• 6370 Citations
1978 …2020

Research output per year

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Personal profile

Research interests

Our laboratory studies potassium channels which are key elements which control and shape electrical activity in the brain, heart, and other excitable tissues. These channels are major determinants of behavior and higher brain function. The potassium channels we study are involved in human disease (e.g. epilepsy, cardiac arrhythmia), basic physiology (e.g. control of blood pressure, protection from hypoxia), and higher brain function (e.g. learning and memory). Our approach is a comparative genomic one which involves comparing the structure and function of potassium channels in different species (e.g. humans, rodents, Drosophila and the nematode worm C. elegans). These comparisons have led us to many fundamental insights about the basic function, development, and regulation of potassium channels, and their role in behavior. The techniques we use in our laboratory include genetics and genomics, the creation and use of transgenic animals, molecular biology, and biophysical studies which include electrophysiological recordings of both native cells and heterologous cell systems which we use to express our cloned channels. In general, ion channels are the major effector molecules through which neurotransmitters and many hormones act. Ion channels are the “transistors” (electronic switches) of the brain that generate and propagate electrical signals in the aqueous environment of the brain that resembles dilute seawater, a reflection of the evolutionary origin of the nervous system in the sea. Ion channels not only generate active electrical responses, but they set the resting potentials of cells, as well. Without them, life as we know it would not exist, much less higher brain function.

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Research Output

Coupling of Ca2+and voltage activation in BK channels through the aB helix/voltage sensor interface

Geng, Y., Deng, Z., Zhang, G., Budelli, G., Butler, A., Yuan, P., Cui, J., Salkoff, L., Salkoff, L. & Magleby, K. L., Jun 23 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 25, p. 14512-14521 10 p.

Research output: Contribution to journalArticle

  • Oxytocin can regulate myometrial smooth muscle excitability by inhibiting the Na + -activated K + channel, Slo2.1

    Ferreira, J. J., Butler, A., Stewart, R., Gonzalez-Cota, A. L., Lybaert, P., Amazu, C., Reinl, E. L., Wakle-Prabagaran, M., Salkoff, L., England, S. K. & Santi, C. M., Jan 1 2019, In : Journal of Physiology. 597, 1, p. 137-149 13 p.

    Research output: Contribution to journalArticle

  • 9 Scopus citations

    Sodium-activated potassium channels moderate excitability in vascular smooth muscle

    Li, P., Halabi, C. M., Stewart, R., Butler, A., Brown, B., Xia, X., Santi, C., England, S., Ferreira, J., Mecham, R. P. & Salkoff, L., Oct 1 2019, In : Journal of Physiology. 597, 20, p. 5093-5108 16 p.

    Research output: Contribution to journalArticle

  • A genetic variant of the sperm-specific SLO3 K+ channel has altered pH and Ca2+ sensitivities

    Geng, Y., Ferreira, J. J., Dzikunu, V., Butler, A., Lybaert, P., Yuan, P., Magleby, K. L., Salkoff, L. & Santi, C. M., May 26 2017, In : Journal of Biological Chemistry. 292, 21, p. 8978-8987 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • 12 Scopus citations

    Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels

    Zhang, G., Geng, Y., Jin, Y., Shi, J., McFarland, K., Magleby, K. L., Salkoff, L. & Cui, J., Mar 6 2017, In : The Journal of general physiology. 149, 3, p. 373-387 15 p.

    Research output: Contribution to journalArticle

    Open Access
  • 11 Scopus citations