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Personal profile

Research interests

The development of genomics, bioinformatics and statistical methods as they apply to the study of cancer biology and medicine. A particular focus on the translation of genomics data from whole genome, exome and transcriptome sequencing into clinically actionable observations and personalized cancer therapies.

Fingerprint Dive into the research topics where Malachi Griffith is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 18 Similar Profiles
Genome Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Mutation Medicine & Life Sciences
RNA Sequence Analysis Medicine & Life Sciences
Transcriptome Medicine & Life Sciences
Genes Medicine & Life Sciences
Breast Neoplasms Medicine & Life Sciences
High-Throughput Nucleotide Sequencing Medicine & Life Sciences

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Research Output 2003 2019

  • 7863 Citations
  • 67 Article
  • 5 Comment/debate
  • 3 Letter
  • 1 Conference article

Accounting for proximal variants improves neoantigen prediction

Hundal, J., Kiwala, S., Feng, Y. Y., Liu, C. J., Govindan, R., Chapman, W., Uppaluri, R., Swamidass, J., Griffith, O., Mardis, E. R. & Griffith, M., Jan 1 2019, In : Nature Genetics. 51, 1, p. 175-179 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Major Histocompatibility Complex
2 Citations (Scopus)

Standard operating procedure for somatic variant refinement of sequencing data with paired tumor and normal samples

Barnell, E. K., Ronning, P., Campbell, K. M., Krysiak, K., Ainscough, B. J., Sheta, L. M., Pema, S. P., Schmidt, A. D., Richters, M., Cotto, K. C., Danos, A. M., Ramirez, C., Skidmore, Z. L., Spies, N. C., Hundal, J., Sediqzad, M. S., Kunisaki, J., Gomez, F., Trani, L., Matlock, M. & 4 othersWagner, A. H., Swamidass, J., Griffith, M. & Griffith, O., Apr 1 2019, In : Genetics in Medicine. 21, 4, p. 972-981 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
3 Citations (Scopus)

A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion

Miller, C., Tricarico, C., Skidmore, Z. L., Uy, G., Lee, Y-S., Hassan, A., O'Laughlin, M. D., Schmidt, H., Tian, L., Duncavage, E., Griffith, M., Griffith, O., Welch, J. & Wartman, L., Jun 12 2018, In : Blood advances. 2, 11, p. 1295-1299 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Leukemic Gene Expression Regulation
Fusion Oncogene Proteins
mRNA Cleavage and Polyadenylation Factors
Chromosomes, Human, Pair 15
Genetic Translocation
2 Citations (Scopus)

Adapting crowdsourced clinical cancer curation in CIViC to the ClinGen minimum variant level data community-driven standards

Clinical Genome Resource Somatic Working Group and Clinical Interpretation of Variants in Cancer team members, Nov 1 2018, In : Human mutation. 39, 11, p. 1721-1732 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Hospital Distribution Systems
Social Adjustment
1 Citation (Scopus)

A deep learning approach to automate refinement of somatic variant calling from cancer sequencing data

Ainscough, B. J., Barnell, E. K., Ronning, P., Campbell, K. M., Wagner, A. H., Fehniger, T., Dunn, G., Uppaluri, R., Govindan, R., Rohan, T. E., Griffith, M., Mardis, E. R., Swamidass, J. & Griffith, O., Dec 1 2018, In : Nature Genetics. 50, 12, p. 1735-1743 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Machine Learning