Personal profile
Research interests
Dr. Wiley develops informatics methods to enable electronic health record-based research and clinical innovation through EHR-linked biobanks and the learning health system. She is an expert in computational phenotyping and EHR data harmonization and was the informatics lead for the implementation of a comprehensive tobacco cessation service at the University of Colorado Cancer Center through the Cancer Center Cessation Initiative (C3I). She is an internationally recognized expert in informatics education developing the Coursera Clinical Data Science Specialization, a series of six massively open online courses with more than 40,000 enrollments globally. Dr. Wiley is an Associate Professor of Neurology in the Washington University School of Medicine and the Institute for Informatics, Data Science and Biostatistics (I²DB) where she also serves as Director of Clinical Data Science in the Office of the Chief Research Information Officer. She is a regular contributor to the informatics community chairing or vice-chairing several AMIA conferences and serving on numerous committees and task forces. She is a Fellow of both the American College of Medical Informatics (FACMI) and AMIA (FAMIA).
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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PhenoFit: A framework for determining computable phenotyping algorithm fitness for purpose and reuse
Wiley, L. K., Rasmussen, L. V., Levinson, R. T., Malinowski, J., Manemann, S. M., Wilson, M. P., Chapman, M., Pacheco, J. A., Walunas, T. L., Starren, J. B., Bielinski, S. J. & Richesson, R. L., Feb 1 2026, In: Journal of the American Medical Informatics Association. 33, 2, p. 536-542 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Presence of midsagittal tissue bridges and walking ability 1-year post spinal cord injury
Thornton, W. A., Tefertiller, C., Weber, K. A., Mañago, M., Wiley, L., Connor, J., Stevens-Lapsley, J., Pfyffer, D. & Smith, A. C., 2026, (Accepted/In press) In: Journal of Spinal Cord Medicine.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Characterizing substructure via mixture modeling in large-scale genetic summary statistics
Colorado Center for Personalized Medicine, Feb 6 2025, In: American journal of human genetics. 112, 2, p. 235-253 19 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Developing and sustaining inclusive language in biomedical informatics communications: an AMIA Board of Directors endorsed paper on the Inclusive Language and Context Style Guidelines
Bear Don’t Walk, O., Haldar, S., Wei, D., Huang, H., Rivera, R. L., Fan, J. W., Keloth, V. K., Leung, T. I., Desai, P., Korngiebel, D. M., Grossman Liu, L., Pichon, A., Subbian, V., Solomonides, A., Wiley, L. K., Ogunyemi, O., Jackson, G. P., Dankwa-Mullan, I., Dirks, L. G. & Everhart, A. R. & 11 others, , Aug 1 2025, In: Journal of the American Medical Informatics Association. 32, 8, p. 1380-1387 8 p.Research output: Contribution to journal › Review article › peer-review
2 Link opens in a new tab Scopus citations -
Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants
Regeneron Genetics Center, GHS-RGC DiscovEHR Collaboration & Penn Medicine BioBank, Feb 7 2025, In: Science. 387, 6734, eadp4753.Research output: Contribution to journal › Article › peer-review
Open Access31 Link opens in a new tab Scopus citations