Lucinda Antonacci-Fulton

A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Li, X., Chen, H., Selvaraj, M. S., Van Buren, E., Zhou, H., Wang, Y., Sun, R., McCaw, Z. R., Yu, Z., Jiang, M. Z., DiCorpo, D., Gaynor, S. M., Dey, R., Arnett, D. K., Benjamin, E. J., Bis, J. C., Blangero, J., Boerwinkle, E. & Bowden, D. W. & 181 others, Brody, J. A., Cade, B. E., Carson, A. P., Carlson, J. C., Chami, N., Chen, Y. D. I., Curran, J. E., de Vries, P. S., Fornage, M., Franceschini, N., Freedman, B. I., Gu, C., Heard-Costa, N. L., He, J., Hou, L., Hung, Y. J., Irvin, M. R., Kaplan, R. C., Kardia, S. L. R., Kelly, T. N., Konigsberg, I., Kooperberg, C., Kral, B. G., Li, C., Li, Y., Lin, H., Liu, C. T., Loos, R. J. F., Mahaney, M. C., Martin, L. W., Mathias, R. A., Mitchell, B. D., Montasser, M. E., Morrison, A. C., Naseri, T., North, K. E., Palmer, N. D., Peyser, P. A., Psaty, B. M., Redline, S., Reiner, A. P., Rich, S. S., Sitlani, C. M., Smith, J. A., Taylor, K. D., Tiwari, H. K., Vasan, R. S., Viali, S., Wang, Z., Wessel, J., Yanek, L. R., Yu, B., de las Fuentes, L., de Andrade, M., Zoellner, S., Zody, M., Ziv, E., Zhu, X., Zhao, W., Zhao, S. X., Zhang, Y., Zekavat, S. M., Yu, K., Yang, I., Xu, H., Wu, J., Wu, B., Wong, Q., Winterkorn, L., Wilson, J., Wilson, C., Williams, S., Williams, L. K., Williams, K., Willer, C., Weng, L. C., Weiss, S. T., Weir, B., Weinstock, J., Weeks, D. E., Watt, J., Watson, K., Wang, J., Wang, H., Wang, F. F., Walts, A., Wallace, R., Walker, T., Vrieze, S., VandeHaar, P., Van Den Berg, D., Vaidya, D., Tsai, M., Tracy, R., Tong, C., Tishkoff, S., Tirschwell, D., Tinker, L., Threlkeld, M., Thornton, T. A., Telen, M., Taylor, S., Taylor, M., Taub, M., Tang, H., Taliun, D., Sériès, F., Szpiro, A., Sylvia, J., Sung, Y. J., Su, J. L., Streeten, E., Storm, G., Stilp, A. M., Sotoodehnia, N., Sofer, T., Snyder, M., Snively, B., Smoller, S., Smith, T., Smith, N., Smith, J., Smith, A. V., Skomro, R., Silverman, E., Silver, B., Shoemaker, M. B., Sheu, W. H. H., Shetty, A., Shetty, A., Sherman, S. L., Sheehan, V., Seidman, J., Seidman, C., Sciurba, F., Schwartz, D., Schwander, K., Santibanez, J., Sankaran, V. G., Sandow, K., Salzberg, S., Salvi, S., Salimi, S., Saleheen, D., Sabino, E. C., Ryan, K., Ruuska, S., Russell, P., Runnels, A., Ruczinski, I., Roselli, C., Dan Roden, R., Robine, N., Robillard, R., Sefuiva Reupena, M., Regan, E., Reeves, C., Reed, R., Ratan, A., Rasmussen-Torvik, L., Rao, D. C., Rajendran, M., Rafaels, N., Qin, Z., Qiao, D., Qasba, P., Preuss, M., Boorgula, M. P., Becker, J. P., Post, W., Pollin, T., Pleiness, J., Phillips, L. S., Peters, U., Perry, J., Perez, M., Peralta, J. M., Parker, C., Papanicolaou, G., Fulton, L. & Dutcher, S. K., Feb 2025, In: Nature Computational Science. 5, 2, p. 125-143 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Regeneron Genetics Center, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Choi, S. H., Jurgens, S. J., Xiao, L., Hill, M. C., Haggerty, C. M., Sveinbjörnsson, G., Morrill, V. N., Marston, N. A., Weng, L. C., Pirruccello, J. P., Arnar, D. O., Gudbjartsson, D. F., Mantineo, H., von Falkenhausen, A. S., Natale, A., Tveit, A., Geelhoed, B. & Roselli, C. & 182 others, Van Wagoner, D. R., Darbar, D., Haase, D., Soliman, E. Z., Davogustto, G. E., Jun, G., Calkins, H., Anderson, J. L., Brody, J. A., Halford, J. L., Barnard, J., Hokanson, J. E., Smith, J. D., Bis, J. C., Young, K., Johnson, L. S. B., Risch, L., Gula, L. J., Kwee, L. C., Chaffin, M. D., Kühne, M., Preuss, M., Gupta, N., Nafissi, N. A., Smith, N. L., Nilsson, P. M., van der Harst, P., Wells, Q. S., Judy, R. L., Schnabel, R. B., Johnson, R., Smit, R. A. J., Gabriel, S., Knight, S., Furukawa, T., Blackwell, T. W., Nauffal, V., Wang, X., Min, Y. I., Yoneda, Z. T., Laksman, Z. W. M., Bezzina, C. R., Alonso, A., Psaty, B. M., Albert, C. M., Arking, D. E., Roden, D. M., Chasman, D. I., Rader, D. J., Conen, D., McManus, D. D., Fatkin, D., Benjamin, E. J., Boerwinkle, E., Marcus, G. M., Christophersen, I. E., Smith, J. G., Roberts, J. D., Raffield, L. M., Shoemaker, M. B., Cho, M. H., Cutler, M. J., Rienstra, M., Chung, M. K., S. Olesen, M., Sinner, M. F., Sotoodehnia, N., Kirchhof, P., Loos, R. J. F., Nazarian, S., Mohanty, S., Damrauer, S. M., Kaab, S., Heckbert, S. R., Redline, S., Shah, S. H., Tanaka, T., Ebana, Y., Wolf, S. E., Widom, L., Verweij, N., Ulloa, R. H., Staples, J. C., Siminovitch, K., Shuldiner, A., Schleicher, T. D., Salerno, W., Reid, J. G., Rasool, A., Pradhan, M., Polanco, T., Panea, R., Padilla, M. S., Overton, J. D., Orelus, M., O’Keeffe, S., Nielsen, J., Nafde, M., Mitnaul, L. J., Mighty, J., Maxwell, E. K., Mansfield, A. J., Manoochehri, K., Lotta, L. A., Lopez, A., Li, D., Lattari, M., Lanche, R., Krasheninina, O., Khalid, S., Karalis, K., Jones, M. B., Hawes, A., Habegger, L., Gu, Z., Fuller, E. D., Forsythe, C., Ferreira, M. A. R., Eom, G., Economides, A., Deubler, A., De, T., Coppola, G., Cantor, M., Boutkov, B., Beechert, C., Baras, A., Balasubramanian, S., Bai, X., Abecasis, G., Zoellner, S., Zody, M., Zhu, X., Zhao, W., Zhao, S. X., Zhang, Y., Zekavat, S. M., Yu, K., Yang, I., Yanek, L., Xu, H., Wu, J., Wong, Q., Winterkorn, L., Wilson, J., Wilson, C., Williams, L. K., Williams, K., Willer, C., Wessel, J., Weiss, S. T., Weir, B., Weinstock, J., Weeks, D. E., Watt, J., Watson, K., Wang, J., Wang, H., Wang, F. F., Walts, A., Wallace, R., Walker, T., Vrieze, S., VandeHaar, P., Van Den Berg, D., Vaidya, D., Tsai, M., Tracy, R., Tong, C., Tiwari, H., Tishkoff, S., Tirschwell, D., Tinker, L., Threlkeld, M., Thornton, T. A., Telen, M., Sung, Y. J., Rao, D. C., Gu, C. C., Fulton, L., Dutcher, S. K. & de las Fuentes, L., Mar 2025, In: Nature Genetics. 57, 3, p. 548-562 15 p., e020163.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

The Somatic Mosaicism across Human Tissues Network

The Somatic Mosaicism across Human Tissues Network, Tool and Technology Development, Data Analysis Center (UM1DA058230), Genome Characterization Center, Tissue Procurement Center (U24MH133204), Organizational Center (U24NS132103), National Institutes of Health, University of Massachusetts Chan Medical School – Thomas G. Fazzio (UG3NS132136), Case Western University – Fulai Jin (UG3NS132061), Broad Institute of MIT and Harvard – Fei Chen (UG3NS132135), Dana Farber Cancer Institute – Kathleen H. Burns (UG3NS132127), Boston’s Children Hospital – Christopher A. Walsh (UG3NS132138), New York University – Gilad D. Evrony (UG3NS132024), Weill Cornell Medicine – Dan A. Landau (UG3NS132139), University of Utah – Gabor T. Marth (UG3NS132134), Mayo Clinic – Alexej Abyzov (UG3NS132128), Baylor College of Medicine – Fritz J. Sedlazeck (UG3NS132105), Baylor College of Medicine – Chenghang Zong (UG3NS132132), Stanford University – Alexander E. Urban (UG3NS132146) & Boston’s Children Hospital – Sangita Choudhury (UG3NS132144) & 6 others, University of Michigan – Ryan E. Mills (UG3NS132084), New York Genome Center – Soren Germer (UM1DA058236), Washington University – Ting Wang (UM1DA058219), Broad Institute of MIT and Harvard – Kristin G. Ardlie (UM1DA058235), Baylor College of Medicine – Richard A. Gibbs (UM1DA058229) & University of Washington and Seattle Children’s Research Institute – James T. Bennett (UM1DA058220), Jul 3 2025, In: Nature. 643, 8070, p. 47-59 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

7 Scopus citations

Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 2025, In: Genome biology. 26, 1, 273.

Research output: Contribution to journal › Article › peer-review

Open Access

A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels

Trans-Omics for Precision Medicine (TOPMed) program, The INVENT Consortium, de Vries, P. S., Reventun, P., Brown, M. R., Heath, A. S., Huffman, J. E., Le, N. Q., Bebo, A., Brody, J. A., Temprano-Sagrera, G., Raffield, L. M., Ozel, A. B., Thibord, F., Jain, D., Lewis, J. P., Rodriguez, B. A. T., Pankratz, N., Taylor, K. D. & Polasek, O. & 182 others, Chen, M. H., Yanek, L. R., Carrasquilla, G. D., Marioni, R. E., Kleber, M. E., Trégouët, D. A., Yao, J., Li-Gao, R., Joshi, P. K., Trompet, S., Martinez-Perez, A., Ghanbari, M., Howard, T. E., Reiner, A. P., Arvanitis, M., Ryan, K. A., Bartz, T. M., Rudan, I., Faraday, N., Linneberg, A., Ekunwe, L., Davies, G., Delgado, G. E., Suchon, P., Guo, X., Rosendaal, F. R., Klaric, L., Noordam, R., van Rooij, F., Curran, J. E., Wheeler, M. M., Osburn, W. O., O'Connell, J. R., Boerwinkle, E., Beswick, A., Psaty, B. M., Kolcic, I., Souto, J. C., Becker, L. C., Hansen, T., Doyle, M. F., Harris, S. E., Moissl, A. P., Deleuze, J. F., Rich, S. S., van Hylckama Vlieg, A., Campbell, H., Stott, D. J., Soria, J. M., de Maat, M. P. M., Almasy, L., Brody, L. C., Auer, P. L., Abe, N., Abecasis, G., Aguet, F., Albert, C., Alonso, A., Ament, S., Anderson, P., Anugu, P., Applebaum-Bowden, D., Ardlie, K., Arking, D., Arnett, D. K., Ashley-Koch, A., Aslibekyan, S., Assimes, T., Auer, P., Avramopoulos, D., Ayas, N., Balasubramanian, A., Barnard, J., Barnes, K., Barr, R. G., Barron-Casella, E., Barwick, L., Beaty, T., Beck, G., Becker, D., Becker, L., Beer, R., Beitelshees, A., Benjamin, E., Benos, T., Bezerra, M., Bielak, L., Bis, J., Blackwell, T., Blangero, J., Blue, N., Bowden, D. W., Bowler, R., Brody, J., Broeckel, U., Broome, J., Brown, D., Bunting, K., Burchard, E., Bustamante, C., Buth, E., Cade, B., Cardwell, J., Carey, V., Carrier, J., Carson, A. P., Carty, C., Casaburi, R., Casas Romero, J. P., Casella, J., Castaldi, P., Chaffin, M., Chang, C., Chang, Y. C., Chasman, D., Chavan, S., Chen, B. J., Chen, W. M., Ida Chen, Y. D., Cho, M., Choi, S. H., Chuang, L. M., Chung, M., Chung, R. H., Clish, C., Comhair, S., Conomos, M., Cornell, E., Correa, A., Crandall, C., Crapo, J., Cupples, L. A., Curran, J., Curtis, J., Custer, B., Damcott, C., Darbar, D., David, S., Davis, C., Daya, M., de Andrade, M., de las Fuentes, L., de Vries, P., DeBaun, M., Deka, R., DeMeo, D., Devine, S., Dinh, H., Doddapaneni, H., Duan, Q., Dugan-Perez, S., Duggirala, R., Durda, J. P., Dutcher, S. K., Eaton, C., El Boueiz, A., Ellinor, P., Emery, L., Erzurum, S., Farber, C., Farek, J., Fingerlin, T., Flickinger, M., Fornage, M., Franceschini, N., Frazar, C., Fu, M., Fullerton, S. M., Fulton, L., Gabriel, S., Gan, W., Gao, S., Gao, Y., Gass, M., Geiger, H., Gelb, B., Geraci, M., Germer, S., Gerszten, R., Gu, C. C., Rao, D. C. & Sung, Y. J., May 2 2024, In: Blood. 143, 18, p. 1845-1855 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Lucinda Antonacci-Fulton

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Collaborations and top research areas from the last five years

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A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

The Somatic Mosaicism across Human Tissues Network

Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals

A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels