Lilianna Solnica-Krezel

Professor of Developmental Biology, Head of the Department of Developmental Biology, Alan A and Edith L Wolff Professor of Developmental Biology

    • 12370 Citations
    1985 …2020

    Research output per year

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    Personal profile

    Research interests

    We are investigating the cellular and molecular genetic mechanisms underlying vertebrate gastrulation, a crucial period of embryogenesis during which the germ layers are formed and then shaped into the vertebrate body plan with organ rudiments. Gastrulation entails a combination of inductive events that specify cell identities with massive cell movements and rearrangements that fashion the body plan. The complex and dynamic nature of gastrulation makes it a challenging but intellectually fascinating object of study. In humans, 25-50% of pregnancies end in early miscarriages of largely unknown genetic origin. Moreover, the molecular regulation of tumor growth and metastasis show striking parallels to those underlying gastrulation movements, underscoring the practical significance of gastrulation research. We are addressing the mechanisms of gastrulation in the zebrafish (Danio rerio) and human embryonic stem cells.

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    Research Output

    Cellular and molecular mechanisms of convergence and extension in zebrafish

    Williams, M. L. K. & Solnica-Krezel, L., 2020, Current Topics in Developmental Biology. Solnica-Krezel, L. (ed.). Academic Press Inc., p. 377-407 31 p. (Current Topics in Developmental Biology; vol. 136).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • 3 Scopus citations

    De novo EIF2AK1 and EIF2AK2 Variants Are Associated with Developmental Delay, Leukoencephalopathy, and Neurologic Decompensation

    Undiagnosed Diseases Network, Apr 2 2020, In : American journal of human genetics. 106, 4, p. 570-583 14 p.

    Research output: Contribution to journalArticle

  • Derivation of trophoblast stem cells from naïve human pluripotent stem cells

    Dong, C., Beltcheva, M., Gontarz, P., Zhang, B., Popli, P., Fischer, L. A., Khan, S. A., Park, K. M., Yoon, E. J., Xing, X., Kommagani, R., Wang, T., Solnica-Krezel, L. & Theunissen, T. W., Feb 2020, In : eLife. 9, e52504.

    Research output: Contribution to journalArticle

    Open Access
  • 9 Scopus citations

    Maternal contributions to gastrulation in zebrafish

    Solnica-Krezel, L., 2020, Current Topics in Developmental Biology. Marlow, F. L. (ed.). Academic Press Inc., p. 391-427 37 p. (Current Topics in Developmental Biology; vol. 140).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Open Access
  • 2 Scopus citations