• 1483 Citations
20022020

Research output per year

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Personal profile

Research interests

A unique characteristic of tissue stem cells is the ability to self-renew, a process that enables the life-long maintenance of many organs. Stem cell self-renewal is dependent on the synthesis of telomere repeats by the enzyme telomerase. Defects in telomerase and in telomere maintenance genes result in diverse disease states, including dyskeratosis congenita, pulmonary fibrosis, aplastic anemia, liver cirrhosis and cancer. Many of these disease states share a tissue failure phenotype, such as loss of bone-marrow cells or failure of pulmonary epithelium, suggesting that stem cell dysfunction is a common pathophysiological mechanism underlying these telomere diseases. My lab is interested in deciphering the molecular mechanisms behind telomere-induced stem cell disease and for that we are using a variety of methods, from classic biochemistry to recently developed gene targeting techniques, to understand and restore telomere homeostasis in human stem cells with deficient telomerase. Our goal is to provide the molecular knowledge necessary for new treatment options for these syndromes.

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Research Output

Adapting to my brain

Batista, L., Feb 28 2020, In : Science. 367, 6481, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita

Shukla, S., Jeong, H. C., Sturgeon, C. M., Parker, R. & Batista, L. F. Z., Jun 23 2020, In : Blood Advances. 4, 12, p. 2717-2722 6 p.

Research output: Contribution to journalArticle

Open Access
  • PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

    Quinet, A., Tirman, S., Jackson, J., Šviković, S., Lemaçon, D., Carvajal-Maldonado, D., González-Acosta, D., Vessoni, A. T., Cybulla, E., Wood, M., Tavis, S., Batista, L. F. Z., Méndez, J., Sale, J. E. & Vindigni, A., Feb 6 2020, In : Molecular cell. 77, 3, p. 461-474.e9

    Research output: Contribution to journalArticle

  • 12 Scopus citations

    Tumor propagating cells: drivers of tumor plasticity, heterogeneity, and recurrence

    Vessoni, A. T., Filippi-Chiela, E. C., Lenz, G. & Batista, L. F. Z., Mar 5 2020, In : Oncogene. 39, 10, p. 2055-2068 14 p.

    Research output: Contribution to journalReview article

  • 3 Scopus citations

    Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita

    Fok, W. C., Shukla, S., Vessoni, A. T., Brenner, K. A., Parker, R., Sturgeon, C. M. & Batista, L. F. Z., Mar 21 2019, In : Blood. 133, 12, p. 1308-1312 5 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations