Research output per year
Research output per year
Search results
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2025
Interspecies Comparison of Multilayer Mechanical Properties of Synovium Using Atomic Force Microscopy
Akanda, S. R., Walter, C., Davis, A. L., Jing, L., Pathak, A. & Setton, L. A., Feb 1 2025, In: Tissue Engineering - Part A. 31, 3-4, p. 100-107 8 p.Research output: Contribution to journal › Article › peer-review
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2024
A multiphasic model for determination of mouse ascending thoracic aorta mass transport properties with and without aneurysm
Kailash, K. A., Akanda, S. R., Davis, A. L., Crandall, C. L., Castro, L. A., Setton, L. & Wagenseil, J. E., 2024, (Accepted/In press) In: Biomechanics and Modeling in Mechanobiology.Research output: Contribution to journal › Article › peer-review
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Grand Challenges at the Interface of Engineering and Medicine
Subramaniam, S., Akay, M., Anastasio, M. A., Bailey, V., Boas, D., Bonato, P., Chilkoti, A., Cochran, J. R., Colvin, V., Desai, T. A., Duncan, J. S., Epstein, F. H., Fraley, S., Giachelli, C., Grande-Allen, K. J., Green, J., Guo, X. E., Hilton, I. B., Humphrey, J. D. & Johnson, C. R. & 30 others, , 2024, In: IEEE Open Journal of Engineering in Medicine and Biology. 5, p. 1-13 13 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Tunable Viscoelasticity of Alginate Hydrogels via Serial Autoclaving
Moheimani, H., Stealey, S., Neal, S., Ferchichi, E., Zhang, J., Foston, M., Setton, L. A., Genin, G. M., Huebsch, N. & Zustiak, S. P., Dec 27 2024, In: Advanced Healthcare Materials. 13, 32, 2401550.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2023
Harmonization and standardization of nucleus pulposus cell extraction and culture methods
Basatvat, S., Bach, F. C., Barcellona, M. N., Binch, A. L., Buckley, C. T., Bueno, B., Chahine, N. O., Chee, A., Creemers, L. B., Dudli, S., Fearing, B., Ferguson, S. J., Gansau, J., Gantenbein, B., Gawri, R., Glaeser, J. D., Grad, S., Guerrero, J., Haglund, L. & Hernandez, P. A. & 32 others, , Mar 2023, In: JOR Spine. 6, 1, e1238.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2022
A multiphasic model for determination of water and solute transport across the arterial wall: effects of elastic fiber defects
Guang, Y., Cocciolone, A. J., Crandall, C. L., Johnston, B. B., Setton, L. A. & Wagenseil, J. E., Feb 2022, In: Archive of Applied Mechanics. 92, 2, p. 447-459 13 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Hydraulic permeability and compressive properties of porcine and human synovium
Rohanifar, M., Johnston, B. B., Davis, A. L., Guang, Y., Nommensen, K., Fitzpatrick, J. A. J., Pham, C. N. & Setton, L. A., Feb 15 2022, In: Biophysical Journal. 121, 4, p. 575-581 7 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Single Cell RNA-Sequence Analyses Reveal Uniquely Expressed Genes and Heterogeneous Immune Cell Involvement in the Rat Model of Intervertebral Disc Degeneration
Rohanifar, M., Clayton, S. W., Easson, G. W. D., Patil, D. S., Lee, F., Jing, L., Barcellona, M. N., Speer, J. E., Stivers, J. J., Tang, S. Y. & Setton, L. A., Aug 2022, In: Applied Sciences (Switzerland). 12, 16, 8244.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
2021
Bioactive in situ crosslinkable polymer-peptide hydrogel for cell delivery to the intervertebral disc in a rat model
Barcellona, M. N., Speer, J. E., Jing, L., Patil, D. S., Gupta, M. C., Buchowski, J. M. & Setton, L. A., Sep 1 2021, In: Acta Biomaterialia. 131, p. 117-127 11 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
Development of a library of laminin-mimetic peptide hydrogels for control of nucleus pulposus cell behaviors
Speer, J. E., Barcellona, M. N., Lu, M. Y., Zha, Z., Jing, L., Gupta, M. C., Buchowski, J. M., Kelly, M. P. & Setton, L. A., 2021, In: Journal of Tissue Engineering. 12Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Electric Field Stimulation for the Functional Assessment of Isolated Dorsal Root Ganglion Neuron Excitability
Berke, I. M., McGrath, T. M., Stivers, J. J., Gui, C., Barcellona, M. N., Gayoso, M. G., Tang, S. Y., Cao, Y. Q., Gupta, M. C. & Setton, L. A., Mar 2021, In: Annals of biomedical engineering. 49, 3, p. 1110-1118 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Fund Black scientists
Stevens, K. R., Masters, K. S., Imoukhuede, P. I., Haynes, K. A., Setton, L. A., Cosgriff-Hernandez, E., Lediju Bell, M. A., Rangamani, P., Sakiyama-Elbert, S. E., Finley, S. D., Willits, R. K., Koppes, A. N., Chesler, N. C., Christman, K. L., Allen, J. B., Wong, J. Y., El-Samad, H., Desai, T. A. & Eniola-Adefeso, O., Feb 4 2021, In: Cell. 184, 3, p. 561-565 5 p.Research output: Contribution to journal › Article › peer-review
111 Scopus citations -
Integrin and syndecan binding peptide-conjugated alginate hydrogel for modulation of nucleus pulposus cell phenotype
Tan, X., Jain, E., Barcellona, M. N., Morris, E., Neal, S., Gupta, M. C., Buchowski, J. M., Kelly, M., Setton, L. A. & Huebsch, N., Oct 2021, In: Biomaterials. 277, 121113.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
Integrin-mediated interactions with a laminin- presenting substrate modulate biosynthesis and phenotypic expression for cells of the human nucleus pulposus
Speer, J., Barcellona, M., Jing, L., Liu, B., Lu, M., Kelly, M., Buchowski, J., Zebala, L., Luhmann, S., Gupta, M. & Setton, L., Jan 1 2021, In: European Cells and Materials. 41, p. 793-810 18 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
NF-κB-mediated effects on behavior and cartilage pathology in a non-invasive loading model of post-traumatic osteoarthritis
Berke, I. M., Jain, E., Yavuz, B., McGrath, T., Chen, L., Silva, M. J., Mbalaviele, G., Guilak, F., Kaplan, D. L. & Setton, L. A., Feb 2021, In: Osteoarthritis and Cartilage. 29, 2, p. 248-256 9 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Size-Dependent Effective Diffusivity in Healthy Human and Porcine Joint Synovium
Guang, Y., Davis, A. L., McGrath, T. M., Pham, C. T. N., Fitzpatrick, J. A. J. & Setton, L. A., Apr 2021, In: Annals of biomedical engineering. 49, 4, p. 1245-1256 12 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2020
Combined Experimental Approach and Finite Element Modeling of Small Molecule Transport through Joint Synovium to Measure Effective Diffusivity
Guang, Y., Mcgrath, T. M., Klug, N. R., Nims, R. J., Shih, C. C., Bayguinov, P. O., Guilak, F., Pham, C. T. N., Fitzpatrick, J. A. J. & Setton, L. A., Apr 1 2020, In: Journal of Biomechanical Engineering. 142, 4, 041010.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Control of adhesive ligand density for modulation of nucleus pulposus cell phenotype
Barcellona, M. N., Speer, J. E., Fearing, B. V., Jing, L., Pathak, A., Gupta, M. C., Buchowski, J. M., Kelly, M. & Setton, L. A., Aug 2020, In: Biomaterials. 250, 120057.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
Verteporfin treatment controls morphology, phenotype, and global gene expression for cells of the human nucleus pulposus
Fearing, B. V., Speer, J. E., Jing, L., Kalathil, A., P. Kelly, M., M. Buchowski, J., P. Zebala, L., Luhmann, S., C. Gupta, M. & A. Setton, L., Dec 2020, In: JOR Spine. 3, 4, e1111.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
2019
Behavioral Compensations and Neuronal Remodeling in a Rodent Model of Chronic Intervertebral Disc Degeneration
Leimer, E. M., Gayoso, M. G., Jing, L., Tang, S. Y., Gupta, M. C. & Setton, L. A., Dec 1 2019, In: Scientific reports. 9, 1, 3759.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape
Fearing, B. V., Jing, L., Barcellona, M. N., Witte, S. E., Buchowski, J. M., Zebala, L. P., Kelly, M. P., Luhmann, S., Gupta, M. C., Pathak, A. & Setton, L. A., Dec 2019, In: FASEB Journal. 33, 12, p. 14022-14035 14 p.Research output: Contribution to journal › Article › peer-review
Open Access63 Scopus citations -
2018
Amino Acid Profile of Synovial Fluid Following Intra-articular Ankle Fracture
Leimer, E. M., Tanenbaum, L. M., Nettles, D. L., Bell, R. D., Easley, M. E., Setton, L. A. & Adams, S. B., Oct 1 2018, In: Foot and Ankle International. 39, 10, p. 1169-1177 9 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells
Tang, R., Jing, L., Willard, V. P., Wu, C. L., Guilak, F., Chen, J. & Setton, L. A., Mar 9 2018, In: Stem Cell Research and Therapy. 9, 1, 61.Research output: Contribution to journal › Article › peer-review
Open Access72 Scopus citations -
2017
CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory Environments
Farhang, N., Brunger, J. M., Stover, J. D., Thakore, P. I., Lawrence, B., Guilak, F., Gersbach, C. A., Setton, L. A. & Bowles, R. D., Aug 2017, In: Tissue Engineering - Part A. 23, 15-16, p. 738-749 12 p.Research output: Contribution to journal › Article › peer-review
Open Access70 Scopus citations -
Inflammatory Microenvironment Persists After Bone Healing in Intra-articular Ankle Fractures
Adams, S. B., Leimer, E. M., Setton, L. A., Bell, R. D., Easley, M. E., Huebner, J. L., Stabler, T. V., Kraus, V. B., Olson, S. A. & Nettles, D. L., May 1 2017, In: Foot and Ankle International. 38, 5, p. 479-484 6 p.Research output: Contribution to journal › Article › peer-review
42 Scopus citations -
Lipid profile of human synovial fluid following intra-articular ankle fracture
Leimer, E. M., Pappan, K. L., Nettles, D. L., Bell, R. D., Easley, M. E., Olson, S. A., Setton, L. A. & Adams, S. B., Mar 1 2017, In: Journal of Orthopaedic Research. 35, 3, p. 657-666 10 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Regulation of human nucleus pulposus cells by peptide-coupled substrates
Bridgen, D. T., Fearing, B. V., Jing, L., Sanchez-Adams, J., Cohan, M. C., Guilak, F., Chen, J. & Setton, L. A., Jun 2017, In: Acta Biomaterialia. 55, p. 100-108 9 p.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
2016
Identifying molecular phenotype of nucleus pulposus cells in human intervertebral disc with aging and degeneration
Tang, X., Jing, L., Richardson, W. J., Isaacs, R. E., Fitch, R. D., Brown, C. R., Erickson, M. M., Setton, L. A. & Chen, J., Aug 1 2016, In: Journal of Orthopaedic Research. 34, 8, p. 1316-1326 11 p.Research output: Contribution to journal › Article › peer-review
Open Access59 Scopus citations -
In vivo luminescent imaging of NF-κB activity and NF-κB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy
Bowles, R. D., Karikari, I. O., Vanderwerken, D. N., Sinclair, M. S., Bell, R. D., Riebe, K. J., Huebner, J. L., Kraus, V. B., Sempowski, G. D. & Setton, L. A., Mar 1 2016, In: European Journal of Pain (United Kingdom). 20, 3, p. 365-376 12 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
N-cadherin is key to expression of the nucleus pulposus cell phenotype under selective substrate culture conditions
Hwang, P. Y., Jing, L., Chen, J., Lim, F. L., Tang, R., Choi, H., Cheung, K. M., Risbud, M. V., Gersbach, C. A., Guilak, F., Leung, V. Y. & Setton, L. A., Jun 13 2016, In: Scientific reports. 6, 28038.Research output: Contribution to journal › Article › peer-review
Open Access48 Scopus citations -
2015
Inflammatory cytokines and matrix metalloproteinases in the synovial fluid after intra-articular ankle fracture
Adams, S. B., Setton, L. A., Bell, R. D., Easley, M. E., Huebner, J. L., Stabler, T., Kraus, V. B., Leimer, E. M., Olson, S. A. & Nettles, D. L., Nov 1 2015, In: Foot and Ankle International. 36, 11, p. 1264-1271 8 p.Research output: Contribution to journal › Article › peer-review
80 Scopus citations -
N-Cadherin-Mediated Signaling Regulates Cell Phenotype for Nucleus Pulposus Cells of the Intervertebral Disc
Hwang, P. Y., Jing, L., Michael, K. W., Richardson, W. J., Chen, J. & Setton, L. A., Mar 2015, In: Cellular and Molecular Bioengineering. 8, 1, p. 51-62 12 p.Research output: Contribution to journal › Article › peer-review
34 Scopus citations -
Sustained intra-articular delivery of IL-1Ra from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis
Kimmerling, K. A., Furman, B. D., Mangiapani, D. S., Moverman, M. A., Sinclair, S. M., Huebner, J. L., Chilkoti, A., Kraus, V. B., Setton, L. A., Guilak, F. & Olson, S. A., 2015, In: European Cells and Materials. 29, p. 124-140 17 p.Research output: Contribution to journal › Article › peer-review
Open Access81 Scopus citations -
Synthesis and characterization of silk fibroin microparticles for intra-articular drug delivery
Mwangi, T. K., Bowles, R. D., Tainter, D. M., Bell, R. D., Kaplan, D. L. & Setton, L. A., May 15 2015, In: International Journal of Pharmaceutics. 485, 1-2, p. 7-14 8 p., 14695.Research output: Contribution to journal › Article › peer-review
52 Scopus citations -
2014
In vivo luminescence imaging of nf-kb activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis
Bowles, R. D., Mata, B. A., Bell, R. D., Mwangi, T. K., Huebner, J. L., Kraus, V. B. & Setton, L. A., Mar 2014, In: Arthritis and Rheumatology. 66, 3, p. 637-646 10 p.Research output: Contribution to journal › Article › peer-review
46 Scopus citations -
Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell lines
Karikari, I. O., Gilchrist, C. L., Jing, L., Alcorta, D. A., Chen, J., Richardson, W. J., Gabr, M. A., Bell, R. D., Kelley, M. J., Bagley, C. A. & Setton, L. A., Sep 1 2014, In: Journal of Neurosurgery: Spine. 21, 3, p. 386-393 8 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Photocrosslinkable laminin-functionalized polyethylene glycol hydrogel for intervertebral disc regeneration
Francisco, A. T., Hwang, P. Y., Jeong, C. G., Jing, L., Chen, J. & Setton, L. A., Mar 2014, In: Acta Biomaterialia. 10, 3, p. 1102-1111 10 p.Research output: Contribution to journal › Article › peer-review
Open Access71 Scopus citations -
Screening of hyaluronic acid-poly(ethylene glycol) composite hydrogels to support intervertebral disc cell biosynthesis using artificial neural network analysis
Jeong, C. G., Francisco, A. T., Niu, Z., Mancino, R. L., Craig, S. L. & Setton, L. A., Aug 2014, In: Acta Biomaterialia. 10, 8, p. 3421-3430 10 p.Research output: Contribution to journal › Article › peer-review
Open Access45 Scopus citations -
The role of extracellular matrix elasticity and composition in regulating the nucleus pulposus cell phenotype in the intervertebral disc: A narrative review
Hwang, P. Y., Chen, J., Jing, L., Hoffman, B. D. & Setton, L. A., Feb 2014, In: Journal of Biomechanical Engineering. 136, 2, 021010.Research output: Contribution to journal › Article › peer-review
Open Access84 Scopus citations -
2013
A genetically engineered thermally responsive sustained release curcumin depot to treat neuroinflammation
Sinclair, S. M., Bhattacharyya, J., McDaniel, J. R., Gooden, D. M., Gopalaswamy, R., Chilkoti, A. & Setton, L. A., 2013, In: Journal of Controlled Release. 171, 1, p. 38-47 10 p.Research output: Contribution to journal › Article › peer-review
Open Access50 Scopus citations -
Differentiation of Mouse Induced Pluripotent Stem Cells (iPSCs) into Nucleus Pulposus-Like Cells In Vitro
Chen, J., Lee, E. J., Jing, L., Christoforou, N., Leong, K. W. & Setton, L. A., Sep 25 2013, In: PloS one. 8, 9, e75548.Research output: Contribution to journal › Article › peer-review
Open Access62 Scopus citations -
Human umbilical cord mesenchymal stromal cells exhibit immature nucleus pulposus cell phenotype in a laminin-rich pseudo-three-dimensional culture system
Chon, B. H., Lee, E. J., Jing, L., Setton, L. A. & Chen, J., 2013, In: Stem Cell Research and Therapy. 4, 5, 120.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
Injectable laminin-functionalized hydrogel for nucleus pulposus regeneration
Francisco, A. T., Mancino, R. J., Bowles, R. D., Brunger, J. M., Tainter, D. M., Chen, Y. T., Richardson, W. J., Guilak, F. & Setton, L. A., Oct 2013, In: Biomaterials. 34, 30, p. 7381-7388 8 p.Research output: Contribution to journal › Article › peer-review
Open Access92 Scopus citations -
Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc
Bridgen, D. T., Gilchrist, C. L., Richardson, W. J., Isaacs, R. E., Brown, C. R., Yang, K. L., Chen, J. & Setton, L. A., Oct 2013, In: Journal of Orthopaedic Research. 31, 10, p. 1661-1667 7 p.Research output: Contribution to journal › Article › peer-review
47 Scopus citations -
2012
Differential expression of galectin-1 and its interactions with cells and laminins in the intervertebral disc
Jing, L., So, S., Lim, S. W., Richardson, W. J., Fitch, R. D., Setton, L. A. & Chen, J., Dec 2012, In: Journal of Orthopaedic Research. 30, 12, p. 1923-1931 9 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Getting your research out there: open access & more.
Setton, L. A., Yin, F. C., Margulies, S. S., Sakiyama-Elbert, S. E. & Beizer, D., Dec 2012, In: Annals of biomedical engineering. 40, 12, p. 2503-2504 2 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Global metabolic profiling of human osteoarthritic synovium
Adams, S. B., Setton, L. A., Kensicki, E., Bolognesi, M. P., Toth, A. P. & Nettles, D. L., Jan 2012, In: Osteoarthritis and Cartilage. 20, 1, p. 64-67 4 p.Research output: Contribution to journal › Article › peer-review
Open Access89 Scopus citations -
Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis
Allen, K. D., Mata, B. A., Gabr, M. A., Huebner, J. L., Adams, S. B., Kraus, V. B., Schmitt, D. O. & Setton, L. A., Apr 17 2012, In: Arthritis Research and Therapy. 14, 2, R78.Research output: Contribution to journal › Article › peer-review
Open Access64 Scopus citations -
2011
Attenuation of inflammatory events in human intervertebral disc cells with a tumor necrosis factor antagonist
Sinclair, S. M., Shamji, M. F., Chen, J., Jing, L., Richardson, W. J., Brown, C. R., Fitch, R. D. & Setton, L. A., Jul 1 2011, In: Spine. 36, 15, p. 1190-1196 7 p.Research output: Contribution to journal › Article › peer-review
Open Access45 Scopus citations -
Extracellular matrix ligand and stiffness modulate immature nucleus pulposus cell-cell interactions
Gilchrist, C. L., Darling, E. M., Chen, J. & Setton, L. A., Nov 7 2011, In: PloS one. 6, 11, e27170.Research output: Contribution to journal › Article › peer-review
Open Access89 Scopus citations