Lee Ratner

Professor of Medicine, Professor of Molecular Microbiology, Alan A and Edith L Wolff Professor of Oncology

    • 16290 Citations
    1977 …2020

    Research output per year

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    Personal profile

    Research interests

    Dr Ratner’s basic research is involved in a molecular dissection of virus-cell interactions. We focus on two retroviurses: Human T-Cell Leukemia Virus Type 1 (HTLV-1) which causes a specific form of lymphoma, and Human Immunodeficiency Viruses (HIV) Types 1 and 2. Our studies of HTLV-1 are concerned with analysis of the mechanisms of leukemogenesis through studies of: transforming determinants in an infectious immortalizing HTLV-1 proviral clone; transgenic models utilizing the HTLV-1 trans-activator protein, which results in a lymphoproliferative malignancy; and identification and characterization of the receptor for the virus. Our studies of HIV-1 focus on two distinct questions: 1) How does viral protein X (Vpx) enhance virus replication in quiescent cells? 2) How does the viral envelope interact with the receptor (CD4) and coreceptor (CXCR4 or CCR5) to allow virus entry? For these studies, we utilize infectious molecular clones of HIV-1 and HIV-2, cell culture and animal studies, small molecule and siRNA inhibitors, as well as viral and cellular cofactor mutants. Information from these studies has been applied to developing novel therapeutic approaches for HTLV-1 and HIV-1 infections. Dr Ratner’s clinical research is focused on human retrovirus-associated cancers. He has participated and/or led clinical trials HIV-associated lymphomas, anal carcinomas, and Kaposi’s sarcoma. He has also led multicenter trials of HTLV-1 associated leukemia/lymphoma.

    Areas of Clinical Interest

    HIV, AIDS, human immunodeficiency virus, hematology, oncology, AIDS-related malignancies

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    Research Output

    Impact of Myc in HIV-associated non-Hodgkin lymphomas treated with EPOCH and outcomes with vorinostat (AMC-075 trial)

    Ramos, J. C., Sparano, J. A., Chadburn, A., Reid, E. G., Ambinder, R. F., Siegel, E. R., Moore, P. C., Rubinstein, P. G., Durand, C. M., Cesarman, E., Aboulafia, D., Baiocchi, R., Ratner, L., Kaplan, L., Capoferri, A. A., Lee, J. Y., Mitsuyasu, R. & Noy, A., Sep 10 2020, In : Blood. 136, 11, p. 1284-1297 14 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma

    Rauch, D. A., Olson, S. L., Harding, J. C., Sundaramoorthi, H., Kim, Y., Zhou, T., MacLeod, A. R., Challen, G. & Ratner, L., Aug 28 2020, In : Retrovirology. 17, 1, p. 27 1 p.

    Research output: Contribution to journalArticle

    Open Access
  • Molecular biology of human T cell leukemia virus

    Ratner, L., Mar 2020, In : Seminars in Diagnostic Pathology. 37, 2, p. 104-109 6 p.

    Research output: Contribution to journalReview article

  • 1 Scopus citations

    Predicting the future: adult T-cell leukemia

    Ratner, L., Jun 4 2020, In : Blood. 135, 23, p. 2013-2014 2 p.

    Research output: Contribution to journalArticle

    Open Access

    The dual-specificity kinase DYRK1A modulates the levels of cyclin L2 to control HIV replication in macrophages

    Kisaka, J. K., Ratner, L. & Kyei, G. B., Mar 1 2020, In : Journal of virology. 94, 6, e01583-19.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations