Laura Heitsch

Assistant Professor of Emergency Medicine, Assistant Professor of Neurology

    • 1274
      Citations
    20072022

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    • 2022

      Accelerating Prediction of Malignant Cerebral Edema After Ischemic Stroke with Automated Image Analysis and Explainable Neural Networks

      Foroushani, H. M., Hamzehloo, A., Kumar, A., Chen, Y., Heitsch, L., Slowik, A., Strbian, D., Lee, J. M., Marcus, D. S. & Dhar, R., Apr 2022, In: Neurocritical Care. 36, 2, p. 471-482 12 p.

      Research output: Contribution to journalArticlepeer-review

      4 Scopus citations
    • Accurate Prediction of Persistent Upper Extremity Impairment in Patients With Ischemic Stroke

      de Havenon, A., Heitsch, L., Sunmonu, A., Braun, R., Lohse, K., Cole, J. W., Mistry, E., Lindgren, A., Worrall, B. B. & Cramer, S. C., May 2022, In: Archives of Physical Medicine and Rehabilitation. 103, 5, p. 964-969 6 p.

      Research output: Contribution to journalArticlepeer-review

    • A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype

      GeneStroke Consortium and International Stroke Genetics Consortium, Jul 8 2022, In: Frontiers in Cardiovascular Medicine. 9, 940696.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      1 Scopus citations
    • Association of Stroke Lesion Pattern and White Matter Hyperintensity Burden With Stroke Severity and Outcome

      Bonkhoff, A. K., Hong, S., Bretzner, M., Schirmer, M. D., Regenhardt, R. W., Arsava, E. M., Donahue, K., Nardin, M., Dalca, A., Giese, A. K., Etherton, M. R., Hancock, B. L., Mocking, S. J. T., Mcintosh, E., Attia, J., Benavente, O., Cole, J. W., Donatti, A., Griessenauer, C., Heitsch, L., & 37 othersHolmegaard, L., Jood, K., Jimenez-Conde, J., Kittner, S., Lemmens, R., Levi, C., Mcdonough, C. W., Meschia, J., Phuah, C. L., Rolfs, A., Ropele, S., Rosand, J., Roquer, J., Rundek, T., Sacco, R. L., Schmidt, R., Sharma, P., Slowik, A., Soederholm, M., Sousa, A., Stanne, T. M., Strbian, D., Tatlisumak, T., Thijs, V., Vagal, A., Wasselius, J., Woo, D., Zand, R., Mcardle, P., Worrall, B. B., Jern, C., Lindgren, A. G., Maguire, J., Golland, P., Bzdok, D., Wu, O. & Rost, N. S., Sep 27 2022, In: Neurology. 99, 13, p. E1364-E1379

      Research output: Contribution to journalArticlepeer-review

      1 Scopus citations
    • Automated Measurement of Net Water Uptake From Baseline and Follow-Up CTs in Patients With Large Vessel Occlusion Stroke

      Kumar, A., Chen, Y., Corbin, A., Hamzehloo, A., Abedini, A., Vardar, Z., Carey, G., Bhatia, K., Heitsch, L., Derakhshan, J. J., Lee, J. M. & Dhar, R., Jun 27 2022, In: Frontiers in Neurology. 13, 898728.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      1 Scopus citations
    • Deep profiling of multiple ischemic lesions in a large, multi-center cohort: Frequency, spatial distribution, and associations to clinical characteristics

      the MRI-GENIE GISCOME Investigators, the International Stroke Genetics Consortium, Aug 25 2022, In: Frontiers in Neuroscience. 16, 994458.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke

      Bitar, L., Uphaus, T., Thalman, C., Muthuraman, M., Gyr, L., Ji, H., Domingues, M., Endle, H., Groppa, S., Steffen, F., Koirala, N., Fan, W., Ibanez, L., Heitsch, L., Cruchaga, C., Lee, J. M., Kloss, F., Bittner, S., Nitsch, R., Zipp, F., & 1 othersVogt, J., Apr 20 2022, In: Science translational medicine. 14, 641, eabk0135.

      Research output: Contribution to journalArticlepeer-review

      5 Scopus citations
    • International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery

      International Stroke Genetics Consortium, Mar 2022, In: International Journal of Stroke. 17, 3, p. 260-268 9 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      7 Scopus citations
    • Multi-Ancestry GWAS reveals excitotoxicity associated with outcome after ischaemic stroke

      Ibanez, L., Heitsch, L., Carrera, C., Farias, F. H. G., Del Aguila, J. L., Dhar, R., Budde, J., Bergmann, K., Bradley, J., Harari, O., Phuah, C. L., Lemmens, R., Souza, A. A. V. O., Moniche, F., Cabezas-Juan, A., Arenillas, J. F., Krupinksi, J., Cullell, N., Torres-Aguila, N., Muiño, E., & 56 othersCárcel-Márquez, J., Marti-Fabregas, J., Delgado-Mederos, R., Marin-Bueno, R., Hornick, A., Vives-Bauza, C., Navarro, R. D., Tur, S., Jimenez, C., Obach, V., Segura, T., Serrano-Heras, G., Chung, J. W., Roquer, J., Soriano-Tarraga, C., Giralt-Steinhauer, E., Mola-Caminal, M., Pera, J., Lapicka-Bodzioch, K., Derbisz, J., Davalos, A., Lopez-Cancio, E., Muñoz, L., Tatlisumak, T., Molina, C., Ribo, M., Bustamante, A., Sobrino, T., Castillo-Sanchez, J., Campos, F., Rodriguez-Castro, E., Arias-Rivas, S., Rodríguez-Yáñez, M., Herbosa, C., Ford, A. L., Gutierrez-Romero, A., Uribe-Pacheco, R., Arauz, A., Lopes-Cendes, I., Lowenkopf, T., Barboza, M. A., Amini, H., Stamova, B., Ander, B. P., Sharp, F. R., Moon Kim, G., Bang, O. Y., Jimenez-Conde, J., Slowik, A., Stribian, D., Tsai, E. A., Burkly, L. C., Montaner, J., Fernandez-Cadenas, I., Lee, J. M. & Cruchaga, C., Jul 1 2022, In: Brain. 145, 7, p. 2394-2406 13 p.

      Research output: Contribution to journalArticlepeer-review

      4 Scopus citations
    • Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations

      Temprano-Sagrera, G., Sitlani, C. M., Bone, W. P., Martin-Bornez, M., Voight, B. F., Morrison, A. C., Damrauer, S. M., de Vries, P. S., Smith, N. L., Sabater-Lleal, M., Dehghan, A., Heath, A. S., Morrison, A. C., Reiner, A. P., Johnson, A., Richmond, A., Peters, A., van Hylckama Vlieg, A., McKnight, B., Psaty, B. M., & 363 othersHayward, C., Ward-Caviness, C., O’Donnell, C., Chasman, D., Strachan, D. P., Tregouet, D. A., Mook-Kanamori, D., Gill, D., Thibord, F., Asselbergs, F. W., Leebeek, F. W. G., Rosendaal, F. R., Davies, G., Homuth, G., Temprano, G., Campbell, H., Taylor, H. A., Bressler, J., Huffman, J. E., Rotter, J. I., Yao, J., Wilson, J. F., Bis, J. C., Hahn, J. M., Desch, K. C., Wiggins, K. L., Raffield, L. M., Bielak, L. F., Yanek, L. R., Kleber, M. E., Mueller, M., Kavousi, M., Mangino, M., Liu, M., Brown, M. R., Conomos, M. P., Jhun, M. A., Chen, M. H., de Maat, M. P. M., Pankratz, N., Smith, N. L., Peyser, P. A., Elliot, P., Wei, P., Wild, P. S., Morange, P. E., van der Harst, P., Yang, Q., Le, N. Q., Marioni, R., Li, R., Damrauer, S. M., Cox, S. R., Trompet, S., Felix, S. B., Völker, U., Tang, W., Koenig, W., Jukema, J. W., Guo, X., Lindstrom, S., Wang, L., Smith, E. N., Gordon, W., van Hylckama Vlieg, A., de Andrade, M., Brody, J. A., Pattee, J. W., Haessler, J., Brumpton, B. M., Suchon, P., Chen, M. H., Turman, C., Germain, M., Wiggins, K. L., MacDonald, J., Braekkan, S. K., Armasu, S. M., Pankratz, N., Jackson, R. D., Nielsen, J. B., Giulianini, F., Puurunen, M. K., Ibrahim, M., Heckbert, S. R., Bammler, T. K., Frazer, K. A., McCauley, B. M., Taylor, K., Pankow, J. S., Reiner, A. P., Gabrielsen, M. E., Deleuze, J. F., O’Donnell, C. J., Kim, J., McKnight, B., Kraft, P., Hansen, J. B., Rosendaal, F. R., Heit, J. A., Psaty, B. M., Tang, W., Kooperberg, C., Hveem, K., Ridker, P. M., Morange, P. E., Johnson, A. D., Kabrhel, C., Trégouët, D. A., Smith, N. L., Malik, R., Chauhan, G., Traylor, M., Sargurupremraj, M., Okada, Y., Mishra, A., Rutten-Jacobs, L., Giese, A. K., van der Laan, S. W., Gretarsdottir, S., Anderson, C. D., Chong, M., Adams, H. H. H., Ago, T., Almgren, P., Amouyel, P., Ay, H., Bartz, T. M., Benavente, O. R., Bevan, S., Boncoraglio, G. B., Brown, R. D., Butterworth, A. S., Carrera, C., Carty, C. L., Chen, W. M., Cole, J. W., Correa, A., Cotlarciuc, I., Cruchaga, C., Danesh, J., de Bakker, P. I. W., DeStefano, A. L., den Hoed, M., Duan, Q., Engelter, S. T., Falcone, G. J., Gottesman, R. F., Grewal, R. P., Gudnason, V., Gustafsson, S., Haessler, J., Harris, T. B., Hassan, A., Havulinna, A. S., Heckbert, S. R., Holliday, E. G., Howard, G., Hsu, F. C., Hyacinth, H. I., Arfan Ikram, M., Ingelsson, E., Irvin, M. R., Jian, X., Jiménez-Conde, J., Johnson, J. A., Jukema, J. W., Kanai, M., Keene, K. L., Kissela, B. M., Kleindorfer, D. O., Kooperberg, C., Kubo, M., Lange, L. A., Langefeld, C. D., Langenberg, C., Launer, L. J., Lee, J. M., Lemmens, R., Leys, D., Lewis, C. M., Lin, W. Y., Lindgren, A. G., Lorentzen, E., Magnusson, P. K., Maguire, J., Manichaikul, A., McArdle, P. F., Meschia, J. F., Mitchell, B. D., Mosley, T. H., Nalls, M. A., Ninomiya, T., O’Donnell, M. J., Psaty, B. M., Pulit, S. L., Rannikmäe, K., Reiner, A. P., Rexrode, K. M., Rice, K., Rich, S. S., Ridker, P. M., Rost, N. S., Rothwell, P. M., Rotter, J. I., Rundek, T., Sacco, R. L., Sakaue, S., Sale, M. M., Salomaa, V., Sapkota, B. R., Schmidt, R., Schmidt, C. O., Schminke, U., Sharma, P., Slowik, A., Sudlow, C. L. M., Tanislav, C., Tatlisumak, T., Taylor, K. D., Thijs, V. N. S., Thorleifsson, G., Thorsteinsdottir, U., Tiedt, S., Trompet, S., Tzourio, C., van Duijn, C. M., Walters, M., Wareham, N. J., Wassertheil-Smoller, S., Wilson, J. G., Wiggins, K. L., Yang, Q., Yusuf, S., Amin, N., Aparicio, H. S., Arnett, D. K., Attia, J., Beiser, A. S., Berr, C., Buring, J. E., Bustamante, M., Caso, V., Cheng, Y. C., Hoan Choi, S., Chowhan, A., Cullell, N., Dartigues, J. F., Delavaran, H., Delgado, P., Dörr, M., Engström, G., Ford, I., Gurpreet, W. S., Hamsten, A., Heitsch, L., Hozawa, A., Ibanez, L., Ilinca, A., Ingelsson, M., Iwasaki, M., Jackson, R. D., Jood, K., Jousilahti, P., Kaffashian, S., Kalra, L., Kamouchi, M., Kitazono, T., Kjartansson, O., Kloss, M., Koudstaal, P. J., Krupinski, J., Labovitz, D. L., Laurie, C. C., Levi, C. R., Li, L., Lind, L., Lindgren, C. M., Lioutas, V., Mei Liu, Y., Lopez, O. L., Makoto, H., Martinez-Majander, N., Matsuda, K., Minegishi, N., Montaner, J., Morris, A. P., Muiño, E., Müller-Nurasyid, M., Norrving, B., Ogishima, S., Parati, E. A., Reddy Peddareddygari, L., Pedersen, N. L., Pera, J., Perola, M., Pezzini, A., Pileggi, S., Rabionet, R., Riba-Llena, I., Ribasés, M., Romero, J. R., Roquer, J., Rudd, A. G., Sarin, A. P., Sarju, R., Sarnowski, C., Sasaki, M., Satizabal, C. L., Satoh, M., Sattar, N., Sawada, N., Sibolt, G., Sigurdsson, Á., Smith, A., Sobue, K., Soriano-Tárraga, C., Stanne, T., Colin Stine, O., Stott, D. J., Strauch, K., Takai, T., Tanaka, H., Tanno, K., Teumer, A., Tomppo, L., Torres-Aguila, N. P., Touze, E., Tsugane, S., Uitterlinden, A. G., Valdimarsson, E. M., van der Lee, S. J., Völzke, H., Wakai, K., Weir, D., Williams, S. R., Wolfe, C. D. A., Wong, Q., Xu, H., Yamaji, T., Sanghera, D. K., Melander, O., Jern, C., Strbian, D., Fernandez-Cadenas, I., Longstreth, W. T., Rolfs, A., Hata, J., Woo, D., Rosand, J., Pare, G., Hopewell, J. C., Saleheen, D., Stefansson, K., Worrall, B. B., Kittner, S. J., Seshadri, S., Fornage, M., Markus, H. S., Howson, J. M. M., Kamatani, Y., Debette, S. & Dichgans, M., Jun 1 2022, In: Journal of Thrombosis and Haemostasis. 20, 6, p. 1331-1349 19 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • Performance of Automated RAPID Intracranial Hemorrhage Detection in Real-World Practice: A Single-Institution Experience

      Eldaya, R. W., Kansagra, A. P., Zei, M., Mason, E., Holder, D., Heitsch, L., Vo, K. D. & Goyal, M. S., Sep 1 2022, In: Journal of computer assisted tomography. 46, 5, p. 770-774 5 p.

      Research output: Contribution to journalArticlepeer-review

    • Sex-specific lesion pattern of functional outcomes after stroke

      Bonkhoff, A. K., Bretzner, M., Hong, S., Schirmer, M. D., Cohen, A., Regenhardt, R. W., Donahue, K. L., Nardin, M. J., Dalca, A. V., Giese, A. K., Etherton, M. R., Hancock, B. L., Mocking, S. J. T., McIntosh, E. C., Attia, J., Benavente, O. R., Bevan, S., Cole, J. W., Donatti, A., Griessenauer, C. J., & 38 othersHeitsch, L., Holmegaard, L., Jood, K., Jimenez-Conde, J., Kittner, S. J., Lemmens, R., Levi, C. R., McDonough, C. W., Meschia, J. F., Phuah, C. L., Rolfs, A., Ropele, S., Rosand, J., Roquer, J., Rundek, T., Sacco, R. L., Schmidt, R., Sharma, P., Slowik, A., Söderholm, M., Sousa, A., Stanne, T. M., Strbian, D., Tatlisumak, T., Thijs, V., Vagal, A., Wasselius, J., Woo, D., Zand, R., McArdle, P. F., Worrall, B. B., Jern, C., Lindgren, A. G., Maguire, J., Fox, M. D., Bzdok, D., Wu, O. & Rost, N. S., 2022, In: Brain Communications. 4, 2, fcac020.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      4 Scopus citations
    • 2021

      Early Neurological Change After Ischemic Stroke Is Associated With 90-Day Outcome

      Heitsch, L., Ibanez, L., Carrera, C., Binkley, M. M., Strbian, D., Tatlisumak, T., Bustamante, A., Ribó, M., Molina, C., Dávalos, A., López-Cancio, E., Muñoz-Narbona, L., Soriano-Tárraga, C., Giralt-Steinhauer, E., Obach, V., Slowik, A., Pera, J., Lapicka-Bodzioch, K., Derbisz, J., Sobrino, T., & 30 othersCastillo, J., Campos, F., Rodríguez-Castro, E., Arias-Rivas, S., Segura, T., Serrano-Heras, G., Vives-Bauza, C., Díaz-Navarro, R., Tur, S., Jimenez, C., Martí-Fàbregas, J., Delgado-Mederos, R., Arenillas, J., Krupinski, J., Cullell, N., Torres-Aguila, N. P., Muiño, E., Cárcel-Márquez, J., Moniche, F., Cabezas, J. A., Ford, A. L., Dhar, R., Roquer, J., Khatri, P., Jiménez-Conde, J., Fernandez-Cadenas, I., Montaner, J., Rosand, J., Cruchaga, C. & Lee, J. M., Jan 1 2021, In: Stroke. 52, 1, p. 132-141 10 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      22 Scopus citations
    • Excessive White Matter Hyperintensity Increases Susceptibility to Poor Functional Outcomes After Acute Ischemic Stroke

      The MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium, Sep 10 2021, In: Frontiers in Neurology. 12, 700616.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      4 Scopus citations
    • Hemispheric CSF volume ratio quantifies progression and severity of cerebral edema after acute hemispheric stroke

      Dhar, R., Hamzehloo, A., Kumar, A., Chen, Y., He, J., Heitsch, L., Slowik, A., Strbian, D. & Lee, J. M., Nov 2021, In: Journal of Cerebral Blood Flow and Metabolism. 41, 11, p. 2907-2915 9 p.

      Research output: Contribution to journalArticlepeer-review

      4 Scopus citations
    • MRI Radiomic Signature of White Matter Hyperintensities Is Associated With Clinical Phenotypes

      the MRI-GENIE GISCOME Investigators the International and Stroke Genetics Consortium, Jul 12 2021, In: Frontiers in Neuroscience. 15, 691244.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      5 Scopus citations
    • Outcome after acute ischemic stroke is linked to sex-specific lesion patterns

      MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium, Dec 1 2021, In: Nature communications. 12, 1, 3289.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      24 Scopus citations
    • Rp11-362k2.2:Rp11-767i20.1 genetic variation is associated with post-reperfusion therapy parenchymal hematoma. a gwas meta-analysis

      International Stroke Genetic Consortium & Spanish Stroke Genetic Consortium, Jul 2 2021, In: Journal of Clinical Medicine. 10, 14, 3137.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      4 Scopus citations
    • Single nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma

      The International Stroke Genetic Consortium and the Spanish Stroke Genetic Consortium, Aug 1 2021, In: Brain. 144, 8, p. 2416-2426 11 p.

      Research output: Contribution to journalArticlepeer-review

      7 Scopus citations
    • 2020

      Brain Volume: An Important Determinant of Functional Outcome After Acute Ischemic Stroke

      MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium, May 2020, In: Mayo Clinic Proceedings. 95, 5, p. 955-965 11 p.

      Research output: Contribution to journalArticlepeer-review

      8 Scopus citations
    • Quantitative Serial CT Imaging-Derived Features Improve Prediction of Malignant Cerebral Edema after Ischemic Stroke

      Foroushani, H. M., Hamzehloo, A., Kumar, A., Chen, Y., Heitsch, L., Slowik, A., Strbian, D., Lee, J. M., Marcus, D. S. & Dhar, R., Dec 2020, In: Neurocritical Care. 33, 3, p. 785-792 8 p.

      Research output: Contribution to journalArticlepeer-review

      11 Scopus citations
    • Reduction in Cerebrospinal Fluid Volume as an Early Quantitative Biomarker of Cerebral Edema after Ischemic Stroke

      Dhar, R., Chen, Y., Hamzehloo, A., Kumar, A., Heitsch, L., He, J., Chen, L., Slowik, A., Strbian, D. & Lee, J. M., Feb 1 2020, In: Stroke. p. 462-467 6 p.

      Research output: Contribution to journalArticlepeer-review

      18 Scopus citations
    • 2019

      Genome-wide association study of white blood cell counts in patients with ischemic stroke

      Torres-Aguila, N. P., Carrera, C., Giese, A. K., Cullell, N., Muiño, E., Cárcel-Márquez, J., Gallego-Fabrega, C., González-Sánchez, J., Del Mar Freijo, M., Álvarez-Sabín, J., Molina, C., Ribó, M., Jimenez-Conde, J., Roquer, J., Sobrino, T., Campos, F., Castillo, J., Muñoz-Narbona, L., Lopez-Cancio, E., Dàvalos, A., & 15 othersDiaz-Navarro, R., Tur, S., Vives-Bauza, C., Serrano-Heras, G., Segura, T., Krupinski, J., Delgado-Mederos, R., Martí-Fàbregas, J., Heitsch, L., Ibañez, L., Cruchaga, C., Rost, N. S., Montaner, J., Lee, J. M. & Fernandez-Cadenas, I., Dec 1 2019, In: Stroke. 50, 12, p. 3618-3621 4 p.

      Research output: Contribution to journalArticlepeer-review

      6 Scopus citations
    • Overlap in the Genetic Architecture of Stroke Risk, Early Neurological Changes, and Cardiovascular Risk Factors

      International Stroke Genetics Consortium and the MEGASTROKE Consortium, 2019, In: Stroke. 50, 6, p. 1339-1345 7 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      12 Scopus citations
    • PATJ Low Frequency Variants Are Associated with Worse Ischemic Stroke Functional Outcome: A Genome-Wide Meta-Analysis

      Mola-Caminal, M., Carrera, C., Soriano-Tárraga, C., Giralt-Steinhauer, E., Díaz-Navarro, R. M., Tur, S., Jiménez, C., Medina-Dols, A., Cullell, N., Torres-Aguila, N. P., Muiño, E., Rodríguez-Campello, A., Ois, A., Cuadrado-Godia, E., Vivanco-Hidalgo, R. M., Hernandez-Guillamon, M., Solé, M., Delgado, P., Bustamante, A., García-Berrocoso, T., & 45 othersMendióroz, M., Castellanos, M., Serena, J., Martí-Fàbregas, J., Segura, T., Serrano-Heras, G., Obach, V., Ribó, M., Molina, C. A., Alvarez-Sabín, J., Palomeras, E., Freijo, M., Font, M. A., Rosand, J., Rost, N. S., Gallego-Fabrega, C., Lee, J. M., Heitsch, L., Ibanez, L., Cruchaga, C., Phuah, C. L., Lemmens, R., Thijs, V., Lindgren, A., Maguire, J., Rannikmae, K., Sudlow, C. L., Jern, C., Stanne, T. M., Lorentzen, E., Muñoz-Narbona, L., Dávalos, A., López-Cancio, E., Worrall, B. B., Woo, D., Kittner, S. J., Mitchell, B. D., Montaner, J., Roquer, J., Krupinski, J., Estivill, X., Rabionet, R., Vives-Bauzá, C., Fernández-Cadenas, I. & Jimenez-Conde, J., Jan 4 2019, In: Circulation research. 124, 1, p. 114-120 7 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      29 Scopus citations
    • Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study

      Larsson, S. C., Traylor, M., Burgess, S., Boncoraglio, G. B., Jern, C., Michaëlsson, K., Markus, H. S., Malik, R., Chauhan, G., Sargurupremraj, M., Okada, Y., Mishra, A., Rutten-Jacobs, L., Giese, A. K., Van Der Laan, S. W., Gretarsdottir, S., Anderson, C. D., Chong, M., Adams, H. H. H., Ago, T., & 237 othersAlmgren, P., Amouyel, P., Ay, H., Bartz, R. M., Benavente, O. R., Bevan, S., Brown, R. D., Butterworth, A. S., Carrera, C., Carty, C. L., Chasman, D. I., Chen, W. M., Cole, J. W., Correa, A., Cotlarciuc, I., Cruchaga, C., Danesh, J., De Bakker, P. I. W., Destefano, A. L., Hoed, M. D., Duan, Q., Engelter, S. T., Falcone, G. J., Gottesman, R. F., Grewal, R. P., Gudnason, V., Gustafsson, S., Haessler, J., Harris, T. B., Hassan, A., Havulinna, A. S., Heckbert, S. R., Holliday, E. G., Howard, G., Hsu, F. C., Hyacinth, H. I., Ikram, M. A., Ingelsson, E., Irvin, M. R., Jian, X., Jiménez-Conde, J., Johnson, J. A., Jukema, J. W., Kanai, M., Keene, K. L., Kissela, B. M., Kleindorfer, D. O., Kooperberg, C., Kubo, M., Lange, L. A., Langefeld, C. D., Langenberg, C., Launer, L. J., Lee, J. M., Lemmens, R., Leys, D., Lewis, C. M., Lin, W. Y., Lindgren, A. G., Lorentzen, E., Magnusson, P. K., Maguire, J., Manichaikul, A., McArdle, P. F., Meschia, J. F., Mitchell, B. D., Mosley, T. H., Nalls, M. A., Ninomiya, T., O'Donnell, M. J., Psaty, B. M., Pulit, S. L., Rannikmäe, K., Reiner, A. P., Rexrode, K. M., Rice, K., Rich, S. S., Ridker, P. M., Rost, N. S., Rothwell, P. M., Rotter, J. I., Rundek, T., Sacco, R. L., Sakaue, S., Sale, M. M., Salomaa, V., Sapkota, B. R., Schmidt, R., Schmidt, C. O., Schminke, U., Sharma, P., Slowik, A., Sudlow, C. L. M., Tanislav, C., Tatlisumak, T., Taylor, K. D., Thijs, V. N. S., Thorleifsson, G., Thorsteinsdottir, U., Tiedt, S., Trompet, S., Tzourio, C., Van Duijn, C. M., Walters, M., Wareham, N. J., Wassertheil-Smoller, S., Wilson, J. G., Wiggins, K. L., Yang, Q., Yusuf, S., Amin, N., Aparicio, H. S., Arnett, D. K., Attia, J., Beiser, A. S., Berr, C., Buring, J. E., Bustamante, M., Caso, V., Cheng, Y. C., Choi, S. H., Chowhan, A., Cullell, N., Dartigues, J. F., Delavaran, H., Delgado, P., Dörr, M., Engström, G., Ford, I., Gurpreet, W. S., Hamsten, A., Heitsch, L., Hozawa, A., Ibanez, L., Ilinca, A., Ingelsson, M., Iwasaki, M., Jackson, R. D., Jood, K., Jousilahti, P., Kaffashian, S., Kalra, L., Kamouchi, M., Kitazono, T., Kjartansson, O., Kloss, M., Koudstaal, P. J., Krupinski, J., Labovitz, D. L., Laurie, C. C., Levi, C. R., Li, L., Lind, L., Lindgren, C. M., Lioutas, V., Liu, Y. M., Lopez, O. L., Makoto, H., Martinez-Majander, N., Matsuda, K., Minegishi, N., Montaner, J., Morris, A. P., Muiño, E., Müller-Nurasyid, M., Norrving, B., Ogishima, S., Parati, E. A., Peddareddygari, L. R., Pedersen, N. L., Pera, J., Perola, M., Pezzini, A., Pileggi, S., Rabionet, R., Riba-Llena, I., Ribasés, M., Romero, J. R., Roquer, J., Rudd, A. G., Sarin, A. P., Sarju, R., Sarnowski, C., Sasaki, M., Satizabal, C. L., Satoh, M., Sattar, N., Sawada, N., Sibolt, G., Sigurdsson, Á., Smith, A., Sobue, K., Soriano-Tárraga, C., Stanne, T., Stine, O. C., Stott, D. J., Strauch, K., Takai, T., Tanaka, H., Tanno, K., Teumer, A., Tomppo, L., Torres-Aguila, N. P., Touze, E., Tsugane, S., Uitterlinden, A. G., Valdimarsson, E. M., Van Der Lee, S. J., Völzke, H., Wakai, K., Weir, D., Williams, S. R., Wolfe, C. D. A., Wong, Q., Xu, H., Yamaji, T., Sanghera, D. K., Melander, O., Strbian, D., Fernandez-Cadenas, I., Longstreth, W. T., Rolfs, A., Hata, J., Woo, D., Rosand, J., Pare, G., Hopewell, J. C., Saleheen, D., Stefansson, K., Worrall, B. B., Kittner, S. J., Seshadri, S., Fornage, M., Howson, J. M. M., Kamatani, Y., Debette, S. & Dichgans, M., Feb 26 2019, In: Neurology. 92, 9, p. E944-E950

      Research output: Contribution to journalArticlepeer-review

      Open Access
      31 Scopus citations
    • The Extended Treatment Window's Impact on Emergency Systems of Care for Acute Stroke

      Miller, J. B., Heitsch, L., Madsen, T. E., Oostema, J., Reeves, M., Zammit, C. G., Sabagha, N., Sozener, C., Lewandowski, C. & Schrock, J. W., Jul 2019, In: Academic Emergency Medicine. 26, 7, p. 744-751 8 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      6 Scopus citations
    • Validation of a clinical-genetics score to predict hemorrhagic transformations after rtPA

      Spanish Stroke Genetic Consortium, Aug 27 2019, In: Neurology. 93, 9, p. e851-e863

      Research output: Contribution to journalArticlepeer-review

      8 Scopus citations
    • 2018
      Open Access
      165 Scopus citations
    • Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

      Neurology Working Group of the CHARGE Consortium, NINDS Stroke Genetics Network (SiGN), UK Young Lacunar DNA Study, MEGAST ROKE Consortium, AFGen Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, International Genomics of Blood Pressure (iGEN-BP) Consortium, INVENT Consortium, STA RNET BioBank Japan Cooperative Hospital Group, COMPASS Consortium, EPIC-CVD Consortium, EPIC-InterAct Consortium, International Stroke Genetics Consortium (ISGC) & METAST ROKE Consortium, Apr 1 2018, In: Nature Genetics. 50, 4, p. 524-537 14 p.

      Research output: Contribution to journalArticlepeer-review

      601 Scopus citations
    • 2017

      Genetic variation at 16q24.2 is associated with small vessel stroke

      on behalf of the International Stroke Genetics Consortium & METASTROKE, UK Young Lacunar DNA Study, NINDS Stroke Genetics Network, Neurology Working Group of the CHARGE Consortium, Mar 1 2017, In: Annals of neurology. 81, 3, p. 383-394 12 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      55 Scopus citations
    • 2016

      Automated quantification of cerebral edema following hemispheric infarction: Application of a machine-learning algorithm to evaluate CSF shifts on serial head CTs

      Chen, Y., Dhar, R., Heitsch, L., Ford, A., Fernandez-Cadenas, I., Carrera, C., Montaner, J., Lin, W., Shen, D., An, H. & Lee, J. M., 2016, In: NeuroImage: Clinical. 12, p. 673-680 8 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      44 Scopus citations
    • CSF Volumetric Analysis for Quantification of Cerebral Edema After Hemispheric Infarction

      Dhar, R., Yuan, K., Kulik, T., Chen, Y., Heitsch, L., An, H., Ford, A. & Lee, J. M., Jun 1 2016, In: Neurocritical Care. 24, 3, p. 420-427 8 p.

      Research output: Contribution to journalArticlepeer-review

      25 Scopus citations
    • Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

      Deming, Y., Xia, J., Cai, Y., Lord, J., Del-Aguila, J. L., Fernandez, M. V., Carrell, D., Black, K., Budde, J., Ma, S., Saef, B., Howells, B., Bertelsen, S., Bailey, M., Ridge, P. G., Holtzman, D., Morris, J. C., Bales, K., Pickering, E. H., Lee, J. M., & 5 othersHeitsch, L., Kauwe, J., Goate, A., Piccio, L. & Cruchaga, C., Jan 4 2016, In: Scientific reports. 6, 18092.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      17 Scopus citations
    • Streamlined hyperacute magnetic resonance imaging protocol identifies tissue-type plasminogen activator-eligible stroke patients when clinical impression is stroke mimic

      Goyal, M. S., Hoff, B. G., Williams, J., Khoury, N., Wiesehan, R., Heitsch, L., Panagos, P., Vo, K. D., Benzinger, T., Derdeyn, C. P., Lee, J. M. & Ford, A. L., 2016, In: Stroke. 47, 4, p. 1012-1017 6 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      20 Scopus citations
    • Systematic Molecular Phenotyping: A Path Toward Precision Emergency Medicine?

      Limkakeng, A. T., Monte, A. A., Kabrhel, C., Puskarich, M., Heitsch, L., Tsalik, E. L. & Shapiro, N. I., Oct 1 2016, In: Academic Emergency Medicine. 23, 10, p. 1097-1106 10 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      9 Scopus citations
    • 2014

      Accuracy of emergency medical services-reported last known normal times in patients suspected with acute stroke

      Curfman, D., Connor, L. T., Moy, H. P., Heitsch, L., Panagos, P., Lee, J. M., Tan, D. K. & Ford, A. L., May 2014, In: Stroke. 45, 5, p. 1275-1279 5 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      8 Scopus citations
    • Degradation of benzodiazepines after 120 days of EMS deployment

      Neurological Emergencies Treatment Trials investigators, Jul 1 2014, In: Prehospital Emergency Care. 18, 3, p. 368-374 7 p.

      Research output: Contribution to journalArticlepeer-review

      13 Scopus citations
    • 2013

      Profiles of the national institutes of health stroke scale items as a predictor of patient outcome

      Sucharew, H., Khoury, J., Moomaw, C. J., Alwell, K., Kissela, B. M., Belagaje, S., Adeoye, O., Khatri, P., Woo, D., Flaherty, M. L., Ferioli, S., Heitsch, L., Broderick, J. P. & Kleindorfer, D., Aug 2013, In: Stroke. 44, 8, p. 2182-2187 6 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      29 Scopus citations
    • 2010

      How much would performing diffusion-weighted imaging for all transient ischemic attacks increase MRI utilization?

      Adeoye, O., Heitsch, L., Moomaw, C. J., Alwell, K., Khoury, J., Woo, D., Flaherty, M. L., Ferioli, S., Khatri, P., Broderick, J. P., Kissela, B. M. & Kleindorfer, D., Oct 2010, In: Stroke. 41, 10, p. 2218-2222 5 p.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      13 Scopus citations