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Personal profile

Research interests

The development of genomics, bioinformatics and statistical methods as they apply to the study of cancer biology and medicine. A particular focus on the translation of genomics data from whole genome, exome and transcriptome sequencing into clinically actionable observations and personalized cancer therapies.

Fingerprint Dive into the research topics where Malachi Griffith is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 7 Similar Profiles
Genome Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Mutation Medicine & Life Sciences
RNA Sequence Analysis Medicine & Life Sciences
Transcriptome Medicine & Life Sciences
Genes Medicine & Life Sciences
Breast Neoplasms Medicine & Life Sciences
High-Throughput Nucleotide Sequencing Medicine & Life Sciences

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Research Output 2003 2019

  • 8059 Citations
  • 70 Article
  • 5 Comment/debate
  • 3 Letter
  • 1 Conference article
1 Citation (Scopus)

Accounting for proximal variants improves neoantigen prediction

Hundal, J., Kiwala, S., Feng, Y. Y., Liu, C. J., Govindan, R., Chapman, W., Uppaluri, R., Swamidass, J., Griffith, O., Mardis, E. R. & Griffith, M., Jan 1 2019, In : Nature Genetics. 51, 1, p. 175-179 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Peptides
Major Histocompatibility Complex
Immunotherapy
Neoplasms
1 Citation (Scopus)

A Spontaneous Aggressive ERα+ Mammary Tumor Model Is Driven by Kras Activation

Campbell, K. M., O'Leary, K. A., Rugowski, D. E., Mulligan, W. A., Barnell, E. K., Skidmore, Z. L., Krysiak, K., Griffith, M., Schuler, L. A. & Griffith, O., Aug 6 2019, In : Cell Reports. 28, 6, p. 1526-1537.e4

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Prolactin
Tumors
Chemical activation
Breast Neoplasms
Neoplasms

Noninvasive Detection of High-Risk Adenomas Using Stool-Derived Eukaryotic RNA Sequences as Biomarkers

Geneoscopy Scientists, Sep 1 2019, In : Gastroenterology. 157, 3, p. 884-887.e3

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Early Detection of Cancer
Adenoma
Biomarkers
3 Citations (Scopus)

Standard operating procedure for somatic variant refinement of sequencing data with paired tumor and normal samples

Barnell, E. K., Ronning, P., Campbell, K. M., Krysiak, K., Ainscough, B. J., Sheta, L. M., Pema, S. P., Schmidt, A. D., Richters, M., Cotto, K. C., Danos, A. M., Ramirez, C., Skidmore, Z. L., Spies, N. C., Hundal, J., Sediqzad, M. S., Kunisaki, J., Gomez, F., Trani, L., Matlock, M. & 4 others, Wagner, A. H., Swamidass, J., Griffith, M. & Griffith, O., Apr 1 2019, In : Genetics in Medicine. 21, 4, p. 972-981 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Neoplasms
Reading
Artifacts
5 Citations (Scopus)

A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion

Miller, C., Tricarico, C., Skidmore, Z. L., Uy, G., Lee, Y-S., Hassan, A., O'Laughlin, M. D., Schmidt, H., Tian, L., Duncavage, E., Griffith, M., Griffith, O., Welch, J. & Wartman, L., Jun 12 2018, In : Blood advances. 2, 11, p. 1295-1299 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Leukemic Gene Expression Regulation
Fusion Oncogene Proteins
mRNA Cleavage and Polyadenylation Factors
Chromosomes, Human, Pair 15
Genetic Translocation