R. & Wilson, R. K., Dec 16 2010, In: New England Journal of Medicine. 363, 25, p. 2424-2433 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1720 Scopus citations

Effect of zoledronic acid on disseminated tumour cells in women with locally advanced breast cancer: An open label, randomised, phase 2 trial

Aft, R., Naughton, M., Trinkaus, K., Watson, M., Ylagan, L., Chavez-MacGregor, M., Zhai, J., Kuo, S., Shannon, W., Diemer, K., Herrmann, V., Dietz, J., Ali, A., Ellis, M., Weiss, P., Eberlein, T., Ma, C., Fracasso, P. M., Zoberi, I. & Taylor, M. & 4 others, Gillanders, W., Pluard, T., Mortimer, J. & Weilbaecher, K., May 2010, In: The Lancet Oncology. 11, 5, p. 421-428 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

253 Scopus citations

Genome remodelling in a basal-like breast cancer metastasis and xenograft

Ding, L., Ellis, M. J., Li, S., Larson, D. E., Chen, K., Wallis, J. W., Harris, C. C., McLellan, M. D., Fulton, R. S., Fulton, L. L., Abbott, R. M., Hoog, J., Dooling, D. J., Koboldt, D. C., Schmidt, H., Kalicki, J., Zhang, Q., Chen, L., Lin, L. & Wendl, M. C. & 49 others, McMichael, J. F., Magrini, V. J., Cook, L., McGrath, S. D., Vickery, T. L., Appelbaum, E., Deschryver, K., Davies, S., Guintoli, T., Lim, L., Crowder, R., Tao, Y., Snider, J. E., Smith, S. M., Dukes, A. F., Sanderson, G. E., Pohl, C. S., Delehaunty, K. D., Fronick, C. C., Pape, K. A., Reed, J. S., Robinson, J. S., Hodges, J. S., Schierding, W., Dees, N. D., Shen, D., Locke, D. P., Wiechert, M. E., Eldred, J. M., Peck, J. B., Oberkfell, B. J., Lolofie, J. T., Du, F., Hawkins, A. E., Oĝlaughlin, M. D., Bernard, K. E., Cunningham, M., Elliott, G., Mason, M. D., Thompson, D. M., Ivanovich, J. L., Goodfellow, P. J., Perou, C. M., Weinstock, G. M., Aft, R., Watson, M., Ley, T. J., Wilson, R. K. & Mardis, E. R., Apr 15 2010, In: Nature. 464, 7291, p. 999-1005 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1026 Scopus citations

Phosphatidyl-inositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancer

Ellis, M. J., Lin, L., Crowder, R., Tao, Y., Hoog, J., Snider, J., Davies, S., Deschryver, K., Evans, D. B., Steinseifer, J., Bandaru, R., Liu, W., Gardner, H., Semiglazov, V., Watson, M., Hunt, K., Olson, J. & Baselga, J., Jan 2010, In: Breast Cancer Research and Treatment. 119, 2, p. 379-390 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

112 Scopus citations

2009

Acquired copy number alterations in adult acute myeloid leukemia genomes

Walter, M. J., Payton, J. E., Ries, R. E., Shannon, W. D., Deshmukh, H., Zhao, Y., Baty, J., Heath, S., Westervelt, P., Watson, M. A., Tomasson, M. H., Nagarajan, R., O'Gara, B. P., Bloomfield, C. D., Mrózek, K., Selzer, R. R., Richmond, T. A., Kitzman, J., Geoghegan, J. & Eis, P. S. & 9 others, Maupin, R., Fulton, R. S., McLellan, M., Wilson, R. K., Mardis, E. R., Link, D. C., Graubert, T. A., DiPersio, J. F. & Ley, T. J., Aug 4 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 31, p. 12950-12955 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

216 Scopus citations

Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma

Yu, J., Deshmukh, H., Gutmann, R. J., Emnett, R. J., Rodriguez, F. J., Watson, M. A., Nagarajan, R. & Gutmann, D. H., Nov 2009, In: Neurology. 73, 19, p. 1526-1531 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

101 Scopus citations

Gene expression profiles of ductal versus acinar adenocarcinoma of the prostate

Sanati, S., Watson, M. A., Salavaggione, A. L. & Humphrey, P. A., Oct 2009, In: Modern Pathology. 22, 10, p. 1273-1279 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples

Payton, J. E., Grieselhuber, N. R., Chang, L. W., Murakami, M., Geiss, G. K., Link, D. C., Nagarajan, R., Watson, M. A. & Ley, T. J., Jun 1 2009, In: Journal of Clinical Investigation. 119, 6, p. 1714-1726 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

124 Scopus citations

Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer

Cheang, M. C. U., Chia, S. K., Voduc, D., Gao, D., Leung, S., Snider, J., Watson, M., Davies, S., Bernard, P. S., Parker, J. S., Perou, C. M., Ellis, M. J. & Nielsen, T. O., May 2009, In: Journal of the National Cancer Institute. 101, 10, p. 736-750 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1779 Scopus citations

Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis

Song, H., Zhang, B., Watson, M. A., Humphrey, P. A., Lim, H. & Milbrandt, J., Sep 17 2009, In: Oncogene. 28, 37, p. 3307-3319 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

87 Scopus citations

Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer

Graveel, C. R., DeGroot, J. D., Su, Y., Koeman, J., Dykema, K., Leung, S., Snider, J., Davies, S. R., Swiatek, P. J., Cottingham, S., Watson, M. A., Ellis, M. J., Sigler, R. E., Furge, K. A. & Vande Woude, G. F., Aug 4 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 31, p. 12909-12914 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

97 Scopus citations

PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer

Crowder, R. J., Phommaly, C., Tao, Y., Hoog, J., Luo, J., Perou, C. M., Parker, J. S., Miller, M. A., Huntsman, D. G., Lin, L., Snider, J., Davies, S. R., Olson, J. A., Watson, M. A., Saporita, A., Weber, J. D. & Ellis, M. J., May 1 2009, In: Cancer research. 69, 9, p. 3955-3962 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

198 Scopus citations

Post-treatment tumor gene expression signatures are more predictive of treatment outcomes than baseline signatures in breast cancer

Lee, S. C., Xu, X., Chng, W. J., Watson, M., Lim, Y. W., Wong, C. I., Iau, P., Sukri, N., Lim, S. E., Yap, H. L., Buhari, S. A., Tan, P., Guo, J., Chuah, B., McLeod, H. L. & Goh, B. C., Nov 1 2009, In: Pharmacogenetics and Genomics. 19, 11, p. 833-842 10 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support

Matkovich, S. J., Van Booven, D. J., Youker, K. A., Torre-Amione, G., Diwan, A., Eschenbacher, W. H., Dorn, L. E., Watson, M. A., Margulies, K. B. & Dorn, G. W., Mar 10 2009, In: Circulation. 119, 9, p. 1263-1271 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

278 Scopus citations

Recurring mutations found by sequencing an acute myeloid leukemia genome

Mardis, E. R., Ding, L., Dooling, D. J., Larson, D. E., McLellan, M. D., Chen, K., Koboldt, D. C., Fulton, R. S., Delehaunty, K. D., McGrath, S. D., Fulton, L. A., Locke, D. P., Magrini, V. J., Abbott, R. M., Vickery, T. L., Reed, J. S., Robinson, J. S., Wylie, T., Smith, S. M. & Carmichael, L. & 38 others, Eldred, J. M., Harris, C. C., Walker, J., Peck, J. B., Du, F., Dukes, A. F., Sanderson, G. E., Brummett, A. M., Clark, E., McMichael, J. F., Meyer, R. J., Schindler, J. K., Pohl, C. S., Wallis, J. W., Shi, X., Lin, L., Schmidt, H., Tang, Y., Haipek, C., Wiechert, M. E., Ivy, J. V., Kalicki, J., Elliott, G., Ries, R. E., Payton, J. E., Westervelt, P., Tomasson, M. H., Watson, M. A., Baty, J., Heath, S., Shannon, W. D., Nagarajan, R., Link, D. C., Walter, M. J., Graubert, T. A., DiPersio, J. F., Wilson, R. K. & Ley, T. J., Sep 10 2009, In: New England Journal of Medicine. 361, 11, p. 1058-1066 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1946 Scopus citations

2008

Celecoxib pre-treatment in human colorectal adenocarcinoma patients is associated with gene expression alterations suggestive of diminished cellular proliferation

Auman, J. T., Church, R., Lee, S. Y., Watson, M. A., Fleshman, J. W. & Mcleod, H. L., Aug 2008, In: European Journal of Cancer. 44, 12, p. 1754-1760 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Copy-number analysis of topoisomerase and thymidylate synthase genes in frozen and FFPE DNAs of colorectal cancers

Yu, J., Miller, R., Zhang, W., Sharma, M., Holtschlag, V., Watson, M. A. & McLeod, H. L., 2008, In: Pharmacogenomics. 9, 10, p. 1459-1466 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Correlating EGFR expression with receptor-binding properties and internalization of⁶⁴Cu-DOTA-cetuximab in 5 cervical cancer cell lines

Eiblmaier, M., Meyer, L. A., Watson, M. A., Fracasso, P. M., Pike, L. J. & Anderson, C. J., Sep 1 2008, In: Journal of Nuclear Medicine. 49, 9, p. 1472-1479 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

88 Scopus citations

Distal airways in mice exposed to cigarette smoke: Nrf2-regulated genes are increased in clara cells

Adair-Kirk, T. L., Atkinson, J. J., Griffin, G. L., Watson, M. A., Kelley, D. G., DeMello, D., Senior, R. M. & Betsuyaku, T., Oct 1 2008, In: American Journal of Respiratory Cell and Molecular Biology. 39, 4, p. 400-411 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

DNA methylotype analysis in colorectal cancer

Yu, J., Freimuth, R. R., Culverhouse, R., Marsh, S., Watson, M. A. & McLeod, H. L., Oct 2008, In: Oncology reports. 20, 4, p. 921-927 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

Ley, T. J., Mardis, E. R., Ding, L., Fulton, B., McLellan, M. D., Chen, K., Dooling, D., Dunford-Shore, B. H., McGrath, S., Hickenbotham, M., Cook, L., Abbott, R., Larson, D. E., Koboldt, D. C., Pohl, C., Smith, S., Hawkins, A., Abbott, S., Locke, D. & Hillier, L. W. & 28 others, Miner, T., Fulton, L., Magrini, V., Wylie, T., Glasscock, J., Conyers, J., Sander, N., Shi, X., Osborne, J. R., Minx, P., Gordon, D., Chinwalla, A., Zhao, Y., Ries, R. E., Payton, J. E., Westervelt, P., Tomasson, M. H., Watson, M., Baty, J., Ivanovich, J., Heath, S., Shannon, W. D., Nagarajan, R., Walter, M. J., Link, D. C., Graubert, T. A., DiPersio, J. F. & Wilson, R. K., Nov 6 2008, In: Nature. 456, 7218, p. 66-72 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1071 Scopus citations

High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas

Deshmukh, H., Yeh, T. H., Yu, J., Sharma, M. K., Perry, A., Leonard, J. R., Watson, M. A., Gutmann, D. H. & Nagarajan, R., Aug 7 2008, In: Oncogene. 27, 34, p. 4745-4751 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

93 Scopus citations

Identification of Somatic JAK1 mutations in patients with acute myeloid leukemia

Xiang, Z., Zhao, Y., Mitaksov, V., Fremont, D. H., Kasai, Y., Molitoris, A., Ries, R. E., Miner, T. L., McLellan, M. D., DiPersio, J. F., Link, D. C., Payton, J. E., Graubert, T. A., Watson, M., Shannon, W., Heath, S. E., Nagarajan, R., Mardis, E. R., Wilson, R. K. & Ley, T. J. & 1 others, Tomasson, M. H., May 1 2008, In: Blood. 111, 9, p. 4809-4812 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

85 Scopus citations

Somatic mutations affect key pathways in lung adenocarcinoma

Ding, L., Getz, G., Wheeler, D. A., Mardis, E. R., McLellan, M. D., Cibulskis, K., Sougnez, C., Greulich, H., Muzny, D. M., Morgan, M. B., Fulton, L., Fulton, R. S., Zhang, Q., Wendl, M. C., Lawrence, M. S., Larson, D. E., Chen, K., Dooling, D. J., Sabo, A. & Hawes, A. C. & 70 others, Shen, H., Jhangiani, S. N., Lewis, L. R., Hall, O., Zhu, Y., Mathew, T., Ren, Y., Yao, J., Scherer, S. E., Clerc, K., Metcalf, G. A., Ng, B., Milosavljevic, A., Gonzalez-Garay, M. L., Osborne, J. R., Meyer, R., Shi, X., Tang, Y., Koboldt, D. C., Lin, L., Abbott, R., Miner, T. L., Pohl, C., Fewell, G., Haipek, C., Schmidt, H., Dunford-Shore, B. H., Kraja, A., Crosby, S. D., Sawyer, C. S., Vickery, T., Sander, S., Robinson, J., Winckler, W., Baldwin, J., Chirieac, L. R., Dutt, A., Fennell, T., Hanna, M., Johnson, B. E., Onofrio, R. C., Thomas, R. K., Tonon, G., Weir, B. A., Zhao, X., Ziaugra, L., Zody, M. C., Giordano, T., Orringer, M. B., Roth, J. A., Spitz, M. R., Wistuba, I. I., Ozenberger, B., Good, P. J., Chang, A. C., Beer, D. G., Watson, M. A., Ladanyi, M., Broderick, S., Yoshizawa, A., Travis, W. D., Pao, W., Province, M. A., Weinstock, G. M., Varmus, H. E., Gabriel, S. B., Lander, E. S., Gibbs, R. A., Meyerson, M. & Wilson, R. K., Oct 23 2008, In: Nature. 455, 7216, p. 1069-1075 7 p.

Research output: Contribution to journal › Article › peer-review

2330 Scopus citations

Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia

Tomasson, M. H., Xiang, Z., Walgren, R., Zhao, Y., Kasai, Y., Miner, T., Ries, R. E., Lubman, O., Fremont, D. H., McLellan, M. D., Payton, J. E., Westervelt, P., DiPersio, J. F., Link, D. C., Walter, M. J., Graubert, T. A., Watson, M., Baty, J., Heath, S. & Shannon, W. D. & 5 others, Nagarajan, R., Bloomfield, C. D., Mardis, E. R., Wilson, R. K. & Ley, T. J., May 1 2008, In: Blood. 111, 9, p. 4797-4808 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

202 Scopus citations

2007

Characterizing the cancer genome in lung adenocarcinoma

Weir, B. A., Woo, M. S., Getz, G., Perner, S., Ding, L., Beroukhim, R., Lin, W. M., Province, M. A., Kraja, A., Johnson, L. A., Shah, K., Sato, M., Thomas, R. K., Barletta, J. A., Borecki, I. B., Broderick, S., Chang, A. C., Chiang, D. Y., Chirieac, L. R. & Cho, J. & 50 others, Fujii, Y., Gazdar, A. F., Giordano, T., Greulich, H., Hanna, M., Johnson, B. E., Kris, M. G., Lash, A., Lin, L., Lindeman, N., Mardis, E. R., McPherson, J. D., Minna, J. D., Morgan, M. B., Nadel, M., Orringer, M. B., Osborne, J. R., Ozenberger, B., Ramos, A. H., Robinson, J., Roth, J. A., Rusch, V., Sasaki, H., Shepherd, F., Sougnez, C., Spitz, M. R., Tsao, M. S., Twomey, D., Verhaak, R. G. W., Weinstock, G. M., Wheeler, D. A., Winckler, W., Yoshizawa, A., Yu, S., Zakowski, M. F., Zhang, Q., Beer, D. G., Wistuba, I. I., Watson, M. A., Garraway, L. A., Ladanyi, M., Travis, W. D., Pao, W., Rubin, M. A., Gabriel, S. B., Gibbs, R. A., Varmus, H. E., Wilson, R. K., Lander, E. S. & Meyerson, M., Dec 6 2007, In: Nature. 450, 7171, p. 893-898 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

970 Scopus citations

Commonly dysregulated genes in murine APL cells

Yuan, W., Payton, J. E., Holt, M. S., Link, D. C., Watson, M. A., DiPersio, J. F. & Ley, T. J., Feb 1 2007, In: Blood. 109, 3, p. 961-970 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin

Sharma, M. K., Mansur, D. B., Reifenberger, G., Perry, A., Leonard, J. R., Aldape, K. D., Albin, M. G., Emnett, R. J., Loeser, S., Watson, M. A., Nagarajan, R. & Gutmann, D. H., Feb 1 2007, In: Cancer research. 67, 3, p. 890-900 11 p.

Research output: Contribution to journal › Article › peer-review

150 Scopus citations

Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia

Link, D. C., Kunter, G., Kasai, Y., Zhao, Y., Miner, T., McLellan, M. D., Ries, R. E., Kapur, D., Nagarajan, R., Dale, D. C., Bolyard, A. A., Boxer, L. A., Welte, K., Zeidler, C., Donadieu, J., Bellanné-Chantelot, C., Vardiman, J. W., Caligiuri, M. A., Bloomfield, C. D. & DiPersio, J. F. & 9 others, Tomasson, M. H., Graubert, T. A., Westervelt, P., Watson, M., Shannon, W., Baty, J., Mardis, E. R., Wilson, R. K. & Ley, T. J., Sep 1 2007, In: Blood. 110, 5, p. 1648-1655 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

Isolation and molecular profiling of bone marrow micrometastases identifies TWIST1 as a marker of early tumor relapse in breast cancer patients

Watson, M. A., Ylagan, L. R., Trinkaus, K. M., Gillanders, W. E., Naughton, M. J., Weilbaecher, K. N., Fleming, T. P. & Aft, R. L., Sep 1 2007, In: Clinical Cancer Research. 13, 17, p. 5001-5009 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

101 Scopus citations

The cancer biomedical informatics grid (caBIG™): Infrastructure and applications for a worldwide research community

Niland, J. C., Townsend, R. M., Annechiarico, R., Johnson, K., Beck, J. R., Manion, F. J., Robbins, R. J., Chute, C. G., Vogel, L. H., Saltz, J. H., Watson, M. A., Casavant, T. L., Soong, S. J., Bondy, J., Fenstermacher, D. A., Becich, M. J., Casagrande, J. T. & Tuck, D. P., 2007, MEDINFO 2007 - Proceedings of the 12th World Congress on Health (Medical) Informatics: Building Sustainable Health Systems. IOS Press, p. 330-334 5 p. (Studies in Health Technology and Informatics; vol. 129).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

31 Scopus citations

2006

A gene expression signature predicts survival of patients with stage I non-small cell lung cancer

Lu, Y., Lemon, W., Liu, P. Y., Yi, Y., Morrison, C., Yang, P., Sun, Z., Szoke, J., Gerald, W. L., Watson, M., Govindan, R. & You, M., Dec 2006, In: PLoS medicine. 3, 12, p. 2229-2243 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

267 Scopus citations

A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer

Potti, A., Mukherjee, S., Petersen, R., Dressman, H. K., Bild, A., Koontz, J., Kratzke, R., Watson, M. A., Kelley, M., Ginsburg, G. S., West, M., Harpole, D. H. & Nevins, J. R., Aug 10 2006, In: New England Journal of Medicine. 355, 6, p. 570-580 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

541 Scopus citations

A targeted apoB38.9 mutation in mice is associated with reduced hepatic cholesterol synthesis and enhanced lipid peroxidation

Lin, X., Chen, Z., Yue, P., Averna, M. R., Ostlund, R. E., Watson, M. A. & Schonfeld, G., Jun 2006, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 290, 6, p. G1170-G1176

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

DNA repair pathway profiling and microsatellite instability in colorectal cancer

Yu, J., Mallon, M. A., Zhang, W., Freimuth, R. R., Marsh, S., Watson, M. A., Goodfellow, P. J. & McLeod, H. L., Sep 1 2006, In: Clinical Cancer Research. 12, 17, p. 5104-5111 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Gene expression patterns in advanced human cervical cancer

Grigsby, P. W., Watson, M., Powell, M. A., Zhang, Z. & Rader, J. S., 2006, In: International Journal of Gynecological Cancer. 16, 2, p. 562-567 6 p.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Large-scale molecular comparison of human Schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues

Miller, S. J., Rangwala, F., Williams, J., Ackerman, P., Kong, S., Jegga, A. G., Kaiser, S., Aronow, B. J., Frahm, S., Kluwe, L., Mautner, V., Upadhyaya, M., Muir, D., Wallace, M., Hagen, J., Quelle, D. E., Watson, M. A., Perry, A., Gutmann, D. H. & Ratner, N., Mar 1 2006, In: Cancer research. 66, 5, p. 2584-2591 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

165 Scopus citations

Mark Watson

Research output

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