Lawrence Snyder

Professor of Neuroscience, Professor of Psychological & Brain Sciences

    • 8109 Citations
    1988 …2020

    Research output per year

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    Personal profile

    Research interests

    My laboratory studies how the brain, and especially the cerebral cortex, combines sensory information with higher order cognition (rules, memory, etc) in order to drive motor commands. Much of our work is focused spatial processing for guiding eye and arm movements. Parietal cortex provides an earlier link in the transformation of visual sensory information into motor commands. Patients with unilateral parietal damage may ignore objects in one half of the world. In severe cases, they may clothe only half of their body or eat from only half of their plate. Spatial memory is affected, and there are often motor deficits as well. We record from individual neurons in the parietal cortex of macaque monkeys during complex tasks in order to understand the role of the cortex in the sensory-motor transformation. The animals are trained to look at and reach for colored spots of light — a monkey video game. We ask how the locations of these spots are represented by neural activity in the brain. What frame of reference is used? Is there a single, generic representation or multiple special purpose representations? How is spatial information from other sensory systems combined with visually-derived information? How is spatial information stored (memory)? How does the nature of the task, and what the animal intends to do, affect parietal processing? Is parietal cortex specifically involved in the learning of new sensory-motor mappings, or in coordinating eye and hand movement? We perform our studies primarily in macaque monkeys, using single and multi-unit neuron recording, reversible inactivation of cortical areas, and MR-based tract tracing, functional MRI activation studies, and functional MRI connectivity studies.

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    Research Output

    Erratum: Local Perturbations of Cortical Excitability Propagate Differentially Through Large-Scale Functional Networks (Cerebral Cortex (2020) DOI: 10.1093/cercor/bhz314)

    Rosenthal, Z. P., Raut, R. V., Yan, P., Koko, D., Kraft, A. W., Czerniewski, L., Acland, B., Mitra, A., Snyder, L. H., Bauer, A. Q., Snyder, A. Z., Culver, J. P., Raichle, M. E. & Lee, J. M., May 14 2020, In : Cerebral Cortex. 30, 5, p. 3431 1 p.

    Research output: Contribution to journalComment/debate

    Open Access
  • Local Perturbations of Cortical Excitability Propagate Differentially Through Large-Scale Functional Networks

    Rosenthal, Z. P., Raut, R. V., Yan, P., Koko, D., Kraft, A. W., Czerniewski, L., Acland, B., Mitra, A., Snyder, L. H., Bauer, A. Q., Snyder, A. Z., Culver, J. P., Raichle, M. E. & Lee, J. M., May 14 2020, In : Cerebral Cortex. 30, 5, p. 3352-3369 18 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Eye-hand re-coordination: A pilot investigation of gaze and reach biofeedback in chronic stroke

    Rizzo, J. R., Beheshti, M., Shafieesabet, A., Fung, J., Hosseini, M., Rucker, J. C., Snyder, L. H. & Hudson, T. E., 2019, Progress in Brain Research. Ramat, S. & Shaikh, A. G. (eds.). Elsevier B.V., p. 361-374 14 p. (Progress in Brain Research; vol. 249).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Dissociation of LFP power and tuning in the frontal cortex during memory

    Holmes, C. D., Papadimitriou, C. & Snyder, L. H., Sep 19 2018, In : Journal of Neuroscience. 38, 38, p. 8177-8186 10 p.

    Research output: Contribution to journalArticle

  • Single Units in the Posterior Parietal Cortex Encode Patterns of Bimanual Coordination

    Mooshagian, E., Wang, C., Holmes, C. D. & Snyder, L. H., May 1 2018, In : Cerebral cortex (New York, N.Y. : 1991). 28, 5, p. 1549-1567 19 p.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations