Artyomov lab works on the understanding immune cell responses through systems level approach. We are focused on linking high-throughput data generation, hypothesis-centered data analysis and experimental validation of the system in question. Major interest is in the integrating epigenetic, transcriptional and metabolic regulation of the immune system on the cellular level. Specifically, we developed state-of-the-art high-throughput transcriptional-metabolic profiling and analysis pipeline. Using it, we discovered and validated novel metabolic mechanisms controlling macrophage polarization as well as provided comprehensive description of the global metabo-transcriptional rewiring. We then followed up on our global reconstruction of metabolic rewiring in macrophages and discovered novel immunoregulatory role for LPS-inducible metabolite itaconate (Cell Metabolism, in press).

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