Laura Ibanez

2024

Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study

Alzheimer's Biomarker Consortium–Down Syndrome & Dominantly Inherited Alzheimer Network, May 2024, In: The Lancet Neurology. 23, 5, p. 500-510 11 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial

Wagemann, O., Liu, H., Wang, G., Shi, X., Bittner, T., Scelsi, M. A., Farlow, M. R., Clifford, D. B., Supnet-Bell, C., Santacruz, A. M., Aschenbrenner, A. J., Hassenstab, J. J., Benzinger, T. L. S., Gordon, B. A., Coalier, K. A., Cruchaga, C., Ibanez, L., Perrin, R. J., Xiong, C. & Li, Y. & 30 others, Morris, J. C., Lah, J. J., Berman, S. B., Roberson, E. D., Van Dyck, C. H., Galasko, D., Gauthier, S., Hsiung, G. Y. R., Brooks, W. S., Pariente, J., Mummery, C. J., Day, G. S., Ringman, J. M., Mendez, P. C., St. George-Hyslop, P., Fox, N. C., Suzuki, K., Okhravi, H. R., Chhatwal, J., Levin, J., Jucker, M., Sims, J. R., Holdridge, K. C., Proctor, N. K., Yaari, R., Andersen, S. W., Mancini, M., Llibre-Guerra, J., Bateman, R. J. & McDade, E., Jun 10 2024, In: JAMA Neurology. 81, 6, p. 582-593 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center

Fernandez, M. V., Liu, M., Beric, A., Johnson, M., Cetin, A., Patel, M., Budde, J., Kohlfeld, P., Bergmann, K., Lowery, J., Flynn, A., Brock, W., Sanchez Montejo, B., Gentsch, J., Sykora, N., Norton, J., Gentsch, J., Valdez, O., Gorijala, P. & Sanford, J. & 24 others, Sun, Y., Wang, C., Western, D., Timsina, J., Mangetti Goncalves, T., Do, A. N., Sung, Y. J., Zhao, G., Morris, J. C., Moulder, K., Holtzman, D. M., Bateman, R. J., Karch, C., Hassenstab, J., Xiong, C., Schindler, S. E., Balls-Berry, J., Benzinger, T. L. S., Perrin, R. J., Denny, A., Snider, B. J., Stark, S. L., Ibanez, L. & Cruchaga, C., Dec 2024, In: Scientific data. 11, 1, 768.

Research output: Contribution to journal › Article › peer-review

Open Access

Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease

Kim, J. J., Vitale, D., Otani, D. V., Lian, M. M., Heilbron, K., Aslibekyan, S., Auton, A., Babalola, E., Bell, R. K., Bielenberg, J., Bryc, K., Bullis, E., Cannon, P., Coker, D., Partida, G. C., Dhamija, D., Das, S., Elson, S. L., Eriksson, N. & Filshtein, T. & 279 others, Fitch, A., Fletez-Brant, K., Fontanillas, P., Freyman, W., Granka, J. M., Hernandez, A., Hicks, B., Hinds, D. A., Jewett, E. M., Jiang, Y., Kukar, K., Kwong, A., Lin, K. H., Llamas, B. A., Lowe, M., McCreight, J. C., McIntyre, M. H., Micheletti, S. J., Moreno, M. E., Nandakumar, P., Nguyen, D. T., Noblin, E. S., O’Connell, J., Petrakovitz, A. A., Poznik, G. D., Reynoso, A., Schloetter, M., Schumacher, M., Shastri, A. J., Shelton, J. F., Shi, J., Shringarpure, S., Su, Q. J., Tat, S. A., Tchakouté, C. T., Tran, V., Tung, J. Y., Wang, X., Wang, W., Weldon, C. H., Wilton, P., Wong, C. D., Iwaki, H., Lake, J., Solsberg, C. W., Leonard, H., Makarious, M. B., Tan, E. K., Singleton, A. B., Bandres-Ciga, S., Noyce, A. J., Gatto, E. M., Kauffman, M., Khachatryan, S., Tavadyan, Z., Shepherd, C. E., Hunter, J., Kumar, K., Ellis, M., Rentería, M. E., Koks, S., Zimprich, A., Schumacher-Schuh, A. F., Rieder, C., Awad, P. S., Tumas, V., Camargos, S., Fon, E. A., Monchi, O., Fon, T., Galleguillos, B. P., Miranda, M., Bustamante, M. L., Olguin, P., Chana, P., Tang, B., Shang, H., Guo, J., Chan, P., Luo, W., Arboleda, G., Orozc, J., del Rio, M. J., Hernandez, A., Salama, M., Kamel, W. A., Zewde, Y. Z., Brice, A., Corvol, J. C., Westenberger, A., Illarionova, A., Mollenhauer, B., Klein, C., Vollstedt, E. J., Hopfner, F., Höglinger, G., Madoev, H., Trinh, J., Junker, J., Lohmann, K., Lange, L. M., Sharma, M., Groppa, S., Gasser, T., Fang, Z. H., Akpalu, A., Xiromerisiou, G., Hadjigorgiou, G., Dagklis, I., Tarnanas, I., Stefanis, L., Stamelou, M., Dadiotis, E., Medina, A., Chan, G. H. F., Ip, N., Cheung, N. Y. F., Chan, P., Zhou, X., Kishore, A., Divya, K. P., Pal, P., Kukkle, P. L., Rajan, R., Borgohain, R., Salari, M., Quattrone, A., Valente, E. M., Parnetti, L., Avenali, M., Schirinzi, T., Funayama, M., Hattori, N., Shiraishi, T., Karimova, A., Kaishibayeva, G., Shambetova, C., Krüger, R., Tan, A. H., Ahmad-Annuar, A., Norlinah, M. I., Murad, N. A. A., Azmin, S., Lim, S. Y., Mohamed, W., Tay, Y. W., Martinez-Ramirez, D., Rodriguez-Violante, M., Reyes-Pérez, P., Tserensodnom, B., Ojha, R., Anderson, T. J., Pitcher, T. L., Sanyaolu, A., Okubadejo, N., Ojo, O., Aasly, J. O., Pihlstrøm, L., Tan, M., Ur-Rehman, S., Veliz-Otani, D., Cornejo-Olivas, M., Doquenia, M. L., Rosales, R., Vinuela, A., Iakovenko, E., Mubarak, B. A., Umair, M., Amod, F., Carr, J., Bardien, S., Jeon, B., Kim, Y. J., Cubo, E., Alvarez, I., Hoenicka, J., Beyer, K., Periñan, M. T., Pastor, P., El-Sadig, S., Brolin, K., Zweier, C., Tinkhauser, G., Krack, P., Lin, C. H., Wu, H. C., Kung, P. J., Wu, R. M., Wu, Y., Amouri, R., Sassi, S. B., Başak, A. N., Genc, G., Çakmak, Ö. Ö., Ertan, S., Martínez-Carrasco, A., Schrag, A., Schapira, A., Carroll, C., Bale, C., Grosset, D., Stafford, E. J., Houlden, H., Morris, H. R., Hardy, J., Mok, K. Y., Rizig, M., Wood, N., Williams, N., Okunoye, O., Lewis, P. A., Kaiyrzhanov, R., Weil, R., Love, S., Stott, S., Jasaityte, S., Dey, S., Obese, V., Espay, A., O’Grady, A., Sobering, A. K., Siddiqi, B., Casey, B., Fiske, B., Jonas, C., Cruchaga, C., Pantazis, C. B., Comart, C., Wegel, C., Hall, D., Hernandez, D., Shiamim, E., Riley, E., Faghri, F., Serrano, G. E., Chen, H., Mata, I. F., Sarmiento, I. J. K., Williamson, J., Jankovic, J., Shulman, J., Solle, J. C., Murphy, K., Nuytemans, K., Kieburtz, K., Markopoulou, K., Marek, K., Levine, K. S., Chahine, L. M., Ibanez, L., Screven, L., Ruffrage, L., Shulman, L., Marsili, L., Kuhl, M., Dean, M., Koretsky, M., Puckelwartz, M. J., Inca-Martinez, M., Louie, N., Mencacci, N. E., Albin, R., Alcalay, R., Walker, R., Chowdhury, S., Dumanis, S., Lubbe, S., Xie, T., Foroud, T., Beach, T., Sherer, T., Song, Y., Nguyen, D., Nguyen, T., Atadzhanov, M., Blauwendraat, C., Nalls, M. A., Foo, J. N. & Mata, I., Jan 2024, In: Nature Genetics. 56, 1, p. 27-36 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden

Dominantly Inherited Alzheimer Network, Jun 2024, In: Alzheimer's and Dementia. 20, 6, p. 4351-4365 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2023

Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease

Millar, P. R., Gordon, B. A., Wisch, J. K., Schultz, S. A., Benzinger, T. L., Cruchaga, C., Hassenstab, J. J., Ibanez, L., Karch, C., Llibre-Guerra, J. J., Morris, J. C., Perrin, R. J., Supnet-Bell, C., Xiong, C., Allegri, R. F., Berman, S. B., Chhatwal, J. P., Chrem Mendez, P. A., Day, G. S. & Hofmann, A. & 13 others, Ikeuchi, T., Jucker, M., Lee, J. H., Levin, J., Lopera, F., Niimi, Y., Sánchez-González, V. J., Schofield, P. R., Sosa-Ortiz, A. L., Vöglein, J., Bateman, R. J., Ances, B. M. & McDade, E. M., Dec 2023, In: Molecular neurodegeneration. 18, 1, 98.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Cell-free RNA signatures predict Alzheimer's disease

Cisterna-García, A., Beric, A., Ali, M., Pardo, J. A., Chen, H. H., Fernandez, M. V., Norton, J., Gentsch, J., Bergmann, K., Budde, J., Perlmutter, J. S., Morris, J. C., Cruchaga, C., Botia, J. A. & Ibanez, L., Dec 15 2023, In: iScience. 26, 12, 108534.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

Towns, C., Richer, M., Jasaityte, S., Stafford, E. J., Joubert, J., Antar, T., Martinez-Carrasco, A., Makarious, M. B., Casey, B., Vitale, D., Levine, K., Leonard, H., Pantazis, C. B., Screven, L. A., Hernandez, D. G., Wegel, C. E., Solle, J., Nalls, M. A., Blauwendraat, C. & Singleton, A. B. & 224 others, Tan, M. M. X., Iwaki, H., Morris, H. R., Gatto, E. M., Kauffman, M., Khachatryan, S., Tavadyan, Z., Shepherd, C. E., Hunter, J., Kumar, K., Ellis, M., Rentería, M. E., Koks, S., Zimprich, A., Schumacher-Schuh, A. F., Rieder, C., Awad, P. S., Tumas, V., Camargos, S., Fon, E. A., Monchi, O., Fon, T., Galleguillos, B. P., Miranda, M., Bustamante, M. L., Olguin, P., Chana, P., Tang, B., Shang, H., Guo, J., Chan, P., Luo, W., Arboleda, G., Orozco, J., del Rio, M. J., Hernandez, A., Salama, M., Kamel, W. A., Zewde, Y. Z., Brice, A., Corvol, J. C., Westenberger, A., Illarionova, A., Mollenhauer, B., Klein, C., Vollstedt, E. J., Hopfner, F., Höglinger, G., Madoev, H., Trinh, J., Junker, J., Lohmann, K., Lange, L. M., Sharma, M., Groppa, S., Gasser, T., Fang, Z. H., Akpalu, A., Xiromerisiou, G., Hadjigorgiou, G., Dagklis, I., Tarnanas, I., Stefanis, L., Stamelou, M., Dadiotis, E., Medina, A., Chan, G. H. F., Ip, N., Cheung, N. Y. F., Chan, P., Zhou, X., Kishore, A., Kp, D., Pal, P., Kukkle, P. L., Rajan, R., Borgohain, R., Salari, M., Quattrone, A., Valente, E. M., Parnetti, L., Avenali, M., Schirinzi, T., Funayama, M., Hattori, N., Shiraishi, T., Karimova, A., Kaishibayeva, G., Shambetova, C., Krüger, R., Tan, A. H., Ahmad-Annuar, A., Norlinah, M. I., Murad, N. A. A., Azmin, S., Lim, S. Y., Mohamed, W., Tay, Y. W., Martinez-Ramirez, D., Rodriguez-Violante, M., Reyes-Pérez, P., Tserensodnom, B., Ojha, R., Anderson, T. J., Pitcher, T. L., Sanyaolu, A., Okubadejo, N., Ojo, O., Aasly, J. O., Pihlstrøm, L., Tan, M., Ur-Rehman, S., Cornejo-Olivas, M., Doquenia, M. L., Rosales, R., Vinuela, A., Iakovenko, E., Mubarak, B. A., Umair, M., Tan, E. K., Foo, J. N., Amod, F., Carr, J., Bardien, S., Jeon, B., Kim, Y. J., Cubo, E., Alvarez, I., Hoenicka, J., Beyer, K., Periñan, M. T., Pastor, P., El-Sadig, S., Zweier, C., Krack, P., Lin, C. H., Wu, H. C., Kung, P. J., Wu, R. M., Wu, Y., Amouri, R., Sassi, S. B., Başak, A. N., Genc, G., Çakmak, Ö. Ö., Ertan, S., Noyce, A., Schrag, A., Schapira, A., Carroll, C., Bale, C., Grosset, D., Houlden, H., Hardy, J., Mok, K. Y., Rizig, M., Wood, N., Williams, N., Okunoye, O., Lewis, P. A., Kaiyrzhanov, R., Weil, R., Love, S., Stott, S., Jasaitye, S., Dey, S., Obese, V., Espay, A., O’Grady, A., Sobering, A. K., Siddiqi, B., Fiske, B., Jonas, C., Cruchaga, C., Comart, C., Wegel, C., Hall, D., Hernandez, D., Shiamim, E., Riley, E., Faghri, F., Serrano, G. E., Chen, H., Mata, I. F., Sarmiento, I. J. K., Williamson, J., Kim, J. J., Jankovic, J., Shulman, J., Solle, J. C., Murphy, K., Nuytemans, K., Kieburtz, K., Markopoulou, K., Marek, K., Levine, K. S., Chahine, L. M., Ibanez, L., Screven, L., Ruffrage, L., Shulman, L., Marsili, L., Kuhl, M., Dean, M., Koretsky, M., Puckelwartz, M. J., Inca-Martinez, M., Louie, N., Mencacci, N. E., Albin, R., Alcalay, R., Walker, R., Bandres-Ciga, S., Chowdhury, S., Dumanis, S., Lubbe, S., Xie, T., Foroud, T., Beach, T., Sherer, T., Song, Y., Nguyen, D., Nguyen, T. & Atadzhanov, M., Dec 2023, In: npj Parkinson's Disease. 9, 1, 131.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease

Dominantly Inherited Alzheimer Network (DIAN) Consortia, Dec 2023, In: npj Parkinson's Disease. 9, 1, 107.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2022

A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype

GeneStroke Consortium and International Stroke Genetics Consortium, Jul 8 2022, In: Frontiers in Cardiovascular Medicine. 9, 940696.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease

Dominantly Inherited Alzheimer Network, Dec 2022, In: Acta Neuropathologica Communications. 10, 1, 29.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke

Bitar, L., Uphaus, T., Thalman, C., Muthuraman, M., Gyr, L., Ji, H., Domingues, M., Endle, H., Groppa, S., Steffen, F., Koirala, N., Fan, W., Ibanez, L., Heitsch, L., Cruchaga, C., Lee, J. M., Kloss, F., Bittner, S., Nitsch, R. & Zipp, F. & 1 others, Vogt, J., Apr 20 2022, In: Science translational medicine. 14, 641, eabk0135.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Multi-Ancestry GWAS reveals excitotoxicity associated with outcome after ischaemic stroke

Ibanez, L., Heitsch, L., Carrera, C., Farias, F. H. G., Del Aguila, J. L., Dhar, R., Budde, J., Bergmann, K., Bradley, J., Harari, O., Phuah, C. L., Lemmens, R., Souza, A. A. V. O., Moniche, F., Cabezas-Juan, A., Arenillas, J. F., Krupinksi, J., Cullell, N., Torres-Aguila, N. & Muiño, E. & 56 others, Cárcel-Márquez, J., Marti-Fabregas, J., Delgado-Mederos, R., Marin-Bueno, R., Hornick, A., Vives-Bauza, C., Navarro, R. D., Tur, S., Jimenez, C., Obach, V., Segura, T., Serrano-Heras, G., Chung, J. W., Roquer, J., Soriano-Tarraga, C., Giralt-Steinhauer, E., Mola-Caminal, M., Pera, J., Lapicka-Bodzioch, K., Derbisz, J., Davalos, A., Lopez-Cancio, E., Muñoz, L., Tatlisumak, T., Molina, C., Ribo, M., Bustamante, A., Sobrino, T., Castillo-Sanchez, J., Campos, F., Rodriguez-Castro, E., Arias-Rivas, S., Rodríguez-Yáñez, M., Herbosa, C., Ford, A. L., Gutierrez-Romero, A., Uribe-Pacheco, R., Arauz, A., Lopes-Cendes, I., Lowenkopf, T., Barboza, M. A., Amini, H., Stamova, B., Ander, B. P., Sharp, F. R., Moon Kim, G., Bang, O. Y., Jimenez-Conde, J., Slowik, A., Stribian, D., Tsai, E. A., Burkly, L. C., Montaner, J., Fernandez-Cadenas, I., Lee, J. M. & Cruchaga, C., Jul 1 2022, In: Brain. 145, 7, p. 2394-2406 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations

Temprano-Sagrera, G., Sitlani, C. M., Bone, W. P., Martin-Bornez, M., Voight, B. F., Morrison, A. C., Damrauer, S. M., de Vries, P. S., Smith, N. L., Sabater-Lleal, M., Dehghan, A., Heath, A. S., Morrison, A. C., Reiner, A. P., Johnson, A., Richmond, A., Peters, A., van Hylckama Vlieg, A., McKnight, B. & Psaty, B. M. & 363 others, Hayward, C., Ward-Caviness, C., O’Donnell, C., Chasman, D., Strachan, D. P., Tregouet, D. A., Mook-Kanamori, D., Gill, D., Thibord, F., Asselbergs, F. W., Leebeek, F. W. G., Rosendaal, F. R., Davies, G., Homuth, G., Temprano, G., Campbell, H., Taylor, H. A., Bressler, J., Huffman, J. E., Rotter, J. I., Yao, J., Wilson, J. F., Bis, J. C., Hahn, J. M., Desch, K. C., Wiggins, K. L., Raffield, L. M., Bielak, L. F., Yanek, L. R., Kleber, M. E., Mueller, M., Kavousi, M., Mangino, M., Liu, M., Brown, M. R., Conomos, M. P., Jhun, M. A., Chen, M. H., de Maat, M. P. M., Pankratz, N., Smith, N. L., Peyser, P. A., Elliot, P., Wei, P., Wild, P. S., Morange, P. E., van der Harst, P., Yang, Q., Le, N. Q., Marioni, R., Li, R., Damrauer, S. M., Cox, S. R., Trompet, S., Felix, S. B., Völker, U., Tang, W., Koenig, W., Jukema, J. W., Guo, X., Lindstrom, S., Wang, L., Smith, E. N., Gordon, W., van Hylckama Vlieg, A., de Andrade, M., Brody, J. A., Pattee, J. W., Haessler, J., Brumpton, B. M., Suchon, P., Chen, M. H., Turman, C., Germain, M., Wiggins, K. L., MacDonald, J., Braekkan, S. K., Armasu, S. M., Pankratz, N., Jackson, R. D., Nielsen, J. B., Giulianini, F., Puurunen, M. K., Ibrahim, M., Heckbert, S. R., Bammler, T. K., Frazer, K. A., McCauley, B. M., Taylor, K., Pankow, J. S., Reiner, A. P., Gabrielsen, M. E., Deleuze, J. F., O’Donnell, C. J., Kim, J., McKnight, B., Kraft, P., Hansen, J. B., Rosendaal, F. R., Heit, J. A., Psaty, B. M., Tang, W., Kooperberg, C., Hveem, K., Ridker, P. M., Morange, P. E., Johnson, A. D., Kabrhel, C., Trégouët, D. A., Smith, N. L., Malik, R., Chauhan, G., Traylor, M., Sargurupremraj, M., Okada, Y., Mishra, A., Rutten-Jacobs, L., Giese, A. K., van der Laan, S. W., Gretarsdottir, S., Anderson, C. D., Chong, M., Adams, H. H. H., Ago, T., Almgren, P., Amouyel, P., Ay, H., Bartz, T. M., Benavente, O. R., Bevan, S., Boncoraglio, G. B., Brown, R. D., Butterworth, A. S., Carrera, C., Carty, C. L., Chen, W. M., Cole, J. W., Correa, A., Cotlarciuc, I., Cruchaga, C., Danesh, J., de Bakker, P. I. W., DeStefano, A. L., den Hoed, M., Duan, Q., Engelter, S. T., Falcone, G. J., Gottesman, R. F., Grewal, R. P., Gudnason, V., Gustafsson, S., Haessler, J., Harris, T. B., Hassan, A., Havulinna, A. S., Heckbert, S. R., Holliday, E. G., Howard, G., Hsu, F. C., Hyacinth, H. I., Arfan Ikram, M., Ingelsson, E., Irvin, M. R., Jian, X., Jiménez-Conde, J., Johnson, J. A., Jukema, J. W., Kanai, M., Keene, K. L., Kissela, B. M., Kleindorfer, D. O., Kooperberg, C., Kubo, M., Lange, L. A., Langefeld, C. D., Langenberg, C., Launer, L. J., Lee, J. M., Lemmens, R., Leys, D., Lewis, C. M., Lin, W. Y., Lindgren, A. G., Lorentzen, E., Magnusson, P. K., Maguire, J., Manichaikul, A., McArdle, P. F., Meschia, J. F., Mitchell, B. D., Mosley, T. H., Nalls, M. A., Ninomiya, T., O’Donnell, M. J., Psaty, B. M., Pulit, S. L., Rannikmäe, K., Reiner, A. P., Rexrode, K. M., Rice, K., Rich, S. S., Ridker, P. M., Rost, N. S., Rothwell, P. M., Rotter, J. I., Rundek, T., Sacco, R. L., Sakaue, S., Sale, M. M., Salomaa, V., Sapkota, B. R., Schmidt, R., Schmidt, C. O., Schminke, U., Sharma, P., Slowik, A., Sudlow, C. L. M., Tanislav, C., Tatlisumak, T., Taylor, K. D., Thijs, V. N. S., Thorleifsson, G., Thorsteinsdottir, U., Tiedt, S., Trompet, S., Tzourio, C., van Duijn, C. M., Walters, M., Wareham, N. J., Wassertheil-Smoller, S., Wilson, J. G., Wiggins, K. L., Yang, Q., Yusuf, S., Amin, N., Aparicio, H. S., Arnett, D. K., Attia, J., Beiser, A. S., Berr, C., Buring, J. E., Bustamante, M., Caso, V., Cheng, Y. C., Hoan Choi, S., Chowhan, A., Cullell, N., Dartigues, J. F., Delavaran, H., Delgado, P., Dörr, M., Engström, G., Ford, I., Gurpreet, W. S., Hamsten, A., Heitsch, L., Hozawa, A., Ibanez, L., Ilinca, A., Ingelsson, M., Iwasaki, M., Jackson, R. D., Jood, K., Jousilahti, P., Kaffashian, S., Kalra, L., Kamouchi, M., Kitazono, T., Kjartansson, O., Kloss, M., Koudstaal, P. J., Krupinski, J., Labovitz, D. L., Laurie, C. C., Levi, C. R., Li, L., Lind, L., Lindgren, C. M., Lioutas, V., Mei Liu, Y., Lopez, O. L., Makoto, H., Martinez-Majander, N., Matsuda, K., Minegishi, N., Montaner, J., Morris, A. P., Muiño, E., Müller-Nurasyid, M., Norrving, B., Ogishima, S., Parati, E. A., Reddy Peddareddygari, L., Pedersen, N. L., Pera, J., Perola, M., Pezzini, A., Pileggi, S., Rabionet, R., Riba-Llena, I., Ribasés, M., Romero, J. R., Roquer, J., Rudd, A. G., Sarin, A. P., Sarju, R., Sarnowski, C., Sasaki, M., Satizabal, C. L., Satoh, M., Sattar, N., Sawada, N., Sibolt, G., Sigurdsson, Á., Smith, A., Sobue, K., Soriano-Tárraga, C., Stanne, T., Colin Stine, O., Stott, D. J., Strauch, K., Takai, T., Tanaka, H., Tanno, K., Teumer, A., Tomppo, L., Torres-Aguila, N. P., Touze, E., Tsugane, S., Uitterlinden, A. G., Valdimarsson, E. M., van der Lee, S. J., Völzke, H., Wakai, K., Weir, D., Williams, S. R., Wolfe, C. D. A., Wong, Q., Xu, H., Yamaji, T., Sanghera, D. K., Melander, O., Jern, C., Strbian, D., Fernandez-Cadenas, I., Longstreth, W. T., Rolfs, A., Hata, J., Woo, D., Rosand, J., Pare, G., Hopewell, J. C., Saleheen, D., Stefansson, K., Worrall, B. B., Kittner, S. J., Seshadri, S., Fornage, M., Markus, H. S., Howson, J. M. M., Kamatani, Y., Debette, S. & Dichgans, M., Jun 1 2022, In: Journal of Thrombosis and Haemostasis. 20, 6, p. 1331-1349 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

New insights into the genetic etiology of Alzheimer’s disease and related dementias

EADB, GR@ACE, DEGESCO, EADI, GERAD, Demgene, FinnGen, ADGC & CHARGE, Apr 1 2022, In: Nature Genetics. 54, 4, p. 412-436 25 p.

Research output: Contribution to journal › Article › peer-review

Open Access

783 Scopus citations

2021

Causal Effect of MMP-1 (Matrix Metalloproteinase-1), MMP-8, and MMP-12 Levels on Ischemic Stroke: A Mendelian Randomization Study

Cárcel-Márquez, J., Cullell, N., Muiño, E., Gallego-Fabrega, C., Lledós, M., Ibañez, L., Krupinski, J., Montaner, J., Cruchaga, C., Lee, J. M., Gill, D., Paré, G., Mola-Caminal, M., Roquer, J., Jimenez-Conde, J., Martí-Fàbregas, J. & Fernandez-Cadenas, I., Jul 1 2021, In: Stroke. 52, 7, p. E316-E320

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Early Neurological Change After Ischemic Stroke Is Associated With 90-Day Outcome

Heitsch, L., Ibanez, L., Carrera, C., Binkley, M. M., Strbian, D., Tatlisumak, T., Bustamante, A., Ribó, M., Molina, C., Dávalos, A., López-Cancio, E., Muñoz-Narbona, L., Soriano-Tárraga, C., Giralt-Steinhauer, E., Obach, V., Slowik, A., Pera, J., Lapicka-Bodzioch, K., Derbisz, J. & Sobrino, T. & 30 others, Castillo, J., Campos, F., Rodríguez-Castro, E., Arias-Rivas, S., Segura, T., Serrano-Heras, G., Vives-Bauza, C., Díaz-Navarro, R., Tur, S., Jimenez, C., Martí-Fàbregas, J., Delgado-Mederos, R., Arenillas, J., Krupinski, J., Cullell, N., Torres-Aguila, N. P., Muiño, E., Cárcel-Márquez, J., Moniche, F., Cabezas, J. A., Ford, A. L., Dhar, R., Roquer, J., Khatri, P., Jiménez-Conde, J., Fernandez-Cadenas, I., Montaner, J., Rosand, J., Cruchaga, C. & Lee, J. M., Jan 1 2021, In: Stroke. 52, 1, p. 132-141 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

Exome-wide rare variant analysis in familial essential tremor

University of Washington Center for Mendelian Genomics (UWCMG), Jan 2021, In: Parkinsonism and Related Disorders. 82, p. 109-116 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders

Yang, C., Farias, F. H. G., Ibanez, L., Suhy, A., Sadler, B., Fernandez, M. V., Wang, F., Bradley, J. L., Eiffert, B., Bahena, J. A., Budde, J. P., Li, Z., Dube, U., Sung, Y. J., Mihindukulasuriya, K. A., Morris, J. C., Fagan, A. M., Perrin, R. J., Benitez, B. A. & Rhinn, H. & 2 others, Harari, O. & Cruchaga, C., Sep 2021, In: Nature neuroscience. 24, 9, p. 1302-1312 11 p.

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Rp11-362k2.2:Rp11-767i20.1 genetic variation is associated with post-reperfusion therapy parenchymal hematoma. a gwas meta-analysis

International Stroke Genetic Consortium & Spanish Stroke Genetic Consortium, Jul 2 2021, In: Journal of Clinical Medicine. 10, 14, 3137.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Single nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma

The International Stroke Genetic Consortium and the Spanish Stroke Genetic Consortium, Aug 1 2021, In: Brain. 144, 8, p. 2416-2426 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2020

CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease

Faura, J., Bustamante, A., Penalba, A., Giralt, D., Simats, A., Martínez-Sáez, E., Alcolea, D., Fortea, J., Lleó, A., Teunissen, C. E., Van Der Flier, W. M., Ibañez, L., Harari, O., Cruchaga, C., Hernández-Guillamón, M., Delgado, P. & Montaner, J., 2020, In: Journal of Alzheimer's Disease. 73, 4, p. 1585-1595 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Examination of the Effect of Rare Variants in TREM2, ABI3, and PLCG2 in LOAD through Multiple Phenotypes

Olive, C., Ibanez, L., Farias, F. H. G., Wang, F., Budde, J. P., Norton, J. B., Gentsch, J., Morris, J. C., Li, Z., Dube, U., Del-Aguila, J., Bergmann, K., Bradley, J., Benitez, B. A., Harari, O., Fagan, A., Ances, B., Cruchaga, C. & Fernandez, M. V., 2020, In: Journal of Alzheimer's Disease. 77, 4, p. 1469-1482 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease

Ibanez, L., Bahena, J. A., Yang, C., Dube, U., Farias, F. H. G., Budde, J. P., Bergmann, K., Brenner-Webster, C., Morris, J. C., Perrin, R. J., Cairns, N. J., O’Donnell, J., Álvarez, I., Diez-Fairen, M., Aguilar, M., Miller, R., Davis, A. A., Pastor, P., Kotzbauer, P. & Campbell, M. C. & 5 others, Perlmutter, J. S., Rhinn, H., Harari, O., Cruchaga, C. & Benitez, B. A., Dec 2020, In: Acta Neuropathologica Communications. 8, 1, 196.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Human immunodeficiency virus continuum of care in 11 european union countries at the end of 2016 overall and by key population: Have we made progress?

European HIV Continuum of Care Working Group, Dec 1 2020, In: Clinical Infectious Diseases. 71, 11, p. 2905-2916 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Overlapping genetic architecture between Parkinson disease and melanoma

GenoMEL Consortium, Essen-Heidelberg Investigators, SDH Study Group, Q-MEGA and QTWIN Investigators, AMFS Investigators, ATHENS Melanoma Study Group, Melanoma-Meta-analysis Consortium & 23andMe Research Team, Feb 1 2020, In: Acta Neuropathologica. 139, 2, p. 347-364 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

The influence of CYP enzymes and ABCB1 on treatment outcomes in schizophrenia: association of CYP1A2 activity with adverse effects

Cendrós, M., Arranz, M. J., Torra, M., Penadés, R., Gonzalez-Rodriguez, A., Brunet, M., Perez-Blanco, J., Ibáñez, L., Serra, A. & Catalán, R., 2020, In: Journal of Translational Genetics and Genomics. 4, p. 210-220 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion

Li, Z., Farias, F. H. G., Dube, U., Del-Aguila, J. L., Mihindukulasuriya, K. A., Fernandez, M. V., Ibanez, L., Budde, J. P., Wang, F., Lake, A. M., Deming, Y., Perez, J., Yang, C., Bahena, J. A., Qin, W., Bradley, J. L., Davenport, R., Bergmann, K., Morris, J. C. & Perrin, R. J. & 4 others, Benitez, B. A., Dougherty, J. D., Harari, O. & Cruchaga, C., Jan 1 2020, In: Acta Neuropathologica. 139, 1, p. 45-61 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

2019

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

the Dominantly Inherited Alzheimer Network (DIAN), Nov 1 2019, In: Nature neuroscience. 22, 11, p. 1903-1912 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

229 Scopus citations

A pharmacogenetic intervention for the improvement of the safety profile of antipsychotic treatments

Arranz, M. J., Gonzalez-Rodriguez, A., Perez-Blanco, J., Penadés, R., Gutierrez, B., Ibañez, L., Arias, B., Brunet, M., Cervilla, J., Salazar, J. & Catalan, R., Dec 1 2019, In: Translational psychiatry. 9, 1, 177.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

Del-Aguila, J. L., Li, Z., Dube, U., Mihindukulasuriya, K. A., Budde, J. P., Fernandez, M. V., Ibanez, L., Bradley, J., Wang, F., Bergmann, K., Davenport, R., Morris, J. C., Holtzman, D. M., Perrin, R. J., Benitez, B. A., Dougherty, J., Cruchaga, C. & Harari, O., Aug 9 2019, In: Alzheimer's Research and Therapy. 11, 1, 71.

Research output: Contribution to journal › Article › peer-review

Open Access

111 Scopus citations

Genome-wide association study of white blood cell counts in patients with ischemic stroke

Torres-Aguila, N. P., Carrera, C., Giese, A. K., Cullell, N., Muiño, E., Cárcel-Márquez, J., Gallego-Fabrega, C., González-Sánchez, J., Del Mar Freijo, M., Álvarez-Sabín, J., Molina, C., Ribó, M., Jimenez-Conde, J., Roquer, J., Sobrino, T., Campos, F., Castillo, J., Muñoz-Narbona, L., Lopez-Cancio, E. & Dàvalos, A. & 15 others, Diaz-Navarro, R., Tur, S., Vives-Bauza, C., Serrano-Heras, G., Segura, T., Krupinski, J., Delgado-Mederos, R., Martí-Fàbregas, J., Heitsch, L., Ibañez, L., Cruchaga, C., Rost, N. S., Montaner, J., Lee, J. M. & Fernandez-Cadenas, I., Dec 1 2019, In: Stroke. 50, 12, p. 3618-3621 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Overlap in the Genetic Architecture of Stroke Risk, Early Neurological Changes, and Cardiovascular Risk Factors

International Stroke Genetics Consortium and the MEGASTROKE Consortium, 2019, In: Stroke. 50, 6, p. 1339-1345 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

PATJ Low Frequency Variants Are Associated with Worse Ischemic Stroke Functional Outcome: A Genome-Wide Meta-Analysis

Mola-Caminal, M., Carrera, C., Soriano-Tárraga, C., Giralt-Steinhauer, E., Díaz-Navarro, R. M., Tur, S., Jiménez, C., Medina-Dols, A., Cullell, N., Torres-Aguila, N. P., Muiño, E., Rodríguez-Campello, A., Ois, A., Cuadrado-Godia, E., Vivanco-Hidalgo, R. M., Hernandez-Guillamon, M., Solé, M., Delgado, P., Bustamante, A. & García-Berrocoso, T. & 45 others, Mendióroz, M., Castellanos, M., Serena, J., Martí-Fàbregas, J., Segura, T., Serrano-Heras, G., Obach, V., Ribó, M., Molina, C. A., Alvarez-Sabín, J., Palomeras, E., Freijo, M., Font, M. A., Rosand, J., Rost, N. S., Gallego-Fabrega, C., Lee, J. M., Heitsch, L., Ibanez, L., Cruchaga, C., Phuah, C. L., Lemmens, R., Thijs, V., Lindgren, A., Maguire, J., Rannikmae, K., Sudlow, C. L., Jern, C., Stanne, T. M., Lorentzen, E., Muñoz-Narbona, L., Dávalos, A., López-Cancio, E., Worrall, B. B., Woo, D., Kittner, S. J., Mitchell, B. D., Montaner, J., Roquer, J., Krupinski, J., Estivill, X., Rabionet, R., Vives-Bauzá, C., Fernández-Cadenas, I. & Jimenez-Conde, J., Jan 4 2019, In: Circulation research. 124, 1, p. 114-120 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study

Larsson, S. C., Traylor, M., Burgess, S., Boncoraglio, G. B., Jern, C., Michaëlsson, K., Markus, H. S., Malik, R., Chauhan, G., Sargurupremraj, M., Okada, Y., Mishra, A., Rutten-Jacobs, L., Giese, A. K., Van Der Laan, S. W., Gretarsdottir, S., Anderson, C. D., Chong, M., Adams, H. H. H. & Ago, T. & 237 others, Almgren, P., Amouyel, P., Ay, H., Bartz, R. M., Benavente, O. R., Bevan, S., Brown, R. D., Butterworth, A. S., Carrera, C., Carty, C. L., Chasman, D. I., Chen, W. M., Cole, J. W., Correa, A., Cotlarciuc, I., Cruchaga, C., Danesh, J., De Bakker, P. I. W., Destefano, A. L., Hoed, M. D., Duan, Q., Engelter, S. T., Falcone, G. J., Gottesman, R. F., Grewal, R. P., Gudnason, V., Gustafsson, S., Haessler, J., Harris, T. B., Hassan, A., Havulinna, A. S., Heckbert, S. R., Holliday, E. G., Howard, G., Hsu, F. C., Hyacinth, H. I., Ikram, M. A., Ingelsson, E., Irvin, M. R., Jian, X., Jiménez-Conde, J., Johnson, J. A., Jukema, J. W., Kanai, M., Keene, K. L., Kissela, B. M., Kleindorfer, D. O., Kooperberg, C., Kubo, M., Lange, L. A., Langefeld, C. D., Langenberg, C., Launer, L. J., Lee, J. M., Lemmens, R., Leys, D., Lewis, C. M., Lin, W. Y., Lindgren, A. G., Lorentzen, E., Magnusson, P. K., Maguire, J., Manichaikul, A., McArdle, P. F., Meschia, J. F., Mitchell, B. D., Mosley, T. H., Nalls, M. A., Ninomiya, T., O'Donnell, M. J., Psaty, B. M., Pulit, S. L., Rannikmäe, K., Reiner, A. P., Rexrode, K. M., Rice, K., Rich, S. S., Ridker, P. M., Rost, N. S., Rothwell, P. M., Rotter, J. I., Rundek, T., Sacco, R. L., Sakaue, S., Sale, M. M., Salomaa, V., Sapkota, B. R., Schmidt, R., Schmidt, C. O., Schminke, U., Sharma, P., Slowik, A., Sudlow, C. L. M., Tanislav, C., Tatlisumak, T., Taylor, K. D., Thijs, V. N. S., Thorleifsson, G., Thorsteinsdottir, U., Tiedt, S., Trompet, S., Tzourio, C., Van Duijn, C. M., Walters, M., Wareham, N. J., Wassertheil-Smoller, S., Wilson, J. G., Wiggins, K. L., Yang, Q., Yusuf, S., Amin, N., Aparicio, H. S., Arnett, D. K., Attia, J., Beiser, A. S., Berr, C., Buring, J. E., Bustamante, M., Caso, V., Cheng, Y. C., Choi, S. H., Chowhan, A., Cullell, N., Dartigues, J. F., Delavaran, H., Delgado, P., Dörr, M., Engström, G., Ford, I., Gurpreet, W. S., Hamsten, A., Heitsch, L., Hozawa, A., Ibanez, L., Ilinca, A., Ingelsson, M., Iwasaki, M., Jackson, R. D., Jood, K., Jousilahti, P., Kaffashian, S., Kalra, L., Kamouchi, M., Kitazono, T., Kjartansson, O., Kloss, M., Koudstaal, P. J., Krupinski, J., Labovitz, D. L., Laurie, C. C., Levi, C. R., Li, L., Lind, L., Lindgren, C. M., Lioutas, V., Liu, Y. M., Lopez, O. L., Makoto, H., Martinez-Majander, N., Matsuda, K., Minegishi, N., Montaner, J., Morris, A. P., Muiño, E., Müller-Nurasyid, M., Norrving, B., Ogishima, S., Parati, E. A., Peddareddygari, L. R., Pedersen, N. L., Pera, J., Perola, M., Pezzini, A., Pileggi, S., Rabionet, R., Riba-Llena, I., Ribasés, M., Romero, J. R., Roquer, J., Rudd, A. G., Sarin, A. P., Sarju, R., Sarnowski, C., Sasaki, M., Satizabal, C. L., Satoh, M., Sattar, N., Sawada, N., Sibolt, G., Sigurdsson, Á., Smith, A., Sobue, K., Soriano-Tárraga, C., Stanne, T., Stine, O. C., Stott, D. J., Strauch, K., Takai, T., Tanaka, H., Tanno, K., Teumer, A., Tomppo, L., Torres-Aguila, N. P., Touze, E., Tsugane, S., Uitterlinden, A. G., Valdimarsson, E. M., Van Der Lee, S. J., Völzke, H., Wakai, K., Weir, D., Williams, S. R., Wolfe, C. D. A., Wong, Q., Xu, H., Yamaji, T., Sanghera, D. K., Melander, O., Strbian, D., Fernandez-Cadenas, I., Longstreth, W. T., Rolfs, A., Hata, J., Woo, D., Rosand, J., Pare, G., Hopewell, J. C., Saleheen, D., Stefansson, K., Worrall, B. B., Kittner, S. J., Seshadri, S., Fornage, M., Howson, J. M. M., Kamatani, Y., Debette, S. & Dichgans, M., Feb 26 2019, In: Neurology. 92, 9, p. E944-E950

Research output: Contribution to journal › Article › peer-review

Open Access

47 Scopus citations

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk

Deming, Y., Filipello, F., Cignarella, F., Cantoni, C., Hsu, S., Mikesell, R., Li, Z., Del-Aguila, J. L., Dube, U., Farias, F. G., Bradley, J., Budde, J., Ibanez, L., Fernandez, M. V., Blennow, K., Zetterberg, H., Heslegrave, A., Johansson, P. M., Svensson, J. & Nellgård, B. & 16 others, Lleo, A., Alcolea, D., Clarimon, J., Rami, L., Molinuevo, J. L., Suárez-Calvet, M., Morenas-Rodríguez, E., Kleinberger, G., Ewers, M., Harari, O., Haass, C., Brett, T. J., Benitez, B. A., Karch, C. M., Piccio, L. & Cruchaga, C., Aug 14 2019, In: Science translational medicine. 11, 505, eaau2291.

Research output: Contribution to journal › Article › peer-review

Open Access

149 Scopus citations

TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

Del-Aguila, J. L., Benitez, B. A., Li, Z., Dube, U., Mihindukulasuriya, K. A., Budde, J. P., Farias, F. H. G., Fernández, M. V., Ibanez, L., Jiang, S., Perrin, R. J., Cairns, N. J., Morris, J. C., Harari, O. & Cruchaga, C., May 8 2019, In: Molecular neurodegeneration. 14, 1, 18.

Research output: Contribution to journal › Article › peer-review

Open Access

62 Scopus citations

Validation of a clinical-genetics score to predict hemorrhagic transformations after rtPA

Spanish Stroke Genetic Consortium, Aug 27 2019, In: Neurology. 93, 9, p. e851-e863

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2018

Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline

Alzheimer's Disease Neuroimaging Initiative (ADNI), 2018, In: Journal of Alzheimer's Disease. 62, 2, p. 745-756 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

Evaluation of gene-based family-based methods to detect novel genes associated with familial late onset Alzheimer disease

NIA-LOAD family study group & NCRAD, Apr 4 2018, In: Frontiers in Neuroscience. 12, APR, 209.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Genetic susceptibility to invasive pneumococcal disease

Betriu, A. S., Arranz, M. J., Güerri-Fernández, R., Pérez, M., Monzón, H., Payeras, A., Andrés, M., Torviso, J., Ibañez, L., Garau, J. & Calbo, E., Apr 2018, In: Infection, Genetics and Evolution. 59, p. 126-131 6 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Neurology Working Group of the CHARGE Consortium, NINDS Stroke Genetics Network (SiGN), UK Young Lacunar DNA Study, MEGAST ROKE Consortium, AFGen Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, International Genomics of Blood Pressure (iGEN-BP) Consortium, INVENT Consortium, STA RNET BioBank Japan Cooperative Hospital Group, COMPASS Consortium, EPIC-CVD Consortium, EPIC-InterAct Consortium, International Stroke Genetics Consortium (ISGC) & METAST ROKE Consortium, Apr 1 2018, In: Nature Genetics. 50, 4, p. 524-537 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1018 Scopus citations

Pleiotropic effects of variants in dementia genes in Parkinson disease

Ibanez, L., Dube, U., Davis, A. A., Fernandez, M. V., Budde, J., Cooper, B., Diez-Fairen, M., Ortega-Cubero, S., Pastor, P., Perlmutter, J. S., Cruchaga, C. & Benitez, B. A., Apr 10 2018, In: Frontiers in Neuroscience. 12, APR, 230.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms

the, Dominantly Inherited Alzheimer Network (DIAN), Disease Neuroimaging Initiative (ADNI), NIA-LOAD family study, Cruchaga, C., Fernandez, M. V., Ibanez, L., Holtzman, D. M., Fagan, A. M., Morris, J. C., Bateman, R. J. & Harari, O., Feb 2018, In: Alzheimer's and Dementia. 14, 2, p. 205-214 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

92 Scopus citations

2017

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

Huang, K. L., Marcora, E., Pimenova, A. A., Di Narzo, A. F., Kapoor, M., Jin, S. C., Harari, O., Bertelsen, S., Fairfax, B. P., Czajkowski, J., Chouraki, V., Grenier-Boley, B., Bellenguez, C., Deming, Y., McKenzie, A., Raj, T., Renton, A. E., Budde, J., Smith, A. & Fitzpatrick, A. & 27 others, Bis, J. C., DeStefano, A., Adams, H. H. H., Ikram, M. A., Van Der Lee, S., Del-Aguila, J. L., Fernandez, M. V., Ibañez, L., Sims, R., Escott-Price, V., Mayeux, R., Haines, J. L., Farrer, L. A., Pericak-Vance, M. A., Lambert, J. C., Van Duijn, C., Launer, L., Seshadri, S., Williams, J., Amouyel, P., Schellenberg, G. D., Zhang, B., Borecki, I., Kauwe, J. S. K., Cruchaga, C., Hao, K. & Goate, A. M., Aug 1 2017, In: Nature neuroscience. 20, 8, p. 1052-1061 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

263 Scopus citations

Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease

NIA-LOAD family study group & NCRAD, Nov 2017, In: PLoS genetics. 13, 11, e1007045.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels

Ibanez, L., Dube, U., Saef, B., Budde, J., Black, K., Medvedeva, A., Del-Aguila, J. L., Davis, A. A., Perlmutter, J. S., Harari, O., Benitez, B. A. & Cruchaga, C., Nov 15 2017, In: BMC Neurology. 17, 1, 198.

Research output: Contribution to journal › Article › peer-review

Open Access