• 2135 Citations
20002019

Research output per year

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Personal profile

Research interests

The overall goal of our research is to understand why 96% of human prostate adenocarcinomas lose ARF expression even though they are actively proliferating. We hypothesize that loss of ARF leads to deregulated protein synthesis which helps to drive prostate tumorigenesis through a selective mRNA translational program. To test these hypotheses, we are using mouse modeling and in vitro cell culture studies. Because Arf-null mice die by nine months of age from sarcomas and lymphomas before prostate disease can fully develop, we are developing 2 prostate specific knockout models for prostate tumorigenesis: Pb-Cre/Arf-flox and Pb-Cre/Arf-flox/p53-flox. Also, we are using siRNAs directed against p14ARF in primary human prostate epithelial cells to assess the effects of ARF loss on ribosome biogenesis and cell growth and proliferation. Furthering our understanding of the molecular events behind prostate tumorigenesis will help guide identification and therapeutic strategies.

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Research Output

  • 2135 Citations
  • 24 Article
  • 4 Review article
  • 1 Comment/debate
  • 1 Editorial

Acetate Promotes T Cell Effector Function during Glucose Restriction

Qiu, J., Villa, M., Sanin, D. E., Buck, M. D., O'Sullivan, D., Ching, R., Matsushita, M., Grzes, K. M., Winkler, F., Chang, C. H., Curtis, J. D., Kyle, R. L., Van Teijlingen Bakker, N., Corrado, M., Haessler, F., Alfei, F., Edwards-Hicks, J., Maggi, L. B., Zehn, D., Egawa, T. & 5 others, Bengsch, B., Klein Geltink, R. I., Jenuwein, T., Pearce, E. J. & Pearce, E. L., May 14 2019, In : Cell Reports. 27, 7, p. 2063-2074.e5

Research output: Contribution to journalArticle

Open Access
  • 31 Scopus citations

    Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer

    Wagner, A. H., Devarakonda, S., Skidmore, Z. L., Krysiak, K., Ramu, A., Trani, L., Kunisaki, J., Masood, A., Waqar, S., Spies, N. C., Morgensztern, D., Waligorski, J., Ponce, J., Fulton, R., Maggi, L., Weber, J., Watson, M., O’Conor, C. J., Ritter, J., Olsen, R. R. & 10 others, Cheng, H., Mukhopadhyay, A., Can, I., Cessna, M. H., Oliver, T. G., Mardis, E. R., Wilson, R. K., Griffith, M., Griffith, O. & Govindan, R., Dec 1 2018, In : Nature communications. 9, 1, 3787.

    Research output: Contribution to journalArticle

    Open Access
  • 23 Scopus citations

    The Role of RNA Editing in Cancer Development and Metabolic Disorders

    Kung, C. P., Maggi, L. & Weber, J. D., Dec 18 2018, In : Frontiers in Endocrinology. 9, 762.

    Research output: Contribution to journalReview article

    Open Access
  • Sabotaging of the oxidative stress response by an oncogenic noncoding RNA

    Mahajan, N., Wu, H. J., Bennett, R. L., Troche, C., Licht, J. D., Weber, J. D., Maggi, L. B. & Tomasson, M. H., Feb 2017, In : FASEB Journal. 31, 2, p. 482-490 9 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Deficiency of the adaptor protein SLy1 results in a natural killer cell ribosomopathy affecting tumor clearance

    Arefanian, S., Schäll, D., Chang, S., Ghasemi, R., Higashikubo, R., Zheleznyak, A., Guo, Y., Yu, J., Asgharian, H., Li, W., Gelman, A. E., Kreisel, D., French, A. R., Zaher, H., Plougastel-Douglas, B., Maggi, L., Yokoyama, W., Beer-Hammer, S. & Krupnick, A. S., Dec 1 2016, In : OncoImmunology. 5, 12, e1238543.

    Research output: Contribution to journalArticle

  • 2 Scopus citations