Liang Shan

Assistant Professor of Medicine, Assistant Professor of Pathology and Immunology

    • 2808 Citations
    20062020

    Research output per year

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    Personal profile

    Research interests

    Our group has generated novel mouse models that contain multiple human gene knock-ins to improve multilineage differentiation of human hematopoietic stem and progenitor cells and development of functional human immune cells in the mouse system. Using the novel humanized mouse models, my lab focuses on 1) characterization of HIV-1 latent reservoir in tissue-resident CD4+ T cells and tissue macrophages; 2)development of CTL-based and antibody-based strategies to eliminate circulating and tissue residing latent reservoirs for HIV-1; and 3) generation of patient-derived humanized mouse models as a pre-clinical platform to facilitate precision medicine in multiple disease models.

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    Research Output

    • 2808 Citations
    • 25 Article
    • 1 Comment/debate
    • 1 Letter
    • 1 Review article

    Prenatal food insecurity post Hurricane Maria is associated with decreased Veillonella in the infant gut

    Wang, L., de Ángel Solá, D., Acevedo Flores, M., Schriefer, A., Wang, L., Gerónimo López, K., Chang, A., Warner, B., Shan, L., Holtz, L. R. & Rosario Matos, N., 2020, (Accepted/In press) In : Pediatric research.

    Research output: Contribution to journalArticle

  • Publisher Correction: Subsets of ILC3−ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues (Nature Immunology, (2019), 20, 8, (980-991), 10.1038/s41590-019-0425-y)

    Cella, M., Gamini, R., Sécca, C., Collins, P. L., Zhao, S., Peng, V., Robinette, M. L., Schettini, J., Zaitsev, K., Gordon, W., Bando, J. K., Yomogida, K., Cortez, V., Fronick, C., Fulton, R., Lin, L. L., Gilfillan, S., Flavell, R. A., Shan, L., Artyomov, M. N. & 4 others, Bowman, M., Oltz, E. M., Jelinsky, S. A. & Colonna, M., Oct 1 2019, In : Nature immunology. 20, 10, 1 p.

    Research output: Contribution to journalComment/debate

    Open Access
  • 2 Scopus citations

    Subsets of ILC3−ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues

    Cella, M., Gamini, R., Sécca, C., Collins, P. L., Zhao, S., Peng, V., Robinette, M. L., Schettini, J., Zaitsev, K., Gordon, W., Bando, J. K., Yomogida, K., Cortez, V., Fronick, C., Fulton, R., Lin, L. L., Gilfillan, S., Flavell, R. A., Shan, L., Artyomov, M. N. & 4 others, Bowman, M., Oltz, E. M., Jelinsky, S. A. & Colonna, M., Aug 1 2019, In : Nature immunology. 20, 8, p. 980-991 12 p.

    Research output: Contribution to journalArticle

  • 29 Scopus citations

    Family-based study reveals decreased abundance of sputum Granulicatella in asthmatics

    Wang, L., de Ángel Solá, D., Mao, Y., Bielecki, P., Zhu, Y., Sun, Z., Shan, L., Flavell, R. A., Bazzy-Asaad, A. & DeWan, A., Sep 2018, In : Allergy: European Journal of Allergy and Clinical Immunology. 73, 9, p. 1918-1921 4 p.

    Research output: Contribution to journalLetter

    2 Scopus citations

    Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity

    Ring, N. G., Herndler-Brandstetter, D., Weiskopf, K., Shan, L., Volkmer, J. P., George, B. M., Lietzenmayer, M., McKenna, K. M., Naik, T. J., McCarty, A., Zheng, Y., Ring, A. M., Flavell, R. A. & Weissman, I. L., Dec 5 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 49, p. E10578-E10585

    Research output: Contribution to journalArticle

    Open Access
  • 66 Scopus citations