Marianna Ruzinova

2025

HMGA2 Expression Predicts Subtype, Survival, and Treatment Outcome in Pancreatic Ductal Adenocarcinoma

Yamamoto, N., Dobersch, S., Loveless, I., Samraj, A. N., Jang, G. H., Haraguchi, M., Kang, L. I., Ruzinova, M. B., Vij, K. R., Mudd, J. L., Walsh, T., Safyan, R. A., Chiorean, E. G., Hingorani, S. R., Bolton, N. M., Li, L., Fields, R. C., DeNardo, D. G., Notta, F. & Crawford, H. C. & 2 others, Steele, N. G. & Kugel, S., Feb 15 2025, In: Clinical Cancer Research. 31, 4, p. 733-745 13 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2024

Chemokine Receptor 2 Targeted PET/CT Imaging Distant Metastases in Pancreatic Ductal Adenocarcinoma

Zhang, X., Detering, L., Heo, G. S., Sultan, D., Luehmann, H., Li, L., Somani, V., Lesser, J., Tao, J., Kang, L. I., Li, A., Lahad, D., Rho, S., Ruzinova, M. B., DeNardo, D. G., Dehdashti, F., Lim, K. H. & Liu, Y., Jan 12 2024, In: ACS Pharmacology and Translational Science. 7, 1, p. 285-293 9 p.

Research output: Contribution to journal › Article › peer-review

Combined KRAS-MAPK pathway inhibitors and HER2-directed drug conjugate is efficacious in pancreatic cancer

Bulle, A., Liu, P., Seehra, K., Bansod, S., Chen, Y., Zahra, K., Somani, V., Khawar, I. A., Chen, H. P., Dodhiawala, P. B., Li, L., Geng, Y., Mo, C. K., Mahsl, J., Ding, L., Govindan, R., Davies, S., Mudd, J., Hawkins, W. G. & Fields, R. C. & 7 others, DeNardo, D. G., Knoerzer, D., Held, J. M., Grierson, P. M., Wang-Gillam, A., Ruzinova, M. B. & Lim, K. H., Dec 2024, In: Nature communications. 15, 1, 2503.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Missense Mutations in Myc Box I Influence Nucleocytoplasmic Transport to Promote Leukemogenesis

Arthur, N. B. J., Christensen, K. A., Mannino, K., Ruzinova, M. B., Kumar, A., Gruszczynska, A., Day, R. B., Erdmann-Gilmore, P., Mi, Y., Sprung, R., York, C. R., Townsend, R. R., Spencer, D. H., Sykes, S. M. & Ferraro, F., Aug 15 2024, In: Clinical Cancer Research. 30, 16, p. 3622-3639 18 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Post-Transplant Lymphoproliferative Disorders

Dharnidharka, V. R., Ruzinova, M. B. & Marks, L. J., Jan 2024, In: Seminars in Nephrology. 44, 1, 151503.

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

The Post-transplant Lymphoproliferative Disorders - Metagenomic Shotgun Microbial Sequencing (PTLD-MSMS) Study Methods and Protocol

Dharnidharka, V. R., Wylie, K. M., Wylie, T. N., Ruzinova, M. B., Goss, C. W., Storch, G. A., Mehta-Shah, N., Byers, D., Walther, L., Jaza, L., Gu, H., Agarwal, M., Green, M., Moore, E., Swerdlow, S. H., Silveira, F., Marks, L. J., Gratzinger, D., Bagg, A. & Law, S. C. & 1 others, Gandhi, M., Oct 28 2024, In: Transplantation Direct. 10, 11, p. e1723

Research output: Contribution to journal › Article › peer-review

Open Access

Validation of an automated iron stain process for use with bone marrow aspirate smear slides

Shirai, C. L., Ruzinova, M. B., Barber, P., Bianchi, E., Ackerman, J. M., Wang, T., Parrish, S. & Frater, J. L., Sep 2024, In: Journal of Hematopathology. 17, 3, p. 121-128 8 p.

Research output: Contribution to journal › Article › peer-review

2023

Distinct clonal identities of B-ALLs arising after lenolidomide therapy for multiple myeloma

Barnell, E. K., Skidmore, Z. L., Newcomer, K. F., Chavez, M., Campbell, K. M., Cotto, K. C., Spies, N. C., Ruzinova, M. B., Wang, T., Abro, B., Kreisel, F., Parikh, B. A., Duncavage, E. J., Frater, J. L., Lee, Y. S., Hassan, A., King, J. A., Kohnen, D. R., Fiala, M. A. & Welch, J. & 6 others, Uy, G. L., Vij, K., Vij, R., Griffith, M., Griffith, O. L. & Wartman, L. D., Jan 24 2023, In: Blood Advances. 7, 2, p. 236-245 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression

Kong, T., Laranjeira, A. B. A., Yang, K., Fisher, D. A. C., Yu, L. Y., Poittevin De La Frégonnière, L., Wang, A. Z., Ruzinova, M. B., Fowles, J. S., Fulbright, M. C., Cox, M. J., Celik, H., Challen, G. A., Huang, S. & Oh, S. T., Jan 2023, In: Nature Cancer. 4, 1, p. 108-127 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

IMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry

Lu, P., Oetjen, K. A., Bender, D. E., Ruzinova, M. B., Fisher, D. A. C., Shim, K. G., Pachynski, R. K., Brennen, W. N., Oh, S. T., Link, D. C. & Thorek, D. L. J., Dec 2023, In: Nature communications. 14, 1, 1601.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

SOX9 Expression Is Superior to Other Stem Cell Markers K19 and EpCAM in Predicting Prognosis in Hepatocellular Carcinoma

Ruzinova, M. B., Ma, C., Brunt, E. M., Goss, C. W., Vachharajani, N., Chapman, W. C. & Liu, T. C., Jan 1 2023, In: American Journal of Surgical Pathology. 47, 1

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2022

Decitabine salvage for TP53-mutated, relapsed/refractory acute myeloid leukemia after cytotoxic induction therapy

Ferraro, F., Gruszczynska, A., Ruzinova, M. B., Miller, C. A., Percival, M. E., Uy, G. L., Pusic, I., Jacoby, M. A., Christopher, M. J., Kim, M. Y., Westervelt, P., Cashen, A. F., Schroeder, M. A., DiPersio, J. F., Abboud, C. N., Wartman, L. D., Gao, F., Link, D. C., Ley, T. J. & Welch, J. S., Jul 2022, In: Haematologica. 107, 7, p. 1709-1713 5 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

6 Scopus citations

IRAK4 Signaling Drives Resistance to Checkpoint Immunotherapy in Pancreatic Ductal Adenocarcinoma

Somani, V. K., Zhang, D., Dodhiawala, P. B., Lander, V. E., Liu, X., Kang, L. I., Chen, H. P., Knolhoff, B. L., Li, L., Grierson, P. M., Ruzinova, M. B., DeNardo, D. G. & Lim, K. H., Jun 2022, In: Gastroenterology. 162, 7, p. 2047-2062 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Pevonedistat targets malignant cells in myeloproliferative neoplasms in vitro and in vivo via NFκB pathway inhibition

Kong, T., Laranjeira, A. B. A., Collins, T. B., De Togni, E. S., Wong, A. J., Fulbright, M. C., Ruzinova, M., Celik, H., Challen, G. A., Fisher, D. A. C. & Oh, S., Jan 25 2022, In: Blood Advances. 6, 2, p. 611-623 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

2021

CC Chemokine Receptor 2-Targeting Copper Nanoparticles for Positron Emission Tomography-Guided Delivery of Gemcitabine for Pancreatic Ductal Adenocarcinoma

Zhang, X., Detering, L., Sultan, D., Luehmann, H., Li, L., Heo, G. S., Zhang, X., Lou, L., Grierson, P. M., Greco, S., Ruzinova, M., Laforest, R., Dehdashti, F., Lim, K. H. & Liu, Y., Jan 26 2021, In: ACS nano. 15, 1, p. 1186-1198 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

The MK2/Hsp27 axis is a major survival mechanism for pancreatic ductal adenocarcinoma under genotoxic stress

Grierson, P. M., Dodhiawala, P. B., Cheng, Y., Chen, T. H. P., Khawar, I. A., Wei, Q., Zhang, D., Li, L., Herndon, J., Monahan, J. B., Ruzinova, M. B. & Lim, K. H., Dec 1 2021, In: Science translational medicine. 13, 622, abb5445.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

2019

IRAK4 mediates colitis-induced tumorigenesis and chemoresistance in colorectal cancer

Li, Q., Chen, Y., Zhang, D., Grossman, J., Li, L., Khurana, N., Jiang, H., Grierson, P. M., Herndon, J., DeNardo, D. G., Challen, G. A., Liu, J., Ruzinova, M. B., Fields, R. C. & Lim, K. H., 2019, In: JCI Insight. 4, 19, e130867.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Metagenomic analysis of DNA viruses from posttransplant lymphoproliferative disorders

Dharnidharka, V. R., Ruzinova, M. B., Chen, C. C., Parameswaran, P., O'Gorman, H., Goss, C. W., Gu, H., Storch, G. A. & Wylie, K., Mar 2019, In: Cancer medicine. 8, 3, p. 1013-1023 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

TP53 immunohistochemistry correlates with TP53 mutation status and clearance in decitabine-treated patients with myeloid malignancies

Ruzinova, M. B., Lee, Y. S., Duncavage, E. J. & Welch, J. S., Jul 31 2019, In: Haematologica. 104, 8, p. e345-e348

Research output: Contribution to journal › Letter › peer-review

Open Access

26 Scopus citations

2018

Acute graft-versus-host disease following lung transplantation in a patient with a novel TERT mutation

Brestoff, J. R., Vessoni, A. T., Brenner, K. A., Uy, G. L., DiPersio, J. F., Blinder, M., Witt, C. A., Byers, D. E., Hachem, R. R., Truclock, E. P., Early, D. S., Anadkat, M. J., Musiek, A., Javidan-Nejad, C., Balfe, D. M., Rosman, I. S., Liu, C., Zhang, L., Despotis, G. J. & Ruzinova, M. B. & 8 others, Sehn, J. K., Amarillo, I., Heusel, J. W., Swat, W., Kim, B. S., Wartman, L. D., Yusen, R. D. & Batista, L. F. Z., May 1 2018, In: Thorax. 73, 5, p. 489-492 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Distinct clinical and magnetic resonance features of metastatic hepatocellular carcinoma treated with pembrolizumab: A case report of late response after pseudoprogression

Grierson, P., Crites, D., Ruzinova, M. B., Yano, M. & Lim, K. H., 2018, In: Hepatology Communications. 2, 2, p. 148-151 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Immunophenotypic variations in mantle cell lymphoma and their impact on clinical behavior and outcome

Aqil, B., Triska, G., Frater, J., Hassan, A., Ruzinova, M. B., Cashen, A., Reese, Y. & Kreisel, F., Oct 2018, In: Archives of Pathology and Laboratory Medicine. 142, 10, p. 1268-1274 7 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Tumor–Stroma IL1b-IRAK4 feedforward circuitry drives tumor fibrosis, chemoresistance, and poor prognosis in pancreatic cancer

Zhang, D., Li, L., Jiang, H., Li, Q., Wang-Gillam, A., Yu, J., Head, R., Liu, J., Ruzinova, M. B. & Lim, K. H., Apr 2018, In: Cancer research. 78, 7, p. 1700-1712 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

159 Scopus citations

2017

Constitutive IRAK4 activation underlies poor prognosis and chemoresistance in pancreatic ductal adenocarcinoma

Zhang, D., Li, L., Jiang, H., Knolhoff, B. L., Lockhart, A. C., Wang-Gillam, A., DeNardo, D. G., Ruzinova, M. B. & Lim, K. H., Apr 1 2017, In: Clinical Cancer Research. 23, 7, p. 1748-1759 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

Utility of a multidisciplinary tumor board in the management of pancreatic and upper gastrointestinal diseases: an observational study

Brauer, D. G., Strand, M. S., Sanford, D. E., Kushnir, V. M., Lim, K. H., Mullady, D. K., Tan, B. R., Wang-Gillam, A., Morton, A. E., Ruzinova, M. B., Parikh, P. J., Narra, V. R., Fowler, K. J., Doyle, M. B., Chapman, W. C., Strasberg, S. S., Hawkins, W. G. & Fields, R. C., Feb 1 2017, In: HPB. 19, 2, p. 133-139 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

60 Scopus citations

2016

High frequency of KRAS mutation in early onset colorectal adenocarcinoma: implications for pathogenesis

Watson, R., Liu, T. C. & Ruzinova, M. B., Oct 1 2016, In: Human Pathology. 56, p. 163-170 8 p.

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence

Manda, K. R., Tripathi, P., Hsi, A. C., Ning, J., Ruzinova, M. B., Liapis, H., Bailey, M., Zhang, H., Maher, C. A., Humphrey, P. A., Andriole, G. L., Ding, L., You, Z. & Chen, F., Jun 23 2016, In: Oncogene. 35, 25, p. 3282-3292 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

2015

Ciliated hepatic foregut cyst: A report of 6 cases and a review of the English literature

Bishop, K. C., Perrino, C. M., Ruzinova, M. B. & Brunt, E. M., Jul 1 2015, In: Diagnostic Pathology. 10, 1, 81.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Perioperative Therapy for Surgically Resectable Pancreatic Adenocarcinoma

Du, L., DeFoe, M., Ruzinova, M. B., Olsen, J. R. & Wang-Gillam, A., Aug 1 2015, In: Hematology/Oncology Clinics of North America. 29, 4, p. 717-726 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

6 Scopus citations

2011

Eosinophilic myocarditis in hypereosinophilic syndrome.

Roehrl, M. H. A., Alexander, M. P., Hammond, S. B., Ruzinova, M., Wang, J. Y. & O'Hara, C. J., Jul 2011, In: American journal of hematology. 86, 7, p. 607-608 2 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

2010

Altered subcellular localization of c-myc protein identifies aggressive B-cell lymphomas harboring a c-MYC translocation

Ruzinova, M. B., Caron, T. & Rodig, S. J., Jun 1 2010, In: American Journal of Surgical Pathology. 34, 6, p. 882-891 10 p.

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Extranodal natural killer cell/t-cell lymphoma, nasal type, presenting as cutaneous nodules and a small-bowel perforation

Agarwal, P., Ruzinova, M. B., Harris, M. H., Qureshi, A. A. & Stebbins, W. G., Feb 2010, In: American Journal of Dermatopathology. 32, 1, p. 83-85 3 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2005

Induction of complete regressions of oncogene-induced breast tumors in mice

Benezra, R., Henke, E., Ciarrocchi, A., Ruzinova, M., Solit, D., Rosen, N., Nolan, D., Mittal, V. & De Candia, P., 2005, In: Cold Spring Harbor symposia on quantitative biology. 70, p. 375-381 7 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

2003

Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors

Ruzinova, M. B., Schoer, R. A., Gerald, W., Egan, J. E., Pandolfi, P. P., Rafii, S., Manova, K., Mittal, V. & Benezra, R., Oct 2003, In: Cancer Cell. 4, 4, p. 277-289 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

230 Scopus citations

Id proteins in development, cell cycle and cancer

Ruzinova, M. B. & Benezra, R., Aug 1 2003, In: Trends in Cell Biology. 13, 8, p. 410-418 9 p.

Research output: Contribution to journal › Review article › peer-review

507 Scopus citations

2002

A genetic approach to understanding tumor angiogenesis

Benezra, R., De Candia, P., Li, H., Romero, E., Lyden, D., Rafii, S. & Ruzinova, M., 2002, In: Cold Spring Harbor symposia on quantitative biology. 67, p. 249-254 6 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Marianna Ruzinova

Research output

Search results