Research Output per year
Research Output per year
Assistant Professor of Medicine, Assistant Professor of Cell Biology and Physiology
Research output per year
The broad context of my ongoing research has been focused on understanding the physiological and pathological roles of ATP-sensitive potassium (KATP) channels. KATP channels are expressed in many tissues (brain, heart, muscle and pancreas) linking metabolism to membrane electrical activity. Mutations on ATP-sensitive K+ (KATP) channels are the main cause of several human diseases including Neonatal Diabetes Mellitus, Congenital Hyperinsulinism, brain disorders and Cantu syndrome. In pancreatic β--cells, KATP channels critically link glucose metabolism to insulin secretion. In the last few years, I focused my research on the role and consequences of altered KATP channels in insulin secretion; and more recently, on understanding the underlying mechanism/s of pancreatic β-cell exhaustion and glucotoxicity in diabetes . I have been also studying the consequences of altered KATP channels in extra-pancreatic tissues (heart, vasculature).
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Review article › peer-review