• 450 Citations

Research output per year

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Personal profile

Research interests

The overall goals of my research are to define the role of podocyte endoplasmic reticulum (ER) stress in the pathogenesis of nephrotic syndrome (NS) and to investigate potential therapies. NS is an important kidney disease, which causes heavy proteinuria, hypoalbuminemia, hyperlipidemia, and increased risk of progressive loss of kidney function. However, there is no effective treatment for most cases of NS associated with genetic mutations. We are utilizing a combination of stably transfected cell lines, transgenic and knockout animal models, and NS patient samples. The integrated approach enables us to delineate the podocyte ER stress signaling cascades, to identify novel biomarkers, and to investigate mechanism-based therapies.

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Research Output

  • 450 Citations
  • 14 Article
  • 3 Review article

Genetic and Clinical Predictors of Age of ESKD in Individuals With Autosomal Dominant Tubulointerstitial Kidney Disease Due to UMOD Mutations

Kidd, K., Vylet'al, P., Schaeffer, C., Olinger, E., Živná, M., Hodaňová, K., Robins, V., Johnson, E., Taylor, A., Martin, L., Izzi, C., Jorge, S. C., Calado, J., Torres, R. J., Lhotta, K., Steubl, D., Gale, D. P., Gast, C., Gombos, E., Ainsworth, H. C. & 22 others, Chen, Y. M., Almeida, J. R., de Souza, C. F., Silveira, C., Raposeiro, R., Weller, N., Conlon, P. J., Murray, S. L., Benson, K. A., Cavalleri, G. L., Votruba, M., Vrbacká, A., Amoroso, A., Gianchino, D., Caridi, G., Ghiggeri, G. M., Divers, J., Scolari, F., Devuyst, O., Rampoldi, L., Kmoch, S. & Bleyer, A. J., Sep 2020, In : Kidney International Reports. 5, 9, p. 1472-1485 14 p.

Research output: Contribution to journalArticle

Open Access
  • Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome

    Park, S. J., Kim, Y., Yang, S. M., Henderson, M. J., Yang, W., Lindahl, M., Urano, F. & Chen, Y. M., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 28, p. 14154-14163 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • 9 Scopus citations

    Endoplasmic reticulum stress and monogenic kidney diseases in precision nephrology

    Park, S. J., Kim, Y. & Chen, Y. M., Sep 1 2019, In : Pediatric Nephrology. 34, 9, p. 1493-1500 8 p.

    Research output: Contribution to journalReview article

  • 6 Scopus citations

    A rare case of renal thrombotic microangiopathy associated with Castleman's disease

    Mutneja, A., Cossey, L. N., Liapis, H. & Chen, Y. M., Feb 10 2017, In : BMC Nephrology. 18, 1, 57.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations
  • 8 Scopus citations