Laura Jansen

Associate Professor of Neurology, Associate Professor of Pediatrics

    • 910 Citations

    Research output per year

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    Personal profile

    Research interests

    My research interests are related to conditions that cause epilepsy, autism, and brain malformations in children. My lab uses a combination of biochemical, electrophysiological, genetic, and imaging techniques to analyze human brain specimens and animal and cell culture models. Current projects ongoing in the lab include: 1) Characterizing the development of GABAergic inhibition in the premature and neonatal brain, and determining the effect of conditions causing seizures on this development. 2) Identifying the consequences of abnormal PI3K/AKT/mTOR pathway activity on neuronal signaling. 3) Determining the histopathologic and functional outcomes of genetic mutations that cause neurologic disease in children.

    Areas of Clinical Interest

    Tuberous sclerosis, epilepsy, fetal neurology, neonatal neurology, brain malformations

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    Research Output

    mTORC2 Steals the Spotlight

    Jansen, L. A., Mar 1 2020, In : Epilepsy Currents. 20, 2, p. 116-117 2 p.

    Research output: Contribution to journalComment/debate

    Open Access
  • 1 Scopus citations

    Pathogenic Variants in CEP85L Cause Sporadic and Familial Posterior Predominant Lissencephaly

    University of Washington Center for Mendelian Genomics, Apr 22 2020, In : Neuron. 106, 2, p. 237-245.e8

    Research output: Contribution to journalArticle

  • Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons

    Joshi, S., Roden, W. H., Kapur, J. & Jansen, L. A., Apr 1 2020, In : Annals of Clinical and Translational Neurology. 7, 4, p. 527-542 16 p.

    Research output: Contribution to journalArticle

    Open Access
  • The Epilepsy Genetics Initiative: Systematic reanalysis of diagnostic exomes increases yield

    Epilepsy Genetics Initiative, May 2019, In : Epilepsia. 60, 5, p. 797-806 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • 9 Scopus citations

    The Space-Time Continuum of Cortical Dysplasia

    Jansen, L. A., Jan 1 2019, In : Epilepsy Currents. 19, 1, p. 54-56 3 p.

    Research output: Contribution to journalComment/debate

  • 1 Scopus citations