Personal profile
Research interests
Prevention of cochlear synaptic excitotoxicity in noise-induced hearing loss
Mentoring
We use anatomical and physiological techniques to study synaptic transmission in the cochlea and brain stem in the context of auditory sensory processing and noise-induced hearing loss. Projects include development of therapies to prevent excitotoxicity by antagonizing calcium-permeable AMPA-type glutamate receptors.
Available to Mentor:
- PhD Students
- Postdocs
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Collaborations and top research areas from the last five years
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Female mice lacking GluA3 show early onset of hearing loss, cochlear synaptopathy, and afferent terminal swellings in ambient sound levels
Pal, I., Bhattacharyya, A., V-Ghaffari, B., Williams, E. D., Xiao, M., Rutherford, M. A. & Rubio, M. E., Feb 21 2025, In: iScience. 28, 2, 111799.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Protocol for assessing auditory function, cochlear synaptopathy, and afferent terminal morphology in laboratory mice
Pal, I., Bhattacharyya, A., V-Ghaffari, B., Williams, E. D., Xiao, M., Rutherford, M. A. & Rubio, M. E., Sep 19 2025, In: STAR Protocols. 6, 3, 104040.Research output: Contribution to journal › Article › peer-review
Open Access -
Alzheimer's Disease-Related Analytes Amyloid-β and Tau in Perilymph: Correlation With Patient Age and Cognitive Score
Walia, A., Shew, M. A., Durakovic, N., Herzog, J. A., Cirrito, J. R., Yuede, C. M., Wick, C. C., Manis, M., Holtzman, D. M., Buchman, C. A. & Rutherford, M. A., Dec 2024, In: Otolaryngology - Head and Neck Surgery (United States). 171, 6, p. 1850-1858 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Large-scale annotated dataset for cochlear hair cell detection and classification
Buswinka, C. J., Rosenberg, D. B., Simikyan, R. G., Osgood, R. T., Fernandez, K., Nitta, H., Hayashi, Y., Liberman, L. W., Nguyen, E., Yildiz, E., Kim, J., Jarysta, A., Renauld, J., Wesson, E., Wang, H., Thapa, P., Bordiga, P., McMurtry, N., Llamas, J. & Kitcher, S. R. & 24 others, , Dec 2024, In: Scientific data. 11, 1, 416.Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Scopus citations -
GluA3 subunits are required for appropriate assembly of AMPAR GluA2 and GluA4 subunits on cochlear afferent synapses and for presynaptic ribbon modiolar-pillar morphology
Rutherford, M. A., Bhattacharyya, A., Xiao, M., Cai, H. M., Pal, I. & Rubio, M. E., Jan 17 2023, In: eLife. 12Research output: Contribution to journal › Article › peer-review
Open Access11 Link opens in a new tab Scopus citations