Personal profile
Research interests
Dr. Holtz is a pediatric gastroenterologist at Washington University in St. Louis where she is the founding director of The Celiac Center at St. Louis Children’s Hospital. Her translational lab focuses on the integrated use of epidemiology, bioinformatics, and molecular microbiology to address questions in the developing childhood gut. Her research has centered around understanding how the community of viruses in the infant gut develop and how this community impacts future health and disease. She is also particularly interested in the progression of celiac disease, as we may learn valuable insights into the mechanisms that allow certain children to lose tolerance to gluten.
Clinical interests
pediatric gastroenterology
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Collaborations and top research areas from the last five years
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Credible inferences in microbiome research: ensuring rigour, reproducibility and relevance in the era of AI
Scientific Advisory Board of the Center for Gut Microbiome Research and Education of the American Gastroenterological Association, Nov 2025, In: Nature Reviews Gastroenterology and Hepatology. 22, 11, p. 788-803 16 p.Research output: Contribution to journal › Article › peer-review
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Mild Duodenal Mucosal Injury and Increased Type I Interferon Signaling Are Preludes to Celiac Disease
Ma, C., Bard, A. K., Tycksen, E., Muegge, B. D., Tarr, P. I., Holtz, L. R. & Liu, T. C., Jul 2025, In: Laboratory Investigation. 105, 7, 104170.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Deploying Lactulose as a Prebiotic to Reduce Complications of Chronic Liver Disease
Holtz, L. R. & DeBosch, B. J., Mar 2024, In: Gastroenterology. 166, 3, p. 534-535 2 p.Research output: Contribution to journal › Comment/debate
Open Access3 Link opens in a new tab Scopus citations -
First-in-Human Assessment of Gut Permeability in Crohn's Disease Patients Using Fluorophore Technology
Holtz, L. R., Nix, B. D., Akuse, S. E., Hall-Moore, C., Newberry, R. D., Ciorba, M. A., Deepak, P., Zulfiqar, M., Shieh, J. J., Johnson, J. R., Riley, I. R. & Dorshow, R. B., Jan 2024, In: Gastro Hep Advances. 3, 4, p. 491-497 7 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Scopus citations -
Noninvasive Markers of Inflammation and Protein Loss Augment Diagnosis of Pediatric Celiac Disease
Sutton, K. A., He, M., Ma, C., Liu, T. C., Faubion, W. A., Hoffmann, J., Linneman, L., Rodriguez, C. & Holtz, L. R., May 1 2024, In: Clinical and Translational Gastroenterology. 15, 5, e00695.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations