• 103674 Citations

Research output per year

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Personal profile

Research interests

Dr. Ding`s current research focuses on the discovery of genetic changes (somatic and germline) contributing to human diseases by integrating various data types, including DNA, RNA, and proteomics data. Her research team has developed a collection of widely-used computational tools, including VarScan, SomaticSniper, SciClone, BreakDancer, BreakFusion, MSIsensor, Pindel-C, GenomeVIP, HotSpot3D, PathScan, and MuSiC. Dr. Ding plays significant roles in The Cancer Genome Atlas (TCGA), the International Cancer Genome Consortium (ICGC), and the Clinical Proteomic Tumor Analysis Consortium (CPTAC). She co-chairs the TCGA PanCanAtlas Oncogenic Process Group, the TCGA Sarcoma Analysis Working Group, and the ICGC Mutation Calling Group. Dr. Ding also serves on the Steering Committees of the Genomic Data Commons (GDC), CPTAC, and TCGA. Dr. Ding has successfully led many large-scale, multi-institute studies on the genomics of lung adenocarcinomas, AML, and breast cancer. Building on this foundation, her team has produced a series of seminal publications in the fields of cancer genomics research and cancer biology. Dr. Ding`s lab currently is focusing on understanding tumor microenvironment using new imaging and omics technologies as well as on discovering new cancer treatments using organoid models.

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Research Output

Ancestry-specific predisposing germline variants in cancer

Oak, N., Cherniack, A. D., Mashl, R. J., Carrot-Zhang, J., Chambwe, N., Damrauer, J. S., Knijnenburg, T. A., Robertson, A. G., Yau, C., Zhou, W., Berger, A. C., Newberg, J., Romanel, A., Sayaman, R. W., Demichelis, F., Felau, I., Frampton, G., Han, S., Hoadley, K. A., Kemal, A. & 25 others, Laird, P. W., Lazar, A. J., Le, X., Shen, H., Wong, C. K., Zenklusen, J. C., Ziv, E., Aguet, F., Demchok, J. A., Mensah, M. K. A., Tarnuzzer, R., Wang, Z., Yang, L., Alfoldi, J., Karczewski, K. J., MacArthur, D. G., Frampton, G. M., Benz, C., Stuart, J. M., Hirsch, F. R., Ding, L., Beroukhim, R., Gümüş, Z. H., Plon, S. E. & Huang, K. L., May 29 2020, In : Genome medicine. 12, 1, 51.

Research output: Contribution to journalArticle

Open Access
  • Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer

    Cancer Genome Atlas Analysis Network, May 11 2020, In : Cancer Cell. 37, 5, p. 639-654.e6

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Erratum: Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma (Cell (2019) 179(4) (964–983.e31), (S0092867419311237), (10.1016/j.cell.2019.10.007))

    Clinical Proteomic Tumor Analysis Consortium, Jan 9 2020, In : Cell. 180, 1, 1 p.

    Research output: Contribution to journalComment/debate

    Open Access
  • 2 Scopus citations

    Evolution and structure of clinically relevant gene fusions in multiple myeloma

    Foltz, S. M., Gao, Q., Yoon, C. J., Sun, H., Yao, L., Li, Y., Jayasinghe, R. G., Cao, S., King, J., Kohnen, D. R., Fiala, M. A., Ding, L. & Vij, R., Dec 1 2020, In : Nature communications. 11, 1, 2666.

    Research output: Contribution to journalArticle

    Open Access
  • Pan-cancer analysis of whole genomes

    The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Feb 6 2020, In : Nature. 578, 7793, p. 82-93 12 p.

    Research output: Contribution to journalArticle

    Open Access
  • 125 Scopus citations