Mark Miller

Associate Professor of Medicine, Associate Professor of Pathology and Immunology

    • 8590 Citations
    19952020

    Research output per year

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    Personal profile

    Research interests

    My group is using multi-photon microscopy (MPM) in combination with histological and genetic approaches to study the immune response to bacterial infection in the spleen. The spleen plays a crucial role in host defense by trapping and destroying blood-borne pathogens and triggering the adaptive immune response. However, few details are known regarding how early host-pathogen interactions lead to antigen presentation and immunity. Preliminary results from my lab indicate that bacterial challenge in mice induces the rapid redistribution of splenic macrophages and dendritic cells in a bacteria-specific fashion. Our hypothesis is that tissue remodeling serves an “antigen transport” function that delivers pathogen-derived antigens to distinct microenvironments for presentation. Because both the antigen presenting cell type and the local environment impact the immune response, this could provide a mechanism to tailor immune responses to a wide-range of pathogens. We are focusing our investigations on three key stages of infection: 1) the initial capture and fate of bacteria in marginal zone macrophages and dendritic cells, 2) the migration of these cells in response to infection, and 3) bacterial-antigen presentation in tissue microenvironments and its influence on the subsequent adaptive immune response. Moreover, the multi-dimensional cell tracking data from these studies is being used to create in silico models of infection and immunity in the hope of providing fresh mechanistic insight into microbial pathogenesis and guide vaccine development.

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    Research Output

    T cell response kinetics determines neuroinfection outcomes during murine HSV infection

    Lee, A. G., Scott, J. M., Fabbrizi, M. R., Jiang, X., Sojka, D. K., Miller, M. J., Baldridge, M. T., Yokoyama, W. M. & Shin, H., Mar 12 2020, In : JCI Insight. 5, 5, e134258.

    Research output: Contribution to journalArticle

    Open Access
  • Complement activation on neutrophils initiates endothelial adhesion and extravasation

    Akk, A., Springer, L. E., Yang, L., Hamilton-Burdess, S., Lambris, J. D., Yan, H., Hu, Y., Wu, X., Hourcade, D. E., Miller, M. J. & Pham, C. T. N., Oct 2019, In : Molecular Immunology. 114, p. 629-642 14 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Neutrophil extracellular trap fragments stimulate innate immune responses that prevent lung transplant tolerance

    Scozzi, D., Wang, X., Liao, F., Liu, Z., Zhu, J., Pugh, K., Ibrahim, M., Hsiao, H. M., Miller, M. J., Yizhan, G., Mohanakumar, T., Krupnick, A. S., Kreisel, D. & Gelman, A. E., Apr 2019, In : American Journal of Transplantation. 19, 4, p. 1011-1023 13 p.

    Research output: Contribution to journalArticle

  • 9 Scopus citations

    The secreted kinase ROP17 promotes Toxoplasma gondii dissemination by hijacking monocyte tissue migration

    Drewry, L. L., Jones, N. G., Wang, Q., Onken, M. D., Miller, M. J. & Sibley, L. D., Nov 1 2019, In : Nature microbiology. 4, 11, p. 1951-1963 13 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations

    Anti-JNK2 peptide–siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice

    Pan, H., Palekar, R. U., Hou, K. K., Bacon, J., Yan, H., Springer, L. E., Akk, A., Yang, L., Miller, M. J., Pham, C. T. N., Schlesinger, P. H. & Wickline, S. A., Jan 1 2018, In : International Journal of Nanomedicine. 13, p. 5187-5205 19 p.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations