Mark Lowe

2022

Analysis of INSPPIRE-2 Cohort: Risk Factors and Disease Burden in Children with Acute Recurrent or Chronic Pancreatitis

Uc, A., Cress, G. A., Wang, F., Abu-El-Haija, M., Ellery, K. M., Fishman, D. S., Gariepy, C. E., Gonska, T., Lin, T. K., Liu, Q. Y., Mehta, M., Maqbool, A., McFerron, B. A., Morinville, V. D., Ooi, C. Y., Perito, E. R., Schwarzenberg, S. J., Sellers, Z. M., Serrano, J., Shah, U., & 5 othersTroendle, D. M., Wilschanski, M., Zheng, Y., Yuan, Y. & Lowe, M. E., Nov 1 2022, In: Journal of pediatric gastroenterology and nutrition. 75, 5, p. 643-649 7 p.

Research output: Contribution to journal › Article › peer-review

Health-Related Quality of Life in Pediatric Acute Recurrent or Chronic Pancreatitis: Association With Biopsychosocial Risk Factors

INternational Study Group of Pediatric Pancreatitis: In search for a cuRE (INSPPIRE) and Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC), May 1 2022, In: Journal of pediatric gastroenterology and nutrition. 74, 5, p. 636-642 7 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Interobserver Agreement for CT and MRI Findings of Chronic Pancreatitis in Children: A Multicenter Ancillary Study Under the INSPPIRE Consortium

Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC), Aug 2022, In: American Journal of Roentgenology. 219, 2, p. 303-313 11 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice

Fjeld, K., Gravdal, A., Brekke, R. S., Alam, J., Wilhelm, S. J., El Jellas, K., Pettersen, H. N., Lin, J., Solheim, M. H., Steine, S. J., Johansson, B. B., Njølstad, P. R., Verbeke, C. S., Xiao, X., Lowe, M. E. & Molven, A., Dec 2022, In: Pancreatology. 22, 8, p. 1099-1111 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2021

Adipose saturation reduces lipotoxic systemic inflammation and explains the obesity paradox

Khatua, B., El-Kurdi, B., Patel, K., Rood, C., Noel, P., Crowell, M., Yaron, J. R., Kostenko, S., Guerra, A., Faigel, D. O., Lowe, M. & Singh, V. P., Jan 29 2021, In: Science Advances. 7, 5, eabd6449.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase (CEL) gene determines proteotoxicity

Gravdal, A., Xiao, X., Cnop, M., Jellas, K. E., Johansson, S., Njølstad, P. R., Lowe, M. E., Johansson, B. B., Molven, A. & Fjeld, K., Jan 1 2021, In: Journal of Biological Chemistry. 296, 100661.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Vascular Complications in Pediatric Pancreatitis: A Case Series

Dike, C. R., Cress, G., Fishman, D. S., Gonska, T., Ooi, C. Y., Perito, E. R., Troendle, D., Tsai, C. M., Lowe, M. E. & Uc, A., Oct 1 2021, In: Journal of pediatric gastroenterology and nutrition. 73, 4, p. e94-e97

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

2020

Clinical and Practice Variations in Pediatric Acute Recurrent or Chronic Pancreatitis: Report From the INSPPIRE Study

Dike, C. R., Zimmerman, B., Zheng, Y., Wilschanski, M., Werlin, S. L., Troendle, D., Shah, U., Schwarzenberg, S. J., Pohl, J., Perito, E. R., Ooi, C. Y., Nathan, J. D., Morinville, V. D., McFerron, B., Mascarenhas, M., Maqbool, A., Liu, Q., Lin, T. K., Husain, S. Z., Heyman, M. B., & 9 othersGonska, T., Giefer, M. J., Gariepy, C. E., Fishman, D. S., Bellin, M., Barth, B., Abu-El-Haija, M., Lowe, M. E. & Uc, A., Jul 1 2020, In: Journal of pediatric gastroenterology and nutrition. 71, 1, p. 112-118 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Factors Associated with Frequent Opioid Use in Children with Acute Recurrent and Chronic Pancreatitis

Perito, E. R., Palermo, T. M., Pohl, J. F., Mascarenhas, M., Abu-El-Haija, M., Barth, B., Bellin, M. D., Fishman, D. S., Freedman, S., Gariepy, C., Giefer, M., Gonska, T., Heyman, M. B., Himes, R. W., Husain, S. Z., Lin, T., Liu, Q., Maqbool, A., McFerron, B., Morinville, V. D., & 12 othersNathan, J. D., Ooi, C. Y., Rhee, S., Schwarzenberg, S. J., Shah, U., Troendle, D. M., Werlin, S., Wilschanski, M., Zheng, Y., Zimmerman, M. B., Lowe, M. & Uc, A., Jan 1 2020, In: Journal of pediatric gastroenterology and nutrition. 70, 1, p. 106-114 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation

de Oliveira, C., Khatua, B., Noel, P., Kostenko, S., Bag, A., Balakrishnan, B., Patel, K. S., Guerra, A. A., Martinez, M. N., Trivedi, S., McCullough, A., Lam-Himlin, D. M., Navina, S., Faigel, D. O., Fukami, N., Pannala, R., Phillips, A. E., Papachristou, G. I., Kershaw, E. E., Lowe, M. E., & 1 othersSingh, V. P., Apr 1 2020, In: Journal of Clinical Investigation. 130, 4, p. 1931-1947 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

Pediatric chronic pancreatitis without prior acute or acute recurrent pancreatitis: A report from the INSPPIRE consortium

Abu-El-Haija, M., Lowe, M., Barth, B., Bellin, M. D., Fishman, D. S., Freedman, S., Gariepy, C., Giefer, M. J., Gonska, T., Heyman, M. B., Himes, R., Husain, S., Lin, T. K., Liu, Q., Mascarenhas, M. R., Maqbool, A., McFerron, B., Morinville, V., Nathan, J., Ooi, C. Y., & 9 othersPerito, E., Pohl, J. F., Schwarzenberg, S. J., Shah, U., Troendle, D., Werlin, S., Wilschanski, M., Zimmerman, B. & Uc, A., Jun 2020, In: Pancreatology. 20, 4, p. 781-784 4 p.

Research output: Contribution to journal › Letter › peer-review

6 Scopus citations

Predicting Severity in Acute Pancreatitis in Children: What Can a Quantitative Score Add to Clinical Judgement?

Perito, E. R., Lowe, M. E. & Schwarzenberg, S. J., Oct 1 2020, In: Journal of pediatric gastroenterology and nutrition. 71, 4, p. 419-420 2 p.

Research output: Contribution to journal › Editorial

Open Access

4 Scopus citations

Single nucleotide polymorphisms in CEL-HYB1 increase risk for chronic pancreatitis through proteotoxic misfolding

Cassidy, B. M., Zino, S., Fjeld, K., Molven, A., Lowe, M. E. & Xiao, X., Nov 1 2020, In: Human mutation. 41, 11, p. 1967-1978 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Web-based cognitive-behavioral intervention for pain in pediatric acute recurrent and chronic pancreatitis: Protocol of a multicenter randomized controlled trial from the study of chronic pancreatitis, diabetes and pancreatic cancer (CPDPC)

on behalf of the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer, Jan 2020, In: Contemporary Clinical Trials. 88, 105898.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

2019

Carboxyl Ester Lipase May Not Mediate Lipotoxic Injury during Severe Acute Pancreatitis

Khatua, B., Trivedi, R. N., Noel, P., Patel, K., Singh, R., de Oliveira, C., Trivedi, S., Mishra, V., Lowe, M. & Singh, V. P., Jun 2019, In: American Journal of Pathology. 189, 6, p. 1226-1240 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Chronic Pancreatitis: Pediatric and Adult Cohorts Show Similarities in Disease Progress Despite Different Risk Factors

Schwarzenberg, S. J., Uc, A., Zimmerman, B., Wilschanski, M., Wilcox, C. M., Whitcomb, D. C., Werlin, S. L., Troendle, D., Tang, G., Slivka, A., Singh, V. K., Sherman, S., Shah, U., Sandhu, B. S., Romagnuolo, J., Rhee, S., Pohl, J. F., Perito, E. R., Ooi, C. Y., Nathan, J. D., & 33 othersMuniraj, T., Morinville, V. D., McFerron, B., Mascarenhas, M., Maqbool, A., Liu, Q., Lin, T. K., Lewis, M., Husain, S. Z., Himes, R., Heyman, M. B., Guda, N., Gonska, T., Giefer, M. J., Gelrud, A., Gariepy, C. E., Gardner, T. B., Freedman, S. D., Forsmark, C. E., Fishman, D. S., Cote, G. A., Conwell, D., Brand, R. E., Bellin, M., Barth, B., Banks, P. A., Anderson, M. A., Amann, S. T., Alkaade, S., Abu-El-Haija, M., Abberbock, J. N., Lowe, M. E. & Yadav, D., Apr 1 2019, In: Journal of pediatric gastroenterology and nutrition. 68, 4, p. 566-573 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis: Data from the INSPPIRE Cohort

Bellin, M. D., Lowe, M., Zimmerman, M. B., Wilschanski, M., Werlin, S., Troendle, D. M., Shah, U., Schwarzenberg, S. J., Pohl, J. F., Perito, E., Ooi, C. Y., Nathan, J. D., Morinville, V. D., McFerron, B. A., Mascarenhas, M. R., Maqbool, A., Liu, Q., Lin, T. K., Husain, S. Z., Himes, R., & 9 othersHeyman, M. B., Gonska, T., Giefer, M. J., Gariepy, C. E., Freedman, S. D., Fishman, D. S., Barth, B., Abu-El-Haija, M. & Uc, A., 2019, (Accepted/In press) In: Journal of pediatric gastroenterology and nutrition.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Functional Pancreatic Sphincter Dysfunction in Children: Recommendations for Diagnosis and Management

Lin, T. K., Fishman, D. S., Giefer, M. J., Liu, Q. Y., Troendle, D., Werlin, S., Lowe, M. E. & Uc, A., Dec 1 2019, In: Journal of pediatric gastroenterology and nutrition. 69, 6, p. 704-709 6 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Pancreas Divisum in Pediatric Acute Recurrent and Chronic Pancreatitis: Report from INSPPIRE

Lin, T. K., Abu-El-Haija, M., Nathan, J. D., Palermo, J. P., Barth, B., Bellin, M., Fishman, D. S., Freedman, S. D., Gariepy, C. E., Giefer, M. J., Gonska, T., Heyman, M. B., Himes, R., Husain, S. Z., Liu, Q., Maqbool, A., Mascarenhas, M., McFerron, B., Morinville, V. D., Ooi, C. Y., & 11 othersPerito, E., Pohl, J. F., Rhee, S., Schwarzenberg, S. J., Shah, U., Troendle, D., Werlin, S. L., Wilschanski, M., Zimmerman, M. B., Lowe, M. E. & Uc, A., Jul 1 2019, In: Journal of Clinical Gastroenterology. 53, 6, p. E232-E238

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Precision Medicine in Pancreatic Disease-Knowledge Gaps and Research Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop

Lowe, M. E., Andersen, D. K., Caprioli, R. M., Choudhary, J., Cruz-Monserrate, Z., Dasyam, A. K., Forsmark, C. E., Gorelick, F. S., Gray, J. W., Haupt, M., Kelly, K. A., Olive, K. P., Plevritis, S. K., Rappaport, N., Roth, H. R., Steen, H., Swamidass, S. J., Tirkes, T., Uc, A., Veselkov, K., & 2 othersWhitcomb, D. C. & Habtezion, A., Nov 1 2019, In: Pancreas. 48, 10, p. 1250-1258 9 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Protease-Sensitive Pancreatic Lipase Variants Are Associated with Early Onset Chronic Pancreatitis

Lasher, D., Szabó, A., Masamune, A., Chen, J. M., Xiao, X., Whitcomb, D. C., Barmada, M. M., Ewers, M., Ruffert, C., Paliwal, S., Issarapu, P., Bhaskar, S., Mani, K. R., Chandak, G. R., Laumen, H., Masson, E., Kume, K., Hamada, S., Nakano, E., Seltsam, K., & 9 othersBugert, P., Müller, T., Groneberg, D. A., Shimosegawa, T., Rosendahl, J., Férec, C., Lowe, M. E., Witt, H. & Sahin-Tóth, M., Jun 1 2019, In: American Journal of Gastroenterology. 114, 6, p. 974-983 10 p.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Risk Factors for Rapid Progression from Acute Recurrent to Chronic Pancreatitis in Children: Report from INSPPIRE

Liu, Q. Y., Abu-El-Haija, M., Husain, S. Z., Barth, B., Bellin, M., Fishman, D. S., Freedman, S. D., Gariepy, C. E., Giefer, M. J., Gonska, T., Heyman, M. B., Himes, R., Lin, T. K., Maqbool, A., Mascarenhas, M., McFerron, B. A., Morinville, V. D., Nathan, J. D., Ooi, C. Y., Perito, E. R., & 10 othersPohl, J. F., Rhee, S., Schwarzenberg, S. J., Shah, U., Troendle, D., Werlin, S. L., Wilschanski, M., Zimmerman, M. B., Lowe, M. E. & Uc, A., 2019, In: Journal of pediatric gastroenterology and nutrition. 69, 2, p. 206-211 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Updates in Pediatric Pancreatology: Proceedings of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Frontiers in Pediatric Pancreatology Symposium

Grover, A. S., Freeman, A. J., Abu-El-Haija, M., Eisses, J. F., Gardner, T. B., Liu, Q. Y., Lowe, M. E., Nathan, J. D., Palermo, T. M., Singh, V. K., Trout, A. T., Uc, A., Husain, S. Z. & Morinville, V. D., Feb 1 2019, In: Journal of pediatric gastroenterology and nutrition. 68, 2, p. e27-e33

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2018

Accelerating the drug delivery pipeline for acute and chronic pancreatitis: Summary of the working group on drug development and trials in recurrent acute pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases workshop

Lowe, M. E., Goodman, M. T., Coté, G. A., Glesby, M. J., Haupt, M., Schork, N. J., Singh, V. K., Andersen, D. K., Pandol, S. J., Uc, A. & Whitcomb, D. C., Nov 1 2018, In: Pancreas. 47, 10, p. 1193-1199 7 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Creating the Subspecialty Pediatrics Investigator Network

and the Steering Committee of the Subspecialty Pediatrics Investigator Network, Jan 2018, In: Journal of Pediatrics. 192, p. 3-4.e2

Research output: Contribution to journal › Editorial

Open Access

11 Scopus citations

EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis

Párniczky, A., Abu-El-Haija, M., Husain, S., Lowe, M., Oracz, G., Sahin-Tóth, M., Szabó, F. K., Uc, A., Wilschanski, M., Witt, H., Czakó, L., Grammatikopoulos, T., Rasmussen, I. C., Sutton, R. & Hegyi, P., Mar 2018, In: Pancreatology. 18, 2, p. 146-160 15 p.

Research output: Contribution to journal › Review article › peer-review

71 Scopus citations

Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis

Uc, A., Zimmerman, M. B., Wilschanski, M., Werlin, S. L., Troendle, D., Shah, U., Schwarzenberg, S. J., Rhee, S., Pohl, J. F., Perito, E. R., Palermo, J. J., Ooi, C. Y., Liu, Q., Lin, T. K., Morinville, V. D., McFerron, B. A., Husain, S. Z., Himes, R., Heyman, M. B., Gonska, T., & 8 othersGiefer, M. J., Gariepy, C. E., Freedman, S. D., Fishman, D. S., Bellin, M. D., Barth, B., Abu-El-Haija, M. & Lowe, M. E., Sep 1 2018, In: Pancreas. 47, 8, p. 967-973 7 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

International study group of pediatric pancreatitis: In search for a Cu RE cohort study: Design and rationale for INSPPIRE 2 from the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer

Uc, A., Perito, E. R., Pohl, J. F., Shah, U., Abu-El-Haija, M., Barth, B., Bellin, M. D., Ellery, K. M., Fishman, D. S., Gariepy, C. E., Giefer, M. J., Gonska, T., Heyman, M. B., Himes, R. W., Husain, S. Z., Maqbool, A., Mascarenhas, M. R., McFerron, B. A., Morinville, V. D., Lin, T. K., & 13 othersLiu, Q. Y., Nathan, J. D., Rhee, S. J., Ooi, C. Y., Sellers, Z. M., Schwarzenberg, S. J., Serrano, J., Troendle, D. M., Werlin, S. L., Wilschanski, M., Zheng, Y., Yuan, Y. & Lowe, M. E., Nov 1 2018, In: Pancreas. 47, 10, p. 1222-1228 7 p.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Pediatric Pancreatitis—Molecular Mechanisms and Management

Abu-El-Haija, M. & Lowe, M. E., Dec 2018, In: Gastroenterology Clinics of North America. 47, 4, p. 741-753 13 p.

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Recommendations for diagnosis and management of autoimmune pancreatitis in childhood: Consensus from INSPPIRE

Scheers, I., Palermo, J. J., Freedman, S., Wilschanski, M., Shah, U., Abu-El-Haija, M., Barth, B., Fishman, D. S., Gariepy, C., Giefer, M. J., Heyman, M. B., Himes, R. W., Husain, S. Z., Lin, T. K., Liu, Q., Lowe, M., Mascarenhas, M., Morinville, V., Ooi, C. Y., Perito, E. R., & 8 othersPiccoli, D. A., Pohl, J. F., Schwarzenberg, S. J., Troendle, D., Werlin, S., Zimmerman, B., Uc, A. & Gonska, T., 2018, In: Journal of pediatric gastroenterology and nutrition. 67, 2, p. 232-236 5 p.

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Standard operating procedures for biospecimen collection, processing, and storage: From the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer

Fisher, W. E., Cruz-Monserrate, Z., McElhany, A. L., Lesinski, G. B., Hart, P. A., Ghosh, R., Van Buren, G., Fishman, D. S., Rinaudo, J. A. S., Serrano, J., Srivastava, S., MacE, T., Topazian, M., Feng, Z., Yadav, D., Pandol, S. J., Hughes, S. J., Liu, R. Y., Lu, E., Orr, R., & 8 othersWhitcomb, D. C., Abouhamze, A. S., Steen, H., Sellers, Z. M., Troendle, D. M., Uc, A., Lowe, M. E. & Conwell, D. L., Nov 1 2018, In: Pancreas. 47, 10, p. 1213-1221 9 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

The common truncation variant in pancreatic lipase related protein 2 (PNLIPRP2) is expressed poorly and does not alter risk for chronic pancreatitis

Németh, B. C., Pesei, Z. G., Hegyi, E., Szücs, Á., Szentesi, A., Hegyi, P., Lowe, M. E. & Sahin-Tóth, M., Nov 2018, In: PloS one. 13, 11, e0206869.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2 O-glycans that can be modified by ABO blood group determinants

Jellas, K. E., Johansson, B. B., Fjeld, K., Antonopoulos, A., Immervoll, H., Choi, M. H., Hoem, D., Lowe, M. E., Lombardo, D., Njølstad, P. R., Dell, A., Mas, E., Haslam, S. M. & Molven, A., Dec 14 2018, In: Journal of Biological Chemistry. 293, 50, p. 19476-19491 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2017

Autoimmune Pancreatitis in Children: Characteristic Features, Diagnosis, and Management

Scheers, I., Palermo, J. J., Freedman, S., Wilschanski, M., Shah, U., Abu-El-Haija, M., Barth, B., Fishman, D. S., Gariepy, C., Giefer, M. J., Heyman, M. B., Himes, R. W., Husain, S. Z., Lin, T. K., Liu, Q., Lowe, M., Mascarenhas, M., Morinville, V., Ooi, C. Y., Perito, E. R., & 8 othersPiccoli, D. A., Pohl, J. F., Schwarzenberg, S. J., Troendle, D., Werlin, S., Zimmerman, B., Uc, A. & Gonska, T., Oct 1 2017, In: American Journal of Gastroenterology. 112, 10, p. 1604-1611 8 p.

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Causal evaluation of acute recurrent and chronic pancreatitis in children: Consensus from the INSPPIRE group

Gariepy, C. E., Heyman, M. B., Lowe, M. E., Pohl, J. F., Werlin, S. L., Wilschanski, M., Barth, B., Fishman, D. S., Freedman, S. D., Giefer, M. J., Gonska, T., Himes, R., Husain, S. Z., Morinville, V. D., Ooi, C. Y., Schwarzenberg, S. J., Troendle, D. M., Yen, E. & Uc, A., 2017, In: Journal of pediatric gastroenterology and nutrition. 64, 1, p. 95-103 9 p.

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Early-Onset Acute Recurrent and Chronic Pancreatitis Is Associated with PRSS1 or CTRC Gene Mutations

Giefer, M. J., Lowe, M. E., Werlin, S. L., Zimmerman, B., Wilschanski, M., Troendle, D., Schwarzenberg, S. J., Pohl, J. F., Palermo, J., Ooi, C. Y., Morinville, V. D., Lin, T. K., Husain, S. Z., Himes, R., Heyman, M. B., Gonska, T., Gariepy, C. E., Freedman, S. D., Fishman, D. S., Bellin, M. D., & 3 othersBarth, B., Abu-El-Haija, M. & Uc, A., Jul 2017, In: Journal of Pediatrics. 186, p. 95-100 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

Erratum: A carboxyl ester lipase (CEL) mutant causes chronic pancreatitis by forming intracellular aggregates that activate apoptosis (Journal of Biological Chemistry (2016) 291 (23224-23236) DOI: 10.1074/jbc.M116.734384)

Xiao, X., Jones, G., Sevilla, W. A., Stolz, D. B., Magee, K. E., Haughney, M., Mukherjee, A., Wang, Y. & Lowe, M. E., May 12 2017, In: Journal of Biological Chemistry. 292, 19, p. 7744 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

5 Scopus citations

Risk Factors for Asparaginase-associated Pancreatitis: A Systematic Review

Oparaji, J. A., Rose, F., Okafor, D., Howard, A., Turner, R. L., Orabi, A. I., Byersdorfer, C., Mi, Q., Ritchey, K., Lowe, M. E. & Husain, S. Z., 2017, In: Journal of Clinical Gastroenterology. 51, 10, p. 907-913 7 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Therapeutic endoscopic retrograde cholangiopancreatography in pediatric patients with acute recurrent and chronic pancreatitis

Troendle, D. M., Fishman, D. S., Barth, B. A., Giefer, M. J., Lin, T. K., Liu, Q. Y., Abu-El-Haija, M., Bellin, M. D., Durie, P. R., Freedman, S. D., Gariepy, C., Gonska, T., Heyman, M. B., Himes, R., Husain, S. Z., Kumar, S., Lowe, M. E., Morinville, V. D., Ooi, C. Y., Palermo, J., & 6 othersPohl, J. F., Schwarzenberg, S. J., Werlin, S., Wilschanski, M., Zimmerman, M. B. & Uc, A., 2017, In: Pancreas. 46, 6, p. 764-769 6 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

2016

A Carboxyl Ester Lipase (CEL) mutant causes chronic pancreatitis by forming intracellular aggregates that activate apoptosis

Xiao, X., Jones, G., Sevilla, W. A., Stolz, D. B., Magee, K. E., Haughney, M., Mukherjee, A., Wang, Y. & Lowe, M. E., Oct 28 2016, In: Journal of Biological Chemistry. 291, 44, p. 23224-23236 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

A prognostic tool to predict severe acute pancreatitis in pediatrics

Szabo, F. K., Hornung, L., Oparaji, J. A., Alhosh, R., Husain, S. Z., Liu, Q. Y., Palermo, J., Lin, T. K., Nathan, J. D., Podberesky, D. J., Lowe, M., Fei, L. & Abu-El-Haija, M., May 1 2016, In: Pancreatology. 16, 3, p. 358-364 7 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities

Uc, A., Andersen, D. K., Bellin, M. D., Bruce, J. I., Drewes, A. M., Engelhardt, J. F., Forsmark, C. E., Lerch, M. M., Lowe, M. E., Neuschwander-Tetri, B. A., O'Keefe, S. J., Palermo, T. M., Pasricha, P., Saluja, A. K., Singh, V. K., Szigethy, E. M., Whitcomb, D. C., Yadav, D. & Conwell, D. L., Nov 1 2016, In: Pancreas. 45, 10, p. 1365-1375 11 p.

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Direct costs of acute recurrent and chronic pancreatitis in children in the INSPPIRE registry

Ting, J., Wilson, L., Schwarzenberg, S. J., Himes, R., Barth, B., Bellin, M. D., Durie, P. R., Fishman, D. S., Freedman, S. D., Gariepy, C. E., Giefer, M. J., Gonska, T., Husain, S. Z., Kumar, S., Morinville, V. D., Lowe, M. E., Ooi, C. Y., Pohl, J. F., Troendle, D., Usatin, D., & 4 othersWerlin, S. L., Wilschanski, M., Heyman, M. B. & Uc, A., 2016, In: Journal of pediatric gastroenterology and nutrition. 62, 3, p. 443-449 7 p.

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Lipase Genetic Variants in Chronic Pancreatitis: When the End Is Wrong, All's Not Well

Molven, A., Fjeld, K. & Lowe, M. E., Jun 1 2016, In: Gastroenterology. 150, 7, p. 1515-1518 4 p.

Research output: Contribution to journal › Editorial

11 Scopus citations

Risk factors associated with pediatric acute recurrent and chronic pancreatitis: Lessons from INSPPIRE

Kumar, S., Ooi, C. Y., Werlin, S., Abu-El-Haija, M., Barth, B., Bellin, M. D., Durie, P. R., Fishman, D. S., Freedman, S. D., Gariepy, C., Giefer, M. J., Gonska, T., Heyman, M. B., Himes, R., Husain, S. Z., Lin, T. K., Lowe, M. E., Morinville, V., Palermo, J. J., Pohl, J. F., & 5 othersSchwarzenberg, S. J., Troendle, D., Wilschanski, M., Zimmerman, M. B. & Uc, A., Jun 2016, In: JAMA Pediatrics. 170, 6, p. 562-569 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

161 Scopus citations

2015

A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition

Loverdos, I., Swan, M. C., Shekherdimian, S., Al-Rasheed, A. A., Schneider, R., Fish, J. S., Ngan, B. Y., Adeli, K., Lowe, M. E., Singh, V. P., Sevilla, W. M. A., Langer, J. C. & Gonska, T., May 1 2015, In: Journal of Pediatric Surgery Case Reports. 3, 5, p. 223-226 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding

Szabó, A., Xiao, X., Haughney, M., Spector, A., Sahin-Tóth, M. & Lowe, M. E., Jul 1 2015, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1852, 7, p. 1372-1379 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

ESPGHAN and NASPGHAN Report on the Assessment of Exocrine Pancreatic Function and Pancreatitis in Children

Taylor, C. J., Chen, K., Horvath, K., Hughes, D., Lowe, M. E., Mehta, D., Orabi, A. I., Screws, J., Thomson, M., Van Biervliet, S., Verkade, H. J., Husain, S. Z. & Wilschanski, M., Jul 23 2015, In: Journal of pediatric gastroenterology and nutrition. 61, 1, p. 144-153 10 p.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Forkhead box O6 (FoxO6) depletion attenuates hepatic gluconeogenesis and protects against fat-induced glucose disorder in mice

Calabuig-Navarro, V., Yamauchi, J., Lee, S., Zhang, T., Liu, Y. Z., Sadlek, K., Coudriet, G. M., Piganelli, J. D., Jiang, C. L., Miller, R., Lowe, M., Harashima, H. & Dong, H. H., Jun 19 2015, In: Journal of Biological Chemistry. 290, 25, p. 15581-15594 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

Next Generation of Pancreatic Enzyme Replacement Therapy: Recombinant Microbial Enzymes and Finding the Perfect Lipase

Lowe, M. E. & Whitcomb, D. C., Dec 1 2015, In: Gastroenterology. 149, 7, p. 1678-1681 4 p.

Research output: Contribution to journal › Editorial

6 Scopus citations

Mark Lowe

Research output

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