Research output per year
Research output per year
Personal profile
Research interests
Medical Genetics is the main focus of our lab. Working on the foundation that the Human Genome Project has built, we are constantly trying to characterize un-annotated genes and proteins that are associated with hereditary disorders.
Lysosomes have always been a focused part of our research- characterizing lysosomal proteins can help us discover ways to fight back against lysosomal storage neurodegenerative diseases. Dr. Sardiello characterized TFEB (Transcription Factor EB) in 2009, with a groundbreaking study which refined the role of lysosomes. Since then, the Sardiello lab has been dedicated towards understanding lysosomal protein in an effort to cure or treat Neuronal Ceroid Lipofuscinoses, a specific category of lysosomal storage diseases.
Translational Medicine is one of our lab's biggest priorities. We believe strongly in bench-to-bedside approaches, and work hard to fulfill that ideal. Much of our research is focused on not only characterizing and discovering new scientific concepts, but also on how to deliver the fruit of our discoveries to the patients that need it. The Sardiello Lab is here to help.
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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Atypical free sialic acid storage disorder associated with tissue specific mosaicism of SLC17A5
Undiagnosed Diseases Network, Jan 2025, In: Molecular genetics and metabolism. 144, 1, 109004.Research output: Contribution to journal › Article › peer-review
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Gene therapy ameliorates bowel dysmotility and enteric neuron degeneration and extends survival in lysosomal storage disorder mouse models
Ziółkowska, E. A., Jansen, M. J., Williams, L. L., Wang, S. H., Eultgen, E. M., Takahashi, K., Le, S. Q., Nelvagal, H. R., Sharma, J., Sardiello, M., DeBosch, B. J., Dickson, P. I., Anderson, J. B., Sax, S. E., Wright, C. M., Bradley, R. P., Whiteman, I. T., Makita, T., Grider, J. R. & Sands, M. S. & 2 others, , Jan 15 2025, In: Science translational medicine. 17, 781, eadj1445.Research output: Contribution to journal › Article › peer-review
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Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk
Zhang, X., Kapoor, D., Jeong, S. J., Fappi, A., Stitham, J., Shabrish, V., Sergin, I., Yousif, E., Rodriguez-Velez, A., Yeh, Y. S., Park, A., Yurdagul, A., Rom, O., Epelman, S., Schilling, J. D., Sardiello, M., Diwan, A., Cho, J., Stitziel, N. O. & Javaheri, A. & 3 others, , Feb 2024, In: Nature Metabolism. 6, 2, p. 359-377 19 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy
Wang, B., Martini-Stoica, H., Qi, C., Lu, T. C., Wang, S., Xiong, W., Qi, Y., Xu, Y., Sardiello, M., Li, H. & Zheng, H., Jan 2024, In: Nature neuroscience. 27, 1, p. 48-62 15 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Calpain activity is negatively regulated by a KCTD7–Cullin-3 complex via non-degradative ubiquitination
Sharma, J., Mulherkar, S., Chen, U. I., Xiong, Y., Bajaj, L., Cho, B. K., Goo, Y. A., Leung, H. C. E., Tolias, K. F. & Sardiello, M., Dec 2023, In: Cell Discovery. 9, 1, 32.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations