Personal profile
Research interests
My laboratory studies the function of natural killer (NK) cells, dendritic cells (DC) and plasmacytoid dendritic cells (PDC) in innate immune responses.
NK cell, DC and PDC effector functions are regulated by a balance of activating and inhibitory signals transduced by a variety of distinct receptors. Our previous accomplishments in this field include identifying the human killer cell immunoglobulin-like receptors (KIRs). We also discovered the leukocyte immunoglobulin-like receptors (LILRs) as well as inhibitory and activating receptors that belong to the TREM family. We are actively pursuing the role of TREM-1 in sepsis and the function of TREM-2 in development of dendritic cells, microglia and osteoclasts.
PDC are bone marrow derived cells that specialize in the secretion of IFN-a and IFN-ß in response to DNA and RNA viruses. Presently, we are assessing the function of PDC during immune responses to infections caused by ssRNA viruses (Influenza) and DNA viruses (HSV-1 and MCMV).
Available to Mentor:
- PhD Students
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth
Mateus-Tique, J., Lakshmi, A., Singh, B., Iyer, R., Sánchez-Paulete, A. R., Falcomatà, C., Lin, M., Pantsulaia, G., Tepper, A., Nguyen, T., Amabile, A., Mollaoglu, G., Pia, L., Chhamalwan, D., Le Berichel, J., Potak, H., Colonna, M., Baccarini, A., Brody, J. & Merad, M. & 1 others, , Mar 9 2026, In: Cancer Cell. 44, 3, p. 534-550.e11Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Author Correction: Retargeted oncolytic viruses engineered to remodel the tumor microenvironment for glioblastoma immunotherapy (Nature Cancer, (2025), 6, 12, (1994-2010), 10.1038/s43018-025-01070-6)
Giovannoni, F., Strathdee, C. A., Faust Akl, C., Andersen, B. M., Li, Z., Lee, H. G., Torti, M. F., Rone, J. M., Duart-Abadia, P., Molgora, M., Kong, L., Floyd, M., Teng, J., Gyulakian, Y., Grzesik, P., Farkaly, T., Denslow, A., Feau, S., Rodriguez-Sanchez, I. & Jacques, J. & 6 others, , Jan 2026, In: Nature Cancer. 7, 1, p. 247 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties
Du, S., Ou, F., Drieu, A., Xu, E. Z., Cheng, Y., Storck, S. E., Mamuladze, T., Cao, J., Abduljawad, N., Bhattarai, B., Rustenhoven, J., Mortimer, N., Brioschi, S., Nguyen, K., Rodrigues, P. F., Smirnov, I., Gibson, D., Michael White, J., Beatty, W. & DeNardo, D. & 8 others, , 2026, (Accepted/In press) In: Neuron.Research output: Contribution to journal › Article › peer-review
Open Access -
Divergent ILC3 responses to PDGF-D control mucosal immunity
Fachi, J. L., de Oliveira, S., Trsan, T., Molgora, M., Rodrigues, P. F., Gilfillan, S., Antonova, A. U., Chang, H. W., Penati, S., Cao, S., Cella, M. & Colonna, M., Feb 2026, In: Science immunology. 11, 116, eaea6848.Research output: Contribution to journal › Article › peer-review
-
Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins
Du, S., Nguyen, K. M., Ulezko Antonova, A., Fachi, J. L., Rodrigues, P. F., Verdiani, A., Molgora, M., Smirnov, I., Herz, J., Mamuladze, T., Ponce, J., Swain, A., Bugatti, M., Gilfillan, S., Cella, M., Vermi, W., Kipnis, J., Colonna, M. & Brioschi, S., Mar 2026, In: Nature neuroscience. 29, 3, p. 717-731 15 p.Research output: Contribution to journal › Article › peer-review