Research output per year
Research output per year
Personal profile
Research interests
My research interests are related to conditions that cause epilepsy, autism, and brain malformations in children. My lab uses a combination of biochemical, electrophysiological, genetic, and imaging techniques to analyze human brain specimens and animal and cell culture models. Current projects ongoing in the lab include: 1) Characterizing the development of GABAergic inhibition in the premature and neonatal brain, and determining the effect of conditions causing seizures on this development. 2) Identifying the consequences of abnormal PI3K/AKT/mTOR pathway activity on neuronal signaling. 3) Determining the histopathologic and functional outcomes of genetic mutations that cause neurologic disease in children.
Areas of Clinical Interest
Tuberous sclerosis, epilepsy, fetal neurology, neonatal neurology, brain malformations
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mTORC2 Steals the Spotlight
Jansen, L. A., Mar 1 2020, In: Epilepsy Currents. 20, 2, p. 116-117 2 p.Research output: Contribution to journal › Comment/debate
Open Access1 Scopus citations -
Pathogenic Variants in CEP85L Cause Sporadic and Familial Posterior Predominant Lissencephaly
University of Washington Center for Mendelian Genomics, Apr 22 2020, In: Neuron. 106, 2, p. 237-245.e8Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons
Joshi, S., Roden, W. H., Kapur, J. & Jansen, L. A., Apr 1 2020, In: Annals of Clinical and Translational Neurology. 7, 4, p. 527-542 16 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
The Epilepsy Genetics Initiative: Systematic reanalysis of diagnostic exomes increases yield
Epilepsy Genetics Initiative, May 2019, In: Epilepsia. 60, 5, p. 797-806 10 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
The Space-Time Continuum of Cortical Dysplasia
Jansen, L. A., Jan 1 2019, In: Epilepsy Currents. 19, 1, p. 54-56 3 p.Research output: Contribution to journal › Comment/debate
2 Scopus citations