My main area of interest is understanding the mechanisms by which substrate metabolism affects structure and function. I use multiple imaging modalities including echocardiography, Positron Emission Tomography, Magnetic Resonance Imaging and Spectroscopy to translate findings from animal models to humans. Specific areas of research include: nitric oxide’s effects on skeletal muscle function in heart failure; the effects of metabolic modulation on cancer and diabetes; the effects of heart failure, sex, obesity, insulin resistance, and diabetes on myocardial substrate metabolism, structure, and function; and associations between specific lipids (ceramides) on cardiovascular outcomes. 

Cardiovascular disease, reperfusion therapy, heart disease, estrogen therapy, hypertension, coronary artery bypass graft surgery; supervising and interpreting diagnostic tests, such as echocardiograms, stress echocardiograms, treadmill stress test, holter, event and loop monitors.

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