Personal profile
Research interests
The primary focus of her research is the investigation of the genetic studies of psychiatric illnesses and nicotine and substance dependence, specifically the interplay between nicotine, alcohol, cocaine and other substance dependence, and psychiatric disorders. A recent project is a collaborative multisite study to perform a genome wide association of nicotine dependence using SNPs. This project is being performed in collaboration with Perlegen Sciences, Inc. and will examine 2.2 million SNPs in pooled cases and controls and follow up the most significant 40,000 SNPs with individual genotyping. In addition, 4,000 SNPs in candidate genes will be genotyped.
Clinical interests
Molecular biology, bipolar illness, genetics, genetic analysis, nicotine, marijuana, cocaine, alcohol dependence, smoking, substance dependence, substance abuse, major depressive disorder, alcoholism, depression, family studies
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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Large-scale blood pressure GWAS accounting for gene-depression interactions in 564,680 individuals from diverse populations
Lee, S., Miller, C. L., Bentley, A. R., Brown, M. R., Nagarajan, P., Noordam, R., Morrison, J. L., Schwander, K., Westerman, K., Kho, M., Kraja, A. T., de Vries, P. S., Ammous, F., Aschard, H., Bartz, T. M., Do, A., Dupont, C. T., Feitosa, M. F., Gudmundsdottir, V. & Guo, X. & 129 others, , Apr 9 2026, In: Human Genetics and Genomics Advances. 7, 2, 100566.Research output: Contribution to journal › Article › peer-review
Open Access -
Mapping the genetic landscape across 14 psychiatric disorders
Nicotine Dependence GenOmics (iNDiGO) Consortium, Obsessive-Compulsive Disorder and Tourette Syndrome Working Group of the Psychiatric Genomics Consortium, Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, Anxiety Disorders Working Group of the Psychiatric Genomics Consortium, Attention-Deficit/Hyperactivity Disorder (ADHD) Working Group of the Psychiatric Genomics Consortium, Autism Spectrum Disorders Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Eating Disorders Working Group of the Psychiatric Genomics Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Jan 8 2026, In: Nature. 649, 8096, p. 406-415 10 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Link opens in a new tab Scopus citations -
The relationship between alcohol use disorder, measures of cognitive decline, and Alzheimer disease biomarkers in middle aged and older adults
Hayibor, L. A., Anokhin, A., Fisher, S. L., Goate, A., Foroud, T. M., Schindler, S. E., Bierut, L. J. & Hartz, S. M., Apr 2026, In: Alcohol: Clinical and Experimental Research. 50, 4, e70278.Research output: Contribution to journal › Article › peer-review
Open Access -
Trajectories of genetic risk across dimensions of alcohol use behaviors
COGA Investigators & Spit for Science Working Group, May 2026, In: Addiction. 121, 5, p. 1153-1165 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Attitudes regarding polygenic risk testing for lung cancer: a mixed-methods study
Badr, H., Byun, J., Aldrich, M. C., Bierut, L. J., Chen, L. S., Hung, R. J. & Amos, C. I., Jan 1 2025, In: Annals of Behavioral Medicine. 59, 1, kaaf020.Research output: Contribution to journal › Article › peer-review
Open Access