Lori Setton

Professor of Biomedical Engineering, Chair, Department of Biomedical Engineering, Professor of Mechanical Engineering & Materials Science, Professor of Orthopedic Surgery, The Lucy and Stanley Lopata Distinguished Professor of Biomedical Engineering

    Willing to Mentor

    Available to Mentor:

    PhD/MSTP Students

    • 13841
    1991 …2023

    Research activity per year

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    Research interests

    Research in the Laboratory is focused on understanding the mechanisms for degeneration and regeneration of soft tissues of the musculoskeletal system, including the intervertebral disc, articular cartilage, and meniscus.

    Our research employs tools of mechanical engineering, materials synthesis, and cell and molecular biology to advance use of drug depots and biomaterials as therapies for musculoskeletal pathology.  Ongoing projects include:

    • Synthesis of novel biomaterials for controlling intervertebral disc cell phenotype and metabolism
    • Progenitor cell differentiation to intervertebral disc cell phenotypes
    • Synthesis of novel drug depots for sustained release of inflammatory antagonists in arthritis and disc pathology
    • Studies of cell-cell and cell-matrix interactions that regulate intervertebral disc and progenitor cell phenotypes
    • Preclinical models of arthritis and intervertebral disc disorders and novel assessments of pain and dysfunction. 

    Available to Mentor:

    • PhD/MSTP Students


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