Linda Pike

Ronan, T., Macdonald-Obermann, J. L., Huelsmann, L., Bessman, N. J., Naegle, K. M. & Pike, L. J., Mar 11 2016, In: Journal of Biological Chemistry. 291, 11, p. 5528-5540 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

EGFR oligomerization organizes kinase-active dimers into competent signalling platforms

Needham, S. R., Roberts, S. K., Arkhipov, A., Mysore, V. P., Tynan, C. J., Zanetti-Domingues, L. C., Kim, E. T., Losasso, V., Korovesis, D., Hirsch, M., Rolfe, D. J., Clarke, D. T., Winn, M. D., Lajevardipour, A., Clayton, A. H. A., Pike, L. J., Perani, M., Parker, P. J., Shan, Y. & Shaw, D. E. & 1 others, Martin-Fernandez, M. L., Oct 31 2016, In: Nature communications. 7, 13307.

Research output: Contribution to journal › Article › peer-review

Open Access

128 Scopus citations

2014

Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation

Macdonald-Obermann, J. L. & Pike, L. J., Sep 19 2014, In: Journal of Biological Chemistry. 289, 38, p. 26178-26188 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

85 Scopus citations

2013

Dynamic analysis of the epidermal growth factor (EGF) receptor-ErbB2-ErbB3 protein network by luciferase fragment complementation imaging

Macdonald-Obermann, J. L., Adak, S., Landgraf, R., Piwnica-Worms, D. & Pike, L. J., Oct 18 2013, In: Journal of Biological Chemistry. 288, 42, p. 30773-30784 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2012

Mechanics of EGF receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging

Macdonald-Obermann, J. L., Piwnica-Worms, D. & Pike, L. J., Jan 3 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 1, p. 137-142 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

Negative co-operativity in the EGF receptor

Pike, L. J., Feb 2012, In: Biochemical Society transactions. 40, 1, p. 15-19 5 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

15 Scopus citations

Quantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization

Li, Y., Macdonald-Obermann, J., Westfall, C., Piwnica-Worms, D. & Pike, L. J., Sep 7 2012, In: Journal of Biological Chemistry. 287, 37, p. 31116-31125 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

2011

The membrane-proximal intracellular domain of the epidermal growth factor receptor underlies negative cooperativity in ligand binding

Adak, S., Yang, K. S., Macdonald-Obermann, J. & Pike, L. J., Dec 30 2011, In: Journal of Biological Chemistry. 286, 52, p. 45146-45155 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

The tethering arm of the EGF receptor is required for negative cooperativity and signal transduction

Adak, S., DeAndrade, D. & Pike, L. J., Jan 14 2011, In: Journal of Biological Chemistry. 286, 2, p. 1545-1555 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2010

Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation

Yang, K. S., Macdonald-Obermann, J. L., Piwnica-Worms, D. & Pike, L. J., Jul 30 2010, In: Journal of Biological Chemistry. 285, 31, p. 24014-24022 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Targeting the dimerization of epidermal growth factor receptors with small-molecule inhibitors

Yang, R. Y. C., Yang, K. S., Pike, L. J. & Marshall, G. R., Jul 2010, In: Chemical Biology and Drug Design. 76, 1, p. 1-9 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

2009

Luciferase fragment complementation imaging of conformational changes in the epidermal growth factor receptor

Yang, K. S., Ilagan, M. X. G., Piwnica-Worms, D. & Pike, L. J., Mar 20 2009, In: Journal of Biological Chemistry. 284, 12, p. 7474-7482 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Palmitoylation of the EGF receptor impairs signal transduction and abolishes high-affinity ligand binding

Macdonald-Obermann, J. L. & Pike, L. J., Mar 24 2009, In: Biochemistry. 48, 11, p. 2505-2513 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Role of Lipid Domains in EGF Receptor Signaling

Pike, L. J., Jan 1 2009, Handbook of Cell Signaling, Second Edition. Elsevier, Vol. 1. p. 359-364 6 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

The challenge of lipid rafts

Pike, L. J., Apr 2009, In: Journal of lipid research. 50, SUPPL., p. S323-S328

Research output: Contribution to journal › Review article › peer-review

Open Access

431 Scopus citations

The intracellular juxtamembrane domain of the epidermal growth factor (EGF) receptor is responsible for the allosteric regulation of EGF binding

Macdonald-Obermann, J. L. & Pike, L. J., May 15 2009, In: Journal of Biological Chemistry. 284, 20, p. 13570-13576 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

75 Scopus citations

2008

Correlating EGFR expression with receptor-binding properties and internalization of⁶⁴Cu-DOTA-cetuximab in 5 cervical cancer cell lines

Eiblmaier, M., Meyer, L. A., Watson, M. A., Fracasso, P. M., Pike, L. J. & Anderson, C. J., Sep 1 2008, In: Journal of Nuclear Medicine. 49, 9, p. 1472-1479 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

87 Scopus citations

Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system

Macdonald, J. L. & Pike, L. J., Jan 8 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 1, p. 112-117 6 p.

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, (112-117) DOI:10.1073/pnas.0707080105)

Macdonald, J. L. & Pike, L. J., Jul 1 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 26, p. 9129 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

2007

Oligomerization of the EGF receptor investigated by live cell fluorescence intensity distribution analysis

Saffarian, S., Li, Y., Elson, E. L. & Pikey, L. J., Aug 2007, In: Biophysical Journal. 93, 3, p. 1021-1031 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

172 Scopus citations

2006

Rafts defined: A report on the Keystone symposium on lipid rafts and cell function

Pike, L. J., 2006, In: Journal of lipid research. 47, 7, p. 1597-1598 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1227 Scopus citations

The membrane proximal disulfides of the EGF receptor extracellular domain are required for high affinity binding and signal transduction but do not play a role in the localization of the receptor to lipid rafts

Macdonald, J., Li, Z., Su, W. & Pike, L. J., Aug 2006, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1763, 8, p. 870-878 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2005

Asian scientists and the "glass ceiling" [1] (multiple letters)

Hung, M. C., Fong, K., Li, J. K. K., Mejia, R., Olivero, O., Rivera-Goba, M., Anders, A., Caban, C., Leon-Monzon, M., Marquez, E., Jiang, D., Stewart, J. B. & Pike, L. J., Dec 16 2005, In: Science. 310, 5755, p. 1767-1768 2 p.

Research output: Contribution to journal › Letter › peer-review

1 Scopus citations

A simplified method for the preparation of detergent-free lipid rafts

Macdonald, J. L. & Pike, L. J., 2005, In: Journal of lipid research. 46, 5, p. 1061-1067 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

295 Scopus citations

Epidermal growth factor receptors are localized to lipid rafts that contain a balance of inner and outer leaflet lipids: A shotgun lipidomics study

Pike, L. J., Han, X. & Gross, R. W., Jul 22 2005, In: Journal of Biological Chemistry. 280, 29, p. 26796-26804 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

193 Scopus citations

Growth factor receptors, lipid rafts and caveolae: An evolving story

Pike, L. J., Dec 30 2005, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1746, 3, p. 260-273 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

239 Scopus citations

2004

Lipid rafts: Heterogeneity on the high seas

Pike, L. J., Mar 1 2004, In: Biochemical Journal. 378, 2, p. 281-292 12 p.

Research output: Contribution to journal › Review article › peer-review

626 Scopus citations

Proteomics, genomics and the future of medical education.

Pike, L. J. & Sadler, J. E., Jan 1 2004, In: Missouri Medicine. 101, 5, p. 496-499 4 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

2003

Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects: Studies with cholesterol enantiomers

Westover, E. J., Covey, D. F., Brockman, H. L., Brown, R. E. & Pike, L. J., Dec 19 2003, In: Journal of Biological Chemistry. 278, 51, p. 51125-51133 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

127 Scopus citations

Lipid rafts: Bringing order to chaos

Pike, L. J., Apr 2003, In: Journal of lipid research. 44, 4, p. 655-667 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

1005 Scopus citations

Role of Lipid Domains in EGF Receptor Signaling

Pike, L. J., Jan 1 2003, Handbook of Cell Signaling: Volume 1-3. Elsevier, Vol. 1-3. p. 323-326 4 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2002

Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking

Pike, L. J. & Casey, L., Aug 13 2002, In: Biochemistry. 41, 32, p. 10315-10322 8 p.

Research output: Contribution to journal › Article › peer-review

174 Scopus citations

Lipid rafts are enriched in arachidonic acid and plasmenylethanolamine and their composition is independent of caveolin-1 expression: A quantitative electrospray ionization/mass spectrometric analysis

Pike, L. J., Han, X., Chung, K. N. & Gross, R. W., Feb 12 2002, In: Biochemistry. 41, 6, p. 2075-2088 14 p.

Research output: Contribution to journal › Article › peer-review

459 Scopus citations

Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor

Sun, J., Nanjundan, M., Pike, L. J., Wiedmer, T. & Sims, P. J., May 21 2002, In: Biochemistry. 41, 20, p. 6338-6345 8 p.

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

2001

Dynamic Sensitivity of ATP-sensitive K⁺ Channels to ATP

Loussouarn, G., Pike, L. J., Ashcroft, F. M., Makhina, E. N. & Nichols, C. G., Aug 3 2001, In: Journal of Biological Chemistry. 276, 31, p. 29098-29103 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

2000

Modulation of nucleotide sensitivity of ATP-sensitive potassium channels by phosphatidylinositol-4-phosphate 5-kinase

Shyng, S. L., Barbieri, A., Gumusboga, A., Cukras, C., Pike, L., Davis, J. N., Stahl, P. D. & Nichols, C. G., Jan 18 2000, In: Proceedings of the National Academy of Sciences of the United States of America. 97, 2, p. 937-941 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

64 Scopus citations

1998

Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover

Pike, L. J. & Miller, J. M., Aug 28 1998, In: Journal of Biological Chemistry. 273, 35, p. 22298-22304 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

351 Scopus citations

Compartmentalization of phosphatidylinositol 4,5-bisphosphate in low-density membrane domains in the absence of caveolin

Liu, Y., Casey, L. & Pike, L. J., Apr 28 1998, In: Biochemical and Biophysical Research Communications. 245, 3, p. 684-690 7 p.

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Phosphoinositides in detergent-resistant membrane domains

Pike, L. J., Lia, Y., Chung, K. N. & Heuser, J. Y., 1998, In: FASEB Journal. 12, 8, p. A1278

Research output: Contribution to journal › Article › peer-review

1997

Functional characterization of an epidermal growth factor receptor/RET chimera

Pandit, S. D., O'Hare, T., Donis-Keller, H. & Pike, L. J., 1997, In: Journal of Biological Chemistry. 272, 4, p. 2199-2206 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

1996

Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains

Pike, L. J. & Casey, L., 1996, In: Journal of Biological Chemistry. 271, 43, p. 26453-26456 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

334 Scopus citations

Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains

Hope, H. R. & Pike, L. J., Jun 1996, In: Molecular biology of the cell. 7, 6, p. 843-851 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

217 Scopus citations

The multiple endocrine neoplasia type 2B point mutation alters long-term regulation and enhances the transforming capacity of the epidermal growth factor receptor

Pandit, S. D., Donis-Kellert, H., Iwamoto, T., Tomich, J. M. & Pike, L. J., Mar 8 1996, In: Journal of Biological Chemistry. 271, 10, p. 5850-5858 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access