Maksym Artomov

Assocate Professor of Pathology and Immunology, Associate Professor of Biomedical Engineering

  • 7170 Citations
20032020

Research output per year

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Personal profile

Research interests

Artyomov lab works on the understanding immune cell responses through systems level approach. We are focused on linking high-throughput data generation, hypothesis-centered data analysis and experimental validation of the system in question. Major interest is in the integrating epigenetic, transcriptional and metabolic regulation of the immune system on the cellular level. Specifically, we developed state-of-the-art high-throughput transcriptional-metabolic profiling and analysis pipeline. Using it, we discovered and validated novel metabolic mechanisms controlling macrophage polarization as well as provided comprehensive description of the global metabo-transcriptional rewiring. We then followed up on our global reconstruction of metabolic rewiring in macrophages and discovered novel immunoregulatory role for LPS-inducible metabolite itaconate (Cell Metabolism, in press).

Keywords

  • COVID-19

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Research Output

Author Correction: Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease (Nature Medicine, (2020), 26, 1, (131-142), 10.1038/s41591-019-0695-9)

Zhou, Y., Song, W. M., Andhey, P. S., Swain, A., Levy, T., Miller, K. R., Poliani, P. L., Cominelli, M., Grover, S., Gilfillan, S., Cella, M., Ulland, T. K., Zaitsev, K., Miyashita, A., Ikeuchi, T., Sainouchi, M., Kakita, A., Bennett, D. A., Schneider, J. A., Nichols, M. R. & 5 others, Beausoleil, S. A., Ulrich, J. D., Holtzman, D. M., Artyomov, M. N. & Colonna, M., Jun 1 2020, In : Nature medicine. 26, 6, 1 p.

Research output: Contribution to journalComment/debate

Open Access
  • Barrier-to-autointegration factor 1 protects against a basal cGAS-STING response

    Ma, H., Qian, W., Bambouskova, M., Collins, P. L., Porter, S. I., Byrum, A. K., Zhang, R., Artyomov, M., Oltz, G., Mosammaparast, N., Miner, J. J. & Diamond, M. S., Mar 1 2020, In : mBio. 11, 2, e00136-20.

    Research output: Contribution to journalArticle

    Open Access
  • Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages

    Swain, A., Bambouskova, M., Kim, H., Andhey, P. S., Duncan, D., Auclair, K., Chubukov, V., Simons, D. M., Roddy, T. P., Stewart, K. M. & Artyomov, M. N., Jan 1 2020, (Accepted/In press) In : Nature Metabolism.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

    Zhou, Y., Song, W. M., Andhey, P. S., Swain, A., Levy, T., Miller, K. R., Poliani, P. L., Cominelli, M., Grover, S., Gilfillan, S., Cella, M., Ulland, T. K., Zaitsev, K., Miyashita, A., Ikeuchi, T., Sainouchi, M., Kakita, A., Bennett, D. A., Schneider, J. A., Nichols, M. R. & 5 others, Beausoleil, S. A., Ulrich, J. D., Holtzman, D. M., Artyomov, M. N. & Colonna, M., Jan 1 2020, In : Nature medicine. 26, 1, p. 131-142 12 p.

    Research output: Contribution to journalArticle

  • 24 Scopus citations

    Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue

    Goldberg, E. L., Shchukina, I., Asher, J. L., Sidorov, S., Artyomov, M. N. & Dixit, V. D., Jan 1 2020, In : Nature Metabolism. 2, 1, p. 50-61 12 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations