Maria Remedi

Assistant Professor of Medicine, Assistant Professor of Cell Biology and Physiology

  • 1591 Citations
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Personal profile

Research interests

The broad context of my ongoing research has been focused on understanding the physiological and pathological roles of ATP-sensitive potassium (KATP) channels. KATP channels are expressed in many tissues (brain, heart, muscle and pancreas) linking metabolism to membrane electrical activity. Mutations on ATP-sensitive K+ (KATP) channels are the main cause of several human diseases including Neonatal Diabetes Mellitus, Congenital Hyperinsulinism, brain disorders and Cantu syndrome. In pancreatic β--cells, KATP channels critically link glucose metabolism to insulin secretion. In the last few years, I focused my research on the role and consequences of altered KATP channels in insulin secretion; and more recently, on understanding the underlying mechanism/s of pancreatic β-cell exhaustion and glucotoxicity in diabetes . I have been also studying the consequences of altered KATP channels in extra-pancreatic tissues (heart, vasculature).

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  • 12 Similar Profiles
KATP Channels Medicine & Life Sciences
Insulin Medicine & Life Sciences
Glucose Medicine & Life Sciences
Adenosine Triphosphate Medicine & Life Sciences
Hyperinsulinism Medicine & Life Sciences
Diabetes Mellitus Medicine & Life Sciences
Mutation Medicine & Life Sciences
Islets of Langerhans Medicine & Life Sciences

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Research Output 1997 2019

1 Citation (Scopus)

ABCC9-related Intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9

Smeland, M. F., McClenaghan, C., Roessler, H. I., Savelberg, S., Hansen, G. Å. M., Hjellnes, H., Arntzen, K. A., Müller, K. I., Dybesland, A. R., Harter, T., Sala-Rabanal, M., Emfinger, C. H., Huang, Y., Singareddy, S. S., Gunn, J., Wozniak, D. F., Kovacs, A., Massink, M., Tessadori, F., Kamel, S. M. & 5 others, Bakkers, J., Remedi, M. S., Van Ghelue, M., Nichols, C. G. & van Haaften, G., Dec 1 2019, In : Nature communications. 10, 1, 4457.

Research output: Contribution to journalArticle

Open Access
KATP Channels
Sulfonylurea Receptors
Muscular Diseases
2 Citations (Scopus)

Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets

Emfinger, C. H., Lőrincz, R., Wang, Y., York, N. W., Singareddy, S. S., Ikle, J. M., Tryon, R. C., McClenaghan, C., Shyr, Z. A., Huang, Y., Reissaus, C. A., Meyer, D., Piston, D. W., Hyrc, K., Remedi, M. S. & Nichols, C. G., Jun 2019, In : Physiological Reports. 7, 11, e14101.

Research output: Contribution to journalArticle

Open Access
KATP Channels

The role of membrane excitability in pancreatic β-cell glucotoxicity

Shyr, Z. A., Wang, Z., York, N. W., Nichols, C. G. & Remedi, M. S., Dec 1 2019, In : Scientific reports. 9, 1, 6952.

Research output: Contribution to journalArticle

Open Access
Adenosine Triphosphate
6 Citations (Scopus)

Cardiovascular consequences of KATP overactivity in Cantu syndrome

Huang, Y., McClenaghan, C., Harter, T. M., Hinman, K., Halabi, C. M., Matkovich, S. J., Zhang, H., Brown, G. S., Mecham, R. P., England, S. K., Kovacs, A., Remedi, M. S. & Nichols, C. G., Aug 9 2018, In : JCI Insight. 3, 15

Research output: Contribution to journalArticle

KATP Channels
Blood Vessels
Smooth Muscle
Clustered Regularly Interspaced Short Palindromic Repeats

Contribution of systemic inflammation to permanence of katp-induced neonatal diabetes in mice

Emfinger, C. H., Yan, Z., Welscher, A., Hung, P., McAllister, W., Hruz, P. W., Nichols, C. G. & Remedi, M. S., Dec 2018, In : American Journal of Physiology - Endocrinology and Metabolism. 315, 6, p. E1121-E1132

Research output: Contribution to journalArticle

Insulin Resistance
KATP Channels